• Journal of Ginseng Research
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• v.47 no.2
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• pp.228-236
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• 2023

Background: QiShen YiQi pills (QSYQ) is a Traditional Chinese Medicine (TCM) formula, which has a significant effect on the treatment of patients with myocardial infarction (MI) in clinical practice. However, the molecular mechanism of QSYQ regulation pyroptosis after MI is still not fully known. Hence, this study was designed to reveal the mechanism of the active ingredient in QSYQ. Methods: Integrated approach of network pharmacology and molecular docking, were conducted to screen active components and corresponding common target genes of QSYQ in intervening pyroptosis after MI. Subsequently, STRING and Cytoscape were applied to construct a PPI network, and obtain candidate active compounds. Molecular docking was performed to verify the binding ability of candidate components to pyroptosis proteins and oxygen-glucose deprivation (OGD) induced cardiomyocytes injuries were applied to explore the protective effect and mechanism of the candidate drug. Results: Two drug-likeness compounds were preliminarily selected, and the binding capacity between Ginsenoside Rh2 (Rh2) and key target High Mobility Group Box 1 (HMGB1)was validated in the form of hydrogen bonding. 2 μM Rh2 prevented OGD-induced H9c2 death and reduced IL-18 and IL-1β levels, possibly by decreasing the activation of the NLRP3 inflammasome, inhibiting the expression of p12-caspase1, and attenuating the level of pyroptosis executive protein GSDMD-N. Conclusions: We propose that Rh2 of QSYQ can protect myocardial cells partially by ameliorating pyroptosis, which seems to have a new insight regarding the therapeutic potential for MI.

• Journal of Korean Elementary Science Education
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• v.41 no.1
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• pp.14-29
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• 2022

The purpose of this study is to investigate the components of scientific attitude by some learning topics in the 3rd~6th grade science textbooks that the pre-service elementary school teachers judge to be teachable in class and the educational effects of this analysis activity for the pre-service teachers. The several results of this study are as follows: The pre-service teachers responded that, for all learning topics, they could teach diverse components of scientific attitude and the number of components expressed in their responses is more than the components specified in the teacher's guides. Among the components of scientific attitude, 'curiosity', 'open-mindedness', 'respect for evidence', and 'objectivity' showed relatively high possibility of teaching, while 'honesty', 'collaboration', 'positive acceptance of failure', 'critical mind' and 'suspension of judgment' showed relatively low possibility of teaching. The responses that pre-service teachers judged to be teachable also showed similar patterns in the number of components of scientific attitude and the rate of the components between the learning topics of the 3~4th grades and the learning topics of the 5~6th grades. In addition, this pre-service teachers' analysis activity on the components of scientific attitude by learning topics in science textbooks suggested educational effects such as 'the deep understanding of the components of scientific attitude', 'the understanding and applying the components of scientific attitude in the context of science class', and so on.

• Research in Mathematical Education
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• v.19 no.2
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• pp.101-115
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• 2015

In the present paper, we argue any research concerning human knowledge construction, components, or types needs to clarify its epistemological stance regarding 'knowledge' in that such viewpoint might have much influence on the nature of knowledge the researcher sees and the way in which evidence for knowledge development is gathered. Thus, we suggest two alternative research groups who conducted their studies on mathematical knowledge for teaching with an explicit epistemological standpoint. We finalize our discussion by reviewing concrete examples in the previous literature on teacher knowledge of fraction conducted by the two groups.

• Research in Mathematical Education
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• v.19 no.3
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• pp.155-174
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• 2015

The goal of this study was to examine the three components of a laboratory class cycle that empowered teachers to change their teaching practices. Six teachers and their administrator in an elementary school in the southeastern United States participated in the study. All the teachers were interviewed, and their mathematics lessons were observed at the end of each cycle of laboratory classes. The study revealed how planning, observing, and critiquing mathematics lessons as a team assisted the teachers' learning and teaching. We identified opportunities for the teachers to experiment with different teaching approaches, and we found that support from the team and from the school were key factors for the laboratory class cycle to function effectively.

• Journal of Gifted/Talented Education
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• v.11 no.1
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• pp.19-42
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• 2001

This paper addresses construction of a new network of invention education through the internet and creates a plan to apply it to practical invention education. We examined the status of invention education in Korea, the U.S., and Japan to consider problems of practical invention education and to draw a particular direction for the future invention education. Various papers, books, and documents related invention education were reviewed to make teaching and teaming strategies of invention education. Based on the analyses, criteria of teaching and loaming were identified as how to challenge teachers, students, parents, and administrators to successful implement invention education practices. Using the criteria of teaching and teaming, we designed a framework for a website and constructed a practical website concerned with invention education, including constructive components in the framework. This will require an experimental application during which teachers and researchers can do revisions and add supplementary information. This network system will provide practical information in regard to invention education and created a communications system for in charge of invention education.

• Speech Sciences
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• v.8 no.4
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• pp.185-191
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• 2001

This study was designed to determine what components of spoken language have been relatively neglected in the teaching of listening comprehension in Korea and to suggest a model of listening process. Two types of tests were undertaken using spoken and written forms of English with secondary school teachers of English and college students. Findings: Hearing power has been generally neglected in the teaching of listening comprehension. Hearing power which can be thought as an active process is defined as an ability to transfer the sequence of discrete phonetic segments without word boundary into the sequence of words in phonemic representations by using both nonlinguistic factors and linguistic factors including perception rules based on phonetics and phonology. Vocabularies, hearing-speaking power, syntactic structures and idiomatic expressions are to be taught for spoken English. A model of listening process was suggested and discussed.

• English Language & Literature Teaching
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• v.8 no.2
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• pp.219-243
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• 2003

The purpose of the present study was to develop a new English language model of an integrated syllabus for kindergarteners, in order to teach and learn English. An English syllabus is a tool for realizing the goals of a curriculum, in the planning of language teaching that is primarily concerned with content and method components. Thus appropriate syllabus design can play an important role on the whole effectiveness of early English education, because it presents selection and grading of content and method for English textbooks. The basic principle of the present syllabus is based on the national curriculum of kindergartens. Developing an English syllabus model for kindergarteners could suggest standards and directions for teaching and writing adequate English textbooks for kindergarteners. The syllabus model integrates competence in communication using a proportional approach and focussing on the characteristics of kindergarteners. This study presented an integrated English syllabus for kindergarteners at the ages of five, six, and seven.

• Journal of The Korean Association For Science Education
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• v.38 no.4
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• pp.451-465
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• 2018

The purpose of this study is to investigate the challenges of pre-service teachers for good science teaching with focus on the process of imparting meaning of teaching subject. We have detailed research questions such as, 'What the pre-service teachers thought about teaching subject? How they grasped the meaning of the teaching subject? and What kinds of methods they have used to expose the meaning in their classes?'. We had four pre-service teachers who took the class 'Teaching methods in physics teaching' as voluntary participants in the first semester of 2017. The results show that there are common features in the process of imparting meaning of the teaching subject. The participants started to think about fundamental/existential answer to the question, 'Why should we teach science to students?'. In addition, they grasped the meaning of the teaching subject by using the specific key words. And they tried to link the teaching components with the teaching subject as the center. This challenging process led pre-service teachers to form teachers' identity and to enhance teacher professionalism.

• Journal of Educational Research in Mathematics
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• v.25 no.4
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• pp.617-630
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• 2015

A perspective of the nature of teacher knowledge has a significant impact on why and how we study teacher knowledge. The purpose of this study was to explore the mathematics knowledge in teaching (MKiT) in terms of meanings, characteristics, and analytic methods. MKiT regards teacher knowledge as practical knowledge that has meanings only when it is employed in teaching mathematics. Various components of teacher knowledge interact one another in teaching mathematics. Given this, teacher knowledge is regarded as an organism specific to teaching contexts and it needs to be analyzed by observing lessons or a teacher's actions related directly to the lessons. This paper is expected to induce research on teacher knowledge from the MKiT perspective and urge researchers to have a profound understanding of the nature and analytic methods of teacher knowledge. Some implications of future research are included.

• Research in Mathematical Education
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• v.23 no.4
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• pp.235-254
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• 2020

Through this study, we aimed to capture the nature of a mathematics method course, called "the Curriculum Development and Teaching Methods in Mathematics Education" which is a pedagogy course for teaching for secondary school mathematics taught at a university located in a south eastern part of South Korea. The research participants include three junior students who took the methods course and a local high school math teacher with two professors. The research has three parts. First, we designed a method course to prepare the junior or senior students for a teaching practicum. The individual students gave a mini lecture about a secondary mathematical topic as a course requirement. Second, the three students watched a classroom video-clip of the high school teacher and analyzed his instruction before the actual classroom visits. Furthermore, by "Let's Learn" program for students, the course was associated with a local community through the students and so that they could visit the teacher's classroom three times to observe his math classroom teaching. The students discussed the difference between their own mini lectures and the actual math classroom teaching to develop an understanding of what it entails to teach an actual math class. Third, the first author supervised the students' activities in the program including their report for it to bring out their findings to the class of the method course. We found out this method course provided the students with the experience of various aspects of actual math lesson as well as learning theories about the pedagogy for teaching for secondary school mathematics. We conclude that this course gives a model for the method course in mathematics education for secondary school mathematics.