Journal of Integrative Natural Science (통합자연과학논문집)

The Basic Science Institute Chosun University (조선대학교 기초과학연구원)
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Homology Modelling of Urotension-2 Receptor (UTS2R): Potential Target for Human Pharmacotherapy

  • B, Sathya. (Department of Genetic Engineering, School of Bioengineering, SRM University)
  • Received : 2016.07.21
  • Accepted : 2016.09.25
  • Published : 2016.09.30
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Abstract

Urotensin-2 receptor (UTS2R) is the most potent vasoconstrictor and plays a major role in the pathophysiology of various cardiovascular diseases and becomes a potential target for human pharmacotherapy. The crystal structure of Urotension-2 receptor has not yet been resolved. Hence, in the current study homology modelling of UTS2R was done utilizing the crystal structure of human delta opioid receptor as the template. Since the template has low sequence identity, we have incorporated both comparative modelling and threading approach to generate the three dimensional structure. 10 models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of UTS2R.

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References

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