• 대한한방소아과학회지
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• 제31권4호
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• pp.61-70
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• 2017

Objectives The purpose of this survey is to know the rehabilitation therapists' awareness on the oriental medicine treatments for developmentally delayed children. Methods We distributed questionnaires to 370 rehabilitation therapists and collected 260 of them. We analyzed the data from the collected 260 questionnaires. Results 1. 60% of the participants didn't know what the oriental medicine treatment pertains. 2. 28% of the participants were aware the benefits of the oriental medicine treatment, especially in improving physical fitness and general health. 3. 30% of the participants worried about the side effect of the oriental medicine treatment such as increasing liver somatic index, changing of body weight, muscle stiffness or pain. 4. 53% of the participants said they refer to western medicine primary care doctor when parents of young patients ask rehabilitation therapists about the oriental medicine treatment option for their children. 5. Many participants think that the oriental treatment option should be widely recognized and understood. Conclusions This study shows that the rehabilitation therapists' low awareness about the oriental medicine treatment option for developmentally delayed children.

• BMB Reports
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• 제40권6호
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• pp.1016-1020
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• 2007

In this study, dioscin was isolated from Dioscoreae Rhizoma (DR), which is the rhizome of Dioscorea batatas DECNE. that inhabits broad areas of Korea and Japan. To determine whether dioscin induced growth hormone (GH) release, we evaluated its induction effects on GH release both in vitro and in vivo. The 70% methanol extract of DR, and its n-hexane and n-BuOH fractions, induced rat GH (rGH) release in rat pituitary cells 10-fold, 8-fold, and 5-fold higher than the control ($0.36{\pm}0.02 nM$), respectively (p < 0.05 each). The dioscin-induced rGH release of the cells was concentration-dependent and its $ED_{50}$ was $1.14{\times}10^{-5} M$. Within 90 minutes after intravenous administration of $10{\mu}g$/kg (p < 0.05 at $t_{max}$), dioscin caused the greatest increase in rGH concentration ($C_{max}$) in the rat plasma ($34.16{\pm}14.10 ng/ml$) (n = 4), which was twice as high as the control group ($12.88{\pm}3.29 ng/ml$) (n = 27).

• The Journal of Korean Physical Therapy
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• 제25권1호
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• pp.29-35
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• 2013

Purpose: The purpose of this study was to investigate the correlation between shoulder pain and disability index (SPADI) with participation in badminton and to find the effects of badminton on the shoulder joint. Methods: A questionnaire was answered by 143 people with shoulder pain and disability in badminton clubs located in Busan, Gyeongsangnam-do. Out of the 143 subjects (91 males, 52 females), about half (72 people) were over 40 years old, with 71 people over 50 years old. The questionnaire contained 27 questions involving demographic participation characteristics, playing characteristics, and SPADI. Data analysis was performed using the SPSS statistics program to conduct frequency analysis, cross analysis, the t-test, and one-way analysis of variance. Results: The correlation between badminton career, frequency of play, and SPADI was statistically significant. There was a significant increase in SPADI scores for players over 40 years old. The over 40 year old group with less than 5 years of badminton had a significantly increase in SPADI score. The over 50 year old group showed a significantly lower SPADI score compared with the over 40 group. Conclusion: We suggest that beginner badminton players learn correct posture and badminton skills from professionals, participate regularly, and maintain an appropriate intensity/frequency of badminton.

• Molecules and Cells
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• 제45권10호
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• pp.738-748
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• 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed a serious threat to global public health. A novel vaccine made from messenger RNA (mRNA) has been developed and approved for use at an unprecedented pace. However, an increased risk of myocarditis has been reported after BNT162b2 mRNA vaccination due to unknown causes. In this study, we used single-cell RNA sequencing and single-cell T cell receptor sequencing analyses of peripheral blood mononuclear cells (PBMCs) to describe, for the first time, changes in the peripheral immune landscape of a patient who underwent myocarditis after BNT162b2 vaccination. The greatest changes were observed in the transcriptomic profile of monocytes in terms of the number of differentially expressed genes. When compared to the transcriptome of PBMCs from vaccinated individuals without complications, increased expression levels of IL7R were detected in multiple cell clusters. Overall, results from this study can help advance research into the pathogenesis of BNT162b2-induced myocarditis.

• 혜화의학회지
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• 제9권1호
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• pp.547-594
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• 2000

I. Introduction The essence of Oriental medicine consists of ancient books, experienced doctors and succeeded skills of common society. Many famous doctors studied medical science by their fathers or teachers. So the history of medical science is long. $\ll$DangDaeMyeongIImJeungJeongHwa(當代名醫臨證精華)$\gg$ written by SaWoogWang(史宇廣) and DanSeoGeon(單書健) has many medical experience of famous doctors. So it has important historical value. Bi(痺) means blocking. BiJeung is one kind of symptoms making muscles, bones and jonts feel pain, numbness or edema. For example it can be gout or SLE etc. So I studied ${\ll}BiJeungJuJip{\gg}$. II. Final Decision Following decisions of Chinese doctors of 20th century are as follows ; 1. JuYangChun(朱良春) emphasized on IkSinJangDok(益腎壯督) to treat BiJeong. And he devided WanBi(頑痺) as PungHanSeup(風寒濕), DamEo(痰瘀), YeolDok(熱毒), SinHeo(腎虛). He used insects for medicine. 2. ChoSuDoek(焦樹德) introduced past prescription. He used ChiBiTang(治痺湯) to treat HaengBi(行痺), TongBi(痛痺), ChakBi(着痺). He insisted that Han(寒; coldness) and Seup(濕; dampness) be Eum(陰) and Pung(風; wind) can change his character to be Eum. After all BiJeung is usually EumJeung. So he used GaeJi(桂枝) and BuJa(附子). By the way he used ChungYeolSanBiTang(淸熱散痺湯) for YeolBi, BoSinGeoHanChiWangTang SaBok(王士福) emphasized on the importance of medicine. He introduced many treatments like CheongYeol(情熱) for YeolBi and YiO(二烏) for HanBi. And he divided BiJeung period for three steps. At 1st step, we must use GeoSa(祛邪), at 2nd step, we must use BuJeong(扶正) and at 3rd step, we must use BoHyeol(補血), he insisted. And he introduced many herbs to treat BiJeung. 4. JeongGwangJeok(丁光迪) said that GaeJi(桂枝), MaHwang(麻黃), OYak(烏蘖) and BuJa(附子) are very important for TongRak(通絡). And pain usually results from Han(寒), so he liked to use hot-character herbs. 5. MaGi(馬志) insisted that BiJeung usually result from ChilJeong(七情). And he liked to use insects for treatment of BiJeung. 6. WeolSeokMu(越錫武) introduced 8 kinds of treatments and divided BiJeung period. Also he divided BeJeung for PungBi(風痺), HanBi(寒痺) and SeupBi(濕痺). 7. SeoGeaHam(徐季含) observed many patients and concluded that 86.7% of BiJeung is HeuJeung(虛症). 8. YuJiMyeong(劉志明) said that YeolBi is important and CheongYeol is also important. So he emphasized on DangGyuiJeomTongTang(當歸拈痛湯) and SeonBiTang(宣痺湯). 9. WangLiChu(汪履秋) studied cause of WanBi. Internal cause is GiHyeolHeo(氣血虛) and GanSinHeo(肝腎虛) and external cause is SaGi(邪氣) he insisted. 10. WangSaSang(王士相) said that YeolBi can be SeupYeolBi or EumHeuYeolBi(陰虛熱痺) and HanSeupBi(寒濕痺) is rare. He use WooBangJaSan(牛蒡子散) and BangPungHwan(防風丸) for SeupYeolBi, DangGyuiSaYeokTang(當歸四逆湯) for HanSeupBi. 11. JinTaekGang(陳澤江) treated YeolBi with BaekHoGaGyeJiTang(自虎加桂枝湯) and SaMyoSan(四妙散). If they don't have effect, he tried to cure BiJeung step by step. And he used e term of GeunBi(筋痺) and BangGiMogwaEIInTang(防己木瓜薏苡仁湯) was good for GeunBi. 12. MaSeoJeong(麻瑞亭) said that PungSeupYeokJeul(風濕歷節) is BiJeung and it is related to GanBinSin(肝脾腎; liver, Spleen, Kindey). And he emphasized on balance WiGi(衛氣) and YoungHeul(營血). 13. SaJeJu(史濟桂) said that GeunGolBi(筋骨痺) is similar to arthritis and sometimes called ChakBi. And SinBi(腎痺) is terminal stage of ChakBi, he said. He also used insects for treatment. 14. JeongJeNam(丁濟南) tried to cure SLE and used GyeJi, CheonCho(川椒), SinGeunCho(伸筋草), SunRyeongBi(仙靈脾), HyconSam(玄蔘) and GamCho(甘草). 15. JinGYungHwa(陳景和) emphasized on diagnosis of tongue. If the color of tongue is blue, it usually has EoHyeol(瘀血), for example. And he also used insects. 16. JuSongI(朱松毅) tried to devide YeolBi with OnByeong(溫病), Wi(衛), Gi(氣) and Hyeol(血). 17. RuDaBong(蔞多峰) said that JyeongHeo(正虛), OiSa(外邪) and EoHyeol are closely related. And he explained BiJeung by deviding the body into the part, for example head, neck, shoulder, waist, upper limb and lower limb. 18. YuMuBo(劉茂甫) defined PungHanSyubBi as chronic stage and YeolBi as acute stage.

• 대한화장품학회지
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• 제44권2호
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• pp.151-159
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• 2018

본 연구에서는 물사과 가지 추출물 및 용매 분획물의 항산화 활성과 세포보호효과를 검색하고 유효성분을 분리하여 화학구조를 규명하였다. 물사과 가지 추출물 및 용매 분획물의 DPPH 및 $ABTS^+$ 라디칼 소거 활성을 측정한 결과, 에틸아세테이트 및 부탄올 분획물에서 우수한 라디칼 소거 활성이 있음을 확인하였다. 또한 $H_2O_2$로 유도된 세포 손상에 대한 세포보호효과를 확인한 결과, $20{\mu}g/mL$의 농도에서 추출물 및 에틸아세테이트 분획물에서 보호효과가 나타남을 확인하였다. 항산화 활성이 좋은 에틸아세테이트 분획물에서 유효성분을 찾고자 medium pressure liquid chromatography (MPLC)를 실시하여 2개의 화합물을 분리하였으며 $^1H$ 및 $^{13}C$ NMR 데이터 분석 및 문헌 비교를 통하여 화학구조를 동정하였다; pinocembrin (1), desmethoxymatteucinol (2). 분리된 화합물에 대한 DPPH 및 $ABTS^+$ 라디칼 소거 활성을 측정한 결과, 화합물 1, 2 모두 농도의존적으로 우수한 라디칼 소거 활성이 나타났다. $100{\mu}M$의 농도에서 화합물 1, 2는 $H_2O_2$로 유도된 세포손상에 대하여 세포보호효과를 나타냈다. 이러한 연구 결과를 바탕으로 물사과 가지 추출물은 천연 항산화 소재로써 활용 가능할 것이라 사료된다.

• 대한물리치료과학회지
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• 제18권1호
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• pp.21-32
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• 2011

Objective: This study was conducted to describe physical therapists' attitudes and beliefs towards Korean Government's National Long Term Care Insurance Program implemented last July 2008. Design: A survey research. Methodology: Participants were 143 physical therapists working in General Hospitals or University Hospitals in Busan, Korea. Each of the participants completed a questionnaire which was comprised of 22 questions. Among the 22 questions, 7 of these were independent variables such as gender, age, career, etc. while 15 of these questions were dependent variables such as the subject's expectations and reactions on the said program, opinions of the participants on the impact of the program to old people's families and relatives, participant's sentiments on social effects of this program to the society, etc. Data collection was conducted from the $20^{th}$ of July to the $5^{th}$ of August, 2008. Data were analyzed by Chi-square test, frequency and cross tabs using SPSS/PC program. Results: Based on the survey conducted, it showed that 50.3% were female respondents, 53.8% were on their twenties, 31.5% of the total respondents were married and that a percentage of 82.4% had working experiences below 10 years. About 80.4% of respondents were satisfied of their jobs and 32.4%of the respondents graduated from three - year college degree, 49.3% of the respondents graduated from four-year college degree. 95.1% of the total respondents knew the existence of the national long term care insurance program of the government and almost 78% got the information of the said program via internet, news paper or T.V. About 86% of the respondents believe that there will be future improvements in the quality of life in Korea through the said program and 82% said that there will be an increase sense of responsibility among family members to take care of their old relatives. 67.2 % of respondents believe that problems regarding old people will be solved through the government's national long term care insurance program. In aspect of Physical Therapy, 50% of the respondents expected generation of more jobs especially to physical therapists and 95% of the respondents want to work in any position in the said program especially those are more experienced ones. Conclusion: Physical Therapists in Korea are aware of the existence of the National Long Term Care Insurance Program of the Korean Government. Based on the gathered results from the survey, many experienced physical therapists of the country wanted to acquire positions in the said program especially that their expertise are needed in the said field. Through this study, it is evident that many physical therapists of the country have positive vibes on the said program and are optimistic on the outcomes of the said insurance program.

• 한국환경농학회지
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• 제30권4호
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• pp.466-472
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• 2011

본 연구는 국내에서 개발된 형질전환 콩 재배 시 토양 미생물 군집에 미치는 영향과 수평적 유전자 이동 여부를 알아보기 위해 수행되었다. 성숙기 토양의 미생물 군집밀도의 경우 형질전환 콩 근권 토양 미생물 군집밀도가 비 형질전환 콩 근권 토양과 유사하여 형질전환 콩 재배가 근권 토양 미생물에 영향을 미치지 않는 것으로 나타났다. 근권 토양의 우점 미생물 분포 양상 분석 결과, Proteobacteria, Firmicutes와 Actinobacteria 순으로 나타났으며 점유율은 다소 차이를 보였으나 우점종은 거의 유사하였다. 근권 토양 DNA에 대한 DGGE 분석 결과, 형질전환 콩과 비 형질전환 콩의 근권 토양 미생물 군집의 변화는 보이지 않았다. 형질전환 콩 재배에 따른 토양의 화학성을 분석한 결과, 형질전환 콩과 비 형질전환 콩의 근권 미생물상의 명확한 차이가 나타날 정도로 토양간 화학성의 차이는 크지 않았다. 형질전환 작물에 도입된 유전자군을 대상으로 식물체와 근권 토양 DNA에 대한 PCR 분석을 수행한 결과 수평적 유전자 이동성은 일어나지 않은 것으로 추정되었다.

• Weed & Turfgrass Science
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• 제2권3호
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• pp.242-247
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• 2013

현재 유기재배에서 잡초 방제를 위한 방법은 관행방법에 비해 효과적이지 못하다. 본 연구는 하늘타리의 잎, 줄기, 열매, 뿌리 추출물 중 어느 부위에서 제초 효과가 가장 높은지를 알아보기 위해서 각 부위별로 물, 열수 그리고 에탄올로 추출하였다. 또한 위의 추출방법 중 제초활성능력이 뛰어난 것을 hexane, chloroform, ethyl acetate, BuOH, $H_2O$로 용매분획하여 잠재적 제초 성분에 대한 특성을 조사하였다. 전반적으로 오이와 보리의 발아율, 초장 및 근장 억제는 추출방법 중 물 추출법이 가장 효과적이었고, 식물체 부위별로는 열매에서 가장 효과적이었다. Ethyl acetate, butanol, chloroform, hexane, water의 용매분획에서 오이와 보리의 발아율, 초장 및 근장 저해는 물 층에서 가장 좋았고 그 밖의 분획에서는 차이가 없었다. 5% 물 층 추출물 발아전 처리에 의해 바랭이와 까마중의 생장량은 80~100% 억제되었으나, 이 추출물에 의한 오이와 보리뿐만 아니라 잡초종(바랭이, 까마중 등) 경엽처리에 의한 생육저해 효과는 없었다. 본 연구결과로 볼 때 하늘타리 추출물을 친환경 또는 유기농 재배에 잡초방제를 위해 사용할 수 있을 것으로 본다.

• 마케팅과학연구
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• 제19권4호
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• pp.32-43
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• 2009

信任在心理学, 经济学, 社会学中已被广泛研究, 其重要性不仅在市场营销中被强调, 在一般商业原则中也被强调. 供应商和买家之间的关系与过去不同, 过去的关系需要相当大的私人网络优势, 并可能涉及不道德的商业行为. 而在以工业营销成功的为核心的二十一世纪激烈的全球竞争中, 供应商和买家之间的关系是伙伴关系. 在相互合作的高级别信任的基础上, 通过交换的关系, 这会给买家和供应商带来长期的利益, 竞争力增强和交易成本的降低以及其他福利. 尽管现有的研究有信任的重要性, 但是在购买与供应关系中却忽视了信任的作用, 也没有系统地分析信任对关系的影响. 因此, 深入研究, 确定买家和商业服务供应商之间信任和关系绩效之间的联系是绝对需要的. 本研究中的商业服务, 包括那些支持制造业, 正作为下一代经济增长的引擎而吸引着人们的注意. 韩国政府已选择其作为制造业发展的战略领域. 由于商业服务开放市场的需求日趋激烈, 商业服务业的竞争力应该比以往得到更多的提倡. 本研究的目的是探索相互信任对买家和供应商之间的关系绩效的影响. 具体来说, 本研究在商业服务交易中提出了一个关于信任-关系绩效的理论模型, 并实证检验根据模型而提出的假设. 这项研究表明, 研究结果有战略意义. 本研究通过多种方法收集经验数据. 这些方法包括通过电话, 邮件和面试. 作为样本的公司是在韩国供应和购买商业服务的以知识为本的公司. 本研究收集的是二进的基础数据. 每个样本公司对包括购买公司及其相应的供应公司. 并跟踪调查每个公司对的相互信任. 本研究为商业服务的买卖双方提出了信任-关系绩效的模型. 该模型由信任和它的前因和后果. 买家的信任分为对供应公司的信任和对销售人员的信任. 根据Doney 和Cannon (1997)的研究我们在个人水平和组织水平上观察信任. 通常情况下, 买方是信任的受体, 但这项研究我们建议以供应商为观察受体. 因此, 它独特的关注了双边角度的知觉风险. 换言之, 供应商和买家一样, 是信任的主体, 因为交易通常是双边的. 从这个角度来看, 供应商对买家信任和买方对供货商的信赖一样重要. 供应商的信任从某种程度上受它信任的买方公司和买家的影响. 这种使用个人水平和组织水平的信任分类是根据Doney 和Cannon (1997)的研究. 信任影响供应商的选择, 这是一项双向放的工作. 供应商们积极参与供应商选择过程中, 和买家密切的一起工作. 此外, 该过程从某种程度上受每一方信任的合作伙伴的影响. 挑选过程包括一些步骤: 识别, 信息检索, 供应商选择和绩效评价. 作为这一进程的结果, 买家和供应商都进行绩效评估, 并就这些结果为基础, 采取有形或无形的纠正行动. 本研究中使用的关于信任的测量问项是根据Mayer, Davis 和 Schoorman (1995) 以及Mayer和Davis (1999)的研究发展起来的. 根据他们的建议, 有关信任的三个方面的研究包括有能力, 善和完整. 根据商业服务这个背景我们调整了原来的问题. 例如, 如 "他/她的专业能力" 已被改为 "当我们讨论我们的产品时销售人员表现出专业能力. "这项研究使用的测量问项不同于在以往的研究中使用的问项（Rotter 1967; Sullivan和Peterson 1982; Dwyer和Oh 1987. 本研究中有关信任的前因后果的测量问项是根据Doney和Cannon (1997)的研究为基础制定的. 根据商业服务这个背景我们调整了原来的问题. 特别是, 问题被设计为对买家和供应商以解决下列因素: 信誉 (诚信, 客户服务, 良好意愿), 市场地位 (公司规模, 市场份额, 在行业中的地位), 愿意定制（产品, 过程, 交付), 信息共享(专有信息, 个人信息), 愿意保持良好关系, 认为专业, 权威授权, 买方与卖方的相似性, 以及接触频率. 作为信任相应的变量, 我们对关系绩效进行了测试. 关系绩效分为有形的影响, 无形影响, 和副作用. 有形的影响包括财务业绩;无形的影响, 包括关系的改善, 网络开发, 以及内部员工的满意度;副作用包括既不是有形影响也不是无形影响的影响. 我们联系了350对公司, 105对公司答复了我们. 由于不完整我们删除了5对公司, 105对公司被用于数据分析. 用于数据分析的回应率为30%(三百五十零分之一百零五), 高于工业营销的平均回复比率. 至于回复的公司的特点, 大多数的公司运作的商业服务既为买方(85.4%)也为供应商(81.8%). 大部分买家是做消费品贸易(76%), 而供应商的大部分(70%)是做工业品贸易. 这可能意味着买家的过程是购入材料, 部件和组件从而生产消费品成品. 正如他们对他们与合作伙伴关系的长度的报告表示, 供应商比买家有更长的商业关系. 假设1测试买方-供应方特点对信任的影响. 销售人员的专业度(t=2.070, p<0.05)和权威授权(t=2.328, p<0.05)积极影响买方对供应方的信任. 另一方面, 权威授权(t=2.192, p<0.05)积极影响供应方对买方的信任. 对买方和供应方来说, 权威授权的程度对保持对彼此的信任有关键作用. 假设2测试买卖双方关系特点对信任的影响. 买家倾向于信任供应方, 因为供应方总是尽全力联系买方(t=2.212, p<0.05)这种倾向性在供应方方面也表现得很强(t=2.591, p<0.01). 另一方面, 供应商对买方的信任是由于供应商感知买家与自己的相似性(t=2.702, p<0.01). 这一发现证实了Crosby, Evans, 和Cowles(1990)的研究结果. 他们的结果表明供应方和买方通过商务或私务的定期会议来建立彼此的联系. 假设3测试信任对感知风险的影响. 结果表明无论对买方还是供应方, 信任越低, 感知风险就越大(买方: t =-6.621, p<0.01; 供应方: t=-2.437, p<0.05). 有趣的是, 这一趋势已被证明对买方更强. 这种较高水平的感知风险的一个可能的解释是在商业服务交易中买方通常比供应方感知到更大的风险. 为此, 有必要对供应商对买方实施减少风险的战略. 假设4测试信任对信息搜集. 根据结果, 对供应方和买方, 与预期相反, 信任取决于他们合作伙伴的名誉(买方t=2.929, p<0.01; 供应方t=2.711, p<0.05). 这一发现表明, 具有良好信誉的供应商往往是可信的. 以往的经验并没有显示出任何与买家或供应商信任的重要关系. 假设5测试信任对供应方/买方选择的影响. 与买方不同, 当供应方认为以往与买方的交易重要时, 供应方倾向信任买方(t=2.913 p<0.01). 但是, 本研究并没有现实资源忠诚和买方对供应方的信任之间有显著关系. 假设6测试的是信任对关系绩效的影响. 对买方和供应方, 当财务表现被报告提高时, 他们比较信任他们的合作伙伴(买方: t=2.301, p<0.05;供应方: t=3.692, p<0.01). 有趣的是, 这种趋势在供应方比较明显. 类似的, 当竞争力被报告提高时, 买卖双方比较信任他们的合作伙伴(买方t=3.563, p<0.01 ; 供应方t=3.042, p<0.01). 对供应方来说, 当对买方信任时效率和生产力会提高(t=2.673, p<0.01). 其他绩效指标与信任没有显著关系. 这项研究结果有一定的战略意义. 首先和最重要的是, 以信任为基础的交易对供应商和买家而言都是有益的. 根据研究证实, 通过努力建立和保持相互信任可以使财务表现提高. 同样, 可以通过同样的努力提高竞争力. 第二, 以信任为基础的交易能够减少购买情况中的感知风险. 这对供应商和买家都有启示. 人们普遍认为, 在一个高度参与的采购情况中买家感知到更高的风险. 为了减少风险, 以往的研究已建议供应商制定降低风险的策略. 而本研究的特点是从双边角度关注知觉风险. 换言之, 供应商也容易存在风险, 特别是当他们提供的服务, 需要非常先进的技术, 操作和维护. 因此, 购买者和供应商必须一起密切合作解决问题. 因此, 相互信任在问题解决过程中起着关键作用. 第三, 在这项研究中发现, 销售人员有更多的授权, 他或她越被信任. 这一发现从战术角度看是非常重要的. 建立信任是一个长期的任务, 然而, 当互信尚未开发, 供应商能够通过授权销售人员做出某些决定来克服遇到的问题, 这一结论也适用于供应商.