• Journal of Communications and Networks
• /
• v.6 no.1
• /
• pp.68-77
• /
• 2004

In the near future packet networks should support applications which can not predict their traffic requirements in advance, but still have tight quality of service requirements, e.g., guaranteed bandwidth, jitter, and packet loss. These dynamic characteristics mean that the sources can be made to modify their data transfer rates according to network conditions. Depending on the customer&; needs, network operator can differentiate incoming connections and handle those in the buffers and the interfaces in different ways. In this paper, dynamic QoS-aware scheduling algorithm is presented and investigated in the single node case. The purpose of the algorithm is in addition to fair resource sharing to different types of traffic classes with different priorities ?to maximize revenue of the service provider. It is derived from the linear type of revenue target function, and closed form globally optimal formula is presented. The method is computationally inexpensive, while still producing maximal revenue. Due to the simplicity of the algorithm, it can operate in the highly nonstationary environments. In addition, it is nonparametric and deterministic in the sense that it uses only the information about the number of users and their traffic classes, not about call density functions or duration distributions. Also, Call Admission Control (CAC) mechanism is used by hypothesis testing.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.2 no.6
• /
• pp.29-37
• /
• 1994

Active noise control of random noise which propatate in the vehicle cabin as a form of spherical wave is the target of this study. In the previous study, the adaptive algorithm for adaptive controller is presented for the application in active noise control system. And for the preliminary study of adaptive active noise control in vehicle cabin as a real system, a computer simulation is performed on the effectiveness of the adaptive algorithm in the amplitude of the pressure fluctuation. This work studies the implementation of multi-channel feedforward adaptive algorithm for the reduction of the noise inside a vehicle cabin using a number of secondary sources derived by adaptive filtering of reference noise source. Multi-channel adaptive feedforward algorithm are verified in numerical simulation and semi-experimental justification of developed system is made on a domestic passenger car. In the results of semi-experimental study, the noise of specific region in the interior of automobile are reduced for the appreciabe sound pressure level in the operating engine rpm and finally this study suggests the capabilities of the real time active noise control in 3 dimensional acoustic fields.

• Current Optics and Photonics
• /
• v.5 no.2
• /
• pp.164-172
• /
• 2021

In this paper a catadioptric laser-irradiation-precision test system is designed, to achieve a high-precision laser-irradiation-accuracy test. In this system, we adopt the method of imaging the entire target surface at a certain distance to realize the measurement of laser-irradiation precision. The method possesses the advantages of convenient operation, high sensitivity, and good stability. To meet the test accuracy requirement of 100 mm/km (0.01%), the coma, field curvature, and distortion over the entire field of view should be eliminated from the optical system's design. Taking into account the whole length of the tube and the influence of stray light on the structure type, a catadioptric system with a hood added near the primary imaging surface is designed. After optimization using the ZEMAX software, the modulation transfer function (MTF) of the designed optical system is 0.6 at 30 lp/mm, the full-field-of-view distortion is better than 0.18%, and the energy concentration in the 10-㎛-radius surrounding circle reaches about 90%. The illumination-accuracy test results show that the measurement accuracy of the radiation hit rate is better than 50 mm when the test distance is 1 km, which is better than the requirement of 100 mm/km for the laser-irradiation-accuracy test.

• Journal of Life Science
• /
• v.30 no.5
• /
• pp.483-490
• /
• 2020

The ubiquitin system uses ligases and deubiquitinases (DUBs) to regulate ubiquitin position on protein substrates and is involved in many biological processes which determine stability, activity, and interaction of the target substrate. DUBs are classified in six groups according to catalytic domain, namely ubiquitin-specific proteases (USPs); ubiquitin C-terminal hydrolases (UCHs); ovarian tumor proteases (OTUs); Machado Joseph Disease proteases (MJDs); motif interacting with Ub (MIU)-containing novel DUB family (MINDY); and Jab1/MPN/MOV34 metalloenzymes (JAMMs). Otubain 1 (OTUB1) is a DUB in the OTU family which possesses both canonical and non-canonical activity and can regulate multiple cellular signaling pathways. In this review, we describe the function of OTUB1 through regulation of its canonical and non-canonical activities in multiple specifically cancer-associated pathways. The canonical activity of OTUB1 inhibits protein ubiquitination by cleaving Lys48 linkages while its non-canonical activity prevents ubiquitin transfer onto target proteins through binding to E2-conjugating enzymes, resulting in the induction of protein deubiquitination. OTUB1 can therefore canonically and non-canonically promote tumor cell proliferation, invasion, and drug resistance through regulating FOXM1, ERα, KRAS, p53, and mTORC1. Moreover, clinical research has demonstrated that OTUB1 overexpresses with high metastasis in many tumor types including breast, ovarian, esophageal squamous, and glioma. Therefore, OTUB1 has been suggested as a diagnosis marker and potential therapeutic target for oncotherapy.

• Industry Promotion Research
• /
• v.5 no.3
• /
• pp.53-60
• /
• 2020

This paper describes the role of counselors' transitional object for the therapeutic activation of clients who have lost the function of selfobject based on Heinz Kohut's Self theory. In this study, it was an opportunity to confirm that human beings need self-target throughout their lives. Next, referring to the process of metamorphic internalization, infants return to reality from a fantasy world, experiencing parental limitations due to optimal frustration through self-targeting. The role of a counselor as a transfer target shall ensure that the counsellor establishes an cohesive self-identity and uses the appropriate self-target. And they should empathize with the over-the-topism and flauntism of the physician, and the counselor should be the object of idealization, giving the interviewer the opportunity to be recognized and identified. The counselor may provide the best frustration for the counsellor during the consultation process. When the counselor acknowledges his mistake, the counselor looks at the counselor realistically and builds a healthy self to achieve transformative internalization. If you form an cohesive self to a physician through counseling, you can empathize with others and form a healthy human relationship. Then you can control your emotions and have a vision. And the patient realizes that he or she has no choice but to live by having a relationship with the right person throughout his or her life.

• Korean Journal of Optics and Photonics
• /
• v.33 no.6
• /
• pp.295-302
• /
• 2022

In this paper, a wedge prism application method was studied to design a full-high-definition (FHD)-class high-resolution flexible endoscope. In the case of the conventional flexible endoscope optical system, the F number is made large or a liquid lens is applied to obtain the same imaging performance in a wide depth of field. However, there is a problem in that the diameter of the optical system increases because an additional light guide and equipment are required. To solve this problem, two wedge prisms were applied to the flexible endoscope optical system to adjust the image distance for each object distance. First, two wedge prisms were symmetrically placed on the designed endoscopic optical system. An image distance satisfying the target imaging performance according to each objective distance was derived. Next, the wedge prism decenter value for controlling the image distance was derived. By combining these two data, a wedge prism decenter value that satisfied the target imaging performance at each object distance was applied in multi configurations. As a result of the optimal design applied with the wedge prism, a target imaging performance of more than 20% of the modulation transfer function for a resolution of 178 cycles/mm was satisfied in the entire depth of field of 100 mm-7 mm.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.12
• /
• pp.7523-7527
• /
• 2013

Thymidylate synthase (TS) catalyzes the transfer of a methyl group from methylenetetrahydrofolate to dUMP to form dTMP. It is a primary target in the chemotherapy of colorectal cancers and some other neoplasms. In order to obtain pure protein for analysis of structure and biological function, an expression vector TS-pET28b (+) was constructed by inserting wild-type human thymidylate synthase (hTS) cDNA into pET28b (+). Then an expression strain was selected after transformation of the recombined plasmid into Rosetta (DE3). Fusion protein with His-tag was efficiently expressed in the form of inclusion bodies after IPTG induction and the content was approximately 40.0% of total bacteria proteins after optimizing expression conditions. When inclusion bodies were washed, dissolved and purified by Ni-NTA under denatured conditions, the purity was up to 90%. On SDS-PAGE and West-blotting, the protein band was found to match well with the predicted relative molecular mass-36kDa. Bioactivity was 0.1 U/mg. The results indicated that high-level expression of wild-type hTS cDNA can be achieved in prokaryotes with our novel method, facilitating research into related chemotherapy.

• Journal of Environmental Health Sciences
• /
• v.37 no.1
• /
• pp.50-56
• /
• 2011

The adsorption capacity of charcoal is a function of the airborne concentration of the target chemical. To evaluate the adsorption capacity of charcoal packed in the cartridges of air purifying respirators, breakthrough tests were conducted with carbon tetrachloride for three commercial cartridges (3M models #7251, #6000 and AX) at 25, 50, 100, 250 and 500 ppm. Adsorption capacities were calculated using a mass transfer balance equation derived from the curve fitting to the breakthrough curves obtained experimentally. Carbon micropore volumes were estimated by iteration to fit the Dubinin/Radushkevich (D/R) adsorption isotherm. They were 0.6566, 0.5727 and 0.3087 g/cc for #7251, #6000 and the AX cartridge, respectively. Above 100 ppm (at high challenge concentrations), #7251 and #6000 showed higher adsorption capacities. However, as the challenge concentration decreased, the adsorption capacities of #7251 and #6000 sharply dropped. On the other hand, the adsorption capacity of the AX cartridge showed little change with the decrease of the challenge concentration. Thus, the AX showed a higher adsorption capacity than #7251 and #6000 at the 5-50 ppm level. It is concluded that service-life tests of cartridges and adsorption capacity tests of charcoal should be conducted at challenge concentration levels reflecting actual working environmental conditions. Alternatively, it is recommended to use the D/R adsorption isotherm to extrapolate adsorption capacity at low concentration levels from the high concentration levels at which breakthrough tests are conducted, at a minimum of two different concentration levels.

• The Transactions of the Korean Institute of Electrical Engineers A
• /
• v.53 no.11
• /
• pp.596-603
• /
• 2004

This paper proposes an expert system based on the pattern recognition method which can enhance the accuracy and effectiveness of real-time bus reconfiguration strategy for the transfer of faulted load when a main transformer fault occurs in the automated substation. The minimum distance classification method is adopted as the pattern recognition method of expert system. The training pattern set is designed MTr by MTr to minimize the searching time for target load pattern which is similar to the real-time load pattern. But the control pattern set, which is required to determine the corresponding bus reconfiguration strategy to these trained load pattern set is designed as one table by considering the efficiency of knowledge base design because its size is small. The training load pattern generator based on load level and the training load pattern generator based on load profile are designed, which are can reduce the size of each training pattern set from max L/sup (m+f)/ to the size of effective level. Here, L is the number of load level, m and f are the number of main transformers and the number of feeders. The one reduces the number of trained load pattern by setting the sawmiller patterns to a same pattern, the other reduces by considering only load pattern while the given period. And control pattern generator based on exhaustive search method with breadth-limit is designed, which generates the corresponding bus reconfiguration strategy to these trained load pattern set. The inference engine of the expert system and the substation database and knowledge base is implemented in MFC function of Visual C++ Finally, the performance and effectiveness of the proposed expert system is verified by comparing the best-first search solution and pattern recognition solution based on diversity event simulations for typical distribution substation.

• Korean Journal of Biological Psychiatry
• /
• v.8 no.2
• /
• pp.220-225
• /
• 2001

As numbers of serotonin's function are so many, studies of serotonin are numerous nowadays. In the beginning, concentration of metabolites such as 5-HIAA was a key issue, but recent studies have been challenged for serotonin receptor genes and their relation to mood disoder. Serotonin transporter(5-HTT) gene is a strong candidate gene of mood disoder for following reason. Serotonin transporter is a key protein in the serotonin pathway as it regulate the concentration of serotonin in the synaptic clept and essential pathophysiology of depression is dysregulation of 5-HTT so that all antidepressants have effect of 5-HTT antagonist. The decrease of 5-HTT in the platelet and in brain of the depressive patients is much consistent results in the studies of the pathophysiology of mood disorder till now. By this, we will be able to develop simple and easy marker for diagnosis, type, and treatment monitoring of depression. Many psychiatrists have sought the independent genes in relation to depression or schizophrenia. Obviously, the hereditary vulnerability contributes to etiology of mood disorders, but it is difficult to discriminate the independent genes because of many environmental factors. Moreover, in the hereditarily complex diseases such as mood disorder, the only vulnerability of gene can not sufficiently explain the etiology. In the future, to exclude the role of the gene-environmental interaction, the methods such as gene transfer can be considered. In the opposite direction, by using the gene destruction method, the role of target genes can be examined. As yet the concept of the gene expression, neural plasticity, neurogenesis and etc, is the elementary stage. The development of this field will help to establish the treatment strategy of chronic and refractory mood disorders.