• The Korean Journal of Pharmacology
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• v.18 no.2
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• pp.27-32
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• 1982

To investigate the relationship between platelet monoamine oxidase activity and serum levels of testosterone and estradiol in schizophrenic patient, 78 chronic patients were compared with 135 normal controls. 1) The monoamine oxidase activity of chronic schizophrenic group was lower than normal group. 2) In normal group, there was no sex difference in monoamine oxidase activity. But in chronic schizophrenic group, the monoamine oxidase activity in male was lower than female. 3) In male schizophrenic group, the serum estradiol level was lower than normal group. 4) In female schizophrenic group, the serum testosterone level was lower than normal group. The significances of relationship between platelet monoamine oxidase activity and sex hormones are discussed.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.4
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• pp.500-503
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• 2002

This study was carried out to investigate the effects of season influencing semen characteristics, frozen-thawed sperm viability and testosterone concentration in Duroc boars. There were no significant differences in the semen volume and sperm concentration of Duroc boars among spring, summer, autumn and winter. However, the pH of sperm-rich and sperm-poor fractions in autumn and winter season was higher than in spring and summer season in Duroc boars. Sperm motility and normal acrosome of raw semen in Duroc boars did not differ significantly among spring, summer, autumn and winter. However, motility and normal acrosome of frozen-thawed sperm were higher in spring season than in summer, autumn and winter. Serum testosterone concentrations in Duroc were higher in spring than summer, autumn and winter. In conclusion, when serum testosterone concentrations were higher in seasons, frozen-thawed sperm viability in Duroc boars were higher.

• Journal of Environmental Health Sciences
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• v.39 no.1
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• pp.43-47
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• 2013

Objectives: We investigated the effects of Korean gastrodia and bee pollen on testosterone production in Sprague-Dawley rats. Methods: This study measured the body weight, consumption of food and water, and serum testosterone concentration in SD rats fed for four weeks with gastrodia and bee pollen. Results: The average body weights after four weeks were $375{\pm}2g$ for the control group, $358{\pm}3g$ for gastrodia consumption, and $354{\pm}2g$ and $367{\pm}8g$ for acorn pollen and Siberian gooseberry pollen, respectively. The average food consumption in SD rats over the four weeks in the control was 23.6 g for gastrodia consumption, 24.3 g and 24.9 g for acorn pollen and Siberian gooseberry pollen, respectively. The average water consumption over the four weeks was 38.33 ml in the control group, 35.0 ml for gastrodia treatment, and 33.3 ml and 33.3 ml for acorn pollen and Siberian gooseberry pollen treatment, respectively. The testosterone secretion levels in the serum of male rats were increased by gastrodia, acorn pollen, and Siberian gooseberry pollen (2.68, 3.00, and 3.28 pg/ml, respectively) compared to the control group (2.23 pg/ml). Conclusions: These results suggest that gastrodia or bee pollen may be developed as a complementary medicine to improve sexual hormone production.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.7B
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• pp.841-847
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• 2011

Testosterone acts to protect the heart as a male hormone. If it is secreted suitably, health, but too less it will have an bad influence in organs of the body. In particular, when normal levels of testosterone secretion is less, arteriosclerosis will be increased risk of heart diseases. According to the amount of testosterone is influenced difference in the ring finger length of male. Therefore, we organize groups of subjects in heart diseases and normal who measure these groups' length of the ring finger and index finger. With this in mind, we carried out analysis of interrelationship in length of the ring finger and heart diseases through cross-comparison analysis in this paper.

• Journal of Animal Reproduction and Biotechnology
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• v.37 no.2
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• pp.87-95
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• 2022

Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the expression of c-Kit and anoctamin 1 (ANO1), another ICC marker, in mouse testes. In addition, the relationship between c-Kit and ANO1 expression and Leydig cell function was investigated. We observed that c-Kit and ANO1 were predominantly expressed in mouse Leydig cells. The mRNA and protein of c-Kit and ANO1 were expressed in TM3, a mouse Leydig cell line. LH induced an increase in intracellular Ca²⁺ concentration, membrane depolarization, and testosterone secretion, whereas these signals were inhibited in the presence of c-Kit and ANO1 inhibitors. These results show that c-Kit and ANO1 are expressed in Leydig cells and are involved in testosterone secretion. Our findings suggest that Leydig cells may act as ICCs in testosterone secretion.

• Korean Journal of Poultry Science
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• v.32 no.2
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• pp.135-141
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• 2005

Changes in serum estradiol, insulin-like growth factor-1, leuteinizing and testosterone levels, and leuteinizing hormone-stimulated testosterone production per testis in vitro from hatching to adulthood were studied in Korean native chickens of 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 21, 24, 28, 32, 44, 52 and 64 weeks (n=13 chickens per group) of age. The changes in the profiles of the levels in the incubation medium of luteinizing hormone-stimulated (100 ng/mL) testosterone secretion per testis in vitro, and the serum LH, testosterone, estradiol, and insulin-like growth factor-I were determined by radioimmunoassay. Serum estradiol levels were not significantly different at week 4 compared to that of 8, 12, 16, 21, 32, :md 44. Significant decreases were observed at weeks 52 and 64. Serum leuteinizing hormone concentrations were not significantly different from 1 week to 12 weeks, increased gradually up to 32 weeks of age, and declined significantly thereafter; the highest value was at 32 weeks, and the lowest value was detected at 2 weeks of age. Serum insulin-like growth factor-I concentrations increased significantly from 1 week to 16 weeks, remained low and unchanged with advancing age. Serum testosterone concentrations were not significantly different at week 1 compared weeks 2, 4, 6, and 8. Significant increases were observed from 10 weeks to 32 weeks of age. Values at weeks 24, 28 and 32 and at weeks 32, 44, 52, and 64 were not significantly different. The highest value was at weeks 28 and the lowest value was detected at weeks 1 week. LH-stimulated testosterone production per testis in vitro increased gradually with age from 1 to 32 weeks and decreased significantly from 44 weeks to 64 weeks of age.

• Korean Journal of Animal Reproduction
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• v.14 no.1
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• pp.66-72
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• 1990

This experiment was conducted to compare the fatty acid composition in the backfat and the levels of testosterone and androstenone in the serum of boars, barrows and gilts. The results obrained are summarized as follows : 1. The contents of palmitic acid and stearic acid in the backfat of barrows increased as their body weight increased and the levels of them were higher in barrows than in boars. However, the contents of oleic acid and linoleic acid were lower in barrows than in boars. 2. The levels of testosterone in boars at 70, 90 and 110 kg of body weight were 3.25, 5.66 and 4.5ng/ml respectively, while those of barrows or gilts were 0.01-0.43ng/ml. 3. The level of androstenone in boars at 110kg of body weight was higher(1.04ng/ml) than that at 70kg of body wight(0.44ng/ml), but there was little difference in the levels of it by body weight or age in barrows and gilts.

• Biomolecules & Therapeutics
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• v.18 no.3
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• pp.257-261
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• 2010

While it's been shown that arsenic impairs male reproductive function, it remains unclear whether the mechanism involves an effect on testosterone (T) production. We examined plasma T and luteinizing hormone (LH) levels in mice given water containing either 20 or 40 mg/L sodium arsenite (SA). The plasma T levels were lower in SA-treated mice than in controls and correlated well with testicular T levels within individuals. However, SA treatment did not significantly affect plasma LH levels. The ratio of plasma T to LH was reduced by the treatment with 40 mg/L SA. These results suggest arsenic-induced defect in testicular testosterone production in mice.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.70-71
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• 2003

Dichlorodiphenyltrichloroethane (DDT), is a widespread environmental pollutant. In this study, we investigated the effect of DDT on testosterone production through aromatase and investigated its molecular mechanism in testicular leydig cell, R2C. We investigated that the effects of DDT on testosterone production and its effects on aromatase activity in R2C cell by radio immunoassay (RIA). (omitted)

• The Korean Journal of Zoology
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• v.36 no.4
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• pp.580-587
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• 1993

북방산개구리의 성체 수컷들 년중 채집하여 gonadosomatic index(GSI)와 정자형성과 정 및 정소내 testosterone양의 변화를 조사하였다 정자형성은 8월에 시작되어 9월에 가장 활발하게 진행되었으며 이때 GSI도 가장 높았고 세정관의 단면적도 가장 넓었다 번식기(2월) 이후 일정기간 동안에는(3월-7월) 정자형성이 정지되었으며, GSI나 세정관의 단면적도 최저치를 나타내었다. 정소내 testosterone양은 11월부터 급격히 증가하여 2월에 가장 높았으며 3월부터 급격히 감소되어 10월 까지 매우 낮은 농도를 유지하였다. Interstitial cell의 수도 동면기간이 찰동기 보다 훨씬 많았으며 핵의 크기도 동면기간이 훨씬 컷다. 따라서 testosterone의 생성 증가와 interstitial cell의 활성화가 일치함을 알 수 있었다. 본 결과들은 북방산개구리의 정 소에서는 정자형성과정이 불연속적으로 일어난다는 것과 2월 이후에는 testosterone의 양이 급격히 줄어드는 것으로 보아 이 개구리의 번식기가 2월임을 확인해 주고 있다.