• BMB Reports
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• 제45권12호
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• pp.693-699
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• 2012

Together with protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs) serve as hallmarks in cellular signal transduction by controlling the reversible phosphorylation of their substrates. The human genome is estimated to encode more than 100 PTPs, which can be divided into eleven sub-groups according to their structural and functional characteristics. All the crystal structures of catalytic domains of sub-groups have been elucidated, enabling us to understand their precise catalytic mechanism and to compare their structures across all sub-groups. In this review, I describe the structure and mechanism of catalytic domains of PTPs in the structural context.

• 한국기계가공학회지
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• 제7권2호
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• pp.3-7
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• 2008

A polishing machine adopting a new unique structural mechanism has been developed, named as a swing-arm type polishing machine. The mechanism is such that the tool path tracks on a spherical surface, of which the diameter is adjusted by setting up the machine mechanism properly. It has a strong benefit especially for polishing axis-symmetric concave mirror surfaces. The swing-arm type polishing machine with 5-axes has been designed in order to polish a concave mirror surface lip to diameter of 2 meters. The drawings are made using 3D CAD and strain-stress analysis has been done by finite element method. AC servo-motor has been used to move the swing arm and a operating software has been developed using a LapVIEW tool. Result of the test run was satisfactory which convinces the usefulness of the swing-arm type polishing machine.

• East Asian Economic Review
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• 제25권1호
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• pp.73-97
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• 2021

China has experienced many structural changes in the process of economic development over the past three decades. Using a time-varying parameter VAR model with stochastic volatility and mixture innovations, this study investigates whether such structural changes in, especially tools and operational aims of monetary policy, affect the monetary transmission mechanism. We find that impulse responses of output growth and inflation to monetary shocks have substantially increased and then reversed to decrease around 2005-2006. This time variation is mainly caused by changes in the monetary transmission mechanism, i.e., the manner in which main macroeconomic variables respond to policy shocks, rather than by changes in volatilities of exogenous shocks. The result implies that aggressive monetary policy to facilitate economic growth in the developing economies may be legitimized, unless it causes inflation seriously.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2006년도 정기 학술대회 논문집
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• pp.922-927
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• 2006

There is a concern with worldwide deterioration of highway bridges, particularly reinforced concrete. The advantages of fibre reinforced plastic(FRP) composites over conventional materials motivate their use in highway bridges for replacement of structures. Recently, an FRP deck has been installed on a state highway, located in New York State, as an experimental project. In this paper, a systematic approach for analysis of this FRP deck bridge is presented. Multi-step linear numerical analyses have been performed using the finite element method to study the structural behavior and the possible failure mechanism of the FRP deck-superstructure system Deck's self-weight and ply orientations at the interface between steel girders and FRP deck are considered in this study. From this research, the results of the numerical analyses were corroborated with field test results. Analytical results reveal several potential failure mechanism for the FRP deck and truss bridge system The results presented in this study may be used to propose engineering design guideline for new and replacement FRP bridge deck structure.

• Earthquakes and Structures
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• 제18권4호
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• pp.519-526
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• 2020

Non-stationary random seismic response and reliability of multi-degree of freedom hysteretic structure system are studied based on the cumulative damage failure mechanism. First, dynamic Eqs. of multi-degree of freedom hysteretic structure system under earthquake action are established. Secondly, the random seismic response of a multi-degree freedom hysteretic structure system is investigated by the combination of virtual excitation and precise integration. Finally, according to the damage state level of structural, the different damage state probability of high-rise frame structure is calculated based on the boundary value of the cumulative damage index in the seismic intensity earthquake area. The results show that under the same earthquake intensity and the same floor quality and stiffness, the lower the floor is, the greater the damage probability of the building structure is; if the structural floor stiffness changes abruptly, the weak layer will be formed, and the cumulative damage probability will be the largest, and the reliability index will be relatively small. Meanwhile, with the increase of fortification intensity, the reliability of three-level structure fortification is also significantly reduced. This method can solve the problem of non-stationary random seismic response and reliability of high-rise buildings, and it has high efficiency and practicability. It is instructive for structural performance design and estimating the age of the structure.

• Wind and Structures
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• 제15권5호
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• pp.423-439
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• 2012

Three common medium- rise building forms were physically tested to study their overall wind induced structural response. Emphasis was placed on the torsional response and its correlation with other peak responses. A higher correlation was found between the peak responses than between the general fluctuating parts of the signals. This suggests a common mechanism causing the peak event, and that this mechanism is potentially different to the mechanism causing the general load fluctuations. The measurements show that about 80% of the peak overall torsion occur simultaneously with the peak overall along wind drag for some generic building shapes. However, the peak torsional response occurs simultaneously with only 30%-40% of the peak overall drag for the rectangular model. These results emphasise the importance of load combinations for building design, which are often neglected in the design of medium sized rigid buildings for which the along-wind drag is dominant. Current design wind loading standards from around the world were evaluated against the results to establish their adequacy for building design incorporating wind-induced torsion effects. Although torsion is frequently neglected, for some structural systems it may become more important.

• 한국소음진동공학회논문집
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• 제26권6_spc호
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• pp.697-704
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• 2016

The second shutdown drive mechanism (SSDM) that is classified into seismic category I as an active mechanical equipment shall maintain the structural integrity and its designed inherent safety functions during and/or after normal operation, anticipated operational occurrences, accidents and seismic occurrences. Therefore, not only a structural integrity assessment through numerical analyses but also a qualification test by using the prototype SSDM shall be conducted to verify the adequacy of the SSDM design. This paper describes a sort of seismic qualification test of the prototype SSDM to demonstrate that the structural integrity and operability (functionality) of SSDM are maintained during and/or after seismic excitations. From the results, this paper shows that the SSDM satisfies all design requirements without any malfunctions during and after the seismic test.

• 한국구조물진단유지관리공학회 논문집
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• 제5권2호
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• pp.121-128
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• 2001

Reinforced concrete frame buildings in regions of low to moderate seismicity are typically designed only for gravity loads with non-seismic detailing provisions of the code. These buildings possess strong beam-weak column, which brings about the brittle structural performance like the column sidesway failure mechanism during the strong lateral load. The objective of this paper is to enhance the column strength and deformation capacity for reconfiguring the structural failure mode by averting a column soft-story collapse and moving to a more ductile beam-sides way mechanism suing new reinforcing materials. Aramid fiber sheet and reinforcing rod-composite materials was used for this purpose. The column was modeled by the 2/3 scale experimental specimen retested. According to the concept of the capacity design, the damaged column was strengthened by the column jacketing using new reinfocing materials such as rod-composite materials. In conclusion, the improvement of the flexural strength is observed and the capacity of the energy dissipation and the ductility is enhanced, too.

• Structural Engineering and Mechanics
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• 제53권1호
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• pp.173-188
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• 2015

Several structural calamities in the second half of the 20th century have shown that adequate collapse-resistance cannot be achieved by designing the individual elements of a structure without taking their interconnectivity into consideration. It has long been acknowledged that membrane behaviour of reinforced concrete structures can significantly increase the robustness of a structure and delay a complete collapse. An experimental large-scale test was conducted on a horizontally restrained, continuous reinforced concrete slab exposed to an artificial failure of the central support and subsequent loading until collapse of the specimen. Within this investigation the development of catenary action associated with the formation of large displacements was observed to increase the ultimate load capacity of the specimen significantly. The development of displacements, strains and horizontal forces within this investigation confirmed a load transfer process from an elastic bending mechanism to a tension controlled catenary mechanism. In this contribution a special focus is directed towards strain and crack development at critical sections. The results of this contribution are of particular importance when validating numerical models related to the development of catenary action in concrete slabs.

• Geomechanics and Engineering
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• 제29권4호
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• pp.391-405
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• 2022

A newly proposed grouting simulation method, the sequential diffusion solidification method was introduced into the numerical simulation of combined bi-borehole grouting. The traditional, critical and difficult numerical problem for the temporal and spatial variation simulation of the slurry is solved. Thus, numerical simulation of grouting and blocking of flowing water in karst conduits is realized and the mechanism understanding of the combined bi-borehole technology is promoted. The sensitivity analysis of the influence factors of combined bi-borehole grouting was investigated. Through orthogonal experiment, the influences of proximal and distal slurry properties, the initial flow velocity of the conduit and the proximal and distal slurry injection rate on the blocking efficiency are compared. The velocity variation, pressure variation and slurry deposition phenomenon were monitored, and the flow field characteristics and slurry outflow behavior were analyzed. The interaction mechanism between the proximal and distal slurries in the combined bi-borehole grouting is revealed. The results show that, under the orthogonal experiment conditions, the slurry injection rate has the greatest impact on blocking. With a constant slurry injection rate, the blocking efficiency can be increased by more than 30% when using slurry with weak time-dependent viscosity behavior in the distal borehole and slurry with strong time-dependent viscosity behavior in the proximal borehole respectively. According to the results of numerical simulation, the grouting scheme of "intercept the flow from the proximal borehole by quick-setting slurry, and grout cement slurry from the distal borehole" is put forward and successfully applied to the water inflow treatment project of China Resources Cement (Pingnan) Limestone Mine.