• 대한화학회지
• /
• 제58권1호
• /
• pp.92-99
• /
• 2014

The pH sensitive hydrogels composed of N-isopropylacrylamide (NIPA) and acryloyl phenylalanine (APA) were prepared by redox polymerization using N,N'-methylenebisacrylamide (MBA) as a crosslinker. Anti-inflammatory and analgesic agent, Keterolac Tromethamine (KT), was loaded successfully into poly(NIPA-co-APA) copolymeric hydrogels by swelling equilibrium method. To understand the nature of drug in the polymeric matrix, the newly synthesized drug loaded poly(NIPA-co-APA) copolymeric hydrogels were characterized by using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques. The scanning electron microscopy (SEM) technique result indicates the spherical smooth surface of the hydrogels. The drug (KT) releasing nature of the poly(NIPA-co-APA) hydrogels was studied in pH 1.2 and 7.4. Effects of drug loading, crosslinking agent, pH and the ionic strength of the external medium on swelling of hydrogels were also investigated.

• 말소리와 음성과학
• /
• 제7권4호
• /
• pp.111-121
• /
• 2015

The present study examines the auditory boundary between Korean /o/ and /u/ on a synthesized vowel continuum by Chinese learners of Korean language. Preceding researches reported that the Chinese learners have difficulty pronouncing Korean monophthongs /o/ and /u/. In this experiment, a nine-step continuum was resynthesized using Praat from a vowel token from a recording of a male announcer who produced it in isolated form. F1 and F2 were synchronously shifted in equal steps in qtone (quarter tone), while F3 and F4 values were held constant for the entire stimuli. A forced choice identification task was performed by the advanced learners who speak Mandarin Chinese as their native language. Their experiment data were compared to a Korean native group. ROC (Receiver Operating Characteristic) analysis and logistic regression were performed to estimate the perceptual boundary. The result indicated the learner group has a different auditory criterion on the continuum from the Korean native group. This suggests that more importance should be placed on hearing and listening training in order to acquire the phoneme categories of the two vowels.

• The Korean Journal of Ecology
• /
• 제12권1호
• /
• pp.37-49
• /
• 1989

When the light stimulus was presented continuously, habituations were formed, after 13 and 14 hrs in amoeba and planaria, repectively. As amoeba more habituated, the light-escaping velocity of streaming was decreased with a negative-exponential function. in two-dimensional electrophoretic patterns of proteins of amoeba habituated, a newly synthesized protein (pI 7.0, MW 20 kD) was detected. Therefore, it is conjectured that similarity or commonality may exist between amoeba and planaria habituations to light, and in these behavioral modifications, specific protein(s) may be involved in molecular level.

• 한국염색가공학회지
• /
• 제25권1호
• /
• pp.18-24
• /
• 2013

A water soluble spironaphthoxazine (SPO) was synthesized, and its spectral properties were determined. Under UV irradiation, colorless SPO shows intensive blue color while the intensity of its initial fluorescence decreased. In addition, SPO also exhibited high sensitivity to pH stimuli both in colorimetry and fluorometry distinguishing from the spectral appearance observed under UV irradiation. Further, integrating these two optical characteristics a three-state switching system can be established, and all interconversions can be observed by naked-eye.

• 한국군사과학기술학회지
• /
• 제6권3호
• /
• pp.74-85
• /
• 2003

NENA(nitratoethyl nitramine) compounds, especially BuNENA(N-butyl-N-(2-nitratoethyl)-nitramine), are of high interest to both rocket propulsion and military high explosives because of low sensitivity to many forms of stimuli, although they are less energetic than conventional nitrate ester plasticizers. One of advantages in using NENAs is that they provide higher impulse at any given flame temperature than conventional propellants do. BuNENA has better thermochemical characteristics(low melting point and low glass transition temperature), therefore has less tendency to crystallize out of matrices. BuNENA was successfully synthesized in a high yield by reaction of n-butyl aminoethanol and 98% nitric acid followed by dehydrogenation of salt mixture by $Ac_2$/$ZnCl_2$.

• 한국고분자학회:학술대회논문집
• /
• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
• /
• pp.101-101
• /
• 2006

We have studied the micellisation of poly(n-butyl acrylate)-block-poly(acrylic acid) and poly(n-butyl acrylate)-graft-poly(acrylic acid) in aqueous solution. The size and structure of the formed micelles was elucidated by scattering and imaging techniques. The micelle structure depends on pH, composition, and topology: graft copolymers form much smaller micelles that block copolymers of similar composition. We have also synthesized block copolymers of acrylic acid and N-isopropylacrylamide (NIPAAm) or N,N-diethylacrylamide (DEAAm). Due to the LCST of polyNIPAAm and polyDEAAm, these block copolymers spontaneously form micelles upon heating and they form inverse micelles upon decreasing pH below 4. If the LCST block is much longer than the PAA one, this presents a very convenient way to prepare crew-cut micelles. The polymers have been successfully used as stabilizers in emulsion polymerization. They also have been conjugated to streptavidin. The conjugates reversibly form mesoscopic particles on heating.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
• /
• pp.429.2-429.2
• /
• 2014

ZnO nanowire is known as synthesizable and good mechanical properties. And, stimuli-responsive polymer is widely used in the application of tunable sensing device. So, we combined these characteristics to make precise tunable sensing devise. In this work, we investigate the dependence of ZnO nanowire alignment and morphology on si substrate using nanosphere template with various conditions via hydrothermal process. Also, pH-temperature dependant tuning ability of nanostructure was studied. The brief experimental scheme is as follow. First, Zno seed layer was coated on a si wafer ($20{\times}20mm$) by spin coater. And then $1.15{\mu}m$ sized close-packed PS nanospheres were formed on a cleaned si substrate by using gas-liquid-solid interfacial self-assembly method. After that, zinc oxide nanowires were synthesized using hydrothermal method. Before the wire growth, to specify the growth site, heat treatment was performed. Finally, NIPAM(N-Isopropylacrylamide) was coated onto as-fabricated nanostructure and irradiated by UV light to form the PNIPAM network. The morphology, structures and optical properties are investigated by FE-SEM(Field Emission Scanning electron Microscopy), XRD(X-ray diffraction), OM(Optical microscopy), and WCA(water contact angle).

• Macromolecular Research
• /
• 제17권7호
• /
• pp.528-532
• /
• 2009

The size and shape of free volume (FV) holes available in membrane materials control the rate of gas diffusion and its permeability. Based on this principle, a segmented, thermo-sensitive polyurethane (TSPU) membrane with functional gate, i.e., the ability to sense and respond to external thermo-stimuli, was synthesized. This smart membrane exhibited close-open characteristics to the size of the FV hole and water vapor permeation and thus can be used as smart food packaging materials. Differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), positron annihilation lifetimes (PAL) and water vapor permeability (WVP) were used to evaluate how the morphological structure of TSPU and the temperature influence the FV holes size. In DSC and DMA studies, TSPU with a crystalline transition reversible phase showed an obvious phase-separated structure and a phase transition temperature at $53^{\circ}C$ (defined as the switch temperature and used as a functional gate). Moreover, the switch temperature ($T_s$) and the thermal-sensitivity of TSPU remained available after two or three thermal cyclic processes. The PAL study indicated that the FV hole size of TSPU is closely related to the $T_s$. When the temperature varied cyclically from $T_s-10{\circ}C$ to $T_s+10^{\circ}C$, the average radius (R) of the FV holes of the TSPU membrane also shifted cyclically from 0.23 to 0.467 nm, exhibiting an "open-close" feature. As a result, the WVP of the TSPU membrane also shifted cyclically from 4.30 to $8.58\;kg/m^2{\cdot}d$, which produced an "increase-decrease" response to the thermo-stimuli. This phase transition accompanying significant changes in the FV hole size and WVP can be used to develop "smart materials" with functional gates and controllable water vapor permeation, which support the possible applications of TSPU for food packaging.

• 폴리머
• /
• 제35권3호
• /
• pp.223-227
• /
• 2011

자극감응성 고분자는 다양한 응용에 중요한 역할을 하는 재료로 널리 연구되어오고 있다. 온도감응성을 가지는 히알루론산 공중합체를 카르복실기 고분자와 생체친화성 히알루론산의 아미드 결합을 통하여 연결시켜 합성하였다. 온도감응성 특징은 두 공중합체 모두에 구현되었으며, 탁도 측정과 rheolgical 결과는 일치하였다. 두 공중합체 중 elastin-like peptide(ELP)를 그래프트 사슬에 둔 공중합체의 경우가 N-ispropylacryamide(PNIPAAm) 경우에 비해 보다 완만한 LCST 변화과정을 보여주었다. PNIPAAm과 ELP의 그래프트 부분 함량이 증가함에 따라 점도가 증가하였고, 비슷한 그래프트 함량에서는 PNIPAAm 공중합체의 점도 증가가 컸다. 이러한 결과를 통해 생체친화성의 히알루론산에 그래프트 사슬을 붙임으로써 온도감응성을 부여할 수 있고, 그 특성을 설계할 수 있음을 알 수 있었다.

• 공업화학
• /
• 제30권6호
• /
• pp.698-706
• /
• 2019

지난 수십 년 동안, 외부 자극에 대한 응답성이 우수하면서도 인체에 적용할 수 있는 소프트 액추에이터 개발을 위한 많은 노력이 이어졌다. 본 연구에서는 동역학적 정밀 제어가 가능한 의료용 소프트 액추에이터를 개발하기 위해, 유해한 화학적 첨가제나 개시제 없이 방사선을 이용하여 전기 자극 반응성과 물리적 특성이 우수한 3차원 가교 구조의 poly(acrylic acid) (PAAc)/poly(vinyl alcohol) (PVA)/poly(ethylene glycol) (PEG) 하이드로겔을 합성하였다. 방사선 조사 후, 모든 하이드로겔은 75% 이상의 겔 분율을 나타내었고, 표면 반사 적외선 분광법을 통해 PAAc/PVA/PEG 하이드로겔이 성공적으로 합성되었음을 확인하였다. 또한 PAAc/PVA/PEG 하이드로겔의 겔 분율, 평형 수분 함량, 압축 강도를 측정하여 감마선의 총 조사 선량과 구성 성분의 함량비 조절에 따른 하이드로겔의 물리적 특성 변화를 확인하였다. 조사된 감마선의 선량이 증가하거나 poly(ethylene glycol) diacrylate (PEGDA)의 함량이 많을수록 PAAc/PVA/PEG 하이드로겔은 높은 가교 밀도와 우수한 기계적 강도를 나타내었다. 또한 PAAc/PVA/PEG 하이드로겔은 3 V의 저전압에서도 전기적인 자극에 반응하였고, 전기장 하에서 이동성 이온의 움직임에 따른 하이드로겔의 밴딩 거동은 하이드로겔의 가교 밀도, 이온기의 함량, 인가 전압 및 전해질 용액의 이온 농도 등을 조절함으로써 제어할 수 있음을 확인하였다.