• Archives of Pharmacal Research
• /
• v.24 no.6
• /
• pp.546-551
• /
• 2001

We have previously shown that, in circular muscle cells of the lower esophageal sphincter (LES) isolated by enzymatic digestion, contraction in response to maximally effective doses of acetylcholine (ACh) or Inositol Triphosphate ($IP_3$) depends on the release of $Ca^{2+}$ from intracellular stores and activation of a $Ca6{2+}$-calmodulin (CaM)-dependent pathway. On the contrary, maintenance of LES tone, and response to low doses of ACh or $IP_3$ depend on a protein kinase C (PKC) mediated pathway. In the present investigation, we have examined requirements for $Ca6{2+}$ regulation of the interaction between CaM- and PKC-dependent pathways in LES contraction. Thapsigargin (TG) treatment for 30 min dose dependently reduced ACh-induced contraction of permeable LES cells in free $Ca6{2+}$ medium. ACh-induced contraction following the low level of reduction of $Ca6{2+}$ stores by a low dose of TG ($10^{-9}{\;}M$) was blocked by the CaM antagonist, CCS9343B but not by the PKC antagonists chelerythrine or H7, indicating that the contraction is CaM-dependent. After maximal reduction in intracellular $Ca{2+}$ from $Ca6{2+}$stores by TG ($10^{-6}{\;}M$), ACh-induced contraction was blocked by chelerythrine or H7, but not by CCS9343B, indicating that it is PKC-dependent. In normal $Ca^{2+}$medium, the contraction by ACh after TG ($10^{-9}{\;}M$) treatment was also CaM-dependent, whereas the contraction by ACh after TG ($10^{-9}{\;}M$) treatment was PKC-dependent. We examined whether PKC activation was inhibited by activated CaM. CCS 7343B Inhibited the CaM-induced contraction, but did not inhibit the DAC-induced contraction. CaM inhibited the DAC-induced contraction in the presence of CCS 9343B. This inhibition by CaM was $Ca{2+}$dependent. These data are consistent with the view that the switch from a PKC-dependent pathway to a CaM dependent pathway can occur and can be regulated by cytosolic $Ca{2+}$ in the LES.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.19 no.3
• /
• pp.179-184
• /
• 2019

In many countries, such as developing countries where electricity is scarce, small wind turbines in the form of Off Grid are an effective solution to solve power supply problems. In some countries, the expansion of power systems and the decline of electricity-intensive areas have led to the use of small wind power in urban road lighting, mobile communications base stations, aquaculture and seawater desalination. With this change, the size of the small wind power industry is expected to have greater potential than large-scale wind power. In the case of small wind power generators, the generator is controlled at a variable speed, and the voltage and current generated by the generator have many harmonic components. To solve this problem, the AC to DC converter to be studied in this paper is a three-phase step-up type converter with a single switch. The inductor current is controlled in discontinuous mode, and has a characteristic of having a unit power factor by eliminating the harmonic of the input current. The proposed converter is composed of LCL filter and three phase rectification boost converter at the input stage and a single phase full bridge for grid connection. It is a control system with energy storage system(ESS) that the system stabilization can be pursued against the electric power.

• Smart Media Journal
• /
• v.8 no.2
• /
• pp.29-38
• /
• 2019

With the advancement of information and communication technology, tactical networks are continuously being converted to All-IP future tactical networks that integrate all application services based on Internet protocol. Futuristic tactical mesh network is built with tactical WAN (wide area network) nodes that are inter-connected by a mesh structure. In order to guarantee QoS (quality of service) of application services, tactical service mesh (TSM) is suggested as an intermediate layer between infrastructure and application layers for futuristic tactical mesh network. The tactical service mesh requires dynamic QoS monitoring and control for intelligent QoS coordination. However, legacy networking nodes used for existing tactical networks are difficult to support these functionality due to inflexible monitoring support. In order to resolve such matter, we propose a tactical mesh WAN node as a hardware/software co-designed networking node in this paper. The tactical mesh WAN node is conceptually designed to have multi-access networking interfaces and virtualized networking switches by leveraging the DANOS whitebox server/switch. In addition, we explain how to apply eBPF-based traffic monitoring to the tactical mesh WAN node and verify the traffic monitoring feasibility for supporting QoS coordination of tactical-mesh traffic.

• Korean Journal of Heritage: History & Science
• /
• v.46 no.2
• /
• pp.26-45
• /
• 2013

Sudden increase exceeding 30million in the number of smart phone users, and rising interest in the technology of augmented reality, is now trying to combine it with AR technology in other areas very much. The field of cultural heritage, which has been constructed by the Internet and 3D technology, is not unusual and this field is now rapidly changing thanks to the AR technology which can make users experience cultural heritage with high reality. The Palaces in Seoul, however, use fragmentary tools of information - lack of heritage commentators, leaflet, etc, even though the number of visitors is gradually increasing. Therefore, three-dimensional and comprehensive cultural heritage information service is needed with the guidance in the mobile era. This study utilizes the AR technology for building the Deoksugung Tourist Information Service Application(App.) applying the markerless-based recognition technology which is a more advanced tool than the location-based AR technology. This new AR technology can switch perceived real images such as the tablet of the King in the Palace of in the real world, patterns and pedestals into virtual world, which can reproduce the damaged cultural assets as 3D. This also composes photos of the past with the current buildings, which can increase people's interest and absorption of the contents, and helps them understand and be aware of Korean traditional culture and cultural heritage effectively. In addition, convergence between IT new technology, Augmented Reality(AR) and humanities through storytelling based implementation of cultural heritage in smart phone is attempted to demonstrate that there is strength in which augmented reality technique exerts infinite creativity based on actual reality world.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
• /
• v.12 no.5
• /
• pp.499-506
• /
• 2019

This paper is concerned with the operating stability of 7kW inverter using SIC hybrid module and verifies the validity of the simulation results by comparing the result of the loss equation and the simulation result, Simulation results using Si module and SiC hybrid module are compared to compare switch loss and diode loss. Through the loss equation calculation, the conduction loss of SiC Hybrid module is 168W, switching loss is 9.3W, diode loss is 10.5nW, When compared with the simulation results, similar values were shown. As a result of comparing the simulation results of the Si module and the SiC Hybrid module, The total device loss of the Si module was 246.2W, and the total device loss of the SiC Hybrid module was 189.9W. The loss difference was 56.3W, which was about 0.8W. thereby verifying the reverse recovery characteristics of the SiC SBD. In addition, temperature saturation test was conducted to confirm the stability of SiC Hybrid module and Si module under high temperature saturation, In the case of the Si module, the output power was stopped at 4kW, and the SiC Hybrid module was confirmed to operate at 7kW. Based on this, an efficiency graph and a temperature graph are presented, and the Si module is graphed up to 4kW and the SiC Hybrid module is graphed up to 7kW.

• KEPCO Journal on Electric Power and Energy
• /
• v.5 no.1
• /
• pp.25-32
• /
• 2019

K-BEMS System was introduced to reduce peak load and to save total energy of the 200 buildings that KEPCO headquarter and branch offices use. And K-BEMS system is composed of PV, battery, and hybrid PCS. KEPCO research institute has carried out this K-BEMS research project for 3 years since January 2016. In this paper, the results of the project are shown. 9 modes of test results of K-BEMS system and are operational problems were analyzed. And measures to cure the trouble are also suggested. Batteries are operated more than 20% of SOC, and less than 20% of SOC battery protection switches are automatically shutting down the system and the system no longer respond to EMS, ending the supply of PV, and so therefore to continue the PV power supply it was turn out to be necessary that the EMS should automatically change its policy to change PV only supply mode automatically when the Battery Switch automatically operated. To operate the system continuously and automatically, it is necessary to modify the minimum operational SOC value, and in addition to that the EMS computer must remember the last shut-down SOC and Voltage which interrupted the system and add some margin to reflect the measurement error in the system.

• Convergence Security Journal
• /
• v.21 no.1
• /
• pp.177-189
• /
• 2021

Defense R&D is a key process for securing weapons systems determined by mid- and long-term needs to cope with changing future battlefield environments. In particular, the test and evaluation provides information necessary to determine whether or not to switch to mass production as the last gateway to research and development of weapons systems and plays an important role in ensuring performance linked to the life cycle of weapons systems. Meanwhile, if you look at the recent changes in the operational environment of the Korean Peninsula and the defense acquisition environment, you can see three main characteristics. First of all, continuous safety accidents occurred during the operation of the weapon system, which increased social interest in the safety of combatants, and the efficient execution of the limited defense budget is required as acquisition costs increase. In addition, strategic approaches are needed to respond to future battlefield environments such as robots, autonomous weapons systems (RAS), and cyber security test and evaluation. Therefore, in this study, we would like to present strategies for improving the testing and evaluation of weapons systems by considering the characteristics of the security environment that has changed recently. To this end, the improvement strategy was derived by analyzing the complementary elements of the current weapon system operational test and evaluation system in a multi-dimensional model and prioritized through the hierarchical analysis method (AHP).

• The Korean Journal of Franchise Management
• /
• v.12 no.1
• /
• pp.21-34
• /
• 2021

Purpose: This study examines the structural relationship between perceived quality, relationship quality, and revisit intention in the context of coffee shop. In this model, perceived quality consists of product, service, and experience quality, and relationship quality consists of satisfaction, trust, and commitment, and performance consists of revisit intention. More specially, this study identifies whether perceived quality plays a mediating role in the relationship between perceived quality and relationship quality and the direct/indirect effects of perceive quality on intention to revisit. Research design, data and methodology: The survey was conducted from September 1 to 30, 2019. The data were collected from 320 respondents and analyzed using structural equation modeling (SEM) with AMOS program. Results: The findings are as follows. First, quality perception of coffee specialty stores had a statistically positive effect on relationship quality, indicating supports H1. Therefore, customers can know that they are aware of the quality of coffee specialty stores, including quality of service and experience as well as products, and that they form relationship quality with coffee specialty stores. Second, relationship quality between coffee shops and customers had a significant positive effect on performance. Thus, H2 was supported. The results show that if the coffee shop does not consider relationship quality as important, customer loyalty decreases, the number of customers decreases, and the number of customers who switch to another coffee shop increases, which can lead to a threat to the coffee shop. Third, in the case of hypothesis H3, it was found that there was a partial mediating effect of satisfaction and trust between quality perception and reuse intention of coffee specialty stores, so hypothesis H3 was partially supported. As commitment appears to have no mediating effect, it can be said that customers who use coffee shops are not only difficult to maintain as regular customers of a particular coffee shop, but also have ample room to move to other coffee shops. Conclusions: Although many scholars point out the importance of service quality, few studies were conducted in the context of the Korean food service industry (including coffee shops). From this perspective, this study tested several hypotheses that the quality (product, service, experience) perceived by customers can have a positive effect on relationship quality and performance (re-visit intention), either directly or indirectly. The findings of this study demonstrate that if the manager of a coffee shop understands the characteristics of quality perceived by customers and the role of relationship quality, the effect of quality perceptions on customers can be maximized in order to maintain the relationship with customers.

• Journal of the Microelectronics and Packaging Society
• /
• v.27 no.4
• /
• pp.97-105
• /
• 2020

Recently, as the data speed and operating frequencies of Ethernet keeps increasing, electro magnetic interference (EMI) also becomes increasing. The generation of such EMI will cause malfunction of near electronic devices. In this study, EMI filters were applied to reduce the EMI generated by DC-DC SMPS (switching mode power supply), which is the main cause of EMI generation of Ethernet switch. As the EMI filter, MLCCs with excellent withstanding voltage characteristics were used, which had advantages in miniaturization and mass production. Two types of EMI MLCC filters were used, which are X-capacitor and X, Y-capacitor. X-capacitor was composed of 2 MLCCs with 10 nF and 100 nF capacity and 1 Mylar capacitor. Y-capacitor was consisted of 6 MLCCs with a capacity of 27 nF. When only X-capacitor was applied as EMI filter, the conductive EMI field strength exceeded the allowable limit in frequency range of 150 kHz ~ 30 MHz. The radiative EMI also showed high EMI strength and very small allowable margin at the specific frequencies. When the X and Y-capacitors were applied, the conductive EMI was greatly reduced, and the radiation EMI was also found to have sufficient margin. In addition, X, Y-capacitors showed very high insulation resistance and withstanding resistance performances. In conclusion, EMI X, Y-capacitors using MLCCs reduced the EMI noise effectively and showed excellent electrical reliability.

• Microbiology and Biotechnology Letters
• /
• v.49 no.1
• /
• pp.101-110
• /
• 2021

Interactions between microalgae and heterotrophic bacteria are common in natural environments. This study investigated the effect of heterotrophic bacteria on the activity of the photosynthetic eukaryotic alga Chlorella sp. MF1907 when cocultured. A total of 31 heterotrophic bacterial isolates belonging to different genera were cocultured with MF1907. Interactions of the alga with Agromyces, Rhodococcus, Sphingomonas, Hyphomicrobium, Rhizobium, and Pseudomonas were positive, while those with Burkholderia, Paraburkholderia, Micrococcus, Arthrobacter, Mycobacterium, Streptomyces, Pedobacter, Mucilaginibacter, Fictibacillus, Tumebacillus, Sphingopyxis, and Erythrobacter were negative (p < 0.05). A turnover experiment demonstrating a switch from heterotrophic to autotrophic activity of MF1907 was performed using 16 isolates exhibiting apparent effects (positive, negative, or neutral). Compared with the results of the coculture experiment, eight isolates exhibited the same outcomes, while the others did not. Consistently, Pseudomonas and Agromyces showed a remarkable positive effect on MF1907 activity, and Burkholderia, Streptomyces, and Erythrobacter had a marked negative effect. Our results suggest that it may be possible to use the isolates for controlling populations of microalgae in natural and engineered environments.