• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.36-44
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• 2011

Objective : Propolis (PP) has been used in oriental medicine. PP has various biological activities. However, its immunoregulatory and anti-inflammatory activities have not been well studied. In this study, I investigated these activities of PP by using ovalbumin-induced allergic asthma in mice. Methods : To examine the effect of PP on allergic asthma, mice were sensitized with $100{\mu}g$ of OVA and 1mg of aluminum potasssium sulfate (Alum; Sigma) intraperitoneally on day 0 and 7. On day 14, mice were challenged on consecutive 3 days with 5% OVA and AHR was assessed 24 hours after the last challenge. To examine severity of AHR, I examined the population of eosinophiles and T cells in spleen and lung and cytokine production in T cells. Futhermore, I examined histological changes during the OVA-induced allergic asthma. Results and Conclusion : PP reduced the population of eosinophil and CD4+ T cells on the OVA-induced AHR mice model. PP also inhibited IL-4 production but increased INF-g production in T cells. These results suggest that PP may be beneficial material for allergic asthma.

• 한방안이비인후피부과학회지
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• 제12권1호
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• pp.356-368
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• 1999

The gu-chang is oriental medical disease name. This study has been carried out to investigate pathogenic factor, pathogenesis, treatment method and medicine of the gu chang by referring to literatures. The results were obtained as follows; 1. Pathogenic factors are pungent taste, stir frying, rich and fatty diet, alchol, disorder of emotion, exogenous pathogen, excessive fatigue and indulgence in sexual activities. 2. Pathogenesis of the gu chang is that the fire heat go up to the mouse. 3. The symptoms are divided into two syndrome. one is sthenia syndrome(實證) - red color and swelling, unendurable pain, strong pulse(脈實), the other is asthenia syndrome(虛症) - pink color, a slight pain, relapse, loose stool, feeble pulse(脈虛). 4. The treatment method is divided into two parts. one is a sthenic syndrome (實證) - clearing strong heat (淸實熱), the other is a asthenic syndrome(虛症) - nourishing yin(滋陰) and clearing deficient heat (淸虛熱), reinforcing the spleen and strengthening middle - JIAO(健脾 補中). 5. The prescription were liang ge san(凉膈散), Ij jhong tang(理中湯) ,xie xim tang(瀉心湯), bu ja li jhong tang, (附子理中湯),liuwei wan(六味元), ba wei wan(八味元), zhuye shigao tang(竹葉石膏湯), si wu tang(四物湯), bu zhong yi gi tang(補中益氣湯) etc.

• 한방안이비인후피부과학회지
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• 제21권2호
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• pp.120-125
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• 2008

Objectives : Medication is important in treatment for children, but prescribing traditional herbal medicine for them is very difficult. The aim of this study was to evaluate the preference for new and traditional dosage form of Onchung-eum. Methods : A total of 24 children who visited Oriental Medical Center of Daegu Hanny University during one month since March 2008 were included in this study. They compared new dosage form of Onchung-eum with traditional thing and evaluated items such as taste, perfume, color, sensation of chewing and texture. Results : As a whole they prefered new dosage form more than traditional thing in a sensory test. And 13(54%) children choose new dosage form as the better one. Conclusions : Considering the above results, the new dosage form might be efficacious to be taken by children. Further studies in other methods and new dosage forms are needed to make prescribing it for children easily.

• 한방안이비인후피부과학회지
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• 제16권2호
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• pp.119-137
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• 2003

Younggaechulgam-tang has been used for treating skin diseases. In this study, I investigated the immunosuppressive effect of Younggaechul-tang in the human T cell line MOLT-4 cells. MOLT-4 cells were stimulated with the phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (PMA) + A23187. The secretion appeared to be greater when cells were stimulated with PHA than with PMA + A23187. Younggaechulgam-tang had no affect proliferation stimulated by PHA. I showed that IL-2 secretion and expression by PHA stimulated MOLT-4 cells were inhibited by Younggaechugam-tang treatment. Maximal inhibition rate of IL-2, TNF-${\alpha}$ secretion was 80$\%$ and 30$\%$, respectively. Younggaechulgam-tang also inhibited nuclear translocation of p65 subunit of nuclear factor-kB and nuclear factor of activated T cells (NFAT). In conclusion, these results suggest that Younggaechulgam-tang may contribute to the immunosuppressive oriental drug clinically.

• 한방안이비인후피부과학회지
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• 제20권2호통권33호
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• pp.230-239
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• 2007

Introduction : Atopic dermatitis is very epidermic disease in these days. Atopic dermatitis is difficult for patient to be treated because there is no specific treatment. The oriental method of atopic dermatitis is varied as patient situation and doctor's view point. The Treatise on Febrile Diseases(傷寒論) may be a hint for atopy disease. Object: Although we use various method such as acupucture, aroma therapy, a medicine for external use, we use the two decoctions in the Treatise on Febrile Diseases according to differentiation of syndromes and abdominal diagnosis. Result : After inpatient treatment in 21 days, the itching, redness, exudation, crust, lichen get better and insomnia and constipation was removed quickly. The SCORAD index is decreased from 84.2 to 25.9. Conclusion : These decoction can treat the atopic dermatitis although there is no symptom in atopy because we cure the all situation of the patient. We can cure the atopic dermatitis not only by routine remedy for various symptoms but also by diagnosis and treatment based on overall analysis of symptoms and signs.

• 한방안이비인후피부과학회지
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• 제16권2호
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• pp.46-56
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• 2003

Objects: The purpose of this thesis is to consider classification of Wibub(위법), heating method of Wibub(위법) and the diseases for which Wibub(위법) is efficacious through bibliographic basements. Methods: We bibliographically studied on Wibub(위법) through 20 existing oriental documents. Results: Summarized as follows; 1. Wibub(위법) is an external therapy of applying heated herbal powder or granules wrapped in a cloth or applying heated implements to the affected part. 2. Wibub(위법) is divided into two types. One is Yakwi(약위) which uses medicine, the other is Wibub(위법) which only uses implements. 3. The heating methods of Wibub(위법) are various. there are using directly heated medicine, using heated implement and using Naengwi(냉위) and Yeolwi(열위) in turns. 4. Wibub(위법) is efficacious for mammary disease like as acute mammaritis, mastitis, anal disease like as hemorrhoids, proctoptosis, sore, muscle disease, multiple abscess, pyogenic infection of bone, gonarthritis externally and efficacious for cold paralysis, cold limbs, vomiting with diarrhea, mass in abdomen, abdominal pain, constipation, urinary disease like as dysuria, ischuria internally. Conclusions: As the aboves. Wibub(위법) is able to be used variously in clinical cases. so we consider that it is necessary to study methods which improve practical use of Wibub(위법).

• 한방안이비인후피부과학회지
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• 제12권1호
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• pp.313-337
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• 1999

In oriental medicine, 'chi(痔)' is 'the prolapsed nodule' in 'Ku-gyu(九竅)', but in this paper, I will write about prolapsed nodule only in anus or around it, chi-jil(痔疾), it called hemorrhoid in western medicine. So in the literatual studies on chi(痔) in anus or around it, the results are as follows. 1. The etiology and pathogenesis of ch.i-jil(痔疾) is wind, wetness, dryness, and heat caused by inrregular diet habit, severe drinking and sexual action, deficiency of ki(氣) and hyeol(血). 2. Characteristic symptoms of chi-jil(痔疾) is the prolapsed nodule in the anus or around it, and general symptoms are hematochezia, pain, hernia, swelling, abcess, and mucosal secretion. 3. Chi-jil(痔疾) is classified eight types by characteristic symptom, shape, etiology and pathogenesis. They are mac-chi(脈痔), jang-chi(腸痔), ki-chi(氣痔), hyeol-chi(血痔), joo-chi(酒痔), mo-chi(牡痔), bin-chi(牡痔), and loo-chi(屢痔)(or young-chi(영痔), choong-chi(蟲痔)). Additionally, they are divided into two parts, internal and external chi-jil(痔疾), as likely as classification of internal and external hemorrhoid in western medicine. 4. Treatment of chi-jil(痔疾) is two methods, internal treatment and external treatment. Internal treatment is per os herb-pharmacotheraphy, external treatment is surgical or the other external pharmacotheraphy. There are several external treatment, these are fumigation-theraphy(熏痔法). irrigation-theraphy(洗痔法), paint-theraphy(塗痔法). withering-theraphy(枯痔法), bending-therphy(結紮法) and incisal -theraphy(切開法).

• 한방안이비인후피부과학회지
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• 제20권2호통권33호
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• pp.171-178
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• 2007

Objective : The aim of this study was to evaluate Yangdorak and D.I.T.I. for analysis of Symptom-complexes. Method : This study was selected 26 acne patients in Dongshin University Oriental Medical Hospital. We used Yangdorak (SME5800N, Sord Medicom Co., Korea) and D.I.T.I. (Digital Infrared Thermal Imaging 256, Dorex Inc, Orange CA, USA) and investigated the results of Yangdorak and D.I.T.I.. We made a comparison according to Deficiency or Excess(虛實) of acne patients. Result : In comparing Yangdorak results according to Deficiency or Excess(虛實) of acne patients, Triple-energizer(三焦), Intestine(大腸), Liver(肝), Stomach(胃) meridian in Excess group are higher than Deficiency group, and Kidney(腎) meridian in Deficiency group are lower than Excess group. D.I.T.I. reveald hyperthemia of face and chest on acne patients. The temperature of face and chest on Excess group is higher than Deficiency group. There is no statistically significant value compared with data of other group.

• 한방안이비인후피부과학회지
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• 제13권1호
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• pp.209-236
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• 2000

This study has been carried out to investigate pathogenic factor and medicine of ja-shi(자시) by referring to literatures. The results were obtained as follows. 1. In oriental medicine, Chashi(차시), Hamshichang(함시창), Hamshi(함시), Jabal(자발), Shichang(시창), Nojaon(로자온), Hamaon(하마온), Jokshiong(적시옹), Hamshidok(함사독), Tabshijong(탑사종), Shijong(시종) were the other names of ja-shi(자시). 2. The pathogenic factors of ja-shi(자시) are wind-heat, wetness-heat, Kihyeolungche(기혈응체), stomach-heat. wetness, wind wetness, and liking greasy and sweet food. 3. In the internal therapy of ja-shi(자시), Bojesodokum(普濟消毒飮), Sasunchunglyangum(四順淸凉飮), Takljsodoksan(托裏消毒散), Shihogalguntang(柴胡葛根湯), Sungsohwan(醒消丸), Gamisodokum(加味消毒飮) and etc. were used. And Radix glycyrrhizae(甘草), Fructus forsythiae(連翹), Radix angelicae gogantis(當歸), Radix scutellariae(황기), Radix bupleuri(柴胡), Radix p]atycodi(桔梗), Radix Ledebounellae(防風), Frustus arctii(牛蒡子), Rhizoma cimicifugae(升麻) and ete. were used as medicine. 4. In the external therapy of ja-shi(자시), Youigumhwangsan(如意金黃散), Okiogo(玉露膏), Igumsan(二金散), Gumhwangsan(金黃膏), Nungo(嫩膏) and etc. were used. And Radix angelicae dahuricae(白芷), Cortex phellodendri(黃栢), Rhizoma rhei(大黃), Indigo maturalis(靑黛), Radix glycyrrhizae(甘草) and etc. were used as medicine.

• 한방안이비인후피부과학회지
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• 제12권1호
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• pp.1-17
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• 1999

Shinisan has been used for treatment of allergic disease in Oriental Medicine. However, its effect in experimental models remains unknown. The mast cell plays a pivotal role in initiating allergic response by secreting intracytoplasmic granular mediators such as histamine. The present report describes an inhibitory effect of Shinisan on mast cell-mediated immediate type allergic reactions. Topical application of compound 48/80 can induce an ear swelling response in normal ($WBB6F_1-+/+$) mice but not in the congenic mast cell-deficient $WBB6F_1-W/W^v$ mice. Shinisan inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80. Shinisan inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by topical application. Shinisan also inhibited concentration-dependently the histamine release from the rat peritoneal mast cells by compound 48/80 or anti-DNP IgE. Moreover, Shinisan had a significant inhibitory effect on compound 48/80-induced systemic anaphylactic reaction. These results indicate that Shinisan inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in vivo and in vitro.