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Quality Control of Radiopharmaceutical (진단용 방사성 의약품의 정도관리)

  • An, Sung-Min;Hong, Tae-Kee;Ham, Jun-Cheol;Kim, Sung-Chul
    • The Journal of the Korea Contents Association
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    • v.9 no.11
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    • pp.240-246
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    • 2009
  • Quality control test in this field of study were carried out in 3 categories, radionuclidic purity, chemical purity and radiochemical purity. Also, indication efficiency was tested every 3 hours changed after binding the radiopharmaceutical to see how long the medicine is available for usage after indicating. The result showed that currently used radiopharmaceutical have good radionuclidic purity and chemical purity. However, radiochemical purity indication showed small differences depending on indication method and indication period. Radiopharmaceutical are indicated by treatment providers, so they need to pay more attention to the indication process and quality control to provide more efficient treatment.

Improvement Factors on Management Performance of Global Distribution Franchise Firms

  • Coo, Byung-Mo
    • Journal of Distribution Science
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    • v.16 no.3
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    • pp.33-47
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    • 2018
  • Purpose - The purpose of this study is to derive the performance improvement factors of courier corporations that operate global franchise systems as business strategies through their brands and to determine. Research design, data, and methodology - In the first study, 129 valid questionnaire sheets were analyzed. In the second study intended to determine whether the four performance improvement factors derived in the first study have positive effects on franchisees' business performance, 781 valid questionnaire sheets secured from six GDFFs were analyzed using AMOS analysis. Results - In the first study, four performance improvement factors were derived. In the second study, hypotheses regarding whether the performance improvement factors: leadership, communication, education and training, and brand, have positive effects on franchisees' business performance were tested, and as a result, one hypothesis was rejected and three hypotheses were adopted. Conclusions - The first and largest contribution of this study is that it derived performance improvement factors from GDFFs. The second contribution is that it determined whether the performance improvement factors that were derived have positive effects on franchisees' business performance with tests. The third contribution is that it created significant implications in terms of other studies, research value, and applications in industry fields.

A Study on the Effect of Inclusions on the Fatigue Life of Titanium Investment Castings (티타늄 정밀주조품의 피로수명에 미치는 개재물의 영향에 관한 연구)

  • Park, Yong-Kuk;Ret, P.L.;Kim, Jin-Gon
    • Journal of Korea Foundry Society
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    • v.26 no.2
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    • pp.85-91
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    • 2006
  • Inclusions in Ti investment castings are generally known to have detrimental effects on the performance of the castings. However, actual inclusions are infrequent and hard to be located. As a result, it is extremely difficult to obtain sufficient amount of fatigue test specimens of titanium investment castings having inclusions in the gage section. Thus, in-depth research of the adverse influence of inclusions is also hindered. To address this problem, a new casting methodology of specimens containing hard alpha inclusions was developed in this study. To guarantee successful introduction of an inclusion and casting, a carefully designed mold with 8 legs and a special tool were employed. After solidification, castings were cut, and X-ray radiography determined that the inclusions were successfully incorporated into the castings. The castings were further prepared to obtain multiple test specimens and they were fatigue-tested consecutively. Fractography analysis confirmed that fatigue cracks initiated at the hard alpha inclusion. In a nonlinear regression model, the fatigue life can be modeled as an exponential function with a negative exponent of the cross-sectional area of an inclusion. The fatigue life of Ti specimens containing inclusions is inversely proportional to the cross-sectional area of an inclusion.

Fabrication and Mechanical Properties of TiNi/6061Al Smart Composite by Permanent Mold Casting (금형주조법을 이용한 TiNi/6061Al 지적복합재료의 제조 및 기계적 특성)

  • Kim, Soon-Kook;Lee, Jun-Hee;Yun, Doo-Pyo;Park, Young-Chul;Lee, Gyu-Chang;Kim, Young-Hee
    • Journal of Korea Foundry Society
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    • v.18 no.6
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    • pp.534-540
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    • 1998
  • 6061Al-matrix composite with TiNi shape memory fiber as reinforcement has been fabricated by Permanent Mold Casting to investigate the mechanical properties of the smart composites. The composites have showed good interface bonding as a result of the analysis of SEM and EDX. The smartness of composite is given due to the shape memory effect of the TiNi fiber which generates compressive residual stresses in the matrix material when heated after being prestrained. The tensile strength of the composites was tested at temperatures between $90^{\circ}C$ and room temperature with increasing amount of pre-strain, and it showed that the tensile strength at $90^{\circ}C$ was higher than that of the room temperature. Especially, the tensile strength of the composite increases with increasing pre-strain. It showed that hardness of matrix was higher than that of common 6061Al alloy.

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Indirection Model and Application of Electronic Mail Control System Considering High Availability (고가용성을 고려한 전자메일통제시스템의 우회 모델 및 응용)

  • Kim Young Soo;Suh Jung Seok
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.9 no.2
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    • pp.348-354
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    • 2005
  • These days, Electronic mail is being used in everyday's life. And on the other hand, we are facing spam mails' problems. Spam mails are widely used by means of marketing in e-Commerce. To block these spam mails, we are using filtering or pricing systems. But these solutions are raising other problems such as impediment in reception or availability caused by false positive or payment resistance. To solve these problems, we propose an Indirect Model on Electronic Mail Control System(IMEMCS) which controls an unsolicited electronic mail and prevents an useful electronic mail from discarding. We design and implement the IMEMCS to enhance the usefulness and the availability. Being tested the IMEMCS to verify the usability and the efficiency, it gave us a very successful result.

Filtration Performance of Fibrous Air Filter under External Electric Field using Insulated Electrodes (외부전기장 적용 섬유상 에어필터의 절연 전극 사용에 따른 여과특성)

  • Ji, Sung-Mi;Sohn, Jong-Ryeul;Park, Hyun-Seol
    • Journal of Korean Society for Atmospheric Environment
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    • v.28 no.6
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    • pp.675-687
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    • 2012
  • Applying an external electric field across air filter media is one of methods to improve the filtration performance. Metal wire meshes have been commonly used as electrodes situated on both sides of a thick filter pad. For a thin filter medium a short circuit, known as the biggest drawback for applying an external electric field to air filter, can occur at the closest point between electrodes. In this study several types of insulated meshes were prepared by coating #50 meshes with a dielectric material, Nylon 66, and the filtration property of air filter was evaluated at the presence of external electric field using those insulated meshes as electrodes and compared with that of filters using bared meshes. The collection efficiency of tested filter was increased from 78% to 95% for singly charged 100 nm particles by application of external electric field. As a result, there was no significant difference in collection efficiency between filters with insulated and bared electrodes. Similar results could be also seen from the tests using polydisperse particles. Finally, through this study, we found that the insulation of mesh electrodes doesn't affect the filtration performance of fibrous air filter under external electric field.

Properties and Kinetics of Glutamate Dehydrogenase of Corynebacterium glutamicum (Corynebacterium glutamicum의 Glutamate Dehydrogenase의 효소학적 성질과 Kinetics)

  • Park, Mee-Sun;Park, Soon-Young;Kim, Sung-Jin;Min, Kyung-Hee
    • Microbiology and Biotechnology Letters
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    • v.17 no.6
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    • pp.552-555
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    • 1989
  • A 150-fold purified preparation of NADPH-specific glutamate dehydrogenase of Corynebacterium glutamicum (1) was used for the determination of kinetic parameters of the substrates, NADPH, NH$_4$Cl, and $\alpha$-ketoglutarate in the direction of glutamate synthesis. The kinetic constants determined from this study suggest a biosynthetic role for the enzyme, Based on the analysis of the result derived from initial velocity, the reaction mechanism was postulated to be ordered addition with NADPH as a first substrate to bind in the forward direction. Of the several metabolites tested for a possible function in the regulation of glutamate dehydrogenase activity, only malate and citrate were appeared to have an appreciable influence on the enzyme, Potassium chloride showed to be the most effective for the enzyme activity.

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An Experimental Study on Slagging/Fouling Characteristics for Various Coals in a 50kWth Pulverized Coal Combustion System (50kWth미분탄 연소 시스템에서 탄종별 슬래깅 및 파울링 특성 연구)

  • Kang, Kieseop;Lee, Jaewook;Chae, Taeyoung;Ryu, Changkook;Yang, Won
    • 한국연소학회:학술대회논문집
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    • 2012.11a
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    • pp.107-109
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    • 2012
  • In Korean coal power plants, rising coal prices have recently led to the rapid utilization of low lank coals such as sub-bituminous coal with low calorific values and low ash fusion temperatures. Using these coals beyond the design range has resulted in important issues including slagging and fouling, which cause negative effects in boiler performances and unstable operations. The purpose of this study is to observe slagging and fouling characteristics resulted from burning various ranks of pulverized coals. We have tested 3 different coals: FLAME(bituminous), KCH(sub-bituminous) and MOOLARBEN(bituminous)coals in the pilot system $50kW_{th}$ scale. A stainless steel tube with preheated air inside was installed in the downstream in order to simulate water wall. Collected ash on the probe and the slag inside the furnace near burner were analyzed by SEM (scanning electron microscopy) to verify the formation degree, surface features and color changes of the pasty ash particles. Induced coupled plasma and energy dispersive X-ray spectroscopy were also performed to figure out the chemical characteristics of collected samples. As a result, KCH was observed that more slag was developed inside the walls of the furnace and on the probe than the other two kinds of coals, as shown in the calculate slagging and fouling indices as well.

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Development of Strain-Specific Primers for Identification of Bifidobacterium bifidum BGN4

  • Youn, So Youn;Ji, Geun Eog;Han, Yoo Ri;Park, Myeong Soo
    • Journal of Microbiology and Biotechnology
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    • v.27 no.5
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    • pp.909-915
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    • 2017
  • Bifidobacterium bifidum BGN4 (BGN4) has many proven beneficial effects, including antiallergy and anticancer properties. It has been commercialized and used in several probiotic products, and thus strain-specific identification of this strain is very valuable for further strain-dependent physiological study. For this purpose, we developed novel multiplex polymerase chain reaction (PCR) primer sets for strain-specific detection of BGN4 in commercial products and fecal samples of animal models. The primer set was tested on seven strains of B. bifidum and 75 strains of the other Bifidobacterium species. The BGN4-specific regions were derived using megaBLAST against genome sequences of various B. bifidum databases and four sets of primers were designed. As a result, only BGN4 produced four PCR products simultaneously whereas the other strains did not. The PCR detection limit using BGN4-specific primer sets was $2.8{\times}10^1CFU/ml$ of BGN4. Those primer sets also detected and identified BGN4 in the probiotic products containing BNG4 and fecal samples from a BGN4-fed animal model with high specificity. Our results indicate that the PCR assay from this study is an efficient tool for the simple, rapid, and reliable identification of BGN4, for which probiotic strains are known.

Effect of Synthetic Surfactants on the Activity of Mutagens (계면활성제가 돌연변이원성 물질의 활성에 미치는 영향)

  • Choi, Yoon-Ho;Chung, Yong
    • Environmental Analysis Health and Toxicology
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    • v.7 no.3_4
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    • pp.69-79
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    • 1992
  • Recently, concerns of water pollution and health risks caused by synthetic detergents have emerged, as the use of various detergents has increased It has been suggested that some surfactants are cocarcinogens. The surfactants tested were linear alkylbenzene sulfonate, sodium lauryl sulfate, polyoxyethylene sorbitan monooleat (tween 80), and the mutagens were 1-nitropyrene, N -methyl- N'-nitro-N -nitrosoguanidine, benzo (a) pyrene, and aflatoxin B$_1$. This study was undertaken to investigate the effects of surfactants on the activity of mytagens using the Ames mutagenic assay with Salmonella typhimurium TA98, TA100. The results were summarized as follows: 1. The surfactants have no mutagenic activity of themselves. 2. Higher doses of surfactants than 100 $\mu\textrm{g}$/plate reduced the number of revertants. It is assumed that the reduction would inhibited cell growth. 3. When the comutagenic ratio is defined as the ratio between mutagenic activity itself and the activity with mutagen and surfactant (drinking water quality standard), LAS showed the comutagenic ratio 0.86-1.17 and SLS 0.74-1.10 as well. According to the comparisons, it could not be recognised for the comutagenicity of drinking water quality standard of surfactant. 4. As increasing the amount of mutagens, the designated amount of surfactant did not affected the mutagen's activity statistically. From the above result, syunthetic surfactants do not present mutagenicity and comutagenicity in the microbial assay.

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