• 한국콘텐츠학회논문지
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• 제15권12호
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• pp.247-256
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• 2015

본 연구는 사회복지시설 종자사의 고객지향적 태도가 고객만족을 위해 중요하다는 문제에서 출발하여 진성리더십이 직무열의, 고객지향성에 미치는 영향을 살펴보고자 하는 목적으로 수행되었다. 고객지향성이라는 직무수행태도에 영향을 미치는 요인은 인지적, 감정적, 행동적 측면에서 구분해서 파악할 수 있다. 본 연구에서는 태도의 인지적 측면인 진성리더십 인식을 독립변수로, 태도의 감정적 측면인 직무열의를 매개변수로, 고객지향성을 종속변수로 하는 연구모형을 구축하고, 연구가설을 검증하기 위하여 실증적 분석을 실시하였다. 본 연구를 위해 용인시 소재 장애인복지시설과 노인복지시설에서 종사하는 230명을 대상으로 설문조사를 실시하였으며 분석방법은 SPSS 22.0과 AMOS 19.0을 사용하여 연구모형의 적합도를 알아보기 위해 구조방정식모형을 사용하였다. 분석결과, 복지시설종사자의 직무소진과 감정노동에 의한 탈진에 반대되는 직무열의라는 긍정적인 직무태도가 매개효과로서 긍정적 효과를 줌으로써 진성리더십과 직무열의는 고객지향성을 향상시킬 수 있음을 분석결과로 도출되었다.

• Archives of Plastic Surgery
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• 제36권1호
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• pp.113-117
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• 2009

Purpose: Although Hydrofluoric acid(HF) is not a strong acid when compared to other hydrogen halides, it is a feared corrosive and is particularly dangerous at higher concentrations. HF burns are characterized by symptoms, often delayed and localized with diluted HF solutions, to include erythema, edema and severe pain. Pain, a well known symptom following exposure to calcium binding. And, EMLA$^{(R)}$ cream is a topical formulation based upon the eutectic mixture of lidocaine and prilocaine and is used in clinical settings to provide pain relief undergoing superficial surgical procedures. The aim of this study is to evaluate effects of EMLA$^{(R)}$ cream, pain - control dressing on the treatment for HF injury wound. Methods: From June 2007 to June 2008, this study was carried out with 10 patients who had HF partial thickness burns. We were applied topically EMLA$^{(R)}$ cream to injured wound with vaseline gauze and 10% calcium gluconate wet gauze dressings. As a principle, in the emergency treatment, partial or complete removal of the bullae along with copious washing with normal saline was done, depending on the degree of HF invasion of the distal digital extremities. The effect of dressing was investigated by visual analogue pain scale. Results: We therefore reviewed 10 cases of HF - induced pain and pain relief treatment principle. The 10 cases who came to the hospital nearly immediately after the injury healed completely without sequelae and EMLA$^{(R)}$ related complications. Conclusion: Proper initial treatment of HF burns are important, if not promptly recognized and properly treated, for produce serious injury. Topical EMLA$^{(R)}$ cream remain a powerful, new advancement for minimizing HF - related pain during dressing procedures. When used appropriately, topical EMLA$^{(R)}$ cream can provide a safe and effective alternative to other forms of HF - pain control treatment.

• KSBB Journal
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• 제29권1호
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• pp.36-41
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• 2014

Skin disease is one of the most common diseases and its incidence is increasing dramatically in modern society. Specially, many attempts have been made to treat chronic skin inflammation diseases, such as psoriasis and atopic dermatitis, but effective therapies for the immune cell-mediated skin diseases, including psoriasis and atopic dermatitis have not been developed. Until recently, several drug candidates which were claimed to be effective for skin diseases have been reported, but most of them are not used to treat chronic skin disease. Especially, Psoriasis is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells and various immune-related cytokines. Formation of new blood vessels starts with early psoriatic changes and disappears with disease clearance. Several angiogenic mediators are up-regulated in psoriasis development. Contact- and mediator-dependent factors derived from keratinocytes, mast cells and immune cells may contribute to the strong blood vessel formation of psoriasis. New technologies and experimental models provide new insights into the role of angiogenesis in psoriasis pathogenesis. TMP and its derivatives themselves effectively inhibited in vitro cell migration, tube formation, and the expression of angiogenic factors. However, TMP and its derivatives induced side effects including hemolysis and local side effects. Therefore, in an attempt to reduce the toxicity and the undesirable side effects of TMP and derivatives, a liposomal formulation was prepared and tested for its effectiveness. TMP and derivatives liposomes retained the effectiveness of TMP in vitro while side effects were reduced. These results support the conclusion that TMP effectively inhibits in vitro angiogenesis, with the possibility that use as a psoriasis relief agent.

• Journal of Pharmaceutical Investigation
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• 제40권6호
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• pp.367-372
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• 2010

Rabeprazole sodium (RPN) is known to be very unstable at acidic condition or some acidic pharmaceutical excipients such as acrylic acid polymer (carbomer 934) with carboxylic acids. Thus, degradation mechanism of binary blends of rabeprazole with pharmaceutical excipients in a solid state without using solvents at three different ratios (3:1, 1:1 and 1:3) was investigated using Fourier transform infrad (FTIR) spectroscopy. Alkalizer (MgO), neutral hydroxypropymethylcellulose (HPMC 4000) were also tested for comparison. The binary blends were stored under accelerated conditions ($40^{\circ}C$/75% relative humidity) for two weeks. The concentration of thioether rabeprazole from the binary blends with acidic carbomer 934 increased as the rabeprazole concentration decreased. In addition, the degradation half-life of rabeprazole as well as the relative peak area ratios obtained from FTIR spectra of S=O stretching at $1094.1\;cm^{-1}$ decreased consistently as the fraction of carbomer 934 increased due to its sensitivity between the basic benzimidazole nitrogen and carboxylic acid group of carbomer 934. The physical appearance also turned into strong brown color in the presence of carbomer 934. In contrast, there were no significant changes in the degradation kinetics of rabeprazole with MgO and HPMC 4000 in a solid state. This present study demonstrated that the solid-state compatibility test with the aid of HPLC chromatographic and FTIR spectral analyses could offer a valuable methodology to select suitable pharmaceutical excipients and to elucidate the degradation mechanism of RPN for drug formulations at the early formulation stages.

• 농약과학회지
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• 제12권2호
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• pp.118-126
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• 2008

침투성 증진을 목적으로 계면활성제가 첨가된 dimethomorph 제제를 살포하였을 때 오이 엽면 침투성에 영향을 미칠 수 있는 요인들을 조사하고 비교 평가함으로써 실용적인 견지에서 각 요인을 고려한 dimethomorph의 제제와 이의 사용 방법을 제시하고자 하였다. 시험한 모든 환경요인과 식물요인 중 dimethomorph의 침투성에 가장 크게 영향을 미치는 요인은 약제를 살포한 후의 온도와, 오이 재배시 채광량과 습도 등의 인자를 반영하는 오이 잎의 왁스량이었다. 약제 살포 후 채광이 양호한 경우 침투성이 증가하였으며, 수화제나 친수기 polyoxyethylene의 길이가 긴 비이온성 계면활성제를 함유하는 아세톤 수용액과 같은 가용화 제제가 습도 변화에 안전하였다. 오이 품종에 따른 dimethomorph의 엽면 침투성 변화는 그리 크지 않았다. 이와 같은 연구 결과를 고려할 때 침투성이 증진된 dimethomorph 제제는 polyoxyethylene의 길이가 긴 비이온성 계면활성제를 함유하는 수화제가 가장 적합하였다. 또한 이러한 제제는 살포 후 온도를 적당하게 유지하고, 너무 강한 햇빛을 피하게 하는 것이 합리적인 사용방법이 될 수 있을 것이다.

• Ocean Systems Engineering
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• 제7권2호
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• pp.143-155
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• 2017

For complex flexible structures such as nets, the determination of drag forces and its deformation is a challenging task. The accurate prediction of loads on cages is one of the key steps in designing fish farm facilities. The basic physics with a simple cage, can be addressed by the use of experimental studies. However, to design more complex cage system for various environmental conditions, a reliable numerical simulation tool is essential. In this work, the current load on a cage is calculated using a Morison-force model applied at instantaneous positions of equivalent-net modeling. Variations of solidity ratio ($S_n$) of the net and current speed are considered. An equivalent array of cylinders is built to represent the physical netting. Based on the systematic comparisons between the published experimental data for Raschel nets and the current numerical simulations, carried out using the commercial software OrcaFlex, a new formulation for $C_d$ values, used in the equivalent-net model, is presented. The similar approach can also be applied to other netting materials following the same procedure. In case of high solidity ratio and current speed, the hybrid model defines $C_d$ as a function of Re (Reynolds number) and $S_n$ to better represent the corresponding weak diffraction effects. Otherwise, the conventional $C_d$ values depending only on Re can be used with including shielding effects for downstream elements. This new methodology significantly improves the agreement between numerical and experimental data.

• 대한기계학회논문집
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• 제18권1호
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• pp.139-149
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• 1994

A numerical simulation of unsteady axisymmetric turbulent flow was performed for a reciprocating engine including port/valve assembly. The governing equations based on a nonorthogonal coordinate formulation with Cartesian velocity components were used and discretised by the finite volume method with non-staggered variable arrangements. The modified $\kappa-\xi$. turbulence model which included the effect of compressibility was used. The results of twodimensional transient calculation for the axisymmetric configuration were compared with the experimental data. Although slightly low rms velocity was predicted compared to the experimental data, predicted velocity distributions at the valve exit and in-cylinder region showed good agreements with the experimental data. The flow at the valve exit was separated at the same valve lift position with the experimental data. Two vortices incylinder region were generated during the initial intake process. The clockwise main vortex became strong and moved upward to the top wall. The counter-clockwise second vortex became weak and stick to the upper left corner of the cylinder. After middle intake process, new vortex adjacent to upper cylinder wall appeared by the piston motion and therefore, the in-cylinder flow was formed into three vortices. The cylinder pressure just before bottom dead center of piston was higher than inlet pressure and then the reverse flow occured at the valve exit. The in-cylinder flow characteristics were strongly dependent on piston motion, but insensitive to valve motion.

• 대한기계학회논문집
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• 제13권4호
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• pp.771-779
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• 1989

본 연구에서는 기판의 양면에 부품이 SMT방법으로 탑재되어 있는 경우에 기판사이에 형성되는 유동채널에서의 열전달 및 유동특성을 연구하였다.

• 대한기계학회논문집
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• 제16권5호
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• pp.829-837
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• 1992

본 연구에서는 열간박판압연공정에서의 소성유동, 롤압력, 온도분포를 예측하 기 위한 새로운 방법을 제안하고 있다. 제안된 방법은 유한요소 수식화에 바탕을 두 고 있으며 박판의 소성유동과 온도판의 소성유동과 롤-박판 접촉면에서의 롤압력을 예 측하기 위하여 Hwang등이 제안한 벌칙 강소성 유한요소 수식화기법을 제시하였으며 제 안된 방법에 대한 해의 정확도는 문헌에서의 이론해와 시뮬레이션 결과를 비교하여 확 인하였다. 또한 박판에서의 온도장, 속도장과 롤에서의 온도장의 연계해석을 위한 반복계산방법이 제안되었다. 제안된 방법들을 이용하여 다양한 공정에 대한 시뮬레 이션을 수생하였으며 다양한 공정조건에 대한 롤-박판 시스템의 열적특성과 롤간극에 서 박판의 유동특성을 조사하였다.

• Nuclear Engineering and Technology
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• 제48권6호
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• pp.1360-1367
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• 2016

This paper introduces a boron meter with improved accuracy compared with other commercially available boron meters. Its design includes a new fitting function and a multi-detector. In pressurized water reactors (PWRs) in Korea, many boron meters have been used to continuously monitor boron concentration in reactor coolant. However, it is difficult to use the boron meters in practice because the measurement uncertainty is high. For this reason, there has been a strong demand for improvement in their accuracy. In this work, a boron meter evaluation model was developed, and two approaches were considered to improve the boron meter accuracy: the first approach uses a new fitting function and the second approach uses a multi-detector. With the new fitting function, the boron concentration error was decreased from 3.30 ppm to 0.73 ppm. With the multi-detector, the count signals were contaminated with noise such as field measurement data, and analyses were repeated 1,000 times to obtain average and standard deviations of the boron concentration errors. Finally, using the new fitting formulation and multi-detector together, the average error was decreased from 5.95 ppm to 1.83 ppm and its standard deviation was decreased from 0.64 ppm to 0.26 ppm. This result represents a great improvement of the boron meter accuracy.