• The Transactions of the Korean Institute of Electrical Engineers P
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• v.58 no.4
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• pp.410-415
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• 2009

With the implementation of electric power industry reform, the utilities are looking for effective ways to improve the economic efficiency. One area in particular, the equipment maintenance, is being scrutinized for reducing costs while keeping a reasonable level of the reliability in the overall system. Here the conventional RCM requires the tradeoff between the upfront maintenance costs and the potential costs of losing loads. In this paper we describe the issues related to applying so-called the "Reliability-centered Maintenance" (RCM) method in managing electric power distribution equipment. The RCM method is especially useful as it explicitly incorporates the cost-tradeoff of interest, i.e. the upfront maintenance costs and the potential interruption costs, in determining which equipment to be maintained and how often. In comparison, the "Time-based Maintenance" (TBM) method, the traditional method widely used, only takes the lifetime of equipment into consideration. In this paper, the modified Markov model for maintenance is developed. First, the existing Markov model for maintenance is explained and analyzed about transformer and circuit breaker, so on. Second, developed model is introduced and described. This model has two different points compared with existing model: TVFR and nonlinear customer interruption cost (CIC). That is, normal stage at the middle of bathtub curve has not CFR but the gradual increasing failure rate and the unit cost of CIC is increasing as the interruption time is increasing. The results of case studies represent the optimal maintenance interval to maintain the equipment with minimum costs. A numerical example is presented for illustration purposes.

• Proceedings of the KOSOMBE Conference
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• v.1990 no.11
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• pp.114-117
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• 1990

EEG signal is analyzed by two methods, analysis by visual inspection of EEG recording sheets and analysis by quantative method. Generally visual inspection method is used in the clinical field. But this method has its limitation because EEG signal is random signal. Therefore it is necessary to analyze EEG signals quantatively to obtain more precise and objective information of neural and brain. In this paper, power spectrum of EEG signal was estimated by AR(AutoRegressive) model in the frequency domain. This process is useful as a preprocessing stage for tomographic brain mapping (TBM) at each frequency, band. As a method for estimating power spectral density of EEG signals, periodogram method, autocorrelation method. covariance method, modified covariance method, and Burg method are tested in this paper.

• 한국터널공학회:학술대회논문집
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• 2005.04a
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• pp.87-104
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• 2005

Rock masses represent natural systems that are inherently complex and in which multiple mechanisms occur. Rock engineering systems such as tunnel and slope interact with surrounding systems through an exchange of both mass and energy. Accordingly the complex nature of rock masses calls for a system approach, and the open nature of rock engineering even requires the engineering to be controlled by a system approach for surrounding environments. However, traditional methods cannot take all variables and their interactions into account and are limited to the system with single mechanisms. Therefore, they are not proper for a complex and open system, and also cannot portray the whole system. Thus, a system approach is indispensable to rock engineering for dealing with the whole of a complex and open system. In this paper Mechanism Path Analysis Methodology (MPAM) Is Introduced for a system approach to rock engineering. The analysis by the methodology gives us all the information of systems behavior in the context of the whole system in order to accomplish the optimum design in accordance with the project objectives and analysis purposes. As an application a conventional model for the evaluation of TBM tunneling performance system is analyzed by MPAM and the result is compared with that by a traditional method.

• Journal of TMJ Balancing Medicine
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• v.4 no.1
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• pp.1-4
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• 2014

Objectives: Intraoral appliances (IOA) are applied in the clinical practice of Korean medicine to improve the balance between yin and yang of the body such as temporomandibular joint balancing medicine. Historical examples of IOA were not well known. This study reports prototype IOA's described in medical classics. Methods: Several medical classics of 12th to 19th centuries were narratively reviewed for prototypical descriptions of IOA's in the context of clinical practice. Results: IOA's in the medical classics reviewed adopted such materials as bamboo, chopsticks, and coins that were adjusted in the height and were used as a temporary IOA's with response of the patient being monitored. IOA's were applied integratively with herbal medicine for diverse complaints such as pain, hearing problem, cough, asthma, and rhinorrhea. Conclusions: Prototype IOA's in the medical classics suggest an individualized, integrative, and holistic principle and usage of IOA's in the tradition of Korean medicine.

• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.46-53
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• 2017

알츠하이머병은 치매를 유발하는 가장 주된 원인 질환으로 환자들은 인지장애를 겪게 된다. 현재 치료약으로 사용되는 약으로는 acetylcholinesterase 저해재가 있지만 이 약들의 효과는 미비하다. 그래서 인지기능에 영향을 미친다고 알려진 신경전달물질인 GABA, Glutamate, acetylcholine의 수치를 조절 할 수 있는 $5-HT_6$ receptor antagonist가 현재 개발되고 있다. 현재 여러 antagonist들이 임상실험 되었고, 인지 능력향상에 효과를 보이고 있다. 그러나, $5-HT_6$ receptor의 구조가 밝혀지지 않아 아직 원자적 수준의 결합 분석이 이루어지지 않았으므로 이 부분에 대한 연구가 필요하다. 따라서 본 연구에서는 Homology modeling을 통해 receptor의 구조를 예측하고, 현재 임상실험 중인 antagonist들 중 7개를 docking을 통해 단백질과 리간드의 결합을 예측하였다. Edison에서 Galaxy TBM과 Galaxy Refine을 사용하여 Homology modeling 한 결과 GPCR의 전형적인 모델에 특징적으로 긴 cterminal을 가졌다는 것을 확인 할 수 있었다. 생성된 구조를 가지고 Edison의 Dock 프로그램으로 7개의 antagonist가 어떠한 결합을 하는지 분석하였다. 그 결과, binding pose에 공통적으로 Trp102, Asp106, Val107, Pro177, Phe188, Val189, Ala192, Phe284, Phe285, Asn288, Thr306, Tyr310이 관여하는 것을 docking을 통해 알 수 있었다. 특히, Phe285는 7개의 antagonist 중에 4개와의 interaction을 하고 있는 것을 관찰하였다. 이 연구를 통하여 $5-HT_6$에 효과적으로 결합하여 치료효과를 낼 수 있는 신약을 개발할 수 있다.

• Proceeding of EDISON Challenge
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• 2015.03a
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• pp.177-183
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• 2015

$\text\tiny{D}$-Psicose 3-Epimerase (DPE)는 $\text\tiny{D}$-Fructose의 C3 Epimerase로써 $\text\tiny{D}$-Fructose를 $\text\tiny{D}$-Psicose로 전환해 주는 효소이다. $\text\tiny{D}$-Psicose는 설탕 대신 사용하는 감미료로 몸에 흡수되지 않아 칼로리가 없다고 알려져 있고 자연에서는 오로지 DPE에 의해서만 생산되는 희귀당이다. 이에 따라 DPE를 통한 $\text\tiny{D}$-Psicose 대량생산의 필요성이 대두되고 있는 등 이 분야에 대한 관심이 뜨거운 실정이다. 본 연구팀은 이 당과 관련된 작용기작 연구를 수행하기 위하여 아직 단백질 3차구조가 알려지지 않은 Clostridium hylemonae DPE (chDPE) 단백질의 3차 구조예측 연구를 수행 하였다. 우리는 HHsearch를 이용하여 agrobacterium tumefaciens의 DPE 외 2개의 구조를 호몰로지 모델링 연구를 위한 주형으로 선정하였다. 다음으로 PROMALS3D를 이용하여 주형들과 chDPE의 multiple sequence alignment를 수행하였고 이를 바탕으로 3차구조 예측 연구를 수행 하였다. 예측된 구조를 검증하기 위하여 ProSA와 Ramachandran plot분석을 이용하였고 Ramachandran plot에서 단백질의 94.8%에 해당하는 잔기들이 favoured regions에 위치하였다. ProSA에서는 Z-score값이 -9.3으로 X-선 결정학이나 핵자기 공명법으로 밝혀진 구조들에서 관측되는 범위 내에 위치하였다. 나아가 예측된 구조에 $\text\tiny{D}$-Psicose와 $\text\tiny{D}$-Fructose의 결합모드를 규명하기 위하여 도킹을 시도하였다. 이번 연구를 통하여 chDPE의 구조를 예측 할 수 있었고 이를 바탕으로 이 단백질의 기능을 이해하는데 도움을 줄 것으로 기대된다.

• Journal of the Korea Society for Simulation
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• v.29 no.2
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• pp.49-61
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• 2020

It is important to operate a limited number of interceptors effectively to counter ballistic missile threats. The existing interceptor operating method determines the number of interceptors according to the level of TBM (Theater Ballistic Missile) engagement effectiveness applied to a defended asset. It can cause either excessive interceptor waste compared to the intercept probability or the intercept probability decrease. Thus, interceptor operating method must be decided considering the number of ballistic missiles, intercept probability and cost. This study proposes a mathematical model to improve the existing interceptor operating method. In addition, the efficiency indicator is proposed for trade-off between intercept probability and cost. As a result of the simulations, the mathematical model-based interceptor operating method can achieve better results than the existing interceptor operating method.

• Proceedings of the KSR Conference
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• 2004.10a
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• pp.308-327
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• 2004

As use of tunnels and subways increase there also are accidents proportionate to it. Daegu Subway Station fire, Hongjimoon tunnel fire led people to be conscious of disaster protection and as a result, there is a trend to adopt standards for fire protection. Accordingly, this thesis is focused on investigating various fire and water protection related issues for subaqueous tunnel under Ran river. The thesis developed evacuation and disaster prevention plan as fire level increases and have identified the suitability of disaster prevention through evacuation and fire simulation, countermeasure of a water leakage during construction and operation considering the subaqueous tunnel. And we selected EPB shield TBM equipment considering the ground condition and effect of boring hole, and accomplished reasonable water protection design through setting goals using event-tree method, as well as examining model test of boring hole and flooding in heavy rain. Also included structured total system consist of water leakage sensing system, water protection gate, pumping system and fire protection system to respond systematically in emergency.

• Journal of TMJ Balancing Medicine
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• v.5 no.1
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• pp.20-26
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• 2015

Four cases of functional cerebrospinal therapy (FCST) were reviewed to see whether any improvement is observed in the X-ray images of open-mouth view and cephalocervical views. Intraoral appliances of TMJ balancing appliance (TBA) and cervical balancing appliance (CBA) and active movement of within range-of-movement of the jaw and the neck were applied to each patient. Improved balance of $2^{nd}$ cervical vertebra position and cervical alignment were observed in all the four cases.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.324-324
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• 2010

핵융합의 고체형 증식(Helium Cooled Solid Breeder : HCSB) 블랑켓(Blanket Module)은 삼중수소 증식을 위해서 Li4SiO4, Li2TiO3, Li2O 및 Li2ZrO3 등의 페블이 고려되고 있다. 이러한 페블을 제조하기 위해서는 먼저 각각의 분말 제조가 선행되어야 한다. 한국의 Test Blanket Module(TBM)은 Li4SiO4 페블을 개발을 개발하여 사용할 예정이고 옵션으로 Li2TiO3 페블을 개발하는 것으로 되어 있다. Li4SiO4 페블을 개발하기 위해서 먼저 분말합성이 필수적이다. Li4SiO4 분말을 합성에 하기 위해서는 Lithium 금속염과 실리카 졸을 용매 및 폴리머 캐리어로서의 두 가지 기능을 하는 에틸렌글리콜에 첨가한 후 가열하여 완전히 용해시킨 후 혼합 용액을 건조시켜 겔형의 전구체를 제조한다. 이를 하소한 후 결정화시켜 Silicate 분말을 얻는데 이때의 건조, 하소 및 결정화 온도의 조건에 따른 분말의 크기 및 특성이 각각 다르다. 즉, 바인더 물질의 비율과 합성온도에 따라 특성이 약간씩 다른 분말을 얻을 수 있었다. 이렇게 얻어진 Silicate 분말은 지르코니아 볼을 이용하여 약 24 시간 동안 볼 밀링 과정을 통해 입도가 작은 미세한 Silicate 분말로 만들었다. 합성된 분말은 여러 가지 시험 및 분석을 통해서 검증되었으며, 불순물 등은 관찰되지 않았다.