• 한국환경생태학회지
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• 제25권6호
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• pp.861-866
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• 2011

우리는 제주도 대정읍에서 뼈나이테법(skeletochronology)을 사용하여 맹꽁이(Kaloula borealis)의 나이구조를 알아보았다. 조사는 번식기인 2009년 6월에 실시하였다. 측정된 개체수는 수컷이 38개체, 암컷이 58개체로 각 개체의 SVL(snout-vent length)과 체중을 측정하고 나이구조를 분석하였다. 수컷의 평균 SVL은 $43.69{\pm}3.44 mm$이며, 암컷은 $46.32{\pm}4.23mm$로 나타나고 있다. 첫 번식에 참여하는 수컷은 2살이고, 암컷은 3살로 나타났다. 가장 나이든 수컷은 8살이며 암컷은 10살이다. 그러므로 이 종의 수명은 수컷에서는 8살, 암컷에서는 10살 이상으로 볼 수 있으며 암수의 수명에서 암컷이 더 오래살고 있다. 또한 이 값은 통계적으로도 유의미하게 나타나고 있다. 성장곡선은 von Bertalanffy growth model을 사용하였으며, 성장계수(K)는 수컷이 0.56이며 암컷은 0.41이다. 최대성장크기는 수컷이 46.41 mm이며 암컷은 50.22 mm로 나타났다.

• 구강회복응용과학지
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• 제28권4호
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• pp.359-370
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• 2012

근관 치료가 시행된 치아의 상당수는 많은 치질의 상실로 인하여 통상적으로 치수관 내에 포스트를 세워 유지를 얻고 코어를 제작하여 최종 보철물을 제작하는 방법으로 치료되고 있다. 포스트와 코어를 이용한 고정성 보철물의 장기적 예후를 보장하고자 하는 많은 노력에도 불구하고, 임상에서는 다양한 합병증이 관찰되고 있다. 이에 본 연구에서는 근관 치료를 받고 포스트와 코어를 시행한 치아에 제작된 고정성 보철물의 임상적 상태를 조사하여 보철 진료의 임상적 참고 자료와 연구의 기초 자료로 도움이 되고자 하였다. 1990년에서 2005년까지 부산대학교병원 치과 보철과에 내원한 환자 중 근관 치료 후 포스트와 코어를 시행하고 고정성 보철물을 치료 받은 환자를 대상으로 고정성 보철물에 연관된 임상적 상태를 조사 평가하여 다음과 같은 결과를 얻었다. 1. 전체 고정성 보철물의 추정 수명은 11.1년이었고, 평균 장착 기간은 $9.7{\pm}3.4$년이었다. 2. 나이와 성별에 따른 수명의 차이는 나타나지 않았다 (P>.05). 3. 악골에 따른 수명의 차이는 나타나지 않았으나 (P>.05), 전후방 위치에서는 전치부에서 수명이 가장 길었고 구치부, 견치를 포함하는 보철물 순으로 수명이 짧았다 (P<.05). 4. 포스트의 재료 및 방법과 고정성 보철물의 종류는 보철물의 수명에 영향을 미치지 않았으나 (P>.05), 보철물의 재료는 수명에 영향을 미쳤다(P<.05). 5. 고정성 보철물의 크기는 보철물의 수명에 영향을 미치지 않았다 (P>.05). 6. 대합치 조건별 고정성 보철물의 수명은 차이가 없었다 (P>.05). 7. 고정성 보철물의 합병증은 치아 우식증 (34.5%), 치주 질환 (25.9%), 치아 파절 (15.5%), 치수 질환 (12.1%) 순이었다. 보철물을 제거한 후 잔존 치질은 51.9%가 수복 불가능한 상태였다.

• 한국응용곤충학회지
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• 제55권2호
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• pp.149-160
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• 2016

기장테두리진딧물의 온도의존적 발육과 산자(산란) 특성을 구명하기 위하여 6개의 항온조건(10, 15, 20, 25, 30, $35{\pm}1.0^{\circ}C$, RH 50~70%, 16L:8D)에서 실험을 실시하였다. 약충의 발육기간은 $10^{\circ}C$에서 42.9일과 $30^{\circ}C$에서 4.7일로 온도가 증가할수록 발육기간이 감소하였다. 약충은 $35^{\circ}C$에서 2영기 이후 성충까지 발육하지 못하였다. 선형모형 결과 약충의 발육영점온도는 $8.3^{\circ}C$, 발육 유효적산온도는 101.6DD 이었다. 약충 발육율과 온도와의 관계는 비선형 Lactin 2으로 잘 설명되었다. 약충 발육기간의 분포는 Weibull 함수를 이용하여 분석하였다. 성충수명은 온도가 증가함에 따라 감소하였는데, $15^{\circ}C$에서 24.0일, $30^{\circ}C$에서 4.3일의 범위에 있었고, $10^{\circ}C$에서 비정상적으로 수명이 짧았다 (11.1일). 총산자수는 $20^{\circ}C$에서 38.2마리로 최대값을 보였고, $10^{\circ}C$에서 3.4마리로 최소값을 나타냈다. 본 실험의 결과를 통하여 무시 성충의 산자모형을 작성할 수 있는 온도별 총산자수 모형, 연령별 누적생존율 모형, 연령별 누적 산자율 모형 및 생리적 연령 계산을 위한 성충 노화율 모형을 제시하였다.

• 한국인구학
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• 제14권1호
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• pp.35-46
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• 1991

Improvements in various health indices have been ushered in, along with soaring economic growth in the last few decades in Korea. Life span of Koreans at present stands at somewhere around age of seventies. It seems of worth to elucidate some facets of health profile of historic Koreans during Yi dynasty encompassing about five hundreds years between the 14th and 19th century. Datas on health of historic Koreans are meager with exception for sovereigns for whom royal archives have been preserved intact through centuries. Though the health environments for monarchs are, no doubt, incomparable to that of the grassroot levels during the same period, health profile of monarchs would facilitate to assess health indices for historic Koreans during Yi dynasty. Arithmetic average of life span of 25 consecutive Kings(omitted the last two Kings under Japanese control) is 44.6 years of age 81 year old for King Yongjo and 16 year old for King Danjong, representing two extremes. The principal causes of death are septicemia, subsequent to infections of soft tissue and ether organs(8 in number, one-thirds of all). Secondly, both epidemic disease and vascular accidents caused deaths of three Kings each. Two kings succumbed to diabets and one suicide. The causes for the remainder, eight kings are hardly ciarified. The monarchs who contributed in establishment of new Yi dynasty with highspirited and disciplined survied beyond their fifties and sixties. In contrast, those who reigned during mid - era of the dynasty at its culmination succumbed to death in their young adulthood, most likely due to their indulgence in court life.

• BMB Reports
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• 제52권1호
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• pp.24-34
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• 2019

Sirtuin is an essential factor that delays cellular senescence and extends the organismal lifespan through the regulation of diverse cellular processes. Suppression of cellular senescence by Sirtuin is mainly mediated through delaying the age-related telomere attrition, sustaining genome integrity and promotion of DNA damage repair. In addition, Sirtuin modulates the organismal lifespan by interacting with several lifespan regulating signaling pathways including insulin/IGF-1 signaling pathway, AMP-activated protein kinase, and forkhead box O. Although still controversial, it is suggested that the prolongevity effect of Sirtuin is dependent with the level of and with the tissue expression of Sirtuin. Since Sirtuin is also believed to mediate the prolongevity effect of calorie restriction, activators of Sirtuin have attracted the attention of researchers to develop therapeutics for age-related diseases. Resveratrol, a phytochemical rich in the skin of red grapes and wine, has been actively investigated to activate Sirtuin activity with consequent beneficial effects on aging. This article reviews the evidences and controversies regarding the roles of Sirtuin on cellular senescence and lifespan extension, and summarizes the activators of Sirtuin including Sirtuin-activating compounds and compounds that increase the cellular level of nicotinamide dinucleotide.

• Journal of Ginseng Research
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• 제41권3호
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• pp.277-283
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• 2017

Background: The ginseng berry has various bioactivities, including antidiabetic, anticancer, antiinflammatory, and antioxidative properties. Moreover, we have revealed that the active antiaging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis, and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to antiaging. Methods: The human melanoma MNT1 cell line was treated with ginseng root extract, ginseng berry extract, or syringaresinol. Then, the cells were analyzed using a melanin assay, and the tyrosinase activity was estimated. The Caenorhabditis elegans wild type N2 strain was used for the life span assay to analyze the antiaging effects of the samples. A lipofuscin fluorescence assay was performed during 10 passages with the syringaresinol treatment. Results: A 7-d treatment with ginseng berry extract reduced melanin accumulation and tyrosinase activity more than ginseng root extract. These results may be due to the active compound of the ginseng berry, syringaresinol. The antimelanogenic activity was strongly coordinated with the activation of the longevity gene foxo3a. Moreover, the ginseng berry extract had more potent antiaging effects, caused a life span extension, and reduced lipofuscin accumulation. Conclusion: Taken together, our results suggest that these antimelanogenic effects and antiaging effects of ginseng berry mediate the activation of antioxidation-FoxO3a signaling.

• 한국간호교육학회지
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• 제15권2호
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• pp.241-250
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• 2009

Purpose: The purpose of this study was to investigate the relationship of stress, perceived health status and Yangsaeng in Korean part-time college students. Yangsaeng is a traditional health care regimen that incorporates specific principles and methods to promote health and prevent illness, with the aim of improving the health and longevity of life. Method: The subjects of this study were 158 part-time college students in Korea. Data were collected by using a self-reported questionnaire on-line. Analysis of data included descriptive statistics, Pearson's correlation coefficient, t-test, ANOVA and Cronbach's $\alpha$. Result: Statistically significant differences were evident in stress according to age, spouse, job, and income. Statistically significant differences were evident in perceived health status according to gender and job. Statistically significant differences were evident in Yangsaeng according to age, job, and income. Yangsaeng positively related to perceived health status and negatively related to stress. Conclusion: The Yangsaeng oriental health care regimen could lower stress levels and maintain a good health perception. Therefore, Yangsaeng could be recommended as a means of health promotion in Korean part-time college students.

• 대한한의학원전학회지
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• 제26권1호
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• pp.1-15
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• 2013

Objective : We tried to seek for conflicts of views among the contents in Sasang Constitutional Medicine and Traditional Medicine based on Huangdi's Internal Classic, and to study about the Range of Lee Je-Ma's Works, therefore finding out the limit of Sasang Constitutional Medicine in view of learning contents and practice of theory. Method : Through the texts of Longevity and Life Preservation in Eastern Medicine, such subjects will be investigated as Lee Je-Ma(李濟馬)'s comments on Huangdi's Internal Classic and views on the herbal medicine, the relations among five viscera(五臟), taeguk(太極), four-constitution(四象), etc. Result : Lee Je-Ma's Sasang Constitutional Medicine does not goes well in harmony with the traditional physiology which is based on the functional five zang system developed in Huangdi's Internal Classic, and is hard to understand because of its four division method rooted in confucius academy. Conclusion : Lee Je-Ma's view of medicine is one of the practical and valuable parts of Korean Medicine, however, its extreme four-division structure theory could be difficult to be accepted as its whole form. This is because he studied himself as a confucian, so that his work might rather be confucian than medical. When he fully devoted himself to Sasang Constitutional Medicine, he already took his age much.

• Natural Product Sciences
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• 제22권3호
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• pp.201-208
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• 2016

Here in this study, we investigated the lifespan-extending effect and underlying mechanism of methanolic extract of Moringa olelifa leaves (MML) using Caenorhabditis elegans (C. elegans) model system. To define the longevity properties of MML we conducted lifespan assay and MML showed significant increase in lifespan under normal culture condition. In addition, MML elevated stress tolerance of C. elegans to endure against thermal, oxidative and osmotic stress conditions. Our data also revealed that increased activities of antioxidant enzymes and expressions of stress resistance proteins were attributed to MML-mediated enhanced stress resistance. We further investigated the involvement of MML on the aging-related factors such as growth, food intake, fertility, and motility. Interestingly, MML significantly reduced growth and egg-laying, suggesting these factors were closely linked with MML-mediated longevity. We also observed the movement of aged worms to estimate the effects of MML on the health span. Herein, MML efficiently elevated motility of aged worms, indicating MML may affect health span as well as lifespan. Our genetic analysis using knockout mutants showed that lifespan-extension activity of MML was interconnected with several genes such as skn-1, sir-2.1, daf-2, age-1 and daf-16. Based on these results, we could conclude that MML prolongs the lifespan of worms via activation of SKN-1 and SIR-2.1 and inhibition of insulin/IGF pathway, followed by DAF-16 activation.

• 기술사
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• 제39권1호
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• pp.70-73
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• 2006

New human sense of value in Knowledge Society of 21th Century is reestablished by that it demanded new thinking for changed today's stage. Reestablishment of new human sense of value is considered by tradition and custom, and now then today's social standard due to focus. Productive human sense of value do to recreate for all round human relations and fertility human life demand it. Korea National Statistical Office(http://www.nso.go.kr-Dec 20. 2005) was officially announced it. that Korean Life Table(2003) presented the reminder of human life and roughly equation model of 'the reminder of human life' is 'Korean average longevity of human life-Present Korean age=About the reminder of human life' on the basic 2003 year. And then we will live a life worth living for our remaining day