• Steel and Composite Structures
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• v.12 no.2
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• pp.167-181
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• 2012

Ultra high performance cementitious composite material is applied to the design of multifunctional permanent form for bridge pier in this paper. The basic properties and calculating constitutive model of ultra high performance cementitious composite are introduced briefly. According to momental theory of thin-walled shell, the analytical solutions of structural behavior parameters including circumferential stress, longitudinal stress and shear stress are derived for UHPCC thin-walled circular tube. Based on relevant code of construction loads (MHURD of PPC 2008), the calculating parameter expression of construction loads for UHPCC thin-walled circular tube is presented. With geometrical dimensions of typical pier, the structural behavior parameters of UHPCC tube under construction loads are calculated. The effects of geometrical parameters of UHPCC tube on structural behavior are analyzed and the design advices for UHPCC tube are proposed. This paper shall provide a scientific reference for UHPCC permanent form design and UHPCC hybrid structure application.

• Structural Engineering and Mechanics
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• v.3 no.3
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• pp.273-287
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• 1995

Stochastic response of systems to random excitation can be estimated by direct integration methods in the time domain such as the stochastic central difference method (SCDM). In this paper, the SCDM is applied to compute the variance and covariance in response of linear and nonlinear structures subjected to random excitation. The accuracy of the SCDM is assessed using two-DOF systems with both deterministic and random material properties excited by white noise. For the former case, closed-form solutions can be obtained. Numerical results also are presented for a simply supported geometrically nonlinear beam. The stiffness of this beam is modeled as a random field, and the beam is idealized by the stochastic finite element method. A perturbation technique is applied to formulate the equations of motion of the system, and the dynamic structural response statistics are obtained in a time domain analysis. The effect of variations in structural parameters and the numerical stability of the SCDM also are examined.

• Steel and Composite Structures
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• v.17 no.5
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• pp.705-719
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• 2014

Composite steel-concrete box girders are frequently used in bridge construction for their economic and structural advantages. An integrated metaheuristic based optimization procedure is proposed for discrete size optimization of straight multi-span steel box girders with the objective of minimizing the self-weight of girder. The metaheuristic algorithm of choice is the Cuckoo Search (CS) algorithm. The optimum design of a box girder is characterized by geometry, serviceability and ultimate limit states specified by the American Association of State Highway and Transportation Officials (AASHTO). Size optimization of a practical design example investigates the efficiency of this optimization approach and leads to around 15% of saving in material.

• Molecules and Cells
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• v.42 no.7
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• pp.512-522
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• 2019

Chromosomes located in the nucleus form discrete units of genetic material composed of DNA and protein complexes. The genetic information is encoded in linear DNA sequences, but its interpretation requires an understanding of three-dimensional (3D) structure of the chromosome, in which distant DNA sequences can be juxtaposed by highly condensed chromatin packing in the space of nucleus to precisely control gene expression. Recent technological innovations in exploring higher-order chromatin structure have uncovered organizational principles of the 3D genome and its various biological implications. Very recently, it has been reported that large-scale genomic variations may disrupt higher-order chromatin organization and as a consequence, greatly contribute to disease-specific gene regulation for a range of human diseases. Here, we review recent developments in studying the effect of structural variation in gene regulation, and the detection and the interpretation of structural variations in the context of 3D chromatin structure.

• Biomedical Science Letters
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• v.27 no.4
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• pp.231-238
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• 2021

Several structural proteins present in keratinocytes of the skin are known to play an important role in the formation of epidermal tissue and barrier function, and the absence of structural proteins in keratinocytes causes various skin diseases. In this study, 42 types of tetrapeptides derived from the sequence of Loricrin, a kind of terminally differentiating structural protein, were synthesized, and skin anti-aging properties were measured by measuring the elastase inhibition, proliferation of skin cells. The anti-aging efficacy was verified and, based on this, it succeeded in selecting one of the most excellent peptides. It is expected that the selected tetrapeptide can be used as a raw material for various cosmetics and quasi-drugs based on anti-aging and skin cell proliferation effects.

• Journal of Electrochemical Science and Technology
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• v.14 no.2
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• pp.120-130
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• 2023

PEMFC has high potential for future development due to its high energy density, eco-friendliness, and high energy efficiency. When it becomes small, light and flexible, it can be competitive as an energy source for portable devices or flexible electronic devices. However, the use of hard and heavy materials for structural rigidity and uniform contact pressure transmission has become an obstacle to reducing the weight and flexibility of PEMFCs. This review intends to provide an example of the application of a new structure and material for lightweight and flexibility. As a lightweight PEMFC, a tubular design is presented and structural advantages through numerical modeling are explained. Manufacturing methods to realize the structural advantages and possibilities of tubular PEMFCs are discussed. In addition, the materials and manufacturing processes used to fabricate lightweight and flexible PEMFCs are described and factors affecting performance are analyzed. Strategies and structural improvements of light and flexible movements are discussed according to the component parts.

• Structural Engineering and Mechanics
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• v.49 no.3
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• pp.285-296
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• 2014

Material damping affects the dynamic behaviors of engineering structures considerably, but up to till now little research is maintained on influence factors of material damping. Based on the damping-stress function of steel, the material damping of steel beams is obtained by calculating the stress distribution of the beams with an analytical method. Some key influence factors of the material damping, such as boundary condition, amplitude and frequency of excitation, load position as well as the cross-sectional dimension of a steel beam are analyzed respectively. The calculated results show that even in elastic scope, material damping does not remain constant but varies with these influence factors. Although boundary condition affects material damping to some extent, such influence can be neglected when the maximum stress amplitude of the beam is less than the fatigue limit of steel. Exciting frequency, load position and cross-section dimension have great effects on the material damping of the beam which maintain the similar changing trend under different boundary conditions respectively.

• Computers and Concrete
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• v.14 no.5
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• pp.599-612
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• 2014

This paper presents the effects of the construction stages using time dependent material properties on the structural behaviour of concrete arch dams. For this purpose, a double curvature Type-5 arch dam suggested in "Arch Dams" symposium in England in 1968 is selected as a numerical example. Finite element models of Type-5 arch dam are modelled using SAP2000 program. Geometric nonlinearity is taken into consideration in the construction stage analysis using P-Delta plus large displacement criterion. In addition, the time dependent material strength variations and geometric variations are included in the analysis. Elasticity modulus, creep and shrinkage are computed for different stages of the construction process. In the construction stage analyses, a total of 64 construction stages are included. Each stage has generally $6000m^3$ concrete volume. Total duration is taken into account as 1280 days. Maximum total step and maximum iteration for each step are selected as 200 and 50, respectively. The structural behaviour of the arch dam at different construction stages has been examined. Two different finite element analyses cases are performed. In the first case, construction stages using time dependent material properties are considered. In the second case, only linear static analysis (not considered construction stages) is taken into account. Variation of the displacements and stresses are obtained from the both analyses. It is highlighted that construction stage analysis using time dependent material strength variations and geometric variations has an important effect on the structural behaviour of arch dams. The maximum longitudinal, transverse and vertical displacements obtained from construction stages and static analyses are 1.35 mm and 0 mm; -8.44 and 6.68 mm; -4.00 and -9.90 mm, respectively. In addition, vertical displacements increase from the base to crest of the dam for both analyses. The maximum S11, S22 and S33 stresses are obtained as 1.60MPa and 2.84MPa; 1.39MPa and 2.43MPa; 0.60MPa and 0.50MPa, respectively. The differences between maximum longitudinal, transverse, and vertical stresses obtained from construction stage and static analyses are 78%, 75%, and %17, respectively. On the other hand, there is averagely 12% difference between minimum stresses for all three directions.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.5
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• pp.42-48
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• 2017

When concrete structures expose to fire, the structures were damaged accompanied with degradation of material properties of concrete. In order to determine the reuse of fire-damaged concrete structures, it is needed a careful determination considering conditions of fire damage, such as exposure temperature and exposure time, and also potential to restore fire damage. This study investigates on the evaluation of residual material properties of fire-damaged concrete under different post-fire curing regimes. An experimental study was performed on concrete samples to measure the dynamic elastic modulus by the impact resonance vibration method. Upon the experimental results, the evidence of restoration of material properties was confirmed on specific post-fire curing regimes, higher humidity conditions. Additionally, a correlation analysis was performed on the dynamic elastic modulus with the tensile strength for identifying the effects of post-fire curing regimes on both material properties of fire-damaged concrete.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.2
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• pp.153-158
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• 2017

In this paper, we take into account topology optimization problems considering spatial randomness in the material property of elastic modulus. Based on 88 lines MATLAB Code, Monte Carlo analysis has been performed for MBB(messerschmidt-$b{\ddot{o}}lkow$-blohm) model using 5,000 random sample fields which are generated by using the spectral representation scheme. The random elastic modulus is assumed to be Gaussian in the spatial domain of the structure. The variability of the volume fraction of the material, which affects the optimum topology of the given problem, is given in terms of correlation distance of the random material. When the correlation distance is small, the randomness in the topology is high and vice versa. As the correlation distance increases, the variability of the volume fraction of the material decreases, which comply with the feature of the linear static analysis. As a consequence, it is suggested that the randomness in the material property is need to be considered in the topology optimization.