• Title/Summary/Keyword: technical regulation

Search Result 412, Processing Time 0.026 seconds

Docosahexaenoic acid reduces adenosine triphosphate-induced calcium influx via inhibition of store-operated calcium channels and enhances baseline endothelial nitric oxide synthase phosphorylation in human endothelial cells

  • Vu, Thom Thi;Dieterich, Peter;Vu, Thu Thi;Deussen, Andreas
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.23 no.5
    • /
    • pp.345-356
    • /
    • 2019
  • Docosahexaenoic acid (DHA), an omega-3-fatty acid, modulates multiple cellular functions. In this study, we addressed the effects of DHA on human umbilical vein endothelial cell calcium transient and endothelial nitric oxide synthase (eNOS) phosphorylation under control and adenosine triphosphate (ATP, $100{\mu}M$) stimulated conditions. Cells were treated for 48 h with DHA concentrations from 3 to $50{\mu}M$. Calcium transient was measured using the fluorescent dye Fura-2-AM and eNOS phosphorylation was addressed by western blot. DHA dose-dependently reduced the ATP stimulated $Ca^{2+}$-transient. This effect was preserved in the presence of BAPTA (10 and $20{\mu}M$) which chelated the intracellular calcium, but eliminated after withdrawal of extracellular calcium, application of 2-aminoethoxy-diphenylborane ($75{\mu}M$) to inhibit store-operated calcium channel or thapsigargin ($2{\mu}M$) to delete calcium store. In addition, DHA ($12{\mu}M$) increased ser1177/thr495 phosphorylation of eNOS under baseline conditions but had no significant effect on this ratio under conditions of ATP stimulation. In conclusion, DHA dose-dependently inhibited the ATP-induced calcium transient, probably via store-operated calcium channels. Furthermore, DHA changed eNOS phosphorylation suggesting activation of the enzyme. Hence, DHA may shift the regulation of eNOS away from a $Ca^{2+}$ activated mode to a preferentially controlled phosphorylation mode.

A Design and Implement of Efficient Agricultural Product Price Prediction Model

  • Im, Jung-Ju;Kim, Tae-Wan;Lim, Ji-Seoup;Kim, Jun-Ho;Yoo, Tae-Yong;Lee, Won Joo
    • Journal of the Korea Society of Computer and Information
    • /
    • v.27 no.5
    • /
    • pp.29-36
    • /
    • 2022
  • In this paper, we propose an efficient agricultural products price prediction model based on dataset which provided in DACON. This model is XGBoost and CatBoost, and as an algorithm of the Gradient Boosting series, the average accuracy and execution time are superior to the existing Logistic Regression and Random Forest. Based on these advantages, we design a machine learning model that predicts prices 1 week, 2 weeks, and 4 weeks from the previous prices of agricultural products. The XGBoost model can derive the best performance by adjusting hyperparameters using the XGBoost Regressor library, which is a regression model. The implemented model is verified using the API provided by DACON, and performance evaluation is performed for each model. Because XGBoost conducts its own overfitting regulation, it derives excellent performance despite a small dataset, but it was found that the performance was lower than LGBM in terms of temporal performance such as learning time and prediction time.

Development of a Techniques of the Performance Test for a Radiation Protection Devices and it's International Standards (방사선 방호용 계측기 성능평가 기술 개발 및 국제 표준)

  • Choi, Kil-Oung;Won, Sung-Ho;Kim, Jung-Ho;Hah, Suck-Ho;Yi, Chul-Young;Kim, Hyun-Moon;Lee, Min-Kee
    • Journal of Radiation Protection and Research
    • /
    • v.33 no.1
    • /
    • pp.1-12
    • /
    • 2008
  • International Standardization in all technical area is gaining its momentum as its impact and implication over global trade is directly linked. The worldwide competition to secure a dominant position in the standardization process is ever growing over the years. In 2005, the International Technical Committee on Nuclear Instrumentation, which is a subunit of International Electro-technical Commission (IEC), was held in Korea under the auspices of MOST (Ministry of Science and Technology). Korea has adopted its Rule and Regulation as the National Standard. As a part of a link to National Mid-and Long-term Atomic Energy R&D Program of MOST, the technical development of a performance test for the radiation monitors was carried out under mechanical environment and electromagnetic immunity conditions. The characteristics of the radiation fields were also evaluated under the conditions and introduced to a techniques of performance test for the radiation protection instrumentation adopted IEC61526 standards and it's results was analyzed. We would like to share the experience gained in these efforts, failure as well as success, and to discuss the problems encountered and serious consideration to be taken into account in the future endeavor.

The Advancement of Conformity Assessment Scheme in Korea (국내 적합성평가제도 선진화 방안)

  • Yoon, In-Chan;Woo, Tae-Hee
    • Journal of the Korea Safety Management & Science
    • /
    • v.10 no.2
    • /
    • pp.113-121
    • /
    • 2008
  • Recently Conformity Assessment Scheme has greatly played a role in development of domestic industry. But it has limits in responding to change of environment surrounding standard. Therefore management environment has been changed, standard has been more important, and new treaties as like WTO/TBT have been appeared. In these respects this research tries to analyze the policy trends of developed countries and problems of domestic institutions. And it tries to propose seven plans to progress Conformity Assessment Scheme including improvement of domestic standard system on the basis of analytical implications.

Analysis on Technical Regulation of RFID in the 860 MHz to 960 MHz band ($860\~960$MHz 대역 RFID 기술기준 분석)

  • Kong Minkue;Kim H.J;Lee J.S.
    • Proceedings of the Korean Information Science Society Conference
    • /
    • 2005.11a
    • /
    • pp.487-489
    • /
    • 2005
  • 국내에서도 RFID(Radio Frequency IDentification) 기술 및 응용 분야가 확대되고 있어 이의 조기 구축을 통한 관련 기술 발전 핀 세계 시장 진출의 기회 확보를 위해 국제 표준에 부합하는 RFID용 주파수 할당 및 관련 기술기준 제반 규정을 정비할 필요성이 대두되었고 이에 2004년 5월 900MHz RFID용 주파수를 결정하였으며, 13.56MHz대와 2.45GHz RFID에 대한 기술 기준이 제정되어 있다. 그러나 새로운 기술 발전 및 응용에 부합되도록 시급히 개정되어야 하여 세계적으로 대두되고 있는 UHF대 RFID에 대한 기술 기준 제정도 국내외 시장의 관점에서 시급히 이루어져야 한다. 국내 RFID산업이 향후 IT분야를 선도할 가장 중요한 산업중의 하나로 인식되어 정부와 산업계가 모두 RFID기술개발을 추진하고 있는 시점에서 국내 기술기준안물 분석하고 기술기준 제정방향을 제안함으로써 가용한 주파수스펙트럼을 효율적으로 사용하고, 보다 빨리 상용화를 실현함으로써 RFID관련 초기 시장형성 및 활성화를 기대할 수 있다.

  • PDF

An analysis of the potential impact of various ozone regulatory standards on mortality

  • Kim, Yong-Ku
    • Journal of the Korean Data and Information Science Society
    • /
    • v.22 no.1
    • /
    • pp.125-136
    • /
    • 2011
  • Ground-level ozone, an air pollutant that is monitored by the Environmental Protection Agency (EPA), damages human health by irritating the respiratory system, reducing lung function, damaging lung cells, and aggravating asthma and other chronic conditions. In March 2008, the EPA strengthened ozone standards by lowering acceptable limits from 84 parts per billion to 75 parts per billion. Here epidemiologic data is used to study the effects of ozone regulation on human health and assessed how various regulatory standards for ozone may affect nonaccidental mortality, including respiratory-related deaths during ozone season. The assessment uses statistical methods based on hierarchical Bayesian models to predict the potential effects of the different regulatory standards. It also analyzes the variability of the results and ho they are impacted by different modeling assumptions. We focused on the technical an statistical approach to assessing relationship between new ozone regulations and mortality while other researches have detailed the relationship between ozone and human mortality. We shows a statistical correlation between ozone regulations and mortality, with lower limits of acceptable ozone linked to a decrease in deaths, and projects that mortality is expected to decrease by reducing ozone regulatory standards.

The Comparative Analysis of National ITS Standardization System (국가 ITS표준화추진체계 운영효율화방안 (한국.미국.일본사례 비교분석을 중심으로))

  • 이용택;이상건;이승환
    • Journal of Korean Society of Transportation
    • /
    • v.20 no.2
    • /
    • pp.171-181
    • /
    • 2002
  • 본 연구는 한국, 미국, 일본의 ITS 표준추진체계 비교분석(Comparative Analysis)을 통해, 국가 ITS표준 추진체계의 운영효율화방안을 제언하는 것이다. 이를 위해 우리나라의 ITS표준추진체계의 문제점을 파악하고, 국외사례분석을 통해 이를 개선할 수 있는 대응방안을 제언하였다. 미국, 일본사례 비교분석결과, 국가ITS표준화추진체계의 효율적 운영을 위해서는 관.민협력적, 범부처적 국가ITS표준추진체계 모델을 정립하고, 국제표준과 연계하여 국가표준, 부처표준, 단체표준을 추진하되, 해당표준이 표준의 기능과 역할에 부합하도록 개발.제정되어야한다. 사업자와 수요자의 다양한 요구(Need)를 신속히 표준화할 수 있도록 단체표준화육성을 통해 국가 표준화하고, 특히 교통안전과 공공성에 관련된 ITS기술은 정부부터가 강력히 규제할 수 있는 기술기준(Technical Regulation)을 도입하도록 하였다. 아울러 표준제정 뿐만 아니라 데이터등록소(Data Registry) 및 웹기반의 표준화활동 등 표준화구축사업을 통해 표준화의 활동을 활성화하도록 제언하였다.

A Study on Evaluation for Risk Level in Transmission Network Connected with Renewable Energy (신재생에너지 계통 연계에 따른 송전망 Risk Level 평가에 대한 연구)

  • Kim, Sung-Yul;Moon, Sang-Kun;Kim, Jin-O
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
    • /
    • v.25 no.2
    • /
    • pp.87-95
    • /
    • 2011
  • A Renewable Portfolio Standard(RPS) is a regulation that requires the increased generation of energy from renewable energy sources such as solar, wind, fuel cell, small hydro, biomass and geothermal. By environmental, technical and these regulatory reasons, the amount of renewable energy sources will be increased in a network. However, it is hard to assess risk of a transmission network with large scale renewable energy sources because the output characteristics of renewable energies are intermittent. This paper evaluates effects of a transmission system with supplemental large scale renewable energies into the existing system. To evaluate these effects, a methodology for risk level of components in a network is proposed considering steady state and contingency N-1 in this paper. We consider line current and bus voltage in each state of a network.

Determining Optimal Installed Capacity and the Interconnected Bus of Renewable Energy Sources Considering the Cost of Energy Not Supplied (정전비용을 고려한 신재생에너지원의 최적 연계 용량 및 연계 위치 결정에 관한 연구)

  • Kim, Sung-Yul;Lee, Sung-Hun;Kim, Jin-O
    • The Transactions of The Korean Institute of Electrical Engineers
    • /
    • v.61 no.10
    • /
    • pp.1393-1398
    • /
    • 2012
  • Due to environmental regulation and technical improvements, renewable energy sources (RES) are increasingly penetrated and operated in power systems. Clean energy technologies have become cost-competitive with conventional power systems, and in the near future, the generation cost of RES is expected to approach grid parity. In this situation, it should be considered an extraordinarily important issue to be maximized resulting in utilization of RES as well as to develop technologies for efficiency improvement of RES. Therefore, in this paper, the method for determining an optimal installed capacity and interconnected location of RES is proposed in order to minimize the cost of energy not supplied, which can contribute to improve distribution reliability.

A Study on the Technical Regulation of Radio Equipment for EAS System (EAS 시스템을 위한 무선기기 출력기준에 관한 연구)

  • Park, Hyoung-Keun;Kim, Sun-Youb;Ra, Yu-Chan
    • Proceedings of the KAIS Fall Conference
    • /
    • 2009.12a
    • /
    • pp.968-972
    • /
    • 2009
  • 본 논문에서는 8.2MHz 대역의 국내 미약 전계 강도 무선기기의 출력제한치를 다른 외국의 기준치와 비교하였다. 이를 통해 국내의 규정이 미국이나 유럽에 비해 낮음을 확인하였고, 이를 검증하기 위해 8.2MHz EAS 시스템의 출력을 측정하였다. 측정 결과, 전계강도값이 각각 $70.6dB{\mu}V/m$$68.3dB{\mu}V/m$로 측정되었는데, 이러한 값은 국내의 현재 기준인 $102.7dB{\mu}V/m$를 초과하는 값임을 확인하였다. 따라서 8.2MHz 대역의 국내기준의 사양 검토가 필요하다고 사료된다.

  • PDF