• IE interfaces
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• v.17 no.4
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• pp.472-481
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• 2004

In this paper, we propose a linear programming model of supply planning process for the supply chain collaboration strategy of a company. The amount of its supplying quantity relies on outsourcing suppliers heavily. Conversely, the revenues of those suppliers are highly dependent on the supplying quota from the supply network planning of the company. In order to keep the supply stable through collaboration, the company builds such a policy to guarantee the fairness on revenue between the supplies. For this, the supply network plan should keep the capacity utilization ratio even for all the suppliers. But the production capacities are different and the distribution of molds is disproportional through suppliers, so the supply network plan is not easily established with simple arithmetic processes. Therefore, we developed the linear programming model with those target function and constraints minimizing the costs for holding inventory and penalty of delayed delivery, simultaneously guaranteeing the even capacity utilization through suppliers. The proposed model has been applied to real case and the evaluation for the planning result from the model would be followed in order to make sure that our model guarantee on extracting the supply network plan subordinated to the policy. Also we mention about further studies for improvement of the model.

• The Journal of the Convergence on Culture Technology
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• v.7 no.4
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• pp.227-236
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• 2021

The purpose of this study is to promote the efficient operation of the Home visit nursing care services by identifying the perception and experience of visiting nurses at the community center. To this end, a methodological triangle study method was applied to visiting nurses. As a result of analysis the delivery system of the home visit nursing care services, the perception and participation experience of nurses, it was found that it is necessary to supplement the program standards such as the number of visiting target, health assesment, and information system for the efficiency of the visit. It is suggested that policy alternatives should be developed by sharing the major issues raised in this study.

• Development and Reproduction
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• v.17 no.1
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• pp.9-16
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• 2013

Coactivator-associated arginine methyltransferase 1 (CARM1) is included in the protein arginine methyltransferase (PRMT) family, which methylates histone arginine residues through posttranslational modification. It has been proposed that CARM1 may up-regulate the expression of pluripotency-related genes through the alteration of the chromatin structure. Mouse embryonic stem cells (mESCs) are pluripotent and have the ability to self-renew. The cells are mainly used to study the genetic function of novel genes, because the cells facilitate the transmission of the manipulated genes into target mice. Since the up-regulated methylation levels of histone arginine residue lead to the maintenance of pluripotency in embryos and stem cells, it may be suggested that CARM1 overexpressing mESCs elevate the expression of pluripotency-related genes in reconstituted embryos for transgenic mice and may resist the differentiation into trophectoderm (TE). We constructed a fusion protein by connecting CARM1 and 7X-arginine (R7). As a cell-penetrating peptide (CPP), can translocate CARM1 protein into mESCs. CPP-CARM1 protein was detected in the nuclei of the mESCs after a treatment of 24 hours. Accordingly, the expression of pluripotency-related genes was up-regulated in CPP-CARM1-treated mESCs. In addition, CPP-CARM1-treated mESC-derived embryoid bodies (EBs) showed an elevated expression of pluripotency-related genes and delayed spontaneous differentiation. This result suggests that the treatment of recombinant CPP-CARM1 protein elevates the expression of pluripotency-related genes of mESCs by epigenetic modification, and this protein-delivery system could be used to modify embryonic fate in reconstituted embryos with mESCs.

• Korean Journal of Veterinary Research
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• v.58 no.4
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• pp.183-192
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• 2018

Although hyaluronic acid (HA) has been developed as a nanoparticle (NP; 320-400 nm) for a drug delivery system, the tissue targeting efficacy and the pharmacokinetics of HA-NPs are not yet fully understood. After a dose of 5 mg/kg of cyanine 5.5-labeled HA-NPs or HA-polymers was intravenously administrated into mice, the fluorescence was measured from 0.5 h to 28 days. The HA-NPs fluorescence was generally stronger than that of HA-polymers, which was maintained at a high level over 7 days in vivo, after which it gradually decreased. Upon ex vivo imaging, liver, spleen, kidney, lung, testis and sublingual gland fluorescences were much higher than that of other organs. The fluorescence of HA-NPs in the liver, spleen and kidney was highest at 30 min, where it was generally maintained until 4 h, while it drastically decreased at 1 day. However, the fluorescence in the liver and spleen increased sharply at 7 days relative to 3 days, then decreased drastically at 14 days. Conversely, the fluorescence of HA-polymers in the lymph node was higher than that of HA-NPs. The results presented herein may have important clinical implications regarding the safety of as self-assembled HA-NPs, which can be widely used in biomedical applications.

• Polymer(Korea)
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• v.30 no.4
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• pp.279-285
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• 2006

Non-viral gene carriers continue to attract a great deal of interest due to advantageous safety profile. Among the non-viral gene carriers, cationic liposomes or synthetic gene carriers are efficient DNA carriers in vitro. but their in vivo applications are greatly hampered because of low biocompatibility. On the other hand, chitosan, a natural cationic polysaccharide, is a candidate non-viral vector for gene delivery because of its low cytotoxicity and high positive charges. In this work, targeted gene carrier was synthesized to target artery wall cells using low molecular water-soluble chitosan (LMWSC). The molecular weight $(M_W)$ and degree of de acetylation (DDA) of LMWSC were measured by relative viscometer and Kina titration. respectively. The structure of LMWSC was analyzed by measuring FTIR, $^1H-NMR,\;and\;^{13}C-NMR$. AWBP-PEG-g-LMWSC was synthesized by conjugation of the artery wall binding peptide (AWBP), a specific targeting peptide, to the end of pegylated LMWSC as a gene carrier to target artery wall cells. The synthesized AWBP-PEG-g-LMWSC were analyzed by measuring FTIR, $^1H-NMR$, zeta -potentiometer, and atomic force microscopy (AFM).

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.1B
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• pp.38-47
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• 2008

The system test was accomplished in delivery time for a suitable of various requirements at the software market. Especially, critical faults must be detected and removed for a close main functions and users against target system. In generally, proposed test methods are executed with a calendar time, not a competitive and effectiveness method as selective software testing. These methods are inapplicable to short term test or early system development stage. Moreover, it's accompanied by heavy cost. Overcoming of these problems, must attempted to new software test method role of core function in the system test. Selective software testing method is decided to mixing with the three-information such as a frequency, complexity of use scenario and fault impact. Using this information, searching a fatal error and usefully system test for an executed test scenario. In this paper, we have proposed new test method and verified testing results for the detection of critical faults or search a fatal errors with a system main function.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.6
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• pp.1706-1727
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• 2023

Under Water Sensor Networks (UWSN) has gained attraction among various communities for its potential applications like acoustic monitoring, 3D mapping, tsunami detection, oil spill monitoring, and target tracking. Unlike terrestrial sensor networks, it performs an acoustic mode of communication to carry out collaborative tasks. Typically, surface sink nodes are deployed for aggregating acoustic phenomena collected from the underwater sensors through the multi-hop path. In this context, UWSN is constrained by factors such as lower bandwidth, high propagation delay, and limited battery power. Also, the vulnerabilities to compromise the aquatic environment are in growing numbers. The paper proposes an Energy-Efficient standalone Intrusion Detection System (EEIDS) to entail the acoustic environment against malicious attacks and improve the network lifetime. In EEIDS, attributes such as node ID, residual energy, and depth value are verified for forwarding the data packets in a secured path and stabilizing the nodes' energy levels. Initially, for each node, three agents are modeled to perform the assigned responsibilities. For instance, ID agent verifies the node's authentication of the node, EN agent checks for the residual energy of the node, and D agent substantiates the depth value of each node. Next, the classification of normal and malevolent nodes is performed by determining the score for each node. Furthermore, the proposed system utilizes the sheep-flock heredity algorithm to validate the input attributes using the optimized probability values stored in the training dataset. This assists in finding out the best-fit motes in the UWSN. Significantly, the proposed system detects and isolates the malicious nodes with tampered credentials and nodes with lower residual energy in minimal time. The parameters such as the time taken for malicious node detection, network lifetime, energy consumption, and delivery ratio are investigated using simulation tools. Comparison results show that the proposed EEIDS outperforms the existing acoustic security systems.

• Journal of Korean Neurosurgical Society
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• v.58 no.1
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• pp.1-8
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• 2015

Treatment of Leptomeningeal carcinomatosis (LMC) from solid cancers has not advanced noticeably since the introduction of intra-cerebrospinal fluid (CSF) chemotherapy in the 1970's. The marginal survival benefit and difficulty of intrathecal chemotherapy injection has hindered its wide spread use. Even after the introduction of intraventricular chemotherapy with Ommaya reservoir, frequent development of CSF flow disturbance, manifested as increased intracranial pressure (ICP), made injected drug to be distributed unevenly and thus, the therapy became ineffective. Systemic chemotherapy for LMC has been limited as effective CSF concentration can hardly be achieved except high dose methotrexate (MTX) intravenous administration. However, the introduction of small molecular weight target inhibitors for primary cancer treatment has changed the old concept of 'blood-brain barrier' as the ultimate barrier to systemically administered drugs. Conventional oral administration achieves an effective concentration at the nanomolar level. Furthermore, many studies report that a combined treatment of target inhibitor and intra-CSF chemotherapy significantly prolongs patient survival. Ventriculolumbar perfusion (VLP) chemotherapy has sought to increase drug delivery to the subarachnoid CSF space even in patients with disturbed CSF flow. Recently authors performed phase 1 and 2 clinical trial of VLP chemotherapy with MTX, and 3/4th of patients with increased ICP got controlled ICP and the survival was prolonged. Further trials are required with newly available drugs for CSF chemotherapy. Additionally, new LMC biologic/pharmacodynamic markers for early diagnosis and monitoring of the treatment response are to be identified with the help of advanced molecular biology techniques.

• The Journal of the Korea Contents Association
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• v.17 no.8
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• pp.570-578
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• 2017

This study aims to develop suitable and appropriate support models for ADHD children to provide effective and efficient support for the target children. The diverse characteristics of target area, educational, social conditions, and supporting organization and delivery systems have been comprehensively considered. Domestic and overseas literature review has been performed to analyze the status of support services for ADHD children to develop the model. The FGI was adapted to identify eligibility and expectations for the qualification of ADHD children and the awareness and expectations of relevant professionals. Based on the theoretical rationale and empirical analysis results derived from these systematic procedures, suitable and appropriate support models were developed for ADHD children as a special educational subjects. The support model includes the development of individualized support programs for the needs of the entire ADHD student population, which require screening and assessment of the entire student population and requiring support for special needs. Support methods were developed in a system that supports family support, educational support, medical assistance, and medical support.

• KIISE Transactions on Computing Practices
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• v.22 no.5
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• pp.246-251
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• 2016

Recently, the influence of SNS and online media is rapidly growing with a consequent increase in the interest of marketing using these tools. Blog marketing can increase the ripple effect and information delivery in marketing at low cost by prioritizing keyword search results of influential portal sites. However, because of the tough competition to gain top ranking of search results of specific keywords, long-term and proactive efforts are needed. Therefore, we propose a new method that recommends associated keyword groups with the possibility of higher exposure of the blog. The proposed method first collects the documents of blog including search results of target keyword, and extracts and filters keyword with higher association considering the frequency and location information of the word. Next, each associated keyword is compared to target keyword, and then associated keyword group with the possibility of higher exposure is recommended considering the information such as their association, search amount of associated keyword per month, the number of blogs including in search result, and average writhing date of blogs. The experiment result shows that the proposed method recommends keyword group with higher association.