• Nutrition Research and Practice
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• 제14권6호
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• pp.606-620
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• 2020

BACKGROUND/OBJECTIVES: Although some juices affect subjective sleep quality, there is a lack of information on the effect of a specific juice on objective sleep quality and heart rate variability (HRV) during sleep; thus the present study investigated whether a blended juice made from natural extracts influenced sleep quality and HRV during sleep in adults with disturbed sleep. SUBJECTS/METHODS: A randomized, crossover study was conducted on twenty-five adults (15/10, female/male) complaining of difficulty initiating or maintaining nighttime sleep (Pittsburgh sleep quality index [PSQI] ≥ 5). During feeding sessions (FS), subjects received sleep-inducing juice made of natural ingredients (250 mL/trial) twice a day for 8 weeks or non-FS (N-FS) for 8 weeks while maintaining normal activities. Sleep quality and parameters were recorded via wearable actigraph for 7 consecutive days, and PSQI scores were assessed before and after the intervention. HRV was also monitored at rest and during sleep. RESULTS: After receiving the sleep-inducing juice intervention (FS), PSQI scores were significantly decreased (P < 0.001) and correlated with a significant decline in fatigue severity scale and visual analogue scale levels (P < 0.05; both). HRV indices of vagal activity were significantly improved during FS (P < 0.05), and no significant differences in N-FS were observed. Sleep efficiency and total sleep time increased significantly (P < 0.05) and sleep latency, total counts, sleep fragmentation index, and movement index, decreased significantly (P < 0.05, all 4) during FS, with no significant differences-observed during N-FS. CONCLUSIONS: This study results demonstrated that an 8-week course of sleep-inducing juice has led to improve sleep quality, suggesting an enhanced cardiac vagal tone during sleep. Thus, it could be a well-tolerated option for adults with disturbed sleep.

• 한국식품조리과학회지
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• 제16권4호
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• pp.321-327
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• 2000

본 연구는 부추김치의 담금방법에 따른 부재료가 발효숙성에 미치는 영향을 알아보기 위하여 소금을 첨가한 처리구 A, 간장을 첨가한 처리구 B, 간장과 들깨가루를 첨가한 처리구 C, 멸치액젓을 첨가한 처리구 D, 멸치액젓과 찹쌀풀을 첨가한 거리구 E로 담금 즉시 1$0^{\circ}C$에서 43일간 발효시키면서 색과 조직특성을 알아본 결과는 다음과 같다. 1. 클로로필 및 카로티노이드의 잔존율은 발효숙성이 진행됨에 따라 감소하였다. 발효숙성이 진행됨에 따라 Hunter's color value에서 녹색도를 나타내는“a”값이 감소하였다. 특히 멸치액젓과 찹쌀풀을 첨가한 처리구 E의 녹색이 가장 감소하였다. 2. 수용성 펙틴과 고형분 함량은 전반적으로 발효숙성이 진행됨에 따라 점차로 증가하였는데. 대체로 처리구 B>C>D>E>A의 순이었다. 3. TDF 함량은 발효숙성 초기와 큰 차이가 없다가 발효숙성이 진행됨에 따라 서서히 감소하였다. TDF 함량에서는 큰 차이가 없었으나, SDF와 IDF의 조성에는 변화가 있었는데, 발효숙성 8일째에는 SDF 함량이 전반적으로 5배에서 7배로 증가하였다. 이상의 결과를 종합해 볼 때, 본 실험의 조건하에서 발효숙성은 처리구 B>C>E>D>A의 순으로 빨리 진행되어 간장은 부추김치의 발효숙성을 빠르게 하였으며, 들깨가루 첨가는 발효숙성 말기에 오히려 발효숙성을 촉진하였고, 멸치액젓과 찹쌀풀 첨가는 부추김치의 변색을 가장 빨리 유발하였다는 결과로 보아 담금방법에 따라 부추김치의 발효숙성 양상에 차이가 있음을 알 수 있었다. 따라서 부추김치 담그는 목적에 따라 부재료를 선택하는 것이 바람직할 것으로 생각된다.

• 셀메드
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• 제3권2호
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• pp.10.1-10.8
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• 2013

Cancer is one of the major dreaded diseases causing high mortality. Lung cancer is second in position of all cancer related deaths and mainly divided into two morphologic sub-types: small-cell lung cancer and non-small cell lung cancer (NSCLC). NSCLC is an aggressive neoplasm which hardly responds to any conventional chemotherapy. Epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinase that is mainly over-expressed in NSCLC. EGFR is mainly involved in the pathogenesis and progression of different carcinoma. In vivo and in vitro studies suggest that EGFR and EGF like peptides are often over-expressed in human NSCLC and these proteins are able to induce cell transformation. The conventional therapies mostly inhibit the EGFR activity and expression level in human NSCLC with the use of some EGFR-inhibitors like HKI-272, EKB569, CL-387785 etc. and some synthetic chemotherapeutic drugs like erlotinib, gefitinib, plumbagin, docetaxel, cisplatin etc., alone or in combination of two or more drugs. These therapies selectively act by competitive inhibition of the binding of adenosine triphosphate to the tyrosine kinase domain of the EGFR, resulting in inhibition of the EGFR signaling pathway. But these chemotherapeutic drugs have some cytotoxic activities to the normal cells and have some adverse side-effects. Recent studies on some traditional alternative therapies including some herbal and plant extracts, active ingredients like curcumin, different homeopathic drugs, etc. can target EGFR-signalling in NSCLC with less toxic side-effects are being currently developed.

• 대한수학회지
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• 제46권2호
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• pp.363-447
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• 2009

The author previously defined the spectral invariants, denoted by $\rho(H;\;a)$, of a Hamiltonian function H as the mini-max value of the action functional ${\cal{A}}_H$ over the Novikov Floer cycles in the Floer homology class dual to the quantum cohomology class a. The spectrality axiom of the invariant $\rho(H;\;a)$ states that the mini-max value is a critical value of the action functional ${\cal{A}}_H$. The main purpose of the present paper is to prove this axiom for nondegenerate Hamiltonian functions in irrational symplectic manifolds (M, $\omega$). We also prove that the spectral invariant function ${\rho}_a$ : $H\;{\mapsto}\;\rho(H;\;a)$ can be pushed down to a continuous function defined on the universal (${\acute{e}}tale$) covering space $\widetilde{HAM}$(M, $\omega$) of the group Ham((M, $\omega$) of Hamiltonian diffeomorphisms on general (M, $\omega$). For a certain generic homotopy, which we call a Cerf homotopy ${\cal{H}}\;=\;\{H^s\}_{0{\leq}s{\leq}1}$ of Hamiltonians, the function ${\rho}_a\;{\circ}\;{\cal{H}}$ : $s\;{\mapsto}\;{\rho}(H^s;\;a)$ is piecewise smooth away from a countable subset of [0, 1] for each non-zero quantum cohomology class a. The proof of this nondegenerate spectrality relies on several new ingredients in the chain level Floer theory, which have their own independent interest: a structure theorem on the Cerf bifurcation diagram of the critical values of the action functionals associated to a generic one-parameter family of Hamiltonian functions, a general structure theorem and the handle sliding lemma of Novikov Floer cycles over such a family and a family version of new transversality statements involving the Floer chain map, and many others. We call this chain level Floer theory as a whole the Floer mini-max theory.

• 대한화장품학회지
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• 제24권3호
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• pp.6-16
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• 1998

Ceramides are currently emerging as the major skin care ingredients due to !heir barrier properties in the stratum corneum of the human skin. Thus, major cosmetic companies have developed synthetic ceramide analogs for their own use. In this study, several ceramide mimic compounds , new skin barrier lipids, were designed and synthesized, and their physical and biological properties were investigated to evaluate their skin care capability. Several structures were designed from the variation of hydrophobic alkyl chain and hydrophilic moiety by the use of molecular modeling software. The selected targets were synthesized, and their properties and activities were studied as the pure form, in the emulsion, or in the lamellar mixture containing cholesterol and fatty acid. Some compounds, such as 1,3-bis(N-(2-hydroxyethyl)-palmitoylamino)-2-hydroxypropane, enhanced the restoration of skin barrier damaged by SDS(sodium dodecyl sulfate), and by acetone treatment. The rate of restoration was comparable to that of natural ceramides. The synthesized compounds alleviated SDS induced skin irritation and facilitated lamellar phase liquid crystal formation. The treatment of 1,3-Dis(N-(2-hydroxyethyl)-palmitoylam ino)-2-hyd roxypropane on the acetone damaged skin revealed that the compound promoted the recovery of intercellular lipid lamellar structure of stratum corneum layer. The replacement of palmitoyl groups of the compound with shorter alkyl chain gave lower emulsion viscosity and liquid crystal density, suggesting easier formulation and poorer barrier activity. Most of the synthesized compounds were non-irritable in various toxicological tests proving that they can be safely introduced to the skin care formulations.

• 한국식품영양과학회지
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• 제4권1호
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• pp.31-34
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• 1975

The testing materials which kept perilla frutescens' leaves frezen are divided into four parts, 1. freezing green leaves, 2. glucose added to the leaves dried in the sun, 3. glucose unadded to the leaves dried in the sun and 4. the leaves dried in the immediately after collecting sample. The perilla frutescens' leaves are treated with the artificial digestion test to investigate the effects of the digestibility of ingredients and of protein. The results obtained were as follows ; 1. The digestibility of crude protein of sample using the common leaves dried in the sun immediately after collecting sample was presented highest at 83.15%, the freezing green leaves at 68.35%, glucose added to the leaves dried in the sun at 64.25% and glucose unadded to the leaves dried in the sun at 62.12%. The digestibility of perilla frutescens' by freezing green leaves, glucose added or glucose unadded to the leaves dried in the sun is on the decrease without difference. 2. It was suggested that glucose and reductive sugars to perilla frutescens' leaves is not affected by the decreased digestibility of protein, dince the digestibility of glucose added to the leaves dried in the sun and glucose unadded to the leaves dried in the sun almost never makes a difference. 3. The digestibility of freezing the green leaves for six months was quite different from the leaves that were dried in the sun immediately after collecting sample, in that the leaves that were frozen for six months were decreased 1/5 quantity of the shole crude protein.

• 한국식품저장유통학회지
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• 제13권5호
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• pp.569-573
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• 2006

생리활성물질을 다량 함유하고 있는 노루궁뎅이 버섯을 효과적으로 섭취하기 위하여 분말, 과립, 타블렛, 캅셀 등 다양한 제형으로 가공하였으며 이들의 품질특성을 비교하였다. 수분함량은 분무건조 분말, 과립, 타블렛 순으로 그 값은 각각 4.37%, 3.78%, 3.43%으로 나타났으며 총당 함량은 분무건조 분말이 19.14 g%로 가장 낮은 함량을 보여주었고 단백질 함량은 분무건조 분말, 과립, 타블렛 순으로 그 값은 각각 4.39 g% 1.04g%, 0.75g% 임을 확인하였다. 제형별 수분결합지수는 과립 및 타블렛 제품이 분무건조분말 제품보다 수분결합지수가 낮은 것으로 나타났는데 이는 과립과 타블렛 제조시 가용성의 탄수화물 제제인 부형제가 많이 첨가되었기 때문인 것으로 판단된다. 전체적인 색상을 나타내는 hue angle은 분무건조 분말이 $85.50^{\circ}$, 과립이 $95.37^{\circ}$, 타블렛이 $94.67^{\circ}$로 나타났다. 저장안정성을 확인하기 위한 제형별 흡습특성은 분무건조 분말이 가장 높은 흡습성을 보였으며 과립, 타블렛 순으로 뚜렷한 차이를 나타내어 분무건조 분말보다는 타블렛 형태로 제조한다면 저장성 면에서 더 우수한 제품을 얻을 것으로 사료된다.

• 한국식생활문화학회지
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• 제11권1호
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• pp.83-96
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• 1996

The purpose of this paper is to examine the various kinds of recipes of pheasant through classical cookbooks written from 1670 to 1943 which are the basic materials to the meat cooking. The recipes of pheasant are found 39 times in the literature, which can be classified into eleven groups. Chronologically, the recipe of mandu (ravioli) was first appeared, and guk, tang (soup), kui (roasted), jang (salted meat), chim (steamed), po (dried meat), whe (raw meat), gijim (boiled in soy sauce), cho (sparkly heated in soy sauce and sugar), jolim (hard boiled in soy sauce), and jungol (meat with vegetable cooked in pan) followed in the records. Kui was the most popular one with the frequency of 43.6%, which proves that kui is the most suitable one for pheasant among all of recipes. Mandu and guk, tang were 10.2%, chim and po were found with the same rate of 7.7% and the next ones were jang, gijim, cho, and jungol with the rate of 2.6%. The recipes of pheasant were recorded much less than those of beef, chicken, pork, lamb, and dog meat. Particularly, in comparison with chicken belonging to fowls, the frequency of pheasant cooking did not reach even to one third of that. The Korean recipes of pheasant have been independently developed with originality, having nothing to do with the Chinese ones. The recipes of pheasant before the late 1800s have based on the strict recipe principles along with the spirit of art and sincerity, but they were deteriorated to simple and easy ones discarding principles. The main ingredient was the flesh of pheasant and the sub-ingredients such as flour, pinenut, buckwheat powder, and mushroom were included in common. In additon, oil, soy sauce, black pepper, and stone leek were frequently used as main seasonings.

• 대한한방부인과학회지
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• 제21권3호
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• pp.90-98
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• 2008

Purpose: Menopausal syndrome is caused by urgent changes of sex hormone in women. The hormonal therapy can soothe the problems of menopausal patients, but it can increase the probability of another disease, such as breast cancer, heart attack, etc. So the demand of alternative herb therapy is increasing in Western countries. In Korea, herbal medicine is imported and used by Western doctors. To know and use the alternative herbal medicine, Korean Medical doctors should know their efficacy and safety. Methods: We researched the Medline(Pubmed) with the key word such as 'CAM', 'herb' and 'menopause'. We selected the herbs known as treating the menopausal syndrome and researched the similar or same herbs that are used in Korean medicine by the scientific name and efficient ingredients. To evaluate the efficacy of the herbs, we compared the herbs that were differently defined in alternative and Korean medicine Results: Balm, black cohosh, chaste berry, dong quai. evening primrose oil. ginkgo, St. John's wort, valerian root, and sarsaparilla were chosen as prevalent herbs used in alternative medicine. The pharmacologic effect of Black cohosh, licorice root, St. John's wort were recognized. But these three herbs are not usually prescripted for menopausal patients in Korean medicine. So we could apply these three herbs as one of Korean medical treatments. The efficacy of other herbs cannot be surely prescripted for menopausal patients. Conclusion: The efficacy and safety of alternative medicine is not proved yet. But to diversify the treatmental methods of Korean medicine, we need to prove and use these medicine as one of Korean medical treatment.

• 한국건설순환자원학회논문집
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• 제6권4호
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• pp.342-348
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• 2018

이 연구의 목적은 폐필름 포장재 재활용 성형재의 압축, 인장 및 휨 강도와 변형 특성을 생산 공장에 따라 측정하여 건설 2차제품의 적용 타당성을 평가하는 것이다. 재활용 성형재의 역학적 성능은 저밀도 폴리에틸렌 및 고밀도 폴리에틸렌의 일반적 값 수준으로 있지만 성능의 편차를 줄이고 품질의 안정화를 위해서는 1) 구성재료들의 혼합비율에 따른 재료 성능 평가; 2) 이물질 및 수분 함유량에 따른 재료성능 평가; 3) 다양한 제조 조건(제조공정, 가력 압력 및 폐필름 수거지역과 시기)에 대한 재료성능의 데이터베이스 관리 등의 현장 관리 체계마련이 요구되었다.