• BMB Reports
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• v.50 no.5
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• pp.269-274
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• 2017

The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptor-mediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. When MIF and JAB1 are bound to each other in various intracellular sites, MIF inhibits the positive regulatory effects of JAB1 on the activity of AP-1. The intestinal parasite, Anisakis simplex, has an immunomodulatory effect. The molecular mechanism of action of As-MIF and human JAB1 are poorly understood. In this study, As-MIF and hJAB1 were expressed and purified with high solubility. The structure of As-MIF and hJAB1 interaction was modeled by homology modeling based on the structure of Ace-MIF. This study provides evidence indicating that the MIF domain of As-MIF interacts directly with the MPN domain of hJAB1, and four structure-based mutants of As-MIF and hJAB1 disrupt the As-MIF-hJAB1 interaction.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2000.11a
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• pp.102-105
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• 2000

Recently, applications of integrated large composite structures have been attempted to many structures of vehicles. To improve the cost performance and reliability of the integrated composite structures, it is necessary to judge structural integrity of the composite structures. For the judgement, we need fracture simulation techniques for composite structures. Many researches oil the fracture simulation method using FEM have been reported by now. Most of the researches carried out simulations considering only matrix cracking and fiber breaking as fracture modes, and did not consider delamination. Several papers have reported the delamination simulation, but all these reports require three-dimensional elements or quasi three- dimensional elements for FEM analysis. Among fracture mechanisms of composite laminates, delamination is the most important factor because it causes stiffness degradation in composite structures. It is known that onset and propagation of delamination are dominated by the strain energy release rate and interfacial moment. In this study, laminated composite has been described by using 3 dimensional finite elements. Then impact behavior of the laminated composite is simulated using FEM(ABAQUS/Explicit) with progressive failure mechanism. These results are compared with experimental results.

• Structural Engineering and Mechanics
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• v.41 no.1
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• pp.95-112
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• 2012

In order to analyze the experimental hysteretic behavior of the in-plane loaded reinforced grouted multi-ribbed aerated concrete blocks masonry walls (RGMACBMW), we have carried out the pseudo static testing on the six specimens of RGMACBMW. Based on the test results and shear failure characteristics, the shear force hysteretic curves and displacement envelope curves of the models were obtained and discussed. On the basis of the hysteretic curves a general skeleton curve of the shear force and displacement was formed. The restoring model was adopted to analyze the seismic behavior and earthquake response of RGMACBMW. The deformation capacity of the specimens was discussed, and the formulas for calculating the lateral stiffness of the walls at different loading stages were proposed as well. The average lateral displacement ductility factor of RGMACBMW calculated based on the test results was 3.16. This value illustrates that if the walls are appropriately designed, it can fully meet the seismic requirement of the structures. The quadri-linear restoring models of the walls degradation by the test results accurately reflect the hysteretic behaviors and skeleton curves of the masonry walls. The restoring model can be applied to the RGMACBMW structure in earthquake response analysis.

• Structural Engineering and Mechanics
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• v.61 no.1
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• pp.1-13
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• 2017

The effectiveness of the repair scheme for the damaged captive-columns with CFRPs (Carbon Fiber Reinforced Polymer) was investigated in terms of response quantities such as strength, ductility, dissipated energy and stiffness degradation. Two 1/3 scale, one-story one-bay RC (Reinforced Concrete) frames were designed to represent the substandard RC buildings in Turkish building stock. The first one, which is the reference specimen, is the bare frame without infill wall. Partial infill wall with opening was constructed between the columns of the second frame and this caused captive column defect. Severe damage was observed with the concentration of shear cracks in the second specimen columns. Then, the damaged members were repaired by CFRP wrapping and retested. For the three test series, similar reversed cyclic lateral displacement under combined effect of axial load was applied to the top of the columns. Overall response of the bare frame was dominated by flexural cracks. Brittle type of shear failure in the column top ends was observed in the specimen with partial infill wall. It was observed that former capacity of damaged members of the second frame was recovered by the applied repair scheme. Moreover, ultimate displacement capacity of the damaged frame was improved considerably by CFRP wrapping.

• Structural Engineering and Mechanics
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• v.61 no.1
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• pp.125-142
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• 2017

Extensive research work has been performed on shear strengthening of reinforced concrete (RC) beams retrofitted with externally bonded carbon fiber reinforced polymer (CFRP) in form of strips. However, most of this research work is experimental and very scarce studies are available on numerical modelling of such beams due to truly challenging nature of modelling concrete shear cracking and interfacial interaction between components of such beams. This paper presents an appropriate model for RC beam and to simulate its cracking without numerical computational difficulties, convergence and solution degradation problems. Modelling of steel and CFRP and their interfacial interaction with concrete are discussed. Finally, commercially available non-linear finite element software ABAQUS is used to validate the developed finite element model with key tests performed on full scale T-beams with and without CFRP retrofitting, taken from previous extensive research work. The modelling parameters for bonding behavior of CFRP with special anchors are also proposed. The results presented in this research work illustrate that appropriate modelling of bond behavior of all the three types of interfaces is important in order to correctly simulate the shear behavior of RC beams strengthened with CFRP.

• Steel and Composite Structures
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• v.28 no.1
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• pp.63-71
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• 2018

This paper reports an experimental study that was accomplished to assess the seismic behavior of steel tube reinforced concrete bridge columns (SBCs). The motivation of this study was to verify a supposition that the core steel tube may be terminated at a rational position in the column to minimize the material cost while maintaining the seismic behavior of this composite column. Four SBC specimens were tested under combined constant axial load and cyclic reversed lateral loads. The unique variable in the test matrix was the core steel tube embedment length, which ranged from 1/3 to 3/3 of the column effective height. It is observed that SBCs showed two distinctly different failure patterns, namely brittle shear failure and ductile flexural failure. Tests results indicate that the hysteretic responses of SBCs were susceptible to the core steel tube embedment length. With the increase of this structural parameter, the lateral strength of SBC was progressively improved; the deformability and ductility, however, exhibited a tendency of first increase and then decrease. It is also found that in addition to maintained the rate of stiffness degradation and cumulative energy dissipation basically unchanged, both the ductility and deformability of SBC were significantly improved when the core steel tube was terminated at the mid-height of the column, and these were the most unexpected benefits accompanied with material cost reduction.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.168-173
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• 2004

Fretting is a kind of surface degradation mechanism observed in mechanical components and structures. The fretting damage decrease in 50-70% of the plain fatigue strength. This may be observed in aircraft, automobile and nuclear power plant used in special environment and various loading conditions. In the present study, the characteristics of the fretting fatigue are investigated using the two aluminum alloy(Al2024-T3511 and Al7050-T7451). Through the experiment, it is found that the fretting fatigue strength of the Al7050-T7451 alloy decreased about 50% from the plain fatigue strength, while the fretting fatigue strength of the Al2024-T3511 alloy decreased about 45%. The tire track was widely observed in fracture surface area of oblique crack which was induced by contact pressure. These results can be the basic data to the structural integrity evaluation of aluminum alloy subjected to fretting damage.

• Structural Engineering and Mechanics
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• v.40 no.6
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• pp.847-866
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• 2011

The objective of this study was to experimentally investigate the bond-related tension stiffening behavior of flexural reinforced concrete (RC) beams made with lightweight aggregate concrete (LWAC) under various high-cycle fatigue loading conditions. Based on strain measurements of tensile steel in the RC beams, fatigue-induced degradation of tension stiffening effects was evaluated and was, compared to reinforced normal weight concrete (NWC) beams with equal concrete compressive strengths (40 MPa). According to applied load-mean steel strain relationships, the mean steel strain that developed under loading cycles was divided into elastic and plastic strain components. The experimental results showed that, in the high-cycle fatigue regime, the tension stiffening behavior of LWAC beams was different from that of NWC beams; LWAC beams had a lesser reduction in tension stiffening due to a better bond between steel and concrete. This was reflected in the stability of the elastic mean steel strains and in the higher degree of local plasticity that developed at the primary flexural cracks.

• Nuclear Engineering and Technology
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• v.45 no.2
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• pp.265-276
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• 2013

Pressure tubes made of Zr-2.5 wt% Nb alloy are important components consisting reactor coolant pressure boundary of a pressurized heavy water reactor, in which unanticipated through-wall cracks and rupture may occur due to a delayed hydride cracking (DHC). The Canadian Standards Association has provided deterministic and probabilistic structural integrity evaluation procedures to protect pressure tubes against DHC. However, intuitive understanding and subsequent assessment of flaw behaviors are still insufficient due to complex degradation mechanisms and diverse influential parameters of DHC compared with those of stress corrosion cracking and fatigue crack growth phenomena. In the present study, a deterministic flaw assessment program was developed and applied for systematic integrity assessment of the pressure tubes. Based on the examination results dealing with effects of flaw shapes, pressure tube dimensional changes, hydrogen concentrations of pressure tubes and plant operation scenarios, a simple and rough method for effective cooldown operation was proposed to minimize DHC risks. The developed deterministic assessment program for pressure tubes can be used to derive further technical bases for probabilistic damage frequency assessment.

• Coupled systems mechanics
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• v.3 no.2
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• pp.195-211
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• 2014

When strong seismic forces act on reinforced concrete structures, their beam-column connections are very susceptible to damage during the earthquake event. The aim of this numerical work is to evaluate the influence of the internal steel reinforcement array on the nonlinear response of a RC beam-column connection when it is subjected to strong cyclic loading -as a seismic load. For this, two specimens (extracted from an experimental test of 12 RC beam-column connections reported in literature) were modeled in the Finite Element code FEAP considering different stirrup's arrays. In order to evaluate the nonlinear response of the RC beam-column connection, the 2D model takes into account the nonlinear thermodynamic behavior of each component: for concrete, a damage model is used; for steel reinforcement, it is adopted a classical plasticity model; in the case of the steel-concrete bonding, this one is considered perfect without degradation. At the end, we show a comparison between the experimental test's responses and the numerical results, which includes the distribution of shear stresses and damage inside the concrete core of the beam-column connection; in the other hand, the effects on the connection of a low and high state of confinement are analyzed for all cases.