• Title/Summary/Keyword: substitutes

Search Result 675, Processing Time 0.021 seconds

Designing and Implementing Serious Game for Programming Education (프로그래밍 교육을 위한 기능성 게임의 설계와 구현)

  • Jung, ChanYong
    • Journal of Korea Game Society
    • /
    • v.16 no.6
    • /
    • pp.143-150
    • /
    • 2016
  • Programming is a difficult meat for novices. Educatees nowadays start to play games before they first attend formal education. Serious games offer tools that may have potential to support programming trainers to become more engaged on their learning through a learn while having fun approach. This paper aims to design and implement serious game for programming education. Our serious game substitutes game rules and objects for elements of programming language. We will begin by describing the game mechanics, followed by the general system architecture, finalizing with a small conclusion. We also discuss the implications of our work for the development of the serious game that support the identified features and teach programming concepts.

All-Inside Technique of Anterior Cruciate Ligament Reconstruction using Central Quadriceps Tendon and Patella Bone Block (관절강 내에서 모든 수술 과정을 시행하는 관절경적 전방십자인대 재건술)

  • Jeong, Hwa-Jae
    • Journal of the Korean Arthroscopy Society
    • /
    • v.1 no.1
    • /
    • pp.66-71
    • /
    • 1997
  • The all inside anterior cruciate ligament reconstruction technique places an anterior ligament substitutes within two bony sockets rather than hone tunnel. This approach is accomplished through arthroscopic three portal which avoids the surgical exposure and morbidity associated with creating traditional bone tunnel. This technique has several distinct advantages when compared with the traditional ACL reconstruction through the bone tunnels. It offers the surgeon a less morbid method for ACL reconstruction that positions an ACL substitute at the anatomic attachment sites of the original ACL with two bone sockets, obviating the need for traditional bone tunnels. Graft fixation at or near the anatomic attachment points of the original ACL minimizes creep with early range of motion and reduces the abrasive 'wind-shield wipe' motion of the graft which occur with bone plugs positioned inside bone tunnels. The sagittal posterior angle to the tibial socket increases fixation strength to pullout with anterior translation force for the tibia on the femur. This technique is not graft specific and can accomodate any graft in which graft length can be customized to the intraarticular native ACL length.

  • PDF

Brief Introduction of Traditional Chinese Medicine(TCM) and Possible Measures to Protect the Endangered Species of TCM

  • Kim, Sung-Hoon;Kim, In-Rak
    • The Journal of Korean Medicine
    • /
    • v.18 no.2
    • /
    • pp.366-373
    • /
    • 1997
  • Recently the endangered species of wild fauna and flora used in TCM have been held under a spotlight by CITES-implementing countries. USA and other western countries have suspected Oriental countries might not keep the regulation of CITES effectively for the continuous use of endangered species such as tiger bone, rhino horn, bear gallbladder and others. However, most of Oriental countries have tried to keep CITES truly. The misunderstanding of culture and thought in Oriental countries can be one of important factors. Thus, for effective implementation of CITES, we have to keep communication with western countries especially in the principles of TCM or others and vice versa. In addition, TCM using countries and counterpart countries should prevent illegal trade of endangered species in TCM and also fry to develop natural or synthesized substitutes for endangered species. We have to continue to develop methods to artificially propagate endangered species, while trying to alleviate the ethical problems entailed by breeding in captivity. In south Korea we also have to make known our implementation of CITES such as reinforced law for prohibition of using CITES items, public awareness by training program, brochure and surveys to other countries.

  • PDF

Short-Chain-Length Polyhydroxyalkanoates: Synthesis in Metabolically Engineered Escherichia coli and Medical Applications

  • PARK, SI-JAE;CHOI, JONG-IL;LEE, SANG-YUP
    • Journal of Microbiology and Biotechnology
    • /
    • v.15 no.1
    • /
    • pp.206-215
    • /
    • 2005
  • Polyhydroxyalkanoates (PHAs) are homo or hetero polyesters of (R)-hydroxyalkanoates accumulated in various microorganisms under growth-limiting condition in the presence of excess carbon source. They have been suggested as biodegradable substitutes for chemically synthesized polymers. Recombinant Escherichia coli is one of the promising host strains for the economical production of PHAs, and has been extensively investigated for the process development. The heterologous PHA biosynthetic pathways have been established through the metabolic engineering and inherent metabolic pathways of E. coli have been redirected to supply PHA precursors. Fermentation strategies for cultivating these recombinant E. coli strains have also been developed for the efficient production of PHAs. Nowadays, short-chain-length (SCL) PHAs are being re-invited due to its improved mechanical properties and possible applications in the biomedical area. In this article, recent advances in the development of metabolically engineered E. coli strains for the enhanced production of SCL-PHAs are reviewed. Also, medical applications of SCL-PHAs are discussed.

Two-Dimensional Model of Hidden Markov Lattice (이차원 은닉 마르코프 격자 모형)

  • 신봉기
    • Journal of Korea Multimedia Society
    • /
    • v.3 no.6
    • /
    • pp.566-574
    • /
    • 2000
  • Although a numbed of variants of 2D HMM have been proposed in the literature, they are, in a word, too simple to model the variabilities of images for diverse classes of objects; they do not realize the modeling capability of the 1D HMM in 2D. Thus the author thinks they are poor substitutes for the HMM in 2D. The new model proposed in this paper is a hidden Markov lattice or, we can dare say, a 2D HMM with the causality of top-down and left-right direction. Then with the addition of a lattice constraint, the two algorithms for the evaluation of a model and the maximum likelihood estimation of model parameters are developed in the theoretical perspective. It is a more natural extension of the 1D HMM. The proposed method will provide a useful way of modeling highly variable patterns such as offline cursive characters.

  • PDF

Relationship Management of Multinational Enterprises and its Performance: An Empirical Study of Foreign and Japanese Multinationals (다국적기업의 관계관리와 효과에 관한 실증연구 - 재일외자기업(在日外資企業)과 일계다국적기업(日系多國籍企業)을 대상으로 -)

  • Rha, Hye-Su;Kim, Jung-Uk
    • International Commerce and Information Review
    • /
    • v.10 no.2
    • /
    • pp.391-410
    • /
    • 2008
  • Emphasis on relationship management might be found out from Williamson (1975), who tried to elucidate why an organization exists. According to his transaction cost theory, an organization is established to evade opportunistic actions of the market and build up a hierarchy of value chain. However, judged from the perspective of exchange relationship in a trade, the transaction cost theory was likely to approach to buyer-seller relationship by the mechanism of competition. Therefore, an organization exists to control the competition of the market. Relationship management suggested by relationship marketing focuses on cooperation between buyers and sellers, rather than competition against each other. Relationship management aims to provide a framework for making a market relationship that might become an asset or a resource of the firm. In the process of maintaining and strengthening long-term and cooperative relationship with all stakeholders included customers, suppliers and staff, they continue to create new values. The purpose of this empirical research, by investigating how relationship management of multinational enterprises influences on their competitive advantages and performances, is to suggest that a cooperative relationship established for a long time in the market, so-called quasi-market relationship, substitutes for an organization.

  • PDF

Microvascular autologous submandibular gland transplantation in severe cases of keratoconjunctivitis sicca

  • Su, Jia-Zeng;Cai, Zhi-Gang;Yu, Guang-Yan
    • Maxillofacial Plastic and Reconstructive Surgery
    • /
    • v.37
    • /
    • pp.5.1-5.4
    • /
    • 2015
  • Dry eye syndrome is a relatively common disease of the tears and ocular surfaces that results in discomfort, visual disturbance, and tear film instability with possible damage to the ocular surfaces. Microvascular submandibular gland (SMG) transfer offers a surgical alternative for a permanent autologous substitution of tears using the basal secretion of a transplanted SMG. Long-term follow-up reveals that this technique is a lasting and effective solution for patients with severe dry eye syndrome. The uncomfortable symptoms were relieved, and the frequency of use of pharmaceutical tear substitutes was reduced. Objective examination showed significant improvement in tear film and some features of ocular surface such as breakup time of tear film and corneal staining. Patients may suffer from obstruction of Wharton's duct or epiphora after surgery. Activation of secretion-related receptors could improve the early hypofunction of the denervated SMG and prevent the duct obstruction. Reduction surgery, partial SMG transplantation, uses of atropine gel or Botulinum toxin A could be the choices of treatment for epiphora.

Tooth-derived bone graft material

  • Kim, Young-Kyun;Lee, Junho;Um, In-Woong;Kim, Kyung-Wook;Murata, Masaru;Akazawa, Toshiyuki;Mitsugi, Masaharu
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
    • /
    • v.39 no.3
    • /
    • pp.103-111
    • /
    • 2013
  • With successful extraction of growth factors and bone morphogenic proteins (BMPs) from mammalian teeth, many researchers have supported development of a bone substitute using tooth-derived substances. Some studies have also expanded the potential use of teeth as a carrier for growth factors and stem cells. A broad overview of the published findings with regard to tooth-derived regenerative tissue engineering technique is outlined. Considering more than 100 published papers, our team has developed the protocols and techniques for processing of bone graft material using extracted teeth. Based on current studies and studies that will be needed in the future, we can anticipate development of scaffolds, homogenous and xenogenous tooth bone grafts, and dental restorative materials using extracted teeth.

The Effect of Hyaluronate-Carboxymethyl Cellulose on Bone Graft Substitute Healing in a Rat Spinal Fusion Model

  • Lee, Jung-Hee;Jeong, Bi-O
    • Journal of Korean Neurosurgical Society
    • /
    • v.50 no.5
    • /
    • pp.409-414
    • /
    • 2011
  • Objective : The aim of this study was to evaluate the impact of sodium hyaluronate-sodium carboxymethyl cellulose (HA-CMC), an anti-adhesive material for spinal surgery, on bone fusion by applying it to rat spinal models after lumbar posterolateral fusion. Methods : Lumbar posterolateral fusion was performed at L4-5 using bone graft substitutes in 30 rats. HA-CMC was injected in 15 rats at a dose of 0.2 cc (HA-CMC group) and a saline solution of 0.2 cc in the other 15 rats (control group). Simple radiographs were taken until postoperative 9 weeks with an interval of one week. At postoperative 4 and 9 weeks, three dimensional computed tomography (3D CT) scanning was performed to observe the process of bone fusion. At 9 weeks, bone fusion was confirmed by gross examination and manual palpation. Results : There were no statistically significant differences in bone fusion between the two groups. 3D CT scanning did not reveal significant differences between the groups. The gross examination and manual palpation after autopsy performed at 9 weeks confirmed bone union in 93.3% of both groups. Conclusion : The anti-adhesive material used for spinal surgery did not have adverse effects on spinal fusion in rats.

Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine (고분자 생체재료와 줄기세포를 이용한 조직공학과 재생의학의 최신 동향)

  • Lee, Sang Jin;Yoo, James J.;Atala, Anthony
    • Polymer(Korea)
    • /
    • v.38 no.2
    • /
    • pp.113-128
    • /
    • 2014
  • Tissue engineering and regenerative medicine strategies could offer new hope for patients with serious tissue injuries or end-stage organ failure. Scientists are now applying the principles of cell transplantation, material science, and engineering to create biological substitutes that can restore and maintain normal function in diseased or injured tissues/organs. Specifically, creation of engineered tissue construct requires a polymeric biomaterial scaffold that serves as a cell carrier, which would provide structural support until native tissue forms in vivo. Even though the requirements for scaffolds may be different depending on the target applications, a general function of scaffolds that need to be fulfilled is biodegradability, biological and mechanical properties, and temporal structural integrity. The scaffold's internal architecture should also enhance the permeability of nutrients and neovascularization. In addition, the stem cell field is advancing, and new discoveries in tissue engineering and regenerative medicine will lead to new therapeutic strategies. Although use of stem cells is still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous adult cells have already entered the clinic. This review discusses these tissue engineering and regenerative medicine strategies for various tissues and organs.