• Journal of the Korean Society of Industry Convergence
• /
• v.26 no.3
• /
• pp.471-481
• /
• 2023

Digital twin is considered as a key technology of industry 4.0, thus being essential for the future of industrial production. Despite the significance, a systematic analysis of its technological landscape is lacking. This study aims to investigate the technological development trends and newly emerging technological convergence opportunities in the domain of digital twin by exploiting patent information derived from U SPTO. For this purpose, this study visualized and predicted the convergence dynamics among patent classification codes by adopting patent co-classification analysis and link prediction approach. The findings show that the number of digital twin-related patent applications has increased significantly since 2018. The CPC code G06F showed the highest eigenvector centrality, while G05B was characterized by highest betweenness centrality. According to the predictive model, 41 novel links were revealed, acting as potential technology convergence opportunities. These links were then categorized into 11 different domains. The most dominant category was "digital data processing and artificial intelligence", which could play a foundational role in the diffusion of digital twin technology. The presence of digital twin technology is dominant in manufacturing, but its applications are expected to expand, including "climate change", "healthcare" and "aerospace engineering". The derived insights can support R&D managers and policy makers in formulating R&D strategies and directing future R&D investment decisions.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.37 no.3
• /
• pp.297-303
• /
• 2024

In this study, KTN heterolayer thin films were fabricated by alternately stacking films of K(Ta_0.70Nb_0.30)O₃ and K(Ta_0.55Nb_0.45)O₃ synthesized using the sol-gel method. The sintering temperature and time were 750℃ and 1 hour, respectively. All specimens exhibited a polycrystalline pseudo-cubic crystal structure, with a lattice constant of approximately 0.398 nm. The average grain size was around 130~150 nm, indicating relatively uniform sizes regardless of the number of coatings. The average thickness of a single-coated film was approximately 70 nm. The phase transition temperature of the KTN heterolayer films was found to be approximately 8~12℃. Moreover, the 6-coated KTN heterolayer film displayed an excellent dielectric constant of about 11,000. As the number of coatings increased, and consequently the film thickness, the remanent polarization increased, while the coercive field decreased. The 6-coated KTN heterolayer film exhibited a remanent polarization and coercive field of 11.4 μC/cm² and 69.3 kV/cm at room temperature, respectively. ΔT showed the highest value at a temperature slightly above the Curie temperature, and for the 6-coated KTN heterolayer film, the ΔT and ΔT/ΔE were approximately 1.93 K and 0.128×10^-6 K·m/V around 40℃, respectively.

• BMB Reports
• /
• v.57 no.1
• /
• pp.60-65
• /
• 2024

The CRISPR-Cas9 system has significantly advanced regenerative medicine research by enabling genome editing in stem cells. Due to their desirable properties, mesenchymal stem cells (MSCs) have recently emerged as highly promising therapeutic agents, which properties include differentiation ability and cytokine production. While CRISPR-Cas9 technology is applied to develop MSC-based therapeutics, MSCs exhibit inefficient genome editing, and susceptibility to plasmid DNA. In this study, we compared and optimized plasmid DNA and RNP approaches for efficient genome engineering in MSCs. The RNP-mediated approach enabled genome editing with high indel frequency and low cytotoxicity in MSCs. By utilizing Cas9 RNPs, we successfully generated B2M-knockout MSCs, which reduced T-cell differentiation, and improved MSC survival. Furthermore, this approach enhanced the immunomodulatory effect of IFN-r priming. These findings indicate that the RNP-mediated engineering of MSC genomes can achieve high efficiency, and engineered MSCs offer potential as a promising therapeutic strategy.

• Journal of Information Technology Applications and Management
• /
• v.28 no.1
• /
• pp.63-81
• /
• 2021

The advent of the convergence era led to the convergence of industries while increasing the uncertainty of R&D. R&D uncertainty can be addressed by identifying and addressing industrial innovation patterns, which Neo-Schumpeterian suggested can be identified through the process of identifying the technical characteristics of a particular industry, which can be embodied in the concept of technology trajectory. Thus, this study considered and proposed a method to track the technology trajectory of the convergence industry through topic modeling and patent citation network analysis, and applied it to the micro medical robot industry, which is a representative convergence industry, to track the technology trajectory of active catheter. In particular, it is intended to identify the unique characteristics of the industry by identifying the industry before the promotion of the national-led medical robot industry support policy. Therefore, we tried to understand the innovation pattern of the industry by tracking the technology trajectory of the industry before 2017, the time of full-scale support for the medical robot industry in the United States. Through tracking technology trajectories, the role of each technology classification, the development path, and the knowledge flow between applicants were analyzed empirically. The results of this study are expected to contribute to resolving the remaining uncertainties in the process of establishing an active catheter R&D strategy, one of the leading convergence industries, and furthermore, it is expected to be available for tracking technology trajectories in other industries.

• Journal of Digital Convergence
• /
• v.15 no.2
• /
• pp.165-172
• /
• 2017

In this paper, we analyze the research / technology trends of electric vehicles from 2001 to 2014, through keyword analysis using paper data published in SCIE or SSCI Journal on electric vehicles, time series analysis using patent data by IPC, and network analysis using nodeXL. also we predicted promising technologies of electric vehicles using one of the prediction methods, weighted moving average method. As a result of this study, battery technology among the electric vehicle component technologies appeared as a promising technology.

• Journal of Information Science Theory and Practice
• /
• v.10 no.spc
• /
• pp.1-11
• /
• 2022

As data-based research activities and outcomes increase and ontact or non-face-to-face activities become common, the demand for easy utilization of resources, tools, functions, and easily accessible information required for research in the R&D sector has increased accordingly. With the rapid increase in the demand for collaborative research based on online platforms, research support institutions strive to provide venues for research activities that merge various information and functions. ScienceON, an integrated science & technology (S&T) knowledge infrastructure service developed and operated by the Korea Institute of S&T Information (KISTI), supports open collaboration by connecting and merging all the information, functions, and infrastructure required for research activities. This paper describes the online research activity support tool provided by ScienceON and the remarkable results achieved through this activity. Specifically, the excellent creation of the following flow of meta-material research activities in the ontact space is elucidated. First, the papers required for a meta-material analysis are retrieved, virtual simulation is conducted with the experimental data extracted from the papers, and research data are accumulated. ScienceON's tools for supporting ontact research activity will play a role as an important service in the era of digital transformation and open science.

• Journal of Information Technology Applications and Management
• /
• v.27 no.1
• /
• pp.59-73
• /
• 2020

There is a growing interest in convergence. National R & D is also providing various policies and institutional support to promote convergence research. Convergence research, however, does not clearly specify its characteristics at the academic and government levels. This research proceeds with the process of collecting, refining, analyzing, modeling, verifying and visualizing national R & D data through the National Science and Technology Information Service (NTIS). The method is to derive the convergence research characteristics and to derive through text mining, focusing on the unstructured information of national R & D project data. The study confirmed that there was a difference in perception between the definition of converged research and the research site. In order to improve this, the research suggested that convergence among research subjects, collaboration among research topics reflecting various backgrounds and characteristics of researchers, and analysis of characteristics of convergence research using information were suggested in the process of establishing convergence policy.

• Journal of Adhesion and Interface
• /
• v.20 no.1
• /
• pp.9-14
• /
• 2019

The change of three different reagents for electrical conductive paint using aircraft coating with elapsing time of exposure to different condition was investigated. Three different reagents were poured into the vial bottles, stored in air condition and room temperature and observed with elapsing days. In addition, adhesion property of paint was tried using cross cut tape test after storage of $N_2$ atmosphere. The weight of each different reagent was measured along with elapsing time. To confirm the change of chemical component with exposure of air atmosphere, FT-IR was performed. The weight of part A and Part B decreased slightly whereas the weight of part C decreased rapidly and the precipitation was remained. The part B was cured after exposure of $N_2$ atmosphere and the 2250 cm-1 from FT-IR peak decreased slowly at the same time. It was considered that the water contained in air accelerated the reaction of -NCO functional groups and it caused the curing whereas $N_2$ atmosphere not contained water and it resulted in the retardancy of curing.

• The Korean Journal of Physiology and Pharmacology
• /
• v.25 no.5
• /
• pp.459-466
• /
• 2021

Cardiovascular disease (CVD) and its complications are the leading cause of morbidity and mortality in the world. Because of the side effects and incomplete recovery from current therapy, stem cell therapy emerges as a potential therapy for CVD treatment, and endothelial progenitor cell (EPC) is one of the key stem cells used for therapeutic applications. The effect of this therapy required the expansion of EPC function. To enhance the EPC activation, proliferation, and angiogenesis using dronedarone hydrochloride (DH) is the purpose of this study. DH received approval for atrial fibrillation treatment and its cardiovascular protective effects were already reported. In this study, DH significantly increased EPC proliferation, tube formation, migration, and maintained EPCs surface marker expression. In addition, DH treatment up-regulated the phosphorylation of AKT and reduced the reactive oxygen species production. In summary, the cell priming by DH considerably improved the functional activity of EPCs, and the use of which might be a novel strategy for CVD treatment.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.21 no.8
• /
• pp.9-18
• /
• 2022

As the COVID-19 continues, the demand for robotic technology that can be applied in face-to-face tasks such as delivery and transportation, is increasing. Although these technologies have been developed and applied in various industries, the robots can only be operated in a tidy indoor environment and have limitations in terms of payload. To overcome these problems, we developed a 2 degree of freedom(DOF) environmental adaptive robot leg with a double 1-DOF counterbalance mechanism (CBM) based on wire roller. The double 1-DOF CBM is applied to the two revolute joints of the proposed robot leg to compensate for the weight of the mobile robot platform and part of the payload. In addition, the link of the robot leg is designed in a parallelogram structure based on a belt pulley to enable efficient control of the mobile platform. In this study, we propose the principle and structure of the CBM that is suitable for the robot leg, and design of the counterbalance robot leg module for the environment-adaptive control. Further, we verify the performance of the proposed counterbalance robot leg by using dynamic simulations and experiments.