• 대한치과보철학회지
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• 제42권3호
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• pp.307-326
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• 2004

Statement of problem. The long-term success of implants is the development of a stable direct connection between bone and implant surface, which must be structural and functional. To improve a direct implant fixation to the bone, various strategies have been developed focusing on the surface of materials. Among them, altering the surface properties can modify cellular responses such as cell adhesion, cell motility and bone deposition. Purpose. This study was to evaluate the cellular behaviors on the surface-modified titanium by morphological observation, cellular proliferation and differentiation. Material and methods. Specimens were divided into five groups, depending on their surface treatment: electropolishing(EP) anoclizing(AN), machining(MA), blasting with hydroxyapatite particle(RBM) and electrical discharge machining(EDM). Physicochemical properties and microstructures of the specimens were examined and the responses of osteoblast-like cells were investigated. The microtopography of specimens was observed by scanning electron microscopy(SEM). Surface roughness was measured by a three-dimensional roughness measuring system. The microstructure was analyzed by X-ray diffractometer(XRD) and scanning auger electron microscopy(AES). To evaluate cellular responses to modified titanium surfaces, osteoblasts isolated from neonatal rat were cultured. The cellular morphology and total protein amounts of osteoblast-like cell were taken as the marker for cellular proliferation, while the expression of alkaline phosphatase was used as the early differentiation marker for osteoblast. In addition, the type I collagen production was determined to be a reliable indicator of bone matrix synthesis. Results. 1. Each prepared specimen showed specific microtopography at SEM examination. The RBM group had a rough and irregular pattern with reticulated appearance. The EDM-treated surface had evident cracks and was heterogeneous consisting of broad sheet or plate with smooth edges and clusters of small grains, deep pores or craters. 2. Surface roughness values were, from the lowest to the highest, electropolished group, anodized group, machined group, RBM group and EDM group. 3. All groups showed amorphous structures. Especially anodized group was found to have increased surface oxide thickness and EDM group had titaniumcarbide(TiC) structure. 4. Cells on electropolished, anodized and machined surfaces developed flattened cell shape and cells on RBM appeared spherical and EDM showed both. After 14 days, the cells cultured from all groups were formed to be confluent and exhibited multilayer proliferation, often overlapped or stratified. 5. Total protein amounts were formed to be quite similar among all the group at 48 hours. At 14 days, the electropolished group and the anodized group induced more total protein amount than the RBM group(P<.05). 6. There was no significant difference among five groups for alkaline phosphatase(ALP) activity at 48 hours. The AN group showed significantly higher ALP activity than any other groups at 14 days(P<.05). 7. All the groups showed similar collagen synthesis except the EDM group. The amount of collagen on the electropolished and anodized surfaces were higher than that on the EDM surface(P<.05).

• 한국조경학회지
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• 제33권4호
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• pp.129-142
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• 2005

Korea's pet-related society has been fast growing without the base and preparations of socio-cultural animal welfare. For the most part, Korea's current public parks, in particular, have a space structure in which a lot of friction between the general public who are not fond of dogs and dog owners in public places has been happening unavoidably. A lot of countries that are taking a lead role in animal welfare have built dog parte that the general public and dogs can enjoy together. This research starts with the realization that the concept of 'dog park' needs to be introduced in Korea as more and more Koreans own dogs and other pets. This research aims to provide guidance for dog park planning by drawing a dog park planning model and to promote basics for co-existence of dogs and people in a park and set in place animal welfare early and raise the level of awareness. Total 7 types of dog put 56 planning items including dog zone, dog playground, and agility, and a selective matrix by which it is possible to select essential recommendatory optional items by each type of dog park were drawn in this research. Overall there were the highest needs in separated area for dogs in park. A dog park planning model is designed as follows. 1) To select a dog park type that was introduced. 2) To set up facilities applicable in common and planning items desired in advance by each type. 3) To zone dog park areas by the priority order of planning items that were introduced and to position necessary facilities. 4) To plan program that should be were introduced. A dog park was expected to take some positive roles such as providing opportunities to socialize dogs, activating social communities, more effective park management by participating local community members and so on.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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• pp.537-539
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• 2006

We developed an 4.5" $192{\times}64$ active matrix organic light-emitting diode display on a glass using organic thin-film transistor (OTFT) switching-arrays with two transistors and a capacitor in each sub-pixel. The OTFTs has bottom contact structure with a unique gate insulator and pentacene for the active layer. The width and length of the switching OTFT is $800{\mu}m$ and $10{\mu}m$ respectively and the driving OTFT has $1200{\mu}m$ channel width with the same channel length. On/off ratio, mobility, on-current of switching OTFT and on-current of driving OTFT were $10^6,0.3{\sim}0.5\;cm^2/V{\cdot}sec$, order of 10 ${\mu}A$ and over 100 ${\mu}A$, respectively. AMOLEDs composed of the OTFT switching arrays and OLEDs made using vacuum deposition method were fabricated and driven to make moving images, successfully.

• 한국과학교육학회지
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• 제38권2호
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• pp.219-234
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• 2018

본 연구에서는 국내 교육학 연구에서 거의 사용되지 않던 머신 러닝 기술을 과학 교육 연구에 접목하여, 학생들의 과학 논변 활동에서 나타나는 논변의 구성 요소를 분석하는 과정을 자동화할 수 있는 가능성을 탐색해보았다. 학습 데이터로는 Toulmin이 제안하였던 틀에 따라 학생들의 과학 논변 구성 요소를 코딩한 국내 선행 문헌 18건을 수합하고 정리하여 990개의 문장을 추출하였으며, 테스트 데이터로는 실제 교실 환경에서 발화된 과학 논변 전사 데이터를 사용하여 483개의 문장을 추출하고 연구자들이 사전 코딩을 수행하였다. Python의 'KoNLPy' 패키지와 '꼬꼬마(Kkma)' 모듈을 사용한 한국어 자연어 처리(Natural Language Processing, NLP)를 통해 개별 논변을 구성하는 단어와 형태소를 분석하였으며, 연구자 2인과 국어교육 석사학위 소지자 1인의 검토 과정을 거쳤다. 총 1,473개의 문장에 대한 논변-형태소:품사 행렬을 만든 후에 다섯 가지 방법으로 머신 러닝을 수행하고 생성된 예측 모델과 연구자의 사전 코딩을 비교한 결과, 개별 문장의 형태소만을 고려하였을 때에는 k-최근접 이웃 알고리즘(KNN)이 약 54%의 일치도(${\kappa}=0.22$)를 보임으로써 가장 우수하였다. 직전 문장이 어떻게 코딩되어 있는지에 관한 정보가 주어졌을 때, k-최근접 이웃 알고리즘(KNN)이 약 55%의 일치도(${\kappa}=0.24$)를 보였으며 다른 머신 러닝 기법에서도 전반적으로 일치도가 상승하였다. 더 나아가, 본 연구의 결과는 과학 논변 활동의 분석에서 개별문장을 고려하는 단순한 방법이 어느 정도 유용함과 동시에, 담화의 맥락을 고려하는 것 또한 필요함을 데이터에 기반하여 보여주었다. 또한 머신 러닝을 통해 교실에서 한국어로 이루어진 과학 논변 활동을 분석하여 연구자와 교사들에게 유용하게 사용될 수 있는 가능성을 보여준다.

• 한국전자파학회논문지
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• 제19권2호
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• pp.121-129
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• 2008

본 논문에서는 FMM(Fast Multipole Method)을 적용하여 평면형 다층 구조인 마이크로스트립 프랙탈 안테나 구조에 대한 고속 해석을 구현하였다. 우선 FMM 알고리즘에 이용되는 적분식인 MPIE(Mixed Potential Integral Equation)을 풀기 위해서 실수축 적 분 방법(RAIM: Real-Axis Integration Method)으로부터 정확한 공간 영역 그린함수를 구한다. 구해진 그린함수를 MoM(Method of Moment)을 이용하여 계산할 경우, 연산과 메모리 요구량 $O(N^2)$이 소요되는데, 이를 거대 구조의 해석에 대해 적용할 때나 높은 정확성을 위한 셀(미지수 N) 수의 증가하는 경우 계산량이 기하급수적으로 증가하여 구조 해석에 문제가 된다. FMM은 이와 같은 연산과 메모리 요구량의 문제점을 해결하기 위하여 개발되었다. FMM은 그린함수의 가법 정리(addition theorem)를 이용하여 행렬-벡터 곱의 복잡성을 줄여 연산과 메모리 요구량을 $O(N^{1.5})$으로 줄인다. 시어핀스키(Sierpinski) 프랙탈 안테나의 구조에 대해 MoM과 FMM를 적용, 상용 툴과 계산 결과의 정확성, 계산 시 메모리 크기, 해석 시간 등을 비교하여 효율성을 보여주었다.

• Journal of Preventive Medicine and Public Health
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• 제43권4호
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• pp.319-329
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• 2010

Objectives: This study was performed to determine the levels of quality of life (QOL) according to the grade of long-term care service for the elderly people who were admitted from long-term care insurance, and to reveal its association with the physical and mental functioning such as the Activity of Daily Living (ADL), the Instrumental Activity of Daily Living (IADL), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Mini-Mental State Examination-Korean version (MMSE-K). Methods: The interviews were performed during the period from March 1 to May 31, 2009, for 958 elderly people in urban and rural areas. The questionnaire items included various indices such as the ADL, IADL, CES-D, and MMSE-K, as independent variables and the index of QOL, as the dependent ones. For statistical analysis, t-tests were used for the mean scores of QOL according to gender and the grade of long-term care services, and Spearman's correlation was used for each variable. The effects of physical and mental functioning for QOL were assessed by covariance structure analysis. The statistical significance was set at p<0.05. Results: The mean scores of QOL among all the subjects was $55.4{\pm}15.62$ (Grade I: $49.7{\pm}14.17$, Grade II: $56.8{\pm}14.62$, Grade III: $59.4{\pm}16.36$), and it was lower according to the higher grade of long-term care insurance. In terms of the correlation matrix of the QOL and the physical and mental function factors, the QOL showed positive correlation with the ADL, IADL and MMSE-K, while it had negative correlation with depression. On the analysis of covariance, mental functioning (depression and the MMSE-K) had a greater influence on the level of QOL than the physical functioning (ADL and IADL). Conclusions: The level of the QOL in the elderly people who were admitted from long-term care insurance was lower according to higher the grade of long-term care insurance. Also, the mental functioning (depression and MMSE-K) was more influential on the level of the QOL than the physical functioning (ADL and IADL).

• Archives of Plastic Surgery
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• 제32권3호
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• pp.335-342
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• 2005

This study was undertaken to investigate possibility of the allogenic type I collagen inducing osteoinduction or osteoconduction at critical sized bone defect in the rabbit. Twenty Newzealand white rabbit, weighted from 2.8 kg to 3.5 kg, were used in this study. The skull was exposed and two bony defects were created with diameter of 10 mm. Group I(n=10), the bony defects was grafted from the other side bone. Group II(n=10), the bony defects was grafted by the allogenic type I collagen with bone morphogenic protein(BMP). Group III(n=10), the bony defects was grafted by the allogenic type I collagen only. Group IV(n=10), the bony defects was lefted with no grafts. The grafted bones and allogenic type I collagen were investigated with radiologic densitometry, histologic analysis and immunohistochemistry after 12 weeks. No major difference was observed in the gross finding between Group I, II, III, but dura mater was exposed in bony defect,the Group IV. The radiologic study demonstrated more bony opacity in the Group I, but the other groups did not demonstrate a significant difference. In the histologic study, grafted bone edge was completely consolidated with original bone in group I and new bone ingrew into the grafted allogenic type I collagen(group II, III),but there is no bone regeneration from the original bony edge in the group IV. The percent of the new bone formation by cross-sectional area was considered statistically significant at a p value of less than 0.05(p<0.05). In the immunohistochemistry study about BMP antibodies, the group IV demonstrated osteogenic activity in front of advancing original bone edge, in which the osteoblast stained strongly for BMP antibodies, but other group does not demonstrated any osteoblastic expression. There was no immunologic rejection. In conclusion, this results do not demonstrate that the allogenic type I collagen is useful for bone substitute, but the characters of the collagen, such as pliability, easy-handling, sponge-like structure, are useful in interpositional bone graft substitutes. The further evaluation of long term results about the resorption, immunologic tissue reaction, response of applied tissue growth factor to the allogenic collagen is needed.

• 공업화학
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• 제28권3호
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• pp.263-271
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• 2017

최근에, 질량분석기술의 폴리머 분석에의 응용은 MALDI-TOF MS 개발 이후 급속도로 발전하였다. 이 리뷰 논문은 현재까지 연구된 MALDI-TOF MS의 폴리머 특성분석에의 응용에 관한 최신 논문을 정리하였다. MALDI-TOF MS는 바이오 폴리머와, 합성 폴리머의 평균분자량 분석, 폴리머의 시퀀스 분석을 통한 구조의 해석, 모노머의 조성분석에까지 이용되고 있다. 엔드그룹의 특성과 농도를 분석하는 연구도 많이 진행되었고, 복잡한 폴리머의 분자량의 분석에는 SEC와 MALDI-TOF MS를 연결한 분석법을 추천한다. MALDI에 tandem MS를 결합한 분석기술이나, 이온 모빌리티를 응용한 질량분석기, TOF-SIMS, MALDI-TOF-Imaging 기술도 급격히 발전하고 있으며, 이의 폴리머 특성분석에의 응용은 별도의 분리기술이 필요 없어 앞으로 더 많이 이용될 것으로 생각된다. 분자량, 시퀀스, 그리고 모노머의 조성을 정확하게 계산해주는 소프트웨어와 고분자량(> 100 kDa)의 분석을 가능하게 해주는 기술이 개발된다면, 폴리머를 연구하는 과학자들에게 MALDI-TOF MS의 이용은 문제점을 해결하고, 목적하는 폴리머를 합성하는 데 중요한 수단이 될 것이다.

• Membrane and Water Treatment
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• 제6권5호
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• pp.365-378
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• 2015

Herein, the preparation of anion exchange membrane (AEM) from brominated poly(2,6-dimethyl 1,6-phenylene oxide) BPPO and dimethylaniline (DMA) by phase-inversion process is reported. Anion exchange membranes (AEMs) are prepared by varying the DMA contents. Prepared AEMs show high thermal stability, water uptake (WR) around 202% to 226%, dimensional change ratios of 1.5% to 2.6% and ion exchange capacities (IECs) of 0.34 mmol/g to 0.82 mmol/g with contact angle of $59.18^{\circ}$ to $65.15^{\circ}$. These membranes are porous in nature as confirmed by SEM observation. The porous property of membranes are important as it could reduce the resistance of transportation of ions across the membranes. They have been used in diffusion dialysis (DD) process for recovery of hydrochloric acid (HCl) from the mixture of HCl and ferrous chloride ($FeCl_2$). Presence of $-N+(CH_3)_2C_6H_5Br^-$ as a functional group in membrane matrix facilitates its applications in DD process. The dialysis coefficients of hydrochloric acid ($U_H$) of the membranes are in range of 0.0016 m/h to 0.14 m/h and the separation factors (S) are in range of 2.09 to 7.32 in the $HCl/FeCl_2$ system at room temperature. The porous membrane structure and presence of amine functional group are responsible for the mechanism of diffusion dialysis (DD).

• Spatial Information Research
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• 제22권1호
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• pp.75-84
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• 2014

송전선은 항공사고를 야기하는 대표적인 장애물로써 인지되며, 비행 중 충돌회피를 위해 송전선의 실시간 탐지는 아주 중요하다. 최근 들어 이러한 비행장애물 회피를 위해 기상조건에 영향을 덜 받으며 주야에 관계없이 데이터 획득이 가능한 라이다의 활용이 증가하고 있다. 이에 본 연구에서는 라이다 데이터를 이용하여 비행장애물 회피를 위해 송전선을 고속으로 탐지하는 방법을 개발하였다. 제안된 방법은 먼저 지표면에서 반사된 점을 필터링 과정을 통해 제거하여 비지면점을 추출하고, 이중에서 분산 행렬의 고유값 비율을 이용하여 선형적으로 분포하는 점들을 추출하고, 마지막으로 송전탑(기둥)이나 굴뚝같이 수직방향으로 선형적으로 분포하는 점들이나 길이가 작은 선형점들을 제거한다. 구현된 알고리즘의 성능을 검증하기 위해 송전선이 포함된 영역에서 취득된 실측 및 시뮬레이션 데이터에 적용하였다. 탐지성능은 약 80%정도로 분석되었고, 처리시간은 평균 0.2초가 소요되었다. 향후 제시된 방법을 다양한 시험환경에 대해 실험을 수행하여 개선한다면, 비행장애물 회피용 시스템에 효과적으로 활용될 것을 판단된다.