• Journal of Microbiology and Biotechnology
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• v.10 no.6
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• pp.889-892
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• 2000

Antisense molecules are structurally simple linear oligomers of nucleotides. They can recognize a complementary sequence by base pairing, therefore, antisense drugs composed of 15-16 bases are potentially useful, unlike drugs such as protein agonists, antagonists, and inhibitors. Since antisense oligomers are classified as nucleotides, they are subject to attack by nucleases. In order to be antisense drugs resistant to degradation by nucleases, the structural modifications in the linkages, bases, and sugars to satisfy this requirement are considerable. We attempted in this study, to synthesize 16-mer antisenses with a modified linkage and adenosine. When studying on the three-dimensional structure of the oligomer, however, the existence of isomers may complicate the interpretation of the NMR data. Therefore, an attempt was made to eliminate the above problem, thus, two dimers were synthesized and their structural studies were carried out.

• Journal of the Korea institute for structural maintenance and inspection
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• v.6 no.2
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• pp.225-231
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• 2002

Severe cracks on Reinforced Concrete (RC) structures caused by structural displacement can be often one of the main reasons for the degradation of tensile and flexural rigidities of RC structures and for the deterioration of durability and serviceability of RC structures through accelerated steel corrosion. These combined factors adversely affect the performance of RC concrete, leading to shortened life time of RC structures. In consideration of these problems, we conducted 3 point bending experiments by employing three different types of concrete specimens: fiber-net reinforced concrete (FNRC), polypropylene-fiber reinforced concrete (PFRC), and plain concrete (PC). FNRC is well known for its strong corrosion resistance, light self-weight, and excellent tensile strength, while PFRC is known to be effective in crack control. FNRC was found to have the best first and final crack resistances followed by PFRC and PC, as evidenced by the highest initial crack load and the smallest final crack width, respectively. The FNRC specimens with various tensile strength of fiber net exhibited greater ultimate strengths than those for PFRC and PC. Furthermore, the crack widths of FNRC specimens were smaller than those calculated by the crack-width estimation equation of the KCI and ACI code. Therefore, we conclude that fiber net reinforcement is effective not only on crack control, but also on loading share.

• Structural Engineering and Mechanics
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• v.61 no.1
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• pp.77-90
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• 2017

Glazed curtain walls are façade systems frequently chosen in modern architecture for mid and high-rise buildings. From recent earthquakes surveys it is observed the large occurrence of non-structural components failure, such as storefronts and curtain walls, which causes sensitive economic losses and represents an hazard for occupants and pedestrians safety. In the present study, the behavior of curtain wall stick systems under seismic actions has been investigated through experimental in-plane racking tests conducted at the laboratory of the Construction Technologies Institute (ITC) of the Italian National Research Council (CNR) on two full-scale aluminium/glass curtain wall test units. A finite element model has been calibrated according to experimental results in order to simulate the behavior of such components under seismic excitation. The numerical model investigates the influence of the interaction between glass panels and aluminium frame, the gasket friction and the stiffness degradation of aluminium-to-glass connections due to the high deformation level on the curtain walls behavior. This study aims to give a practical support to researchers and/or professionals who intend to numerically predict the lateral behavior of similar façade systems, so as to avoid or reduce the need of performing expensive experimental tests.

• Journal of the Korea institute for structural maintenance and inspection
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• v.5 no.3
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• pp.181-189
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• 2001

Recently, the need for strengthening reinforced concrete(R.C.) structure has been increased, particularly when there is an increase in load requirements, a change in use, a degradation problem, or design/construction defects. The use of composite materials for structural repair presents several advantages and has been investigated all over the world. It is well known that the incorporation of carbon fiber sheet(CFS) with concrete is one of the most effective ways to strengthen the R.C. structure. In this papers, experimentally investigated the ductile behavior of the R.C. beams strengthened with CFS, and provided the basic data for design of R.C. beams strengthened with CFS. Tests were carried out with 15 beams ($20cm{\times}30cm{\times}240cm$) reinforced with CFS, and with parameters including and the ratio of tensile reinforcement to that of balanced condition and number of CFS. The results show that strengthened and non-strengthened beams exhibit different ductile behovior. Non-strengthened beams showed increase of ductility as amount of the tensile reinforcement decreased. However, bearing capacity of the CFS-strengthened beams are dictated by the strength of the CFS layers that a very high ductility is indicated for the beams with large number of CFS.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.5
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• pp.112-119
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• 2015

In this paper, the strengthening method was proposed for improving the seismic performance of the vulnerable structural frames. To improve the brittle characteristics of columns, aramid fiber sheet was used for the lateral confinement of columns. And to introduce the energy dissipation capacity, a steel damper with S-shaped struts was installed. By making the unreinforced and reinforced specimens with full size specimens were evaluated for lateral load resistance capacity. It was confirmed the strengthening effects by the evaluation of failure shape, strength, stiffness degradation, and energy dissipation capacity. Also from the FE analysis using ABAQUS, the hysteretic behavior of the specimens were predicted and evaluated.

• Structural Monitoring and Maintenance
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• v.6 no.3
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• pp.219-235
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• 2019

Scheduled inspections of common crossings are one of the main cost drivers of railway maintenance. Prognostics and health management (PHM) approach and modern monitoring means offer many possibilities in the optimization of inspections and maintenance. The present paper deals with data driven prognosis of the common crossing remaining useful life (RUL) that is based on an inertial monitoring system. The problem of scheduled inspections system for common crossings is outlined and analysed. The proposed analysis of inertial signals with the maximal overlap discrete wavelet packet transform (MODWPT) and Shannon entropy (SE) estimates enable to extract the spectral features. The relevant features for the acceleration components are selected with application of Lasso (Least absolute shrinkage and selection operator) regularization. The features are fused with time domain information about the longitudinal position of wheels impact and train velocities by multivariate regression. The fused structural health (SH) indicator has a significant correlation to the lifetime of crossing. The RUL prognosis is performed on the linear degradation stochastic model with recursive Bayesian update. Prognosis testing metrics show the promising results for common crossing inspection scheduling improvement.

• International journal of steel structures
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• v.18 no.4
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• pp.1177-1190
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• 2018

This study presents an analytical framework for estimating the thermo-mechanical behavior of a composite beam exposed to fire. The framework involves: a fire simulation from which the evolution of temperature on the structure surface is obtained; data transfer by an interface model, whereby the surface temperature is assigned to the finite element model of the structure for thermo-mechanical analysis; and nonlinear thermo-mechanical analysis for predicting the structural response under high temperatures. We use a plastic-damage model for calculating the response of concrete slabs, and propose a method to determine the stiffness degradation parameter of the plastic-damage model by a nonlinear regression of concrete cylinder test data. To validate simulation results, structural fire experiments have been performed on a real-scale steel-concrete composite beam using the fire load prescribed by ASTM E119 standard fire curve. The calculated evolution of deflection at the center of the beam shows good agreement with experimental results. The local test results as well as the effective plastic strain distribution and section rotation of the composite beam at elevated temperatures are also investigated.

• Journal of the Korean Society for Precision Engineering
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• v.14 no.2
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• pp.66-73
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• 1997

In many optimal methods for the structural design, the structural analysis is performed with the given design parameters. Then the design sensitivity is calculated based on its structural anaysis results. There-after, the design parameters are changed iteratively. But genetic algorithm is a optimal searching technique which is not depend on design sensitivity. This method uses for many design para- meter groups which are generated by a designer. The generated design parameter groups are become initial population, and then the fitness of the all design parameters are calculated. According to the fitness of each parameter, the design parameters are optimized through the calculation of reproduction process, degradation and interchange, and mutation. Those are the basic operation of the genetic algorithm. The changing process of population is called a generation. The basic calculation process of genetic algorithm is repeatly accepted to every generation. Then the fitness value of the element of a generation becomes maximum. Therefore, the design parameters converge to the optimal. In this study, the optimal design pro- cess of a machine tool structure for static loading is presented to determine the optimal base supporting points and structure thickness using a genetic algorithm.

• Journal of The Korean Society of Agricultural Engineers
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• v.65 no.4
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• pp.45-52
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• 2023

This study was conducted to examine the possibility of use as a structural material for ginseng cultivation facilities of recycled plastics. In order to determine the possibility that recycled plastic can replace timber used as a structural material for ginseng cultivation facilities, the specimens collected by elapsed time were compared with timber through bending tests. In addition, in order to analyze the effect of external environmental conditions on recycled plastic products, bending test was conducted with the specimens that had completed weathering test and accelerated heat aging test respectively. As a result, the bending strength of recycled plastic specimens with the elapsed time of 360 days was lower than that of timber. But bending strength of recycled plastic specimens exceeded the design allowable stress standard set by the Korea design standard (MOLIT, 2016). There was no degradation in quality of recycled plastic due to the external environment, and it was found that there would be no problem even if it was used as a structural material for ginseng cultivation facilities.

• Journal of the Korean Wood Science and Technology
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• v.52 no.2
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• pp.101-117
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• 2024

The conversion characteristics of the major components of Liriodendron tulipifera were investigated during acid-catalyzed organosolv pretreatment. Glucan in L. tulipifera was slowly hydrolyzed, whereas xylan was rapidly hydrolyzed. Simultaneous hydrolysis and degradation of xylan and lignin occurred; however, after complete hydrolysis of xylan at higher temperatures, lignin remained and was not completely degraded or solubilized. These conversion characteristics influence the structural properties of glucan in L. tulipifera. Critical hydrolysis of the crystalline regions in glucan occurred along with rapid hydrolysis of the amorphous regions in xylan and lignin. Breakdown of internal lignin and xylan bonds, along with solubilization of lignin, causes destruction of the lignin-carbohydrate complex. Over a temperature of 160℃, the lignin that remained was coalesced, migrated, and re-deposited on the surface of pretreated solid residue, resulting in a drastic increase in the number and content of lignin droplets. From the results, the characteristic conversions of each constituent and the changes in the structural properties in L. tulipifera effectively improved enzymatic hydrolysis in the range of 140℃-150℃. Therefore, it can be concluded that significant changes in the biomass recalcitrance of L. tulipifera occurred during organosolv pretreatment.