• Journal of Digital Convergence
• /
• v.19 no.3
• /
• pp.1-12
• /
• 2021

This study aims to verify the mediating effect of social support in the relationship between online social relations service utilization(PC, mobile) and life satisfaction for middle-aged and Older Adults. For this purpose, the '2017 Digital Devide Survey' data collected by the National Information Society Agency was used, and among 2,300 middle-aged and Older Adults aged 55 or older, 1,488 people using the Internet were selected as the final analysis target. Then, using the structural equation, the mediating effect of social support was verified in the between online social relations service utilization and life satisfaction. As a result, it was verified that higher levels of mobile-based social relations service utilization have a positive effect on social support and life satisfaction. Also, it was confirmed that social support has a mediating effect in the relationship between the utilization of mobile-based social relations service and life satisfaction. However, the utilization of PC-based social relations services did not show to affect social support and life satisfaction. Therefore, the results of this study can be used as basic data for practical measures to increase the connection between mobile-based social relationship service education and social support promotion education for middle-aged and Older Adults. In addition, the study is meaningful in that it overcomes the limitations of measuring the use of online social relations services as one, and selects tools that are practically effective by dividing them into mobile and PC.

• Animal Bioscience
• /
• v.36 no.1
• /
• pp.144-155
• /
• 2023

Objective: Adipocyte differentiation is regulated by a variety of functional genes and noncoding RNAs. However, the role of miRNAs in lipid deposition of goat white adipose tissue is still unclear. Therefore, this study revealed the miRNA expression profile in goat subcutaneous adipocytes by sRNA-seq. Methods: The miRNA expressed in goat subcutaneous preadipocytes and the mature adipocytes were sequenced by sRNA-seq. The differentially expressed miRNAs (DEm) were screened and gene ontology (GO) and Kyoto encyclopedia for genes and genomes (KEGG) analyses were performed. Gain-of-function and loss-of-function combined with oil red O staining, Bodipy staining, and quantitative reverse-transcription polymerase chain reaction (qPCR) were utilized to determine the effect of miR-133a-3p on adipocyte differentiation. Results: A total of 218 DEm were screened out. The target genes of these DEm were significantly enriched in GO items such as biological regulation and in KEGG terms such as FAK signaling pathway and MAPK signaling pathway. qPCR verified that the expression trend of miRNA was consistent with miRNA-seq. The gain-of-function or loss-of-function of miR-133a-3p showed that it promoted or inhibited the accumulation of lipid droplets, and CCAAT enhancer binding protein α (C/EBPα) and C/EBPβ were extremely significantly up-regulated or down-regulated respectively (p<0.01), the loss-of-function also led to a significant down-regulation of peroxisome proliferator activated receptor gamma (PPARγ) (p<0.01). Conclusion: This study successfully identified miRNAs expression patterns in goat subcutaneous adipocytes, and functional identification indicates that miR-133a-3p is a positive regulator of the differentiation process of goat subcutaneous adipocytes. Our results lay the foundation for the molecular mechanism of lipid deposition in meat-source goats from the perspective of miRNA.

• Korea Journal of Hospital Management
• /
• v.17 no.2
• /
• pp.21-33
• /
• 2012

Purpose : This study aims to suggest application of patients DB to hospital marketing by performing market segmentation and selecting target market. Consequently help to establish suited strategy of marketing. Method : 14,072 patients hospitalized in a University Medical Center were recruited into this study. In order to classify the customer groups, cluster analysis was used with RFM(Recency, Frequency, Monetary) model, and 1-way ANOVA verified the differences among groups. And then, sociodemographical status, healthcare utilization and diagnosis(ICD-10) of each group were compared to draw a marketing strategy. Results : Four groups were classified through clustering analysis, and'high use and high profit' and'low use and high profit' groups were selected as a target market. The features of target market were as follows, the female proportion was high; used a private room; hospitalized through the emergency room; had operation; length of stay was long; had many comorbidity and cooperative treatment. There was difference in each feature of target market: as for the'high use and high profit' group, many patients were diagnosed with 'certain infectious and parasitic diseases'; and as for the'low use and high profit'group, the proportion of patients who purchased'industrial accident compensation insurance'and'auto insurance'was relatively high; many patients were diagnosed with'Injury, poisoning and certain other consequences of external causes'. Conclusion : It is needed to establish'positioning' strategy by monitoring and communicating with'high use and high profit' group. And for the case of'low use and high profit' group, it is necessary to make a follow-up management and lead them to have a medical check-up.

• Proceedings of KOSOMES biannual meeting
• /
• 2004.05b
• /
• pp.35-38
• /
• 2004

IMO sub-committee on safety of navigation has worked a draft recommendation for RTE in order to amy a radar target enhancer(RTE) on small ships. According to the draft recommendation for RTE, we need a preliminary research for RTE development and its applicability. In this paper, we investigate the results rf field tests in other countries and analyze technical and critical problems in RTE The results of our analysis will provide helpful comments in IMO subcommmitte as well as in a domestic development of RTE.

• International Journal of Highway Engineering
• /
• v.16 no.3
• /
• pp.85-99
• /
• 2014

PURPOSES : This study has been performed with the objective to determine threshold zone luminance of adaptation luminance by target safety level in a vehicular traffic tunnel with design speed set at 100km/h. METHODS : The study made a miniature capable of portraying changes in luminance distribution within $2{\times}10^{\circ}$ conical field of view of the driver approaching to the tunnel for the test. Test conditions were set based on justifications for CIE 88-1990's threshold zone luminance used as a reference by domestic tunnel light standards (KS C 3703 : 2010). Luminance contrast of object background and object is 23%, object presentation duration is 0.5 seconds, and size of the object background is $7.3{\times}11.5m^2$ RESULTS : Threshold zone luminance was set within adaptation luminance of $100{\sim}3,000cd/m^2$. Adaptation luminance and threshold zone luminance based on 50%, 75% and 90% target safety level all showed a relatively high linear relationship. According to findings in the study, it is not appropriate to specify the relationship between adaptation luminance and threshold zone luminance as luminance ratio. Rather, direct utilization of the linear relationship gained from the study findings appears to be the better solution. CONCLUSIONS : Findings of this study may be used to determine operation of threshold zone luminance based on target safety level. However, a proper verification and validity of test results are required. Furthermore, a study to determine proper threshold zone luminance level considering target safety level reviewed in this study and various decision-making factors such as economic conditions in Korea and energy-related policies should be carried out in addition. Additional tests on adaptation luminance greater than $3,000cd/m^2$ will be performed, through which application scope of the test findings will be broadened.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.43 no.3 s.345
• /
• pp.78-83
• /
• 2006

In this paper, we propose Active bandwidth allocation scheme of multiplexed streamed MPEG video sequences over BcN network. In order to real time processing, multiplexed source is estimated by linear-prediction per measurement period. n the result target quality value were not sufficient, we proposed a over-allocation method and a reallocation one to guarantee QoS. We used two kinds of sources, one is random multiplexed source made of four different video sources, the other is the one considered the arrange of I frame in the sequence. With those sources, we analyzed the linear prediction, compared over-allocation with reallocation method. As a result, In both schemes, the objected target quality value is achieved, the sufficient valuce bandwidth under 10% when measurement period is over 1.8 sec, the utilization is over 0.9. Especially, the Target of quality value of the reallocation scheme is better at the same condition.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.44 no.2
• /
• pp.140-152
• /
• 2021

During the shift from gasoline vehicles to electric ones, auto parts manufacturing companies have realized the importance of improvement in the manufacturing process that does not require any layout changes nor extra investments, while maintaining their current production rate. Due to these reasons, for the auto part manufacturing company, I-company, this study has developed the simulation model of the PUSH system to conduct a process analysis in terms of production rate, WIP level, and logistics work's utilization rate. In addition, this study compares the PUSH system with other three manufacturing systems -KANBAN, DBR, and CONWIP- to compare the performance of these production systems, while satisfying the company's target production rate. With respect to lead-time, the simulation results show that the improvement of 77.90% for the KANBAN system, 40.39% for the CONWIP system, and 69.81% for the DBR system compared to the PUSH system. In addition, with respect to WIP level, the experimental results demonstrate that the improvement of 77.91% for the KANBAN system, 40.41% for the CONWIP system, and 69.82% for the DBR system compared to the PUSH system. Since the KANBAN system has the largest impacts on the reduction of the lead-time and WIP level compared to other production systems, this study recommends the KANBAN system as the proper manufacturing system of the target company. This study also shows that the proper size of moving units is four and the priority allocation of bottleneck process methods improves the target company's WIP and lead-time. Based on the results of this study, the adoption of the KANBAN system will significantly improve the production process of the target company in terms of lead-time and WIP level.

• Herbal Formula Science
• /
• v.32 no.1
• /
• pp.11-28
• /
• 2024

Objectives : GunRyeong-Tang(GRT) is a traditional herbal prescription that combines Oryeongsan and Sagunja-tang. This study employed network analysis methods on the components of GRT and target genes related to diabetes complications to predict the improvement effects of GRT on diabetes complications. Methods : The collection of active compounds of GRT and related target genes involved the utilization of public databases and the PubChem database. We selected diabetes complication-related genes using GeneCards and confirmed their correlation through comparative analysis with the target genes of GRT. We constructed a network using Cytoscape 3.9.1 and conducted topological analysis. To predict the mechanism, we performed functional enrichment analysis based on Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results : Through network analysis, 234 active compounds and 1361 related genes were collected from GRT. A total of 9,136 genes related to diabetes complications were collected, and 1,039 target genes overlapping with the components of GRT were identified. The core genes of this network were TP53, INS, AKT1, ALB, and EGFR. In addition, GRT significantly reduced the H9c2 cell size and the expression of myocardial hypertrophy biomarkers (ANP, BNP), which were increased by high glucose (HG). Conclusions : Through this study, we were able to predict the activity and mechanism of action of GRT on diabetes and diabetic complications, and confirmed the potential of GRT as a treatment for diabetes complications through the effect of GRT on improving myocardial hypertrophy for diabetic cardiomyopathy.

• IE interfaces
• /
• v.17 no.4
• /
• pp.472-481
• /
• 2004

In this paper, we propose a linear programming model of supply planning process for the supply chain collaboration strategy of a company. The amount of its supplying quantity relies on outsourcing suppliers heavily. Conversely, the revenues of those suppliers are highly dependent on the supplying quota from the supply network planning of the company. In order to keep the supply stable through collaboration, the company builds such a policy to guarantee the fairness on revenue between the supplies. For this, the supply network plan should keep the capacity utilization ratio even for all the suppliers. But the production capacities are different and the distribution of molds is disproportional through suppliers, so the supply network plan is not easily established with simple arithmetic processes. Therefore, we developed the linear programming model with those target function and constraints minimizing the costs for holding inventory and penalty of delayed delivery, simultaneously guaranteeing the even capacity utilization through suppliers. The proposed model has been applied to real case and the evaluation for the planning result from the model would be followed in order to make sure that our model guarantee on extracting the supply network plan subordinated to the policy. Also we mention about further studies for improvement of the model.

• Journal of Distribution Science
• /
• v.18 no.9
• /
• pp.67-75
• /
• 2020

Purpose: The purpose of this study is to enhance sales promotion efficiency for using solid refuse fuel facilities. Renewable energy technology using Solid Refuse Fuel (SRF) is an economic efficiency technology that recovers waste by burning various wastes. A survey on the pollutants discharged from the solid fuels facilities was investigated so that the SRF facilities could be expanded, distributed and reflected in the policy. Research design, data, and methodology: In this study, 9 business sites using SRF and Bio-SRF as main raw materials were investigated for 2 years. The characteristics of target business sites such as the type of fuel used, combustion method, combustion temperature, daily fuel consumption and environmental prevention facilities were studied. Results: The average pollution & ammonia concentration of Bio-SRF facilities was found to be 88.15% higher than that of SRF facilities. But the average acetaldehyde concentration of SRF facilities was found to be 88.15% higher than that of Bio-SRF facilities. Conclusions: The main issue is how much electric power generation using combustible materials affects air pollution. The waste recycling law provides the standard value according to the fuel property, but there is a considerable gap with the mixed fuel. Therefore, for efficient utilization of facilities using solid fuel products, additional research is needed to improve the distribution structure of exhaust pollutants is needed.