• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10137-10142
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• 2015

Apoptosis is a general phenomenon of all multicellular organisms and caspases form a group of important proteins central to suicide of cells. Pathologies like cancer, Myocardial infarction, Stroke, Sepsis, Alzheimer's, Psoriasis, Parkinson and Huntington diseases are often associated with change in caspase 3 mediated apoptosis and therefore, caspases may serve as potential inhibitory targets for drug development. In the present study, two series of synthetic acetylated tetrapeptides containing aldehyde and fluromethyl keto groups respectively at the C terminus were proposed. All these compounds were evaluated for binding affinity against caspase 3 structure. In series 1 compound Ac-DEHD-CHO demonstrated appreciable and high binding affinity (Rerank Score: -138.899) against caspase 3. While in series 2 it was Ac-WEVD-FMK which showed higher binding affinity (Rerank Score: -139.317). Further these two compounds met ADMET properties and demonstrated to be non-toxic.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.1-13
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• 2016

The evidence for the existence of a common pathway for health issues in men is presented in this review. Several epidemiological studies have shown that conditions like cardiovascular diseases (CVD), metabolic syndrome, diabetes, lower urinary tract symptom (LUTS), erectile dysfunction (ED), prostate cancer, hypogonadism, depression and suicide can be associated as risk factors for each other. Thus, the risk of CVD is significantly increased in men with metabolic syndrome, ED, hypogonadism, prostate cancer and/or LUTS. In addition, the above mentioned conditions are more prevalent in atherosclerotic patients. In addition, growing evidence indicates that low androgen levels can cause metabolic syndrome. In addition, obesity, dyslipidaemia and diabetes can further reduce androgen levels potentiating their adverse effect. Low testosterone levels are also associated with a higher incidence of aggressive prostate cancer on biopsy and on definitive pathology, and lower probability of abiraterone response in the metastatic setting. Several recent studies point towards diffuse endothelial dysfunction and dysregulated pro-inflammatory state as the biological link between all these disorders. Our current hypothesis is that oxidative stress caused by these dysfunctions explains the pathogenesis of each of these conditions.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.2789-2800
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• 2013

Background: The aim of this systematic review was to investigate whether stem cells could be effectively applied in targeted therapy of breast cancer. Material and Method: A systematic literature search was performed for original articles published from January 2007 until May 2012. Results: Nine studies met the inclusion criteria for phase I or II clinical trials, of which three used stem cells as vehicles, two trials used autologous hematopoetic stem cells and in four trials cancer stem cells were targeted. Mesenchymal stem cells (MSCs) were applied as cellular vehicles to transfer therapeutic agents. Cell therapy with MSC can successfully target resistant cancers. Cancer stem cells were selectively targeted via a proteasome-dependent suicide gene leading to tumor regression. $Wnt/{\beta}$-catenin signaling pathway has been also evidenced to be an attractive CSC-target. Conclusions: This systematic review focused on two different concepts of stem cells and breast cancer marking a turning point in the trials that applied stem cells as cellular vehicles for targeted delivery therapy as well as CSC-targeted therapies. Applying stem cells as targeted therapy could be an effective therapeutic approach for treatment of breast cancer in the clinic and in therapeutic marketing; however this needs to be confirmed with further clinical investigations.

• Journal of the Korean Society of Industry Convergence
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• v.23 no.4_2
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• pp.637-644
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• 2020

Because suicide accidents sometimes were happened in grand bridges over rivers or sea water recently, it will be necessary that prevention measures be made preparation in advance from now on. Additional safety facilities must be needed in addition to existing safety facilities in such a way as this prevention measure. In order to make cable-stayed bridge safe on wind for additional safety facilities, main girder models with added safety facilities for wind-tunnel tests was made, and wind tunnel experiments was carried out to measure aerodynamic force coefficients. Also, wind-resistant analyses of 3D cable-stayed bridge were performed on the basis of wind-tunnel test results. From the wind experiments, force coefficients of main girder with added safety facilities were assessed, and it is known that there are little possibility of galloping and rotation of steel main girder. Finally, from the wind resistant analyses, it was concluded that wind-resistant safety of cable-stayed bridge was secured on wind speed 60.6m/sec.

• The Korean Journal of Health Service Management
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• v.7 no.1
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• pp.155-165
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• 2013

This study aims to identify the significance of adolescent suicidal ideation in a multicultural family, propose suicidal prevention strategies, and provide considerable foundations supporting their secured future. The research results are in the follow. For the results of main factors of relative influence on the suicidal ideation, the relative dangerousness levels were 5.5 times more likely to experience with drugs, 4.5 times more likely to have depressive symptoms, 3.2 times more likely to experience violence at school, and 2.8 times more likely to experience drinking alcohol, 1.4 times more likely to feel unhappiness and 1.3 times more likely to be bad off in economic status, all of which contribute to suicidal ideation. All results turned out to be statistically significant. Therefore, the findings and results of this study indicate that appropriate and practical prevention strategies to address the suicidal behavior of adolescents in a multicultural family need to be carefully considered and designed in a most urgent manner.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.2
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• pp.239-246
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• 2019

Teenagers in multicultural families are more prone to depression and problem behaviors caused by violence such as bullying in schools due to their appearance, language presentation skills, and poor learning abilities compared to teenagers in general families. This study is meaningful in that it provides basic information for prevention measures in intervening with damage caused by school violence such as depression, anxiety, suicidal impulses and emotional and social. For this purpose, a survey of 300 elementary school students from 4 to 6 grade, junior high school, and high school students was conducted. A total of 400 questionnaires were distributed and of thos e 385 were used for the final analysis. The results of the study are as follows. First, the psychological factors of suicidal ideation were higher in the victimized group than school violence. Second, there was a significant difference in the relationship between emotional - social isolation and school violence experience. Third, there was a significant difference in the relationship between experience of suicide ideation and depression as well as anxiety of emotional - social isolation with psychological maladjustment. In conclusion, we plan to find ways to stabilize the multicultural society by providing prevention and protection measures against school violence.

• Journal of Korea Artificial Intelligence Association
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• v.1 no.1
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• pp.1-6
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• 2023

This study developed models using decision forest, support vector machine, and logistic regression methods to predict and prevent suicidal ideation among Korean adolescents. The study sample consisted of 51,407 individuals after removing missing data from the raw data of the 18th (2022) Youth Health Behavior Survey conducted by the Korea Centers for Disease Control and Prevention. Analysis was performed using the MS Azure program with Two-Class Decision Forest, Two-Class Support Vector Machine, and Two-Class Logistic Regression. The results of the study showed that the decision forest model achieved an accuracy of 84.8% and an F1-score of 36.7%. The support vector machine model achieved an accuracy of 86.3% and an F1-score of 24.5%. The logistic regression model achieved an accuracy of 87.2% and an F1-score of 40.1%. Applying the logistic regression model with SMOTE to address data imbalance resulted in an accuracy of 81.7% and an F1-score of 57.7%. Although the accuracy slightly decreased, the recall, precision, and F1-score improved, demonstrating excellent performance. These findings have significant implications for the development of prediction models for suicidal ideation among Korean adolescents and can contribute to the prevention and improvement of youth suicide.

• Journal of Internet Computing and Services
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• v.21 no.2
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• pp.139-148
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• 2020

Due to change in circumstances in the 2000s such as severe birthrate decline and shortened military service period, the armed forces of the Republic of Korea is currently turning to technologies and equipments from manpower, developing it to become high-tech, high-speed, and complex, resulting in an environment in which a single mistake could cause a mass mortality crisis.It is also evident that, considering aspects such as safety training curriculums and achievements of advanced countries and private education, hands-on training is a must in preventing suicides and accidents in the military, and establishing safety training centers is crucial for systematic and effective hands-on training.Soldiers who are joining the army as of now have experienced the Internet ever since they were born and easily use both virtual and augmented reality, and the current level of science and technology has developed to the point where most of the public safety experience centers are able to be replaced by virtual and augmented reality (VR/AR). Therefore, considering the aspects such as installation space, construction costs, maintenance costs, user characteristics, and education effects, other than for those trainings where real models and objects are more effective such as first aid training, it is with a strong recommendation that establishing military safety training facilities with VR/AR (Virtual and augmented reality) is a must in the coming future. We have derived the need for hands-on training by considering the development of virtual and augmented reality (VR/AR), analysis of operation status of the public safety experience centers, characteristics of military units, installation and maintenance costs, and proposed plan to establish safety training centers where effective training performance can be achieved at a lower cost than the public safety experience center. In addition, we suggested the scale of the required safety training center and the composition of the experience rooms considering the number of trainees and the environment of each military units. Given this analysis it will contribute to the prevention of military safety and suicide by building a safety training center in the future.

• Korean Journal of Health Education and Promotion
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• v.30 no.2
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• pp.11-21
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• 2013

Objectives: The objective of this paper is to study influence of self esteem, family support and adaptation to school life on adolscents' suicidal ideation adjsuted for general characteristics effect. Methods: Using cluster sampling, 318 high school freshmen from T city were extracted as survey subjects. Independent t-test, ANOVA, Duncan test, Pearson's correlation coefficients and multiple regression analysis were applied for statistical analysis. Results: Among general characteristics, religion, family income, single-parentedness, health status and school grades were statistically significant with suicidal ideation. Controlling the above variables, increase in self-esteem (${\beta}$=-.300) and family support (${\beta}$=-.267) showed statistically significant decrease in suicidal ideation but adaptation to school life did not. Conclusions: Therefore, it is proposed that measures for enhancement of self esteem and family support to be included in development of suicide prevention programs.

• Journal of the Korean Society of School Health
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• v.28 no.2
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• pp.120-126
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• 2015

Purpose: The purpose of this study was to understand interpersonal dispositions and social support among high school students and identify factors associated with depression. Methods: A total of 604 students (320 males and 284 females) from four high schools conveniently sampled from high schools in the Incheon area participated in a self-administered survey. Results: According to hierarchical multiple regression analysis, the following factors significantly affected the participants' depression levels with the explanatory power of 30.6%: grade, perceived health status, sympathetic-acceptable personality, sociable-friendly personality, rebellious-distrustful personality, parent support, peer support, and the support from community. Conclusion: In this study, interpersonal dispositions and social support were positively associated with depression. These results suggest that strengthening personal relations and social support can help high school students in terms of mental health and suicide prevention.