• 대한전자공학회논문지SD
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• 제46권11호
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• pp.66-76
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• 2009

움직임 추정은 영상 부호화 시스템에서 큰 비중을 차지하는 부분으로, 실시간 동작을 위해서는 효율적인 구조를 필요로 한다. 따라서 H.264 전체 시스템을 위한 움직임 추정기 블록의 구현은 부호화 과정을 고속으로 수행할 수 있도록 별도의 전용 하드웨어 모듈로 설계하는 것이 바람직하다. 본 논문에서는 많은 연산량을 효율적으로 줄일 수 있도록 병렬 처리를 바탕으로 움직임 추정 감지 블록, 41개의 SAD(Sum of Absolute Difference)값 계산 블록, 최소의 SAD값 계산과 움직임 벡터 생성 블록을 제안하고자 한다. 움직임 추정 감지 블록과 최소의 SAD값 계산기에서는 선계산(pre-computation) 방법을 적용함으로써, 입력 Switching Activity를 줄여 고속 구현이 가능하도록 하였으며, 움직임 추정 감지 블록과 41개의 SAD값 계산 블록에서 가장 많은 부분을 차지하는 가산기 구조를 일반적으로 사용되는 Ripple Carry Adder 대신에 Carry Skip Adder를 적용함으로써, Adder Tree 구조를 고속으로 처리할 수 있도록 하였다. 또한 외부에서 탐색 영역 제어와 같은 주요 변수를 쉽게 제어할 수 있도록 하여, 하드웨어 구조의 효율성을 높였다. 시뮬레이션 및 FPGA 검증 결과, 움직임 추정기의 임계 경로를 발생시키는 MED블록에서 일반적인 구조를 적용했을 때보다 19.89%의 Delay 감소 효과를 얻을 수 있었다.

• International Journal of Oral Biology
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• 제31권4호
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• pp.113-118
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• 2006

In the primary sensory neuron of the mesencephalic trigeminal nucleus (MTN), the peripheral axon supplies a large number of annulospiral endings surrounding intrafusal fibers encapsulated in single muscle spindles while the central axon sends only a few number of synapses onto single ${\alpha}-motoneurons({\alpha}-MNs)$. Therefore, the ${\alpha}-{\gamma}$ linkage is thought to be very crucial in the jaw-closing movement. Spike activity in a ${\gamma}-motoneuron\;({\gamma}-MN)$ would induce a large number of impulses in single peripheral axons by activating many intrafusal fibers simultaneously, subsequently causing an activation of ${\alpha}-MNs$ in spite of the small number of synapses. Thus, the activity of ${\gamma}-MNs$ may be vital for modulation of jaw-closing movements. Independently of such a spindle activity modulated by ${\gamma}-MNs$, somatic depolarization in MTN neurons is known to trigger the oscillatory spike activity. Nevertheless, the trafficking of these spikes arising from the two distinct sources of MTN neurons is not well understood. In this short review, switching among multiple functional modes of MTN neurons is discussed. Subsequently, it will be discussed which mode can support the ${\alpha}-{\gamma}$ linkage. In our most recent study, simultaneous patch-clamp recordings from the soma and axon hillock revealed a spike-back-propagation from the spike-initiation site in the stem axon to the soma in response to a somatic current pulse. The persistent $Na^+$ current was found to be responsible for the spike-initiation in the stem axon, the activation threshold of which was lower than those of soma spikes. Somatic inputs or impulses arising from the sensory ending, whichever trigger spikes in the stem axon first, would be forwarded through the central axon to the target synapse. We also demonstrated that at hyperpolarized membrane potentials, 4-AP-sensitive $K^+$ current ($IK_{4-AP}$) exerts two opposing effects on spikes depending on their origins; the suppression of spike initiation by increasing the apparent electrotonic distance between the soma and the spike-initiation site, and the facilitation of axonal spike invasion at higher frequencies by decreasing the spike duration and the refractory period. Through this mechanism, the spindle activity caused by ${\gamma}-MNs$ would be safely forwarded to ${\alpha}-MNs$. Thus, soma spikes shaped differentially by this $IK_{4-AP}$ depending on their origins would reflect which one of the two inputs was forwarded to the target synapses.

• 한국통신학회논문지
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• 제32권8B호
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• pp.553-562
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• 2007

성숙기에 접어든 이동통신 시장은 소비자의 욕구가 다양해지는 반면에, 서비스 차별화가 어려워지고 있으며 번호이동성의 도입으로 인해 전환장벽이 완화되면서 사업자간 고객유지 및 확보를 위한 경쟁이 가속화되고 있다. 또한 HSDPA라는 신규 서비스의 도입으로 세대간 고객전환을 위한 치열한 마케팅 활동이 펼쳐지고 있다. 이러한 상황 속에서 이동통신 사업자에게 지속적 경쟁우위를 가져올 원천으로 브랜드 자산의 중요성이 더욱 대두되고 있다. 그런데 선행연구에서는 이동통신 브랜드 자산에 대한 연구가 제한적으로 수행되고 있으며 특히 CDMA 시장에서 형성된 고객자산이 HSDPA에 미치는 영향을 분석한 연구가 없었다. 이에 본 연구에서는 브랜드 이미지, 고객혜택, 가격, 품질, 마케팅 활동을 중심으로 이동통신 서비스의 브랜드 자산 결정요인을 분석하고 신규 서비스인 HSDPA 서비스 가입에 미치는 영향을 파악하였다. 그리고 본 연구결과를 바탕으로 이동통신 사업자의 브랜드 관리의 전략적 시사점을 제시하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제30권6호
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• pp.902-906
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• 2017

Objective: This study was conducted to characterize the behaviors and the body weight of suckling piglets in different social environments. Methods: Two groups of sows and suckling piglets housed either in individual farrowing crates in separate pens ($1.8{\times}2.4m$, the control group) or in groups of three sows with their piglets in farrowing crates in a large common enclosure ($5.4{\times}2.2m$, the treatment group) were observed with the aid of video technology for 9 consecutive hours on days 1, 2, and 3, after mixing. Results: Suckling, agonistic, and elimination behaviors of suckling piglets were significantly higher in the control group than in the treatment group. Inactive behavior was higher in the treatment group than in the control group. Most of the effects of the social environment on the suckling piglets seem to be the result of large reductions in behaviors and body weight for piglets switching from high activity to low activity. Moreover, suckling behavior and birth body weight were highly correlated with body weight at the end of the test. Conclusion: The social environment that resulted from mixing, thus, had significant effects on the behavior and body weight of suckling piglets, and behavioral characteristics, therefore, should be considered when making improvements to the husbandry and care methods used in swine production.

• Journal of Microbiology and Biotechnology
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• 제14권6호
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• pp.1267-1274
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• 2004

Colostrum contains various kinds of cytokines including TGF-$\beta$ that has potent regulatory effects on cells of the immune system. We compared the levels of TGF-$\beta$1 and TGF-$\beta$2 in bovine and human colostrum. Based on the isoform-specific ELISA, bovine colostrum collected on day 1 post-delivery retained $53.71{\pm}29.55\;ng/ml$ of TGF-$\beta$1 and $40.41{\pm}21.78\;{\mu}g/ml$ of TGF-$\beta$2 (n=4), while in human, $381.45{\pm}158.24\;ng/ml$ of TGF-$\beta$1 and $41.47{\pm}9.63\;ng/ml$ of TGF-$\beta$2 (n=5). Thus, dominant TGF-$\beta$ isoforms were completely opposite between human and bovine colostrum samples. The concentrations of both isoforms declined as lactation proceeded. Biological activities of the colostrum samples were determined using an MV1LU cell line. Consistent with the result from the immunoassay, TGF-$\beta$1 in human and TGF-$\beta$2 in bovine colostrum were responsible for the anti proliferative activity against MV1LU cells. Furthermore, bovine colostrum increased IgA secretion by LPS-stimulated mesenteric lymph node (MLN) cells, and this effect was abrogated by either anti­TGF-$\beta$2 antibody or combined anti-TGF-$\beta$1/$\beta$2 antibody, but not by anti- TGF-$\beta$1 antibody alone. Similarly, TGF-$\beta$2 in bovine colostrum enhanced the Ig germ line (GL) promoter activity, which is the earliest event toward IgA isotype switching. Taken together, these results suggest that TGF-$\beta$ isoforms, differentially expressed in human and bovine colostrum, may promote IgA isotype production in the neonatal intestine.

• 한국컴퓨터정보학회논문지
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• 제13권3호
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• pp.225-236
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• 2008

본 연구는 국제물류시장에서 활동하고 있는 복합운송주선업체가 기존 고객과 지속적인 거래관계를 유지하기 위해 어떤 요인이 중요한지 규명하기 위하여 관계마케팅의 개념과 도구를 적용하여 실증적으로 분석하였다. 연구결과, 고객과 지속적인 관계 지향적인 활동요인으로서 고객과 접촉강도(contact identity with customer), 상호개방성(two-way communication), 협력적 의도(cooperative intention)는 거래관계의 지속성(relationship continuity)에 정(+)의 영향을 미치는 것으로 나타났다. 추가로 구매방식(온라인/오프라인 의존도)과 서비스의 형태(표준과 맞춤형)의 상황별 분석에 있어서는 서비스의 형태별로는 거래의 지속성에 차이가 없었으나, 구매방식별로는 차이가 있는 것으로 나타나 오프라인 거래방식보다 온라인 거래방식 의존도가 높은 경우 거래관계의 지속성을 확보하는데 필요한 별도의 마케팅 전략을 수립하여 실행에 옮길 필요성을 제기하였다. 아울러 복합운송주선업체가 관계마케팅을 활용하는데 따른 시사점과 향후 연구 과제를 제시하였다.

• Molecules and Cells
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• 제24권2호
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• pp.283-287
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• 2007

$TGF-{\beta}1$ induces Ig germ-line ${\alpha}$ ($GL{\alpha}$) transcription and subsequent class switching recombination (CSR) to IgA. In the present study, we investigated the roles of two E3-ubiquitin ligases, Smurfs (HECT type) and Arkadia (RING finger type) on $TGF{\beta}1$-induced IgA CSR. We found that over-expression of Smurf1 and Smurf2 decreased $TGF{\beta}1$-induced $GL{\alpha}$ promoter activity and strengthened the inhibitory effect of Smad7 on the promoter activity. Further, over-expression of Smurf1 and Smurf2 decreased both Smad3/4-mediated and Runx3-mediated $GL{\alpha}$ promoter activities, suggesting that the Smurfs can down-regulate the major $TGF-{\beta}1$ signaling pathway and decrease $GL{\alpha}$ gene expression. In parallel, the over-expressed Smurf1 decreased the expression of endogenous IgA CSR-predictive transcripts ($GLT_{\alpha}$, $PST_{\alpha}$, and $CT_{\alpha}$) and also $TGF{\beta}1$-induced IgA secretion. Conversely over-expression of Arkadia abolished the inhibitory effect of Smad7 on $TGF{\beta}1$-induced $GLT_{\alpha}$ expression and IgA secretion. Similar results were obtained in the presence of over-expressed Smad7 and Smurf1. These results indicate that Arkadia can amplify $TGF{\beta}1$-induced IgA CSR by degrading Smad7, which interacts with Smurf1. We conclude that Smurf and Arkadia have opposite roles in the regulation of $TGF{\beta}1$-induced IgA isotype expression.

• Journal of Microbiology and Biotechnology
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• 제13권4호
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• pp.598-606
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• 2003

Salmonella encodes an enterotoxin (Stn) which possesses biological activity similar to the cholera toxin. Stn contributes significantly to the overall virulence of S. typhimurium in a murine model. The production of Stn is enhanced in a high-osmolarity medium and by contact with epithelial cells. In the present study, the in vitro and in vivo transcriptional regulations of the sin promoter revealed two promoters, P1 and P2. The P1 promoter identified by a primer extension analysis of stn mRNA exhibited a switching mechanism in vivo. Depending on the growth stage, transcription was initiated from different start sites termed $P1_S\;and\;P1_E$. $P1_S$, recognized by RNA polymerase containing ${\sigma}^S(E{\sigma}^S),\;and\;P1_E$, recognized by $E{\sigma}^70$, were activated during the stationary and exponential phases, respectively, while $P1_S\;and\;P1_E$ were both negatively regulated by CRPㆍcAMP and H-NS. Results revealed that $P1_S$ was the responsible promoter activated under a high osmolarity and low pH. The P2 promoter was identified 45 nucleotides downstream from $P1_E$ and negatively controlled by CRPㆍcAMP in vitro. No P2 activity was detected in vivo. The regulation of stn expression monitored using a Pstn::egfp fusion indicated that $E{\sigma}^S$ was required for the induction of stn and various factors were involved in stn regulation inside animal cells.

• 한국ITS학회 논문지
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• 제7권3호
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• pp.95-99
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• 2008

본 논문은 저 전력 설계 자동화를 위한 새로운 최소 자원 상위 레벨 합성 알고리즘을 제안한다. 제안된 알고리즘은 상위 레벨 합성 동안에 기능 연산자의 소비 전력 최소화를 위해 효율적인 접근 방식을 실행한다. 본 논문에서는 CDFG의 스위칭 활동을 감소시키기 위해 모든 제어 스텝을 하나씩 차례로 방문한다. 레지스터 공유 알고리즘은 모든 변수들의 생명 주기를 분석 한 후, 최소의 레지스터들을 결정한다. 또한 기능 단위의 입력 신호의 특성에 따라 모든 제어 스텝을 하나씩 차례로 방문하고, 갈망 방법에 따라 각 제어 스텝의 소비 전력을 최소화하여 자원 할당을 수행한다. 제안된 저 전력설계 자동화를 위한 최소 자원 상위 레벨 합성 알고리즘은 다양한 벤치마크들의 예를 통해 효율성을 입증한다.

• 천문학회보
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• 제38권2호
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• pp.35.1-35.1
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• 2013

By probing nuclear regions and overall properties of AGN hosts as a function of their environments, we aim to observationally examine how AGN activities are related to their surroundings. We have selected eight representative AGN hosts in the Virgo cluster, including seven cluster members (M49, M60, M84, M87, NGC 4435, NGC 4526, NGC 4636) and one galaxy that is likely to be background (NGC 4261) but still close enough to be studied in high resolution. The selected galaxies are located in a range of density regions showing various morphology in 1.4 GHz continuum. High resolution observations with the KVN allow us to access the inner region of the AGN without suffering from dust extinction and synchrotron self-absorption. Since half of our targets are weak to be detected at K-band within its coherence time, we applied phase referencing (fast antenna position switching) to calibrate fast atmospheric phase fluctuations. We successfully detected relatively bright AGNs, such as M87, M84 and NGC4261, but no detection signature was found to the other members of the sample. In this talk, we will present our first results from our KVN observations, while we will discuss in detail the applied technique and our immediate future plans.