• Molecules and Cells
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• v.42 no.10
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• pp.729-738
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• 2019

Autophagy is an important process for protein recycling. Oligomerization of p62/SQSTM1 is an essential step in this process and is achieved in two steps. Phox and Bem1p (PB1) domains can oligomerize through both basic and acidic surfaces in each molecule. The ZZ-type zinc finger (ZZ) domain binds to target proteins and promotes higher-oligomerization of p62. This mechanism is an important step in routing target proteins to the autophagosome. Here, we determined the crystal structure of the PB1 homo-dimer and modeled the p62 PB1 oligomers. These oligomer models were represented by a cylindrical helix and were compared with the previously determined electron microscopic map of a PB1 oligomer. To accurately compare, we mathematically calculated the lead length and radius of the helical oligomers. Our PB1 oligomer model fits the electron microscopy map and is both bendable and stretchable as a flexible helical filament.

• Phonetics and Speech Sciences
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• v.4 no.3
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• pp.111-117
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• 2012

In this paper, we compare the performance of several speaker adaptation methods for a HMM-based Korean speech synthesis system with small amounts of adaptation data. According to objective and subjective evaluations, a hybrid method of constrained structural maximum a posteriori linear regression (CSMAPLR) and maximum a posteriori (MAP) adaptation shows better performance than other methods, when only five minutes of adaptation data are available for the target speaker. During the objective evaluation, we find that the duration models are insufficiently adapted to the target speaker as the spectral envelope and pitch models. To alleviate the problem, we propose the duration rectification method and the duration interpolation method. Both the objective and subjective evaluations reveal that the incorporation of the proposed two methods into the conventional speaker adaptation method is effective in improving the performance of the duration model adaptation.

• Journal of Multimedia Information System
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• v.2 no.3
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• pp.263-274
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• 2015

The subject of this work is the complex discrete systems simulation special features with the aid of dynamic graph models. The proposed simulation technique allows to determine the ways for tasks solutions in terms of discrete systems analysis and synthesis of various complication: one-dimensional and multidimensional, steady and unstable, with the pulse elements abnormal operating mode and others. Often complex control systems analysis and synthesis task solutions, via classical approach comes out to be insolvent, because of the computational problems. The application of graph models allows to perform clear and strict characterization and computer procedures automation. The optimal controls synthesis algorithm presented in this paper, transferring the discrete system from target initial state to target final state within the minimum time, allows to consider the zero initial conditions systems, with the initial potential energy, with the control actions limitations and complex pulse elements operating mode.

• Journal of international Conference on Electrical Machines and Systems
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• v.3 no.3
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• pp.325-330
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• 2014

Eddy current induction is used in a wide range of electronic devices, for example in detection sensors. Due to the advances in computer hardware and software, the need for 3D computation and system comprehension is a requirement to develop and optimize such devices nowadays. Pure theoretical models are mostly limited to special cases. On the other hand, the classical use of commercial Finite Element (FE) electromagnetic 3D models is not computationally efficient and lacks modeling flexibility or robustness. The proposed approach focuses on: (1) implementing theoretical formulations in 3D (FE) model of a detection device as well as (2) an automatic Volumetric Estimation Method (VEM) developed to selectively model the target finite elements. Due to these two approaches, this model is suitable for parametric studies and optimization of the number, location, shape, and size of PCB receivers in order to get the desired target discrimination information preserving high accuracy with tenfold reduction in computation time compared to commercial FE software.

• Journal of Korean Society for Quality Management
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• v.25 no.4
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• pp.57-70
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• 1997

Consider a production system where all manufactured products are screened through automatic inspection equipment. The products for which the measured value of quality characteristic is larger than the lower screening specification limit (SL) and smaller than the u, pp.r screeing specification limit(SU) are accepted. Those smaller than SL are reworked and those larger than SU are excluded from the process. Assuming that the quality characteristic is normally distributed with known variance, this paper suggests cost models which involve inspection cost, production cost, rework cost, exclusion cost and quality cost, and presents the methods of finding the optimal values of the screening specification limits and the process target. Numerical example is given to demonstrate the a, pp.icability of the cost models suggested in this paper.

• International Journal of Aeronautical and Space Sciences
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• v.2 no.2
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• pp.82-94
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• 2001

The purpose of this paper is to analyze the static and dynamic stability-of the unmanned airship under development ; the target airship's over-all length of hull is 50m and the maximum diameter is 12.5m. For the analysis, the dynamic model of an airship was defined and both the nonlinear and linear dynamic equations of motion were derived. Two different configuration models (KA002Y and KA003Y) of the airship were used for the target model of the static stability analysis and the dynamic stability analysis. From the result of analyses, though the airship is unstable in static stability, dynamic characteristics of the airship can provide the stable dynamic stability. All of the results, airship models and dynamic flight equations will be an important basement and basic information for the next step of developing the automatic flight control system(AFCS) and the stability augmentation system(SAS) for the unmanned airship as well as for the stratospheric airship in the future.

• Journal of Integrative Natural Science
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• v.7 no.4
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• pp.234-240
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• 2014

C-C chemokine receptor type 4 (CCR4) is a chemokine receptor with seven transmembrane helices and it belongs to the GPCR family. It plays an important role in asthma, lung disease, atopic dermatitis, allergic bronchopulmonary aspergillosis, cancer, inflammatory bowel disease, the mosquito-borne tropical diseases, such as dengue fever and allergic rhinitis. Because of its role in wide spectrum of disease processes, CCR4 is considered to be an important drug target. Three dimensional structure of the protein is essential to determine the functions. In the present study homology modeling of human CCR4 was performed based on crystal structure of CCR5 chemokine receptor. The generated models were validated using various parameters. Among the generated homology models the best one is selected based on validation result. The model can be used for performing further docking studies to identifying the critical interacting residues.

• Journal of Integrative Natural Science
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• v.10 no.1
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• pp.20-26
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• 2017

Chemerin receptor, which predominantly expressed in immune cells as well as adipose tissue, was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Chemerin is a widely distributed multifunctional secreted protein implicated in immune cell migration, adipogenesis, osteoblastogenesis, angiogenesis, myogenesis, and glucose homeostasis. Recent studies suggest chemerin may play an important role in the pathogenesis of obesity and insulin resistance and it becomes a potential therapeutic target for treating type II diabetes. The crystal structure of chemerin receptor has not yet been resolved. Therefore, in the present study, homology modelling of CMKLR1 was done utilizing the crystal structure of human angiotension receptor in complex with inverse agonist olmesartan as the template. Since the template has low sequence identity, we have incorporated both threading and comparative modelling approach to generate the three dimensional structure. 3D models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of CMKLR1.

• Journal of Integrative Natural Science
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• v.9 no.3
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• pp.185-189
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• 2016

Urotensin-2 receptor (UTS2R) is the most potent vasoconstrictor and plays a major role in the pathophysiology of various cardiovascular diseases and becomes a potential target for human pharmacotherapy. The crystal structure of Urotension-2 receptor has not yet been resolved. Hence, in the current study homology modelling of UTS2R was done utilizing the crystal structure of human delta opioid receptor as the template. Since the template has low sequence identity, we have incorporated both comparative modelling and threading approach to generate the three dimensional structure. 10 models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of UTS2R.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.1
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• pp.160-170
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• 2008

Shape morphing is the process of transforming a source shape, through intermediate shapes, into a target shape. Two main problems to be considered in three dimensional shape morphing are vertex correspondence and path interpolation. In this paper, an approach which uses the linear interpolation of the Laplacian coordinates of the source and target meshes is introduced for the determination of more plausible path when two topologically identical shapes are morphed. When two shapes to be morphed are different in shape and topology, a new method which combines shape deformation theory based on Laplacian coordinate and mean value coordinate with distance field theory is proposed for the efficient treatment of vertex correspondence and path interpolation problems. The validity and effectiveness of the suggested method was demonstrated by using it to morph large and complex polygon models including male and female whole body models.