• 한국자기학회지
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• 제15권1호
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• pp.25-29
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• 2005

고상에피택시방법으로 성장한 YIG 박막의 온도에 따른 자기특성의 변화를 결정이방성과 수직이방성을 중심으로 측정하였다. 고상에피택시법의 열처리 온도가 낮을 경우 전위가 발생하여 응력을 해소함으로써 수직이방성이 유도되지 않았으나 높은 온도에서 열처리된 박막에는 우수한 에피택시성장으로 잔류응력이 축적되어 수직이방성이 유도되었다. 수직이방성자장은 기판과 박막의 열팽창계수의 차이로 결정자기이방성이 없어지는 온도까지 선형으로 감소하였고, 보자력도 온도가 증가하면 감소하였다. YIG(111) 에피택시박막에 수직이방성이 유도되었을 경우 결정이방성상수 $K_1$을 $H_k=4K_1/3M_s$로부터 결정할 수 있었다. 온도에 따른 초자화율의 거동은 Hopkinson 효과로 잘 설명되어졌으며 측정결과를 이용하명 상자성 자화율이 큰 기판위에 성장한 박막의 큐리온도를 쉽게 측정할 수 있었다.

• 동의생리병리학회지
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• 제19권3호
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• pp.690-695
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• 2005

The purpose of this thesis is to dedicate to get the objectivity of herbal medicine treatments by choosing herbs likely to work as antifungal agents against Candida albicans which is the causes of Candida vaginitis, making experiments on them and getting the significant results. Each herb's efficacy on control the number of Candida vaginitis is noticed by using Disk Susceptibility test with six herbs medicine and Broth dilution assay of the culture. Cinamon Ramulus, Pulsatillae Radix, Dictamni Radicis Cortex, Paeoniae Radix, Arecae Semen, Artemisiae Capillaries Herba extracts experimented on the efficiency of antifungal activities against Candida albicans by disk susceptibility test. Pulsatillae Radix has the strongest efficiency. In Dictamni Radicis Cortex never appeared antifungal effect on treatment. MIC (minimal inhibition concentration) in vitro antifungal agents of Cinamon Ramulus, Pulsatillae Radix, Paeoniae Radix, Artemisiae Capillaries Herba extracts against Candida albicans was determined by broth dilution assay. MIC against Candida albicans is that Pulsatillae Radix is 2.5 mg/ml and Cinamon Ramulus is 5 mg/ml and Paeoniae Radix is 10 mg/ml and Artemisiae Capillaries Herba is 40 mg/ml.

• Biomolecules & Therapeutics
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• 제14권1호
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• pp.1-10
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• 2006

Drug dependence deals a heavy socioeconomic burden to the society. For adolescents, the damage from drug dependence is greater than adults considering their higher susceptibility to drug effect and increasing chance for violence leading to criminal punishment process. Habitual drug use depends on genetic and environmental factors and the complex interactions between the two. Mammalian model systems have been useful in understanding the neurochemical and cellular impacts of abused drugs on specific regions of the brain, and in identifying the molecular targets of drugs. More elucidation is required whether biological effects of drugs actually cause the habitual dependence at the cellular level. Although there is much insight available on the nature of drug abuse problems, none of the systems designed to help drug dependent individuals is efficient in screening functional ingredients of the drug, and thus resulting in the failure of helping drug dependent individuals recover from drug dependence. Alternative model systems draw the attention of researchers, such as the invertebrate model systems of nematodes (Caenorhabditis elegans) and fruit flies (Drosophila melanogaster). These models should provide new insight into the mechanisms leading to the behavior of drug users (even functional studies analyzing molecular mechanism), and screening useful components to help remove drug dependence among drug users. The relatively simple anatomy and gene expression of the invertebrate model systems should enable researchers to coordinate current knowledge on drug abuse. Furthermore, the invertebrate model systems should facilitate advance in experiments on the susceptibility of specific genetic backgrounds and the interaction between genetic factors to drug dependence.

• 한국임상수의학회지
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• 제25권5호
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• pp.346-354
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• 2008

The combined effects of EDTA-Tris and eighteen antimicrobial agents have been evaluated in eight clinically isolated methicillin-resistant bacteria (Staphylococcus aureus, Escherichia coli, Streptococcus uberis and Streptococcus agalactiae) from bovine mastitis. The antimicrobial activity was evaluated by measuring the minimal bactericidal concentration (MBC) for the antibiotics alone or in combination with EDTA-Tris in Mueller-Hilton broth and milk. Combined use of EDTA-Tris and antibiotics potentiated or antagonized activity of antibiotics against mastitic pathogens. Milk increased the antibiotic potency of erythromycin and spiramycin on S. aureus. Culture in milk changed patterns of EDTA-Tris combinational effects compared with that in standard Mueller-Hilton broth. Combined with EDTA-Tris in milk, synergic effects were observed in colistin, dihydrostreptomycin, kanamycin, erythromycin, gentamycin, oxytetracycline, streptomycin to E. coli, Str. uberis, and Str. agalactiae. However, significant antagonistic effects of milk on antibiotic susceptibility in combination with EDTA-Tris were noted in neomycin, streptomycin, penicillin, roxithromycin, and amoxicillin. This study indicates that combination therapy of EDTA-Tris with antibiotics in bovine mastitis should be used with caution because of the possible antagonistic effects of antibiotic combination with EDTA-Tris on mastitic pathogens. In addition, antibiotic susceptibility test in combination with EDTA-Tris in milk culture condition can be benefit in search of effective treatment regimen for some antibiotic-resistant bacteria of mastitis.

• 한국응용곤충학회지
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• 제31권4호
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• pp.480-485
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• 1992

키틴생합성저해제인 diflubenzuron을 톱다리개미허리노린재(Riptortus clavatus Thunberg)에 미량국소처리하였을 때 충태 및 영기에 따른 약제의 감수성차이와, 종령약충 처리후 우화율 및 우화성충에 미치는 영향을 조사하였다. Diflubenzuron은 살람효과를 보였으며 산란후 12시간내의 알은 산란후 48~60시간의 알보다 감수성이 높았으나, 알의 나이에 관계없이 처리된 알의 배는 정상적으로 발육하였다. 영기별 감수성은 영기가 진행될수록 낮아져 1령약충이 2령에 비하여 1.5배, 3령약충에 비하여 18.2배, 4령약충에 비하여 39.4배, 5령약충에 비하여 42.4배 높은 감수성을 나타내었다. 종령약충에 처리하였을 때 우화율과 우화성충의 체중, 수명 및 산란율은 현저히 감소하였다.

• 한국응용곤충학회지
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• 제49권4호
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• pp.363-369
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• 2010

친환경 소독 기술인 환경조절열처리(CATTS: controlled atmosphere and temperature treatment system)는 메틸브로마이드 훈증제 처리의 대체 기술로 사용되어 왔다. 본 연구는 저장 곡물 해충인 거짓쌀도둑거저리(Tribolium castaneum)를 CATTS를 통해 저장 기간 중 방제가 가능한 지를 알아보기 위해 시도되었다. 거짓쌀도둑거저리의 성충은 $46^{\circ}C$에서 열충격 감수성을 보였으며 여기에 CA 조건(15% 이산화탄소, 1% 산소)은 감수성을 현격하게 증가시켰다. CATTS 조건($46^{\circ}C$, 15% 이산화탄소 1% 산소)에서 120 분간 노출시켰을 때 유충(초기, 중기, 말기)과 성충 모두 100% 살충율을 나타냈다. CATTS 처리에 대한 감수성이 거짓쌀도둑거저리 발육 시기에 띠라 상이했고 말기 유충에서 높은 내성을 보였다. 거젓쌀도둑거저리 열충격단백질의 발현이 CATTS에 대한 내생과 관련이 있는 것으로 나타났다.

• 한국직업건강간호학회지
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• 제13권2호
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• pp.130-139
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• 2004

Purpose: The purpose of this study is to examine the effect of stretching exercise education on female workers' behavior for preventing musculoskeletal diseases. Method: This study educated occupational health nurses working in Seoul and Kyunggi area for stretching exercise methods and then had them educate female workers in each workplace for the stretching exercise methods. The subjects of this study were 205 female workers and the research period was from June to October 2003. Results: The female workers' self-efficacy on stretching exercise increased significantly. The female workers' perceived susceptibility on stretching exercise increased significantly. As for change in practical intention on preventive behavior for musculoskeletal diseases, those who replied to have a plan to exercise regularly and to want to participate in stretching exercise class increased significantly. According to whether to have subjective musculoskeletal symptoms or not, self-efficacy increased significantly after education in both workers with such symptoms and those without, and perceived susceptibility and cue to action increased significantly after education in workers without such symptoms. Conclusion: It is necessary to develop programs to increase self-efficacy and health belief and to apply them to female workers to prevent musculoskeletal diseases. In addition, it is necessary to provide repeated education for female workers' steady practice of preventive behavior.

• 대한수의학회지
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• 제35권3호
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• pp.563-573
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• 1995

To know the effect of Ivermectin(IVM) toxicity in testis, histopathologic changes as well as clinical signs were observed in experimental animals including dogs by the subcutaneous injection with 3-50mg/kg of IVM. Clinically, it was observed to have depression and ataxia in all groups whereas tremor and coma in mice, rats and guinea pigs, coma in hamsters and rabbits, and tremor and salivation in dogs were shown. The clinical signs were different by the dosage of IVM, species and individuals in all animals. Susceptibility to IVM was most sensitive in dogs, especially in a Tosa dog and this was susceptible in mice, hamsters and rabbits, guinea pigs and rats in order. Microscopical observation revealed that the seminiferous tubules of testis had decreased thickness of germinal epithelium due to the necrosis and desquamation of the spermatids and spermatocytes. The progressive pattern by the times of administration showed vacuolar formation between the layer of spermatids and spermatogonia due to the marked necrosis of spermatocytes and the presence of multinucleated giant cells derived from spermatid throughout the seminiferous tubules of testis. Only a layer of spermatogonia, a few spermatogonia, and Sertoli cells wore observed with atrophied wavelike basement membrane in the seminiferous tubules of testis. Necrotic germinal cells, sloughed immature spermatids and spermatocytes were present in the lumen of epididymis and ductus deferens. Microscopical observation showed different susceptibility to IVM with clinical observation in which it was also most sensitive in dogs, especially in a Tosa dog and this was susceptible in rabbits and guinea pigs, hamsters, rats and mice in order. It was considered that IVM affects mainly spermatocyte or spermatid stage in the spermatogenesis and disturbs their developing beyond these stage.

• 대한수의학회지
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• 제56권1호
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• pp.9-14
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• 2016

The present study evaluated the effects of a mixture of Galla rhois and Cinnamomum cassia extracts (GCE) (1 : 1, w/w) on susceptibility to the colonization of Campylobacter (C.) jejuni in broilers. Eighty two-week-old broilers (n = 20 per group) were used to estimate the efficacy of GCE against C. jejuni infection via drinking water. Antibacterial activity testing revealed that the minimum bactericidal concentration of GCE against C. jejuni was 2.5 mg/mL. Broilers challenged with C. jejuni were administered 0.0 (Non-GCE), 2.5 (GCE-2.5), 5.0 (GCE-5.0) and 10.0 g/L (GCE-10) GCE for 7 days, and the cecal contents were collected from five broilers per group on the 1st, 3rd, 5th, and 7th day post-treatment. On day 3 post-administration, the number of C. jejuni in GCE-5.0 (p < 0.05) and GCE-10 (p < 0.01) was significantly decreased relative to Non-GCE, while on day 7 those in all GCE-treated groups were significantly decreased compared to the Non-GCE group (p < 0.001). Hematological and blood biochemical analysis revealed no significant differences in parameters between the Non-GCE and GCE-treated groups. Based on the results of the present study, GCE was identified as a safe and alternative candidate to suppress C. jejuni colonization in broilers.

• 대한예방한의학회지
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• 제5권1호
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• pp.144-150
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• 2001

The cytotoxic activity of Cratalariae sessiliflorae on cultured NIH 3T3 fibroblasts and human oral epithelioid carcinoma cells (KB) were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) colorimetric method These fractions of methanol extract of Cratalariae sessiliflorae showed inhibitory effect in vitro in the milligram range against KB cell lines. In general, the antitumor activities of these fractions were does-dependent over the milligram range. The comparison of IC50 values of these fractions in tumor cell lines showed that their susceptibility to these fractions decrease in the following order: Fr. 4> Fr. 6> Fr. 10> Fr. 2> Fr. 11> Fr. 3> Fr. 8> Fr. 7> Fr. 9> Fr. 1> Fr. 5 by the MTT assay. These fractions were tested for their cytotoxic effects on NIH 3T3 fibroblasts using MTT assay. They exhibited potent cytotoxic activities in vitro in the milligram range against NIH 3T3 fibroblasts. In general, the cytotoxic activities of these fractions were does-dependent over the milligram range. The comparison of CD50 values of these fractions in NIH 313 fibroblasts shows that their susceptibility to these fractions in decrease the following order: Fr. 10> Fr. 9> Fr. 2 = Fr. 4> Fr. 8> Fr. 11> Fr. 1 = Fr. 7> Fr. 3> Fr. 5 = Fr. 6 by the MTT assay. These results suggests that fraction 5 has the most growth - inhibitory activity against KB cell lines.