• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8793-8796
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• 2014

Objective: To explore the influence of serum vascular endothelial growth factor (VEGF) level on therapeutic outcome and diagnosis/prognostic value in patients with cervical cancer. Materials and Methods: A total of 37 patients diagnosed with cervical cancer by biopsy were selected and treated with concurrent chemoradiotherapy. Double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was adopted before treatment to assess VEGF levels, and its relationships with clinicopathological features and short-term therapeutic effects were analyzed. Results: The median VEGF level in 37 patients before treatment was 647.15 (393.35~1125.16) pg/mL. Serum VEGF levels in patients aged <50 years, in International Federation of Gynecology and Obstetrics (FIGO) stage IIIa~IVa, with lymph node metastasis and tumor size >4 cm were significantly increased (P<0.05). The complete remission (CR) rate was 48.7% (18/37), partial remission (PR) rate was 35.1% (13/37), stable disease (SD) rate was 13.5% (5/37) and progressive disease (PD) rate was 2.70% (1/37), so the objective remission rate (ORR) after treatment was 83.8% (31/37). Logistic regression analysis showed that tumor size and serum VEGF level before treatment were independent risk factors affecting the therapeutic outcome, and the higher the level of serum VEGF, the worse the prognosis when tumor size>4 cm. Some 56.8% of patients manifested with myelosuppression, 37.8% with leucopenia, 24.3% with thrombocytopenia, 5.41% with diarrhea, 46.0% with nausea and vomiting, 21.6% with hair loss and 8.11% with hepatic and renal injury during the treatment. Conclusions: Serum VEGF level may reflect the degree of malignancy of cervical cancer and predict therapeutic effect, which is of great importance to cancer diagnosis and prognosis.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1779-1784
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• 2016

Background: Western physicians tend to favour complete disclosure of a cancer diagnosis to the patient, while non-Western physicians tend to limit disclosure and include families in the process; the latter approach is prevalent in clinical oncology practice in India. Few studies, however, have examined patient preferences with respect to disclosure or the role of family members in the process. Materials and Methods: Structured interviews were conducted with patients (N=127) in the medical oncology clinic of a tertiary referral hospital in Bangalore, India. Results: Patients ranged in age from 18-88 (M=52) and were mostly male (59%). Most patients (72%) wanted disclosure of the diagnosis cancer, a preference significantly associated with higher education and English proficiency. A majority wanted their families to be involved in the process. Patients who had wanted and not wanted disclosure differed with respect to their preferences regarding the particulars of disclosure (timing, approach, individuals involved, role of family members). Almost all patients wanted more information concerning their condition, about immediate medical issues such as treatments or side effects, rather than long-term or non-medical issues. Conclusions: While most cancer patients wanted disclosure of their disease, a smaller group wished that their cancer diagnosis had not been disclosed to them. Regardless of this difference in desire for disclosure, both groups sought similar specific information regarding their cancer and largely favoured involvement of close family in decision making. Additional studies evaluating the influence of factors such as disease stage or family relationships could help guide physicians when breaking bad news.

• 대기
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• 제23권3호
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• pp.265-273
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• 2013

To investigate properties of cloud and rainfall occurred at Boseong on 10 July 2012, Raindrop Size distributions (RSDs) and other parameters were analyzed using observation data collected by Micro Rain Radar (MRR) and PARticle SIze and VELocity (PARSIVEL) disdrometer located in the National center for intensive observation of severe weather at Boseong in the southwest of the Korean peninsula. In addition, time series of RSD parameters, relationship between reflectivity-rain rate, and vertical variation of rain rates-fall velocities below melting layer were examined. As a result, good agreements were found in the reflectivity-rain rate time series as well as their power relationships between MRR and PARSIVEL disdrometer. The rain rate was proportional to reflectivity, mean diameter, and inversely proportional to shape (${\mu}$), slope (${\Lambda}$), intercept ($N_0$) parameter of RSD. In comparison of the RSD, as rain rate was increased, the slope of RSD became less steep and the mean diameter became larger. Also, it was verified that reflectivities are classified in three categories (Category 1: Z (reflectivity) > 40 dBZ, Category 2: 30 dBZ < Z < 40 dBZ, Category 3: Z < 30 dBZ). As reflectivity was increased, rain rate was intensified and larger raindrops were existed, while reflectivity was decreased, shape (${\mu}$), slope (${\Lambda}$), intercept ($N_0$) parameter of RSD were increased. We expected that these results will lead to better understanding of microphysical process in convective rainfall system occurred during short-term period over Korean peninsula.

• 무역상무연구
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• 제13권
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• pp.767-804
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• 2000

International network strategy is intended to examine the validity of existing network-centered theories in order to ascertain why small-and medium-sized enterprises are useful as a strategic correspondence to the internationalization trend. Small-and medium-sized enterprises can be estimated as being vital majorities in terms of their flexibility to meet changable conditions in international marketing compared with the conglomerates Therefore, their dependency on a few conglomerates for the international economy can be diverged. Generally, the successful internationalization of industries can be derived from the creation of suitable strategies for its competence and quality with the effective correction and completion of its strategy and tactics through mistakes. The internationalization strategy of small-and medium-sized enterprises should not be the reckless pursuit of internationalization that depends only on the increase of investment or the simple induction of the other conglomerates strategic models, but it should be accomplished through the evolution and practice of the concrete strategies that will be more proper for the enterprise's property and efficiency. The results of analyses with proof can be summarized with two effects in large in the process of internationalization of domestic small-and medium-sized enterprises. First, the capacity for internationalization of firms results from a long-term training procedure and continuous development of managing activities. Then in time this becomes an important element for the small-and medium-sized firms in terms with its position targeted international trading. However, the domestic enterprises are showing their abilities in the international competition in quantity, and trying to establish relationships between the enterprises through international networks. Second, statistics might not be meaningful in part because of the lack of data for analysis. It seems that more useful results will be derived from obtaining and utilizing sufficient information and from establishing an inter-relationship between the small-and medium-sized enterprises which are investing in foreign companies.

• 대한한의학원전학회지
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• 제23권1호
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• pp.257-277
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• 2010

The purpose of this article is to oversee the theory of Chimibyeong(治未病). The aim of Chimibyeong theory is to prevent disease from occuring, worsening, being delivered and so on. In many books, the word Chimibyeong was used as an alternative name for Yangsaeng(養生) or used as a term of preventing a disease or used as a word meaning treating disease in the early stage. But after the period of "Nangyeong(難經)", people extend the meaning of Chimibyeong to all stages of a disease covering the healthy stage, the early stage, the progressive, and the recovery stage of a disease. Especially in urgent cases when pathogenic factor[邪氣] attacks patient to critical situations, it is also regarded as one way of Chimibyeong to repel pathogenic factor out as soon as possible with proper medicines. These days people suffer from increasing mental stress, lack of rest and human relationships, environmental pollution and chronic diseases and so on, and the situation will grow worse. Many governments employ the health policy where preventing disease takes the highest priority because by doing that they can save a huge budget and minimize the economic and social disorder. In this circumstances the idea of pursuing prevention in the theory of Chimibyeong will help people to maintain healthy conditions.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5517-5522
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• 2014

Oral contraceptive use is the most common type of contraception. More than 300 million women worldwide take oral contraceptives every day. However, there is a concern about the relationship with the incidence of cancer. This analytical retrospective study aimed to investigate the relationship between the incidence of cervical and breast cancers and oral contraceptive use in 128 Iranian patients with cervical cancer, 235 with breast cancer and equal numbers of controls. Data were collected through interviews with an organized set of questions. Details were also extracted from patient files. Data were analyzed using Student's t-test, chi-square and Fisher's exact tests, and Pearson's correlation analysis. The result revealed correlations between both cervical and breast cancers and history of contraceptive pills use. While cervical cancer significantly correlated with duration of use of pills, breast cancer had significant correlations with the type of oral contraceptive and age at first use. No significant relationships were found between the two types of cancer and age at discontinuation of oral contraceptives, patterns of use, and intervals from the last use. The use of oral contraceptives may triple the incidence of cervical cancer and doubles the incidence of breast cancer. Therefore, performing Pap smears every six months and breast cancer screening are warranted for long-term oral contraceptive users.

• 대한지리학회지
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• 제47권6호
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• pp.836-852
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• 2012

이 연구는 중국 내몽고에서의 사막화 방지를 위한 제안과 실천의 변화과정을 기술 분석하였다. 사막화라는 생태문제는 자연적인 것만으로도, 사회적인 것만으로도 환원될 수 없는 다양한 인간과 비인간 행위자들의 구성과정의 결과물이다. 사막화 방지 제안들 속에는 사막화를 정의하기 위해 관계를 맺고 있는 여러 행위자들이 등장하고 있다. 이 행위자들의 차이 그리고 이들의 관계의 차이를 통해서 초원의 위기는 달리 구성되어 왔다. 조림사업, 보호구역, 휴목 금목, 젖소의 도입 등 기존에 내몽고에서 이루어졌던 사막화 방지 제안들은 각기 다른 행위자들의 이해관계를 조율하면서 사막화 방지라는 목적을 달성하기 위해 노력하였지만 한계가 지적되었다. 이러한 위기 구성의 역사에서 가장 마지막에 등장한 초원목계 프로젝트는 '닭'이라는 새로운 행위자의 매개를 통해, 몽고족 목축민의 경제적 위기를 해결하지 못했던 기존의 한계를 극복하는 혁신적인 시도가 되었다.

• 정보관리학회지
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• 제31권2호
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• pp.173-188
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• 2014

본 연구는 다양한 지식이 축적되고 공유되며 구성원 간의 관계와 상호작용을 바탕으로 지식이 생산되고 활용되는 공간인 소셜 러닝 커뮤니티에서 학습자의 지식소싱 행위가 지식활용 성과에 어떠한 영향을 미치는지를 실증적으로 분석하는 것을 목적으로 하였다. 이를 위해 한 대학의 사회과학분야 전공수업에 참여한 55명의 학습자들을 대상으로 소셜 러닝 커뮤니티를 구성하고 한 학기의 소셜 러닝 완료 후 설문조사를 통해 자료를 수집하였으며, 다중회귀분석을 사용하여 지식소싱 행위와 지식활용 성과의 영향관계를 규명하였다. 연구 결과, 양자 지식소싱과 문서 지식소싱은 지식재이용과 지식응용에 영향을 미치며, 그룹 지식소싱은 지식응용과 지식혁신에 영향을 미치는 것으로 나타났다. 본 연구의 결과는 소셜 러닝 커뮤니티에서 지식의 이용 목적에 따라 효율적인 지식소싱 행위를 선택하는데 유용할 것으로 기대된다.

• 대한족부족관절학회지
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• 제10권2호
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• pp.163-167
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• 2006

Purpose: To evaluate the results of extracorporeal shock wave therapy (ESWT) for patients with chronic proximal plantar fascitis. Materials and Methods: Between April 2005 and April 2006, 35 cases (24 patients) who were followed more than 6 months were evaluated. By $EvoTron^{(R)}$, 2 sessions of ESWT (Group 1: 1200 and Group 2: 1500 shock waves / session of $0.12\;mJ/mm^2$) were performed at 2 weeks interval. The mean age was 40.0 (range, 15-59) years. 13 patients were male and 11 patients were female. Visual analogue scale (VAS) on daily activity and a 100-point scoring system including 70 points for pain and 30 points for function were used. The clinical outcomes were rated as follows: excellent, no pain on daily activity; good, less than 50% of previous VAS; fair, 50-75% of previous VAS; or poor, more than 75% of previous VAS. Excellent and good were graded as satisfactory results. We compare clinical results between groups and evaluate the relationships between clinical results and duration of symptom, fascial thickening and previous steroid injection were evaluated. Results: Overall satisfactory rate were 71.4%. There was no significant difference of clinical results between groups. And there were no significant difference between clinical results and duration of symtom, preoperative fascial thickening and previous steroid injection. Conclusions: ESWT for recalcitrant chronic proximal plantar fascitis is useful treatment method with high patient satisfaction and pain relief, but more long-term study must be needed.

• 한국지역지리학회지
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• 제12권2호
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• pp.245-264
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• 2006

많은 개념적 연구와 담론에 의하면, 정보통신기술의 발달은 일상생활의 시공간적 활동에 지대한 영향을 미치고 있다. 그러나 이에 관한 경험적 연구들은 실제 그 영향이 그렇게 크지 않다는 점을 보이고 있다. 이러한 양 입장을 벗어나기 위해, 이 논문에서는 정보통신기술의 발달과 사회공간에 미치는 영향에 관한 연구는 개별 현상이나 의식에 초점을 두기보다는 사회공간적 관계, 즉 네트워크의 변화에 관심을 주어야 한다는 점을 주장한다. 카스텔(Castells), 어리(Urry) 등이 주장하는 바와 같이, 사실 정보기술의 발달은 새로운 정보네트워크의 창출을 의미하며, 그 공간적 측면을 이해하기 위해 '네트워크 사회공간'이라는 용어를 사용할 수 있고, 라투어(Latour) 등이 주장하는 '행위자-연결망'이론이 원용될 수 있다. 이 논문에서는 특히 새로운 사회공간을 구성하는 네트워크는 즉시적 층위, 기능적 층위, 그리고 물질적 층위를 가지는 것으로 이해한다. 또한 네트워크사회공간은 새로운 사회공간적 관련성으로서 중요성을 가질 뿐만 아니라, 네트워크의 결절을 형성하는 주체들의 참여와 이를 통한 정체성의 재구성이라는 점에서도 중요한 의미를 가진다는 점이 강조된다.