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Mechanisms of Contraction Induced by Sodium Depletion in the Rabbit Renal Artery

  • Kim, Se-Hoon;Chang, Seok-Jong
    • The Korean Journal of Physiology
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    • v.25 no.2
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    • pp.159-170
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    • 1991
  • In the rabbit renal artery, mechanisms of contraction by sodium depletion were investigated. The helical strips of isolated renal artery were immersed in the Tris-buffered salt solution. The contractions were recorded isometrically using a strain-gauge transducer. Na-free solution (Na was substituted by Li, choline or sucrose) produced contractions which were dependent on the nature of the Na substitutes. Na-free solution (choline) produced the contraction in ouabain-pretreated artery (Na loaded artery) even in the presence of verapamil. The amplitude of the contraction was dependent on the duration of the pretreatment with ouabain $(10\;^5M)$. Monensin potentiated the effect of ouabain on the contraction. Removal of Ca from bathing solution abolished the contraction and the substitution of Sr for Ca produced the contraction. Divalent cations such as Mg, Mn blocked the depolarization-induced contraction, while they had little effect on the Na-free contraction in Na loaded artery. These results suggest that the contraction induced by Na removal is dependent on the cellular Na content and may be caused by Ca influx via the Na-Ca exchange carrier.

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Machine Learning Approach to the Effects of the Superstore Mandatory Closing Regulation

  • AN, Jiyoung;PARK, Heedae
    • Journal of Distribution Science
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    • v.18 no.2
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    • pp.69-77
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    • 2020
  • Purpose - This paper is aimed to analyze the effects of the mandatory closing regulation targeting large retailers, which has been implemented since 2012 to protect small retailers. We examine the changes in consumers' choice of retailers and their purchasing patterns of agri-food following the implementation of such regulation. Research design, data, and methodology - Household spending patterns were identified through the historical data of household food purchase, consumer panel provided by the Rural Development Administration. Clustering was employed to determine the household spending patterns. Moreover, the different household spending patterns before and after the regulation were comparatively studied. The patterns of consumers' choice of retail stores and shopping baskets by the type of retailers, derived from the respective datasets before and after the regulation, were compared to analyze the effects of the regulation. Results -After the regulation, some consumers who used to shop at large retailers before the regulation changed their shopping places to small retailers. However, the product categories that consumers had mainly purchased before the regulation were rarely changed even after the regulation. Conclusions - Although the regulation helped migrate some of the consumers to small retailers, the regulation seemed to have failed to stimulate consumers to purchase the goods, normally bought at large retailers, from traditional markets. In other words, traditional markets are not effective substitutes for regulation-affected retailers.

Temporal Analysis of Trends in Dissolved Organic Matter in Han River Water

  • Lee, Hye-Won;Choi, Jung-Hyun
    • Environmental Engineering Research
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    • v.14 no.4
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    • pp.256-260
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    • 2009
  • This study used the extensive monitoring datasets of the Korea Ministry of Environment to examine trends in dissolved organic carbon (DOC) in Han River raw water. To estimate the organic contents of water, we adopted allied parameters such as biochemical oxygen demand (BOD) and chemical oxygen demand (COD) as substitutes for DOC. Spatial and temporal analyses were performed on monthly BOD and COD data from 36 monitoring stations (14 for Main Han River, 7 for North Han River and 15 for South Han River) measured from 1989 to 2007. The results of trend analysis indicated that, on the whole, water quality according to BOD showed a downward trend at more than 67% of monitoring stations (9 for Main Han River, 6 for North Han River and 9 for South Han River). However, the water quality of COD showed an upward trend at more than 78% of monitoring stations (8 for Main Han River, 7 for North Han River and 13 for South Han River). The upward trend of COD contrary to the BOD trend indicates that there has been an increase in recalcitrant organic matter in Han River water that is not detectable by means of BOD.

A Study on Microwave-FM-CW Detection System for the Sutomatic Optimal Point Traffic Control (교통신호의 자동최적점제어를 위한 마이크로파 FM-CW 검지계통에 관한 연구)

  • 양흥석;김호윤
    • 전기의세계
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    • v.22 no.1
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    • pp.35-41
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    • 1973
  • An automatic point traffic control method is recommended for more idealistic traffic flow over coarse road netowrks. The automatic control apparatus recommended, consists of a transceiver, amplifier, digital-to-analog converter, signal light controller for emergency and steady state, and digital counter as monitor. The transmitter sends a signal to the target vy means of Microwave-FM-CW and a diode detector picks up the echo signal. Thus the operation of the entire system will be carried out through an open loop state. Some factors necessary for an ideal detector system are rapid response, longevity and stability. An analytical method of the Doppler effect substitutes the conventional frequency deviation into the amplitude of detector output. The changing rate of amplitude is proportional to the voltage of the detector output. Some induced formula from Maxwell's radiation field theory ensures this new method, and, new method, and proves the fact with an experimental data presentation. Stability depends upon Klystron as an oscillator and a diode as a detector. the transceiver installation affects on the response and sensitivity of the system. In accordance with the detector output, several targets are easily classified by amplitudes on the scope. The traffic flow, i.e., target movement which is analyzed by the amplitude method, is shown through the scope and indicates it on the digital counter. The best efficiency for the amplitude analysis can be attained through use of an antenna having the highest sensitivity.

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Effect of Bioactive Glass Addition to the TTCP/DCPA Based Injectable Bone Substitute for Improved Biocompatibility

  • Sadiasa, Alexander;Sarkar, Swapan Kumar;Franco, Rose Ann;Yang, Hun-Mo;Lee, Byong-Taek
    • Proceedings of the Materials Research Society of Korea Conference
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    • 2011.05a
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    • pp.52.1-52.1
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    • 2011
  • In this work, the effect of the addition of bioactive glass in the biocompatibility and mechanical behavior of conventional TTCP/DCPA based bone cement were investigated. The cement was initially modified with chitosan and HPMC which cross-linked with citric acid to improved mechanical properties.The injectable bone substitutes were further modified by adding varying amounts of bioactive glass (0%, 10%, 20% and 30%) and its effects on the biocompatibility of the material were studied. Afterbio-glass powders were mixed with the optimized composition for HPMC and citric acid content,the IBS was incubated at $37^{\circ}C$ at different time intervals and showed progressive formation of HAp with increasing time. Mechanical properties like Vickers hardness and compressive strength were found to increase with the increasing amount of bioactive glass addition and that setting time was shortened. The fabricated IBS morphologies were further characterized using SEM. MTT assay was performed to check the cell cytotoxicity and cell proliferation for 1, 3 and 5 days. Cell morphology, adhesion and proliferation behavior of cell in the IBS by culturing MG-63 cells on the IBS for 20, 60 and 90 mins and 1, 3 and 5 days was also investigated. All the results showed increasing biocompatibility as the bioglass content increased. MTT results found the materials to be cytocompatible and SEM images showed that cells attached and proliferated successfully.

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The Effect of Polysaccharide from Angelica Gigas Nakai on Controlling the Differentiation of Human Embryonic Stem Cells

  • Park, Young-S.;Lee, Jae-E.;Lee, Seo-H.;Lee, Hyeon-Y.
    • Korean Journal of Medicinal Crop Science
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    • v.10 no.4
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    • pp.237-242
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    • 2002
  • It was found that the purified extract from A. gigas Nakai (polysaccharide, M.W., 25 kD) controled differentiating human ES cells. Its optimal supplementation concentration was decided as 0.8 $({\mu}g/ml)$ to efficiently control the differentiation. It also enhanced the cell growth, compared to the control. However, most widely used and commercially available differentiating agent, Leukemia Inhibitory Factor (LIF) negatively affected on the cell growth even though it controls the differentiation of ES cells, down to 40-50 % based on morphological observation and telomerase activity. It was presumed that the extract first affected on cell membrane and resulted in controlling signal system, then amplify gene expression of telomere, which enhanced the telomerase activity up to three times compared to the control. LIF only increased the enzyme activity up to two times. It was confirmed that the extract from A. gigas Nakai could be used for substituting currently used differentiation controlling agent, LIF from animal resources as a cheap plant resource and not affecting the cell growth. It can broaden the application of the plants not only to functional foods and their substitutes but also to fine chemicals and most cutting-edge biopharmaceutical medicine.

RECONSTRUCTION OF INTRAORAL JAW DEFECTS WITH CORTICOCANCELLOUS BLOCK OF MANDIBULAR SYMPHYSIS (하악골 정중부에서 채취한 피질해면골블록을 이용한 구내 골결손부의 재건: 증례보고)

  • Kim, Young-Kyun;Kim, Hyoun-Tae;Cho, Chang-Uk
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.26 no.6
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    • pp.666-671
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    • 2000
  • Objectives: This study evaluated the availability of mandibular symphysis corticocancellous block grafts in patients treated for reconstruction of intraoral jaw defects. Materials & Methods: 8 patients with mandibular and maxillary bony defects were treated with corticocancellous block of symphysis. The types of defects included 4 pathologic jaw defects and 4 vertical and/or horizontal alveolar deficiencies. The age ranged from 13 to 45 years. Additional treatments such as plate fixation, alloplastic bony substitutes, and/or barrier membrane application were perfomred. They were evaluated for complications and healing of defects. Follow-up period ranged from 6 to 15 months. Results: 2 patients experienced complications such as wound dehiscence and mild resorption of exposed bone. None of the patients needed secondary operation. Paresthesia of lip, chin, and teeth were recovered completely by 6 months postoperatively. Reconstructed wound showed favorable healing and bony consolidation. Conclusion: Corticocancellous block of mandibular symphysis can be used for the reconstruction of a variety of intraoral local jaw defects selectively. Advantages were easy fixation of graft, possibility of restoration of original alveolar contour, and decreased donor site morbidity.

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Antimicrobial surfaces for craniofacial implants: state of the art

  • Actis, Lisa;Gaviria, Laura;Guda, Teja;Ong, Joo L.
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.39 no.2
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    • pp.43-54
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    • 2013
  • In an attempt to regain function and aesthetics in the craniofacial region, different biomaterials, including titanium, hydroxyapatite, biodegradable polymers and composites, have been widely used as a result of the loss of craniofacial bone. Although these materials presented favorable success rates, osseointegration and antibacterial properties are often hard to achieve. Although bone-implant interactions are highly dependent on the implant's surface characteristics, infections following traumatic craniofacial injuries are common. As such, poor osseointegration and infections are two of the many causes of implant failure. Further, as increasingly complex dental repairs are attempted, the likelihood of infection in these implants has also been on the rise. For these reasons, the treatment of craniofacial bone defects and dental repairs for long-term success remains a challenge. Various approaches to reduce the rate of infection and improve osseointegration have been investigated. Furthermore, recent and planned tissue engineering developments are aimed at improving the implants' physical and biological properties by improving their surfaces in order to develop craniofacial bone substitutes that will restore, maintain and improve tissue function. In this review, the commonly used biomaterials for craniofacial bone restoration and dental repair, as well as surface modification techniques, antibacterial surfaces and coatings are discussed.

Synthesis and reactivity over molybdenum carbide crystallites

  • Choi, Jeong-Gil
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.20 no.2
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    • pp.74-79
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    • 2010
  • The synthesis and reactivities of molybdenum carbide crystallites were examined in this study. Especially, the effect of synthesis conditions were scrutinized on the preparation of molybdenum carbide crystallites. In order to perform this purpose, various characterization techniques such as BET surface area and oxygen uptake measurements were employed for the synthesized molybdenum carbide crystallites. First of all, the molybdenum carbide crystallites were synthesized using molybdenum oxide crystallites and methane gas or methane-hydrogen mixture. The experimental results showed that BET surface areas ranged from $7.4m^2/g$ to $31m^2/g$ and oxygen uptake values varied from $8.1{\mu}mol/g$ to $24.3{\mu}mol/g$. The Mo compounds were found to be active for ammonia decomposition reaction. Even though there are some molybdenum carbide crystallites that were exceeded by Pt/$Al_2O_3$ crystallite, the steady state reactivities for other molybdenum carbide crystallites were comparable to or even higher than that determined for the Pt/$Al_2O_3$ crystallite. These results implied that molybdenum carbide crystallites could be one of the promising crystallites that might be substitutes for Pt-like noble metal crystallites in the petroleum processes.

Solvent Washing Dry Method for Aqueous Tape Casting

  • Yoon, Seok-Jin;Shin, Hyo-Soon;Park, Ji-Won;Kang, Chong-Yun;Kim, Tae-Song;Kim, Hyun-Jai
    • The Korean Journal of Ceramics
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    • v.7 no.2
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    • pp.55-57
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    • 2001
  • For the fast dry of the aqueous tape, the process which water was replaced by organic solvent was proposed. Socalled, it was the solvent washing dry. Three organic solvents (methanol, ethanol and acetone) were selected for the washing solvent. The weight loss of the washed tapes was measured to evaluate the dry rate of the tapes and dried tapes were examined the generation of the cracks with the variations of the organic solvent and the washing time. Methanol, ethanol and acetone were available organic solvents for this method. The tapes washed in methanol, ethanol and acetone were dried rapidly for twenty minutes. After thirty minutes, the weight losses were not found any more. The solvent of the lower surface tension can decreases the crack of dried tape. If solvent substitutes water completely, though it was fast dried, crack can be eliminated.

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