• Journal of Pharmaceutical Investigation
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• 제22권3호spc1호
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• pp.17-34
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• 1992

A novel drug delivery system, detergent-phospholipid mixed micelles as proliposomes, for water-insoluble compounds was developed by investigating (i) spontaneous formation of small unilamellar vesicles (SUV) from bile salt-egg phosphatidylcholine mixed micelles, (ii) the molecular mechanism of micelle-to-vesicle transition in aqueous mixtures of detergent-phospholipid, (iii) preparation and screening of a suitable liposomal formulation for a lipophilic drug: solubilization of the drug within the lipid bilayer, evaluation of the solubility limit, and characterization of the resulting product with respect to the physical properties and stability of the drug in the system, and (iv) testing antitumor activity in vitro. The results showed that the new carrier had a strong possibility to be a biocompatible universal formulation for water-insoluble drugs.

• Computers and Concrete
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• 제22권1호
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• pp.1-10
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• 2018

In this study an implicit algorithm for modeling of propagation of macrocracks in 3D concrete structures suffering from alkali-silica reaction has been developed and implemented. The formulation of the problem prior to the onset of localized deformation is based on a chemo-elasticity approach. The localized deformation mode, involving the formation of macrocracks, is described using a simplified form of the strong discontinuity approach (SDA) that employs a volume averaging technique enhanced by a numerical procedure for tracing the propagation path in 3D space. The latter incorporates a non-local smoothening algorithm. The formulation is illustrated by a number of numerical examples that examine the crack propagation pattern in both plain and reinforced concrete under different loading scenarios.

• Steel and Composite Structures
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• 제51권2호
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• pp.103-116
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• 2024

Based on the consistent couple stress theory (CCST), we develop a unified formulation for analyzing the static bending and free vibration behaviors of functionally graded (FG) microscale beams (MBs). The strong forms of the CCST-based Euler-Bernoulli, Timoshenko, and Reddy beam theories, as well as the CCST-based sinusoidal, exponential, and hyperbolic shear deformation beam theories, can be obtained by assigning some specific shape functions of the shear deformations varying through the thickness direction of the FGMBs in the unified formulation. The above theories are thus included as special cases of the unified CCST. A comparative study between the results obtained using a variety of CCST-based beam theories and those obtained using their modified couple stress theory-based counterparts is carried out. The impacts of some essential factors on the deformation, stress, and natural frequency parameters of the FGMBs are examined, including the material length-scale parameter, the aspect ratio, and the material-property gradient index.

• Archives of Pharmacal Research
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• 제28권7호
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• pp.848-853
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• 2005

Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activity in vivo. In this study, new anti-inflammatory formulation containing S. deltoides extract as a major ingredient was prepared and in vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part of S. deltoides extract, 0.9 part of Angelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1 % inhibition of AA-induced ear edema at an oral dose of 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7 -day model of multiple treatment of TPA (38.1 % inhibition at 200 mg/kg/day). Furthermore, SAG (50-800 mg/kg/day) as well as S. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin $E_2$ production from the skin lesion of the animals of 7-day model. These results were well correlated with in vitro finding that SAG as well as S. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. Therefore, these results suggest that SAG possesses anti-inflammatory activity in vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed by S. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.

• Steel and Composite Structures
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• 제48권1호
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• pp.73-88
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• 2023

This paper presents a novel implicit level set method for topology optimization of functionally graded (FG) structures with pre-existing discontinuities (pre-cracks) using radial basis functions (RBF). The mathematical formulation of the optimization problem is developed by incorporating RBF-based nodal densities as design variables and minimizing compliance as the objective function. To accurately capture crack-tip behavior, crack-tip enrichment functions are introduced, and an eXtended Finite Element Method (X-FEM) is employed for analyzing the mechanical response of FG structures with strong discontinuities. The enforcement of boundary conditions is achieved using the Hamilton-Jacobi method. The study provides detailed mathematical expressions for topology optimization of systems with defects using FG materials. Numerical examples are presented to demonstrate the efficiency and reliability of the proposed methodology.

• Advances in aircraft and spacecraft science
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• 제1권3호
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• pp.291-310
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• 2014

An advanced model for the linear flutter analysis is introduced in this paper. Higher-order beam structural models are developed by using the Carrera Unified Formulation, which allows for the straightforward implementation of arbitrarily rich displacement fields without the need of a-priori kinematic assumptions. The strong form of the principle of virtual displacements is used to obtain the equations of motion and the natural boundary conditions for beams in free vibration. An exact dynamic stiffness matrix is then developed by relating the amplitudes of harmonically varying loads to those of the responses. The resulting dynamic stiffness matrix is used with particular reference to the Wittrick-Williams algorithm to carry out free vibration analyses. According to the doublet lattice method, the natural mode shapes are subsequently used as generalized motions for the generation of the unsteady aerodynamic generalized forces. Finally, the g-method is used to conduct flutter analyses of both isotropic and laminated composite lifting surfaces. The obtained results perfectly match those from 1D and 2D finite elements and those from experimental analyses. It can be stated that refined beam models are compulsory to deal with the flutter analysis of wing models whereas classical and lower-order models (up to the second-order) are not able to detect those flutter conditions that are characterized by bending-torsion couplings.

• Advances in nano research
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• 제9권1호
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• pp.33-45
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• 2020

Geometrically nonlinear buckling of functionally graded magneto-electro-elastic (FG-MEE) nanoshells with the use of classical shell theory and nonlocal strain gradient theory (NSGT) has been analyzed in present research. Mathematical formulation based on NSGT gives two scale coefficients for simultaneous description of structural stiffness reduction and increment. Functional gradation of material properties is described based on power-law formulation. The nanoshell is under a multi-physical field related to applied voltage, magnetic potential, and mechanical load. Exerting a strong electric voltage, magnetic potential or mechanical load may lead to buckling of nanoshell. Taking into account geometric nonlinearity effects after buckling, the behavior of nanoshell in post-buckling regime can be analyzed. Nonlinear governing equations are reduced to ordinary equations utilizing Galerkin's approach and post-buckling curves are obtained based on an analytical procedure. It will be shown that post-buckling curves are dependent on nonlocal/strain gradient parameters, electric voltage magnitude and sign, magnetic potential magnitude and sign and material gradation exponent.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2004년도 춘계공동학술대회 논문집
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• pp.306-310
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• 2004

In this paper, we consider the Ring Loading Problem with integer demand splitting (RLP). The problem is given with a ring network, in which a required traffic requirement between each selected node pair must be routed on it. Each traffic requirement can be routed in both directions on the ring network while splitting each traffic requirement in two directions only by integer is allowed. The problem is to find an optimal routing of each traffic requirement which minimizes the capacity requirement. Here, the capacity requirement is defined as the maximum of traffic loads imposed on each link on the network. We formulate the problem as an integer program. By characterizing every extreme point solution to the LP relaxation of the formulation, we show that the optimal objective value of the LP relaxation is equal to p or p+0.5, where p is a nonnegative integer. We also show that the difference between the optimal objective value of RLP and that of the LP relaxation is at most 1. Therefore, we can verify that the optimal objective value of RLP is p+1 if that of the LP relaxation is p+0.5. On the other hand, we present a strengthened LP with size polynomially bounded by the input size, which provides enough information to determine if the optimal objective value of RLP is p or p+1.

• Earthquakes and Structures
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• 제18권2호
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• pp.263-273
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• 2020

The use of energy concepts in seismic analysis and design of structures requires the understanding of the input energy response of multi-degree-of-freedom (MDOF) systems subjected to strong ground motions. For design purposes and non-time consuming analysis, however, it would be beneficial to associate the input energy response of MDOF systems with those of single-degree-of-freedom (SDOF) systems. In this paper, the theoretical formulation of energy input to MDOF systems is developed on the basis that only a particular portion of the total mass distributed among floor levels is effective in the nth-mode response. The input energy response histories of several reinforced concrete frames subjected to a set of eleven horizontal acceleration histories selected from actual recorded events and scaled in time domain are obtained. The contribution of the fundamental mode to the total input energy response of MDOF frames is demonstrated both graphically and numerically. The input energy of the fundamental mode is found to be a good indicator of the total energy input to two-dimensional regular MDOF structures. The numerical results computed by the proposed formulation are verified with relative input energy time histories directly computed from linear time history analysis. Finally, the elastic input energies are compared with those computed from time history analysis of nonlinear MDOF systems.

• Journal of Pharmaceutical Investigation
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• 제40권1호
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• pp.33-38
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• 2010

Sibutramine is a serotonin-norepinephrine reuptake inhibitor indicated for the management of obesity in conjunction with a reduced calorie diet. The oral administration of sibutramine is followed by its dose-related side effects. In this study, sibutramine was formulated into drug in adhesive (DIA) patches in an attempt to overcome these problems. The effects of different formulation variables including pressure-sensitive adhesive (PSA), loading amount of drug, thickness of matrix and enhancer on the skin permeation of the drug were evaluated using excised hairless mouse skin. In the acrylic adhesive with carboxyl functional group, low release of sibutramine was observed due to the strong interaction between carboxyl group of adhesive and amine group of sibutramine. The acrylic adhesive without functional group provided good adhesion force and allowed high drug loading. Changing drug load as well as thickness of the matrix was found to alter permeation rate. $Crovol^{(R)}$ PK40 and $Crovol^{(R)}$ A40, were found to be effective enhancers for sibutramine. The optimized patch contained 20% sibutramine, and 5% $Crovol^{(R)}$ A40 as permeation enhancer, in $80\;{\mu}m$ thick Duro-$Tak^{(R)}$ 87-9301 matrix.