• 한국과학교육학회지
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• 제35권1호
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• pp.143-157
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• 2015

본 연구의 목적은 한국 전통 과학 지식의 과학 교육 가능성에 대해 파악하고자 함에 있다. 한국 전통 과학을 소재로 과학적 개념, 역사적 지식, 문화적 경험 등이 포함된 실험과 그룹 활동, 탐방을 포함한 5개 프로그램을 개발했다. 개발한 프로그램의 주제는 역법, 앙부일구의 원리, 과학자 장영실, 한국의 고대 자연 기록, 경복궁 탐방 등이었다. 이 프로그램에 참여한 고등학생들의 프로그램 전후 인식 조사, 수업 관찰 자료, 수업 활동 자료, 면담을 분석한 결과, 학생들의 한국 전통 과학에 대한 인식은 문화적 범주 내에서 과학적 요소를 찾는 수준을 넘어서서 자연 과학으로서의 한국 전통 과학 가치로 변해갔다. 또한, 우리 전통 과학에 대한 기대감을 과학적, 실용적, 정서적 측면에서 표현했는데, 한국 전통과학의 실용적, 정서적 측면들이 학생들에게는 비과학적 측면으로 인식되기도 하였다. 또한 이들은 서양 과학과 한국의 TSK와의 관계를 통해 과학에 대한 세계관을 드러냈는데 크게 다섯가지로 분류되었다. 학생들은 전반적으로 한국 전통 과학을 아끼고 사랑하는 마음을 가지고 있었지만, 한국 전통 과학의 과학적 가치에 대해서는 혼란스러움을 나타냈다. 학생들은 우리가 배우고 있는 과학이 어떠한 의미를 가지고 있는지 고찰하고 과학 교육자들은 그것을 세심하게 검토할 필요성이 제기되었다. 아울러 우리가 한국의 TSK에 대한 지식을 학생들에게 전달하는 방법에 대해 다시 생각해 보고, 한국 TSK에 대한 학문적, 과학교육적인 심층 연구가 이어져야 할 것이다.

• Child Health Nursing Research
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• 제6권1호
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• pp.32-50
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• 2000

A descriptive exploratory design was used in this study to evaluate the effects of sponge bathing on physiological(heart rate, heart period, vagal tone, oxygen saturation, respiration) and behavioral responses in newly born 40 preterm infants from intensive care unit of S University Hospital in Seoul. Data has been collected from October, 1997 to March, 1999. The infants were between 27-33 weeks gestational age at birth, and were free of congenital defects. The subjects entered the protocol when they were medically stable (determined by initiation of feeding and discontinuation of all respiratory support) but still receiving neonatal intensive care. The infants' physiologic parameters were recorded a 10 - minute before, during, and after bathing. Continuous heart rate data were recorded on a notebook computer from the infant's EKG monitor. The data were digitized off-line on software(developed by Lee and Chang in Wavelet program) which detected the peak of the R wave for each heart beat and quantified sequential R-R intervals in msec(i.e. heart periods). Heart period data were edited to remove movement artifact. Heart period data were quantified as : 1) mean heart period; 2) vagal tone. Vagal tone was quantitfied with a noninvasive measure developed by Porges(1985) in Mxedit software. To determine behavioral status, tools were developed by Scafidi et al(1990) were used. Collected data were analyzed with the SPSS program using paried t-test, ANOVA, and Pearson correlation. The result were as follow. 1. The results of the ANOVAs indicated that vagal tone were signifcantly lower during bathing than baseline and post-bathing. There were significant differences in heart period and heart rate levels across the bathing. But the mean oxygen saturations and respirations were no differences. Also, there were no significant differences on behavioral sign, motor activity, behavioral distress, weight changes, morbidity, and hospitalization period. 2. To evaluate the relation between vagal tone and subsequent parameters, the two groups (the high group had 19 subjects and low group had 21subjects) were divided by the mean baseline vagal tone. Vagal tone measured prior to bathing were significantly associated with respiration before bathing, vagal tone during bathing, and the magnitude of change in both vagal tone. But, other subsequent reactivities were no differences in two groups. 3. Correlations were also calculated between vagal tone and the subsequent physiological reactivities from baseline through after- bathing. Correlations were significant between baseline vagal tone and baseline heart rate, between baseline vagal tone and baseline heart period, between baseline vagal tone and oxygen saturation after bathing. In summary, the bathing in this study showed a stressful stimulus on premature infants through there was significance in the physiological parameters. In addition, our study represents the documentation that vagal tone reactivity in response to clearly defined external stimulation provides an index of infant's status.

• 한국항만경제학회지
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• 제28권3호
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• pp.111-125
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• 2012

광양항의 컨테이너 물동량은 인천항이나 평택 당진항에 비해 더딘 증가를 보이고 있으며, 부단위당 부가가치가 낮고 중국시장을 제대로 활용하지 못하고 있다. 광양항은 다른 두 항에 비해 환율계수와 경기계수가 크게 낮아 환율변동과 경기변동에 가장 작은 영향을 받게 되고 그에 따라 경기와 환율의 긍정적 변동을 이용하는데 가장 서투른 항만임을 보인다. 오차수정방정식을 도출하여 오차수정계수가 광양항에서 가장 작아서 적정 물동량 수준에 이르지 못할 경우 물동량 수준으로 돌아가는데 다른 두 항만에 비해 크게 떨어진다는 것을 밝힌다. 이것은 광양항이 다른 두 항만에 비해 물동량 확보능력이 부족하다는 것과, 물동량 부족이 발생할 경우 그것이 오래 지속될 수 있다는 것을 의미한다. 충격반응함수를 이용하여 경기충격이 광양항에 대해 가장 낮은 반응을 야기하여 경기상승에 따른 물동량 증가가 가장 적을 것이라는 것을 밝힌다. 마지막으로 2012년과 2013년의 물동량을 개입-승법계절 ARIMA 모형을 통해 예측하여 광양항은 2012년과 2012년 전년 대비 2.6%, 3.1% 증가하는데 비해, 인천항 6.8%, 8.1%, 평택 당진항 24.2%, 10.3%가 증가하여, 2012년에는 인천항과 물동량 차이가 거의 없는 수준으로 좁혀지고 2013년에는 비교적 큰 차이로 인천항이 광양항을 앞설 것이라는 것을 보인다. 경제적 또는 경제외적 요인의 변화에 대한 광양항의 적응능력이 타 항만에 비해 떨어지고, 그에 따라 다른 항만에 추월당할 상태에 처하고 있다는 것을 밝힌다.

• 한국식품저장유통학회지
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• 제23권7호
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• pp.1026-1032
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• 2016

시기별 병귤 추출물의 항산화 활성은 시기적으로 미숙과 시기인 9월에 가장 높았으며, 이 시기에 총 폴리페놀 함량이 가장 높았다. 특히 rutin, hesperidin, nobiletin의 함량이 높았으며, 이는 항염 활성에 영향을 미치는 것으로 여겨진다. 항염 활성에서는 NO의 생성을 억제하였으며 염증성 cytokine인 TNF-${\alpha}$의 생성 억제 활성이 가장 높았다. 또한 NO 생성을 억제하는 단백질로 알려진 iNOS 단백질의 발현 역시 억제하는 것을 확인 할 수 있었다. 항염 활성에 영향을 미칠 것으로 여겨지는 nobiletin 함량의 경우 12월에 70%이상 감소하는 것을 확인할 수 있었다. 이러한 시기별 플라보노이드 함량 분석결과는 병귤을 천연 소재로 활용하기 위한 수확시기를 확립할 수 있을 것으로 여겨진다.

• Archives of Pharmacal Research
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• 제24권3호
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• pp.224-228
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• 2001

DA-5018, a recently synthesized capsaicin analog, appears to possess potent analgesic activity when administered topically. The objective of this study is to test the feasibility of the topical administration of this compound. Specifically, our goal was to identify vehicle system that permit a reasonable transdermal permeation of the compound in mice. Among the vehicles examined, isopropyl myristate (IPM) showed the largest in vitro permeability across the intact skin (83.6 ${\pm}$ 5.42${\mu}$l/$\textrm{cm}^2$/h ). However, due to the limited solubility of DA-5018 in IPM (0.53 mg/ml), the maximal flux from the IPM medium remained at only 44.3 ${\pm}2.87{\mu}$g/$\textrm{cm}^2$/hr. In order to increase the flux, addition of better solvents for DA-5018 was attempted, under the assumption that flux is the result of both solubility and permeability. Ethoxydiglycol (EG) and oleic acid (OA) were selected as examples of food solvents. The addition of IC or OA to IPM at a 1:1 volume ratio resulted in a comparable increase in the solubility of the compound (i.e., to 61.1 and 50.2 mg/ml for EG and OA, respectively). However, the addition of EG at a 1:1 volume ratio, for example, increased the flux 6.3 fold (i.e., $279{\mu}$g/$\textrm{cm}^2$/hr), while OA, at a 1:1 volume ratio, decreased the flux 5 fold (i.e., $9.26{\mu}$g/$\textrm{cm}^2$//hr). The mechanism of this discrepancy between EG and OA was investigated by measuring the permeabilty of DA-5018 across the stratum corneum-removed skin of the mouse, under the hypothesis that the viable skin layer may serve as a barrier for the permeation of lipophilic substances such as DA 5018. The permeability of DA-5018, from the medium of EG or OA, across the viable skin differed greatly for EG ($0.41{\mu}$l/$\textrm{cm}^2$/hr) and OA ($0.086{\mu}$l/$\textrm{cm}^2$/hr), suggesting that a higher permeability across the viable skin layer is needed for the second solvents. The maximum flux across the intact skin was achieved for DA-5018 when EG was added to IPM at a 1:1 volume ratio. Thus, the use of a binary system appears to be the best approach for realizing the transdermal delivery of DA-5018 at a reasonable rate.

• 한국식품과학회지
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• 제37권2호
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• pp.247-254
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• 2005

유색 감자의 일반적인 성분과 무기질, 색도, anthocyanin의 함량 그리고 생리활성에 대하여 검토하였다. 유색감자 계통별로 횡단면의 색소형성 정도에 따라 A. B, C, D Type둥 4가지 형태로 분류되었다. 일반성분은 수분 함량이 75.7-84.3%, 단백질이 1.3-2.7%, 조섬유 함량이 0.2-0.7% 수준으로 계통에 따라 약간 차이를 보였다. 유색감자내 무기질은 괴경 100g당 2-3mg의 칼슘과 1-2mg의 나트륨, 350-510mg의 칼륨을 함유한 것으로 나타났으며, 무기질 함량은 계통별로 차이를 나타냈다. 색차계를 이용하여 유색감자 횡단면의 색도를 측정한 결과, 색차의 크기는 PL-31>PL-6>PL-28>PL-12>PL-4>PL-17 등의 순으로 나타났으며, 관능검사에 의한 유색강도를 시험한 결과 PL-14>PL-31>PL-28>PL-3>PL-17>PL-6 등으로 나타나서 유사한 경향을 보였다. 총 anthocyanin 색소 함량은 계통별로 큰 차이를 나타내었으며 100g 당 3.3-29.0mg 수준이었으며, PL-28>PL-31>PL-14>PL-12>PL-5 >PL-3의 순으로 높았다. 선발된 품종간 항산화력 비교 실험 결과, PL-6을 제외한 PL-28, PL-31 그리고 자심은 대조구인 ${\alpha}$-tocopherol보다 항산화력 활성이 약간 높았으며, BHA의 항산화력에는 미치지 못하는 것으로 확인되었다. 그리고 Gram(+) 3종과 Gram(-) 3종을 이용한 항균활성을 측정한 결과, 4품종 모두 Gram(+)와 Gram(-) 모두 항균력을 나타내었다. Gram(+)에서는 B. subtilis에 가장 높은 항균활성을 나타내었고, Gram(-)에서는 E. coli에서 항균활성을 나타내는 것으로 확인되었다.

• Journal of Preventive Medicine and Public Health
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• 제34권1호
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• pp.1-8
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• 2001

Objectives : To gather information about the factors which influence the interest and intention of admission into charging nursing hones for the elderly(CNH), as these homes represent an important method for resolving the problems related to the rapid population aging occurring in Korea. Methods : A face-to-face interview survey was carried out with 320(men 159, women 165) patients over 60 years old who were admitted at 2 university hospitals and 5 general hospitals in the Busan area between December 1998 and March 1999. Data were analyzed through t-test, ANOVA, correlation and multiple regression analysis. Results : The mean age and years of education of the study population was 67.0 and 7.7 years, and the types of chronic degenerative disease included musculoskeletal disorders(20.1%), cerebrovascular disease(17.1%), and diabetes(14.3%). The major forms of household living arrangement prior to admission were elderly alone(22.6%), and elderly couple(33.5%), while about half of them(55.5%) didn't want to live with their children id the future. Almost half were paying medication fees by themselves(46.6%). The level of actual intention of admission$(3.07{\pm}1.39)$ into a CNH was lower than that of interest$(3.22{\pm}1.33)$(p<0.01). Multiple analysis revealed that the intention of admission increased with decreasing number of future supportive persons$(\beta=-0.107)$, lower level of activity in daily life$(\beta=-0.447)$, and longer years of education$(\beta=-0.447)$ with 32.7% of $R^2$. As for the factors which determined the admission into a CNH, the fee and facilities were considered to be most important, and professional nursing and physician's care were the most desired services. In nomenclature, they preferred 'elderly hospital' or 'elderly health center' to CNH. Conclusions : Interest in CNH is increasing recently, but existing studies about patient experiences in CHN are still limited. This study may form a basis for future examinations of the needs and uses for CNH. Active financial support and public information are considered by the authors to be important factors for the induction of welfare services for the elderly, though CNH.

• 항공우주정책ㆍ법학회지
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• 제22권2호
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• pp.3-25
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• 2007

In 2002 Republic of Korea successfully launched a self-made mined proportion rocket and it is expected that she will be able to have own space launching system by 2010. According to Article 14 of the Space Exploration Promotion Act, a new law should be established to impose the limit of compensation for the damage by space accident. Therefore, The Space Accident Liability Act was passed in Korean Congress on Nov. 22, 2007 and it will be enforced in six months. The purpose of this Act is to provide reparation for the damage of the third parties that a launch causes; and the Commonwealth should be insured against any possible space accidents to pay for such a damage. Here space accident means the damages to our life, body, and properties from the launching of space objects. There should be an actual loss to establish the compensation of Liability Act. Article 2 in Liability Act defines "damage" as follows: the term "damage" means loss of life, personal injury or loss of or damage to property of persons. Physical and material damages are included in the conception of damage. The meaning of a launching includes any test launch and launch for a real arrangement which will ultimately provides a wide range of compensation. Article 4 indicates that absolute liability should be imposed in compensating for damage by space accidents. Article 4 also indicates that a launching party should be absolutely liable to compensate for the damage caused by its space object on the surface of the Earth. In general, liability stands where fault is. But if the activity is ultra-hazardous and causes serious harm, the individual needs to compensate for the damage unlimitedly. Because of the many launchings for the Seattleite launching, a launching organization is obligated to the liability insurance in preparation for the space accidents. According to the Article 6 of Space Accident Liability Act, to be insured for the compensation for damage is obligatory. It says: "In accordance with Article 11 in the Space Exploration Promotion Act, the person who wants to receive an approval f3r launching needs to be insured in compensation for the possible damage by space accidents.

• Journal of Pharmaceutical Investigation
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• 제32권1호
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• pp.47-54
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• 2002

Cimetropium bromide, a quaternary ammonium compound which is chemically related to scopolamine, exhibits its antispasmodic activity by competing with acetylcholine for the muscarinic receptors of the smooth muscle of gastrointestinal tract. The drug has been used for the treatment of various disorders involving spasms of the musculature of the gastrointestinal, biliary and genitourinary tracts. The purpose of the present study was to evaluate the bioequivalence of two cimetropium bromide tablets, $Algiron^{TM}$ (Boehringer Ingelheim Korea Ltd.) and $Alpit^{TM}$ (Hana Pharmaceutical Co., Ltd.), according to the prior and revised guidelines of Korea Food and Drug Administration (KFDA). The cimetropium bromide release from the two cimetropium bromide tablets in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty normal male volunteers, $25.25{\pm}2.10$ years in age and $65.76{\pm}6.39$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After three tablets containing 50 mg of cimetropium bromide per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of cimetropium bromide in serum were determined using HPLC method with UV detector. The dissolution profiles of two cimetropium bromide tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using non-transformed and logarithmically transformed $AUC_t\;and\;C_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the $Algiron^{TM}$ were 2.19%, -5.97% and 3.49%, respectively. Minimum detectable differences $({\Delta})\;at \;{\alpha}=0.05\;and\;1-{\beta}=0.8$ were less than 20% (e.g., 13.71 %, 19.05% and 15.11% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively). The powers $(1-{\beta})\;at\;{\alpha}=0.05,\;{\Delta}=0.2\;for\;AUC_t$, $C_{max}\;and\;T_{max}$ were 97.79%, 83.22% and 95.60%, respectively. The 90% confidence intervals were within ${\pm}20%$ (e.g., $-5.84{\sim}10.21,\;-17.11{\sim}5.18\;and\;-5.35{\sim}12.33\;for\;AUC_t,\;C_{max}\;and\;T_{max}$, respectively). There were no sequence effect between two tablets in logarithmically transformed $AUC_t\;and\;C_{max}$. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., $0.94{\sim}1.10\;and\;0.85{\sim}1.05\;for\;AUC_t\;and\;C_{max}$, respectively). Two parameters met the criteria of prior and revised KFDA guideline for bioequivalence, indicating that $Alpit^{TM}$ tablet is bioequivalent to $Algiron^{TM}$ tablet.

• 한국의류학회지
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• 제32권9호
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• pp.1333-1342
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• 2008

This study intended to evaluate the visual sensibility of textiles of knitting simulation through the painting function of SDS-ONE, a computer knitting system, with the use of various fancy yarns for hand knitting. For this study, six kinds of fancy yarns with difference manufacturing style and form were selected: loop yarn, tamtam yarn, fur1 yarn, fur2 yarn, ladder yarn, and tape yarn. In order to create a computer knitting simulation, paint function of SDS-ONE was employed to scan the fancy yarns for hand knitting with a scanner. Then, after the registration of the yarns as data, the yarn was brought in for knitting simulation in plain stitch with 3 gauge. After that a survey was conducted involving 60 female experts in their twenties. Using SPSS 12.0, factor analysis, reliability, Pearson correlation coefficient, ANOVA, Duncan test, and regression analysis were performed to analyze the collected data. First, according to the result of analyzing the visual sense factor, three factors of the 'inflexibleness/ruggedness sense', 'lightweight sense', and 'smoothness sense' was extracted. According to the result of analyzing the visual sensibility factor, three factors of the 'activity', 'grace', and 'purity' was extracted. Second, With regard to preference and purchase intention, the knitted fabric with tamtam yarn(H2) was preferred than the other samples, indicating that the respondents had intention to purchase it. As for word-of-mouth intention, H2 ranked the first place, implying the respondents had intention to recommend it to other people. Third, the examination of the use of products each knitting simulation knit found that sweater and muffler are the most appropriate knit products. And H2 was the most suitable sample for sweater and muffler products. This study tried to prove that knit textile can be visually evaluated through a computer knitting simulation without the actual knitting and then to provide accurate data to related companies or the academic circle.