• Food Science and Biotechnology
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• 제16권6호
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• pp.967-974
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• 2007

The present work is aimed to evaluate the protective effect of glutathione-enriched Saccharomyces cerevisiae FF-8 strain on carbon tetrachloride ($CCl_4$)-induced hepatotoxicity and oxidative stress in rats. The activities of liver markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase), lipid peroxidative index (thiobarbituric acid-reactive substances), and the antioxidant status (reduced glutathione) were used to monitor those protective roles of FF-8 strain. The liver marker enzymes in plasma and the lipid peroxidation in the liver were increased when $CCl_4$ was treated but these were significantly decreased by FF-8 strain treatment. The hepatic concentration of glutathione in the current glutathione-enriched FF-8 strain fed animal was approximately twice as high as the normal, but this was slightly increased in response to $CCl_4$ plus glutathione-enriched FF-8 strain. The increased liver triglyceride concentration due to the $CCl_4$ treatment was significantly decreased by FF-8 strain and the reduced level reached to that of normal group. Administration of FF-8 strain in normal rat did not show any signs of harmful effects. Therefore, the current findings suggest that FF-8 strain could be an effective antioxidant with no or negligible side-effects and it might be useful for the purpose of protection treatment of hepatotoxicity and oxidative stress in $CCl_4$-treatment in rat.

• 생태와환경
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• 제56권4호
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• pp.420-429
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• 2023

This study was designed to examine the immune response in Korean rockfish during water temperature fluctuation and to elucidate the factors contributing to streptococcal pathogenesis in cultured Korean rockfish, S. schlegeli. We investigated cumulative mortality against Streptococcus iniae (FP5228 strain) infection in the exposed Korean rockfish (39.7±5.8 g) to environmentally relevant temperature (Control, 23℃; High temperature, 28℃ and 23℃ and 28℃ with 12 hours interval exchange, 23↔28℃) for 48 hours. Also, the expression of the mRNA related to the immune response genes (heat shock protein 70, interleukin1β, lysozyme g-type and thioredoxin-like 1) were measured in spleen and head kidney by real-time PCR analysis in the exposed fish to thermal stress. In this study, the combined stress with bacterial challenge in fishes exposed to thermal stress lowered the survival rate than that of control (23℃). The cumulative mortality in the group of control, 28℃ and 23↔28℃ was 24%, 24% and 40% (P<0.05), respectively. Also, thermal stress modulated the mRNA level of immune related genes; heat shock protein 70, interleukin-1β, lysozyme g-type and thioredoxin-like 1 in Korean rockfish. The present study indicates that a high and sudden water temperature change affect immune responses and reduce the disease resistance in Korean rockfish.

• Structural Engineering and Mechanics
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• 제47권3호
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• pp.421-442
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• 2013

This paper is concerned with the theoretical treatment of transient thermoelastic problems involving a functionally graded hollow cylinder with piecewise power law due to asymmetrical heating from its surfaces. The thermal and thermoelastic constants of each layer are expressed as power functions of the radial coordinate, and their values continue on the interfaces. The exact solution for the two-dimensional temperature change in a transient state, and thermoelastic response of a hollow cylinder under the state of plane strain is obtained herein. Some numerical results for the temperature change and the stress distributions are shown in figures. Furthermore, the influence of the functional grading on the thermal stresses is investigated.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 춘계 학술발표회 초청강연 및 논문집
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• pp.311-317
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• 2008

This study was carried out to improve our understanding about the influence of silt content on the stress-strain of sand under cyclic loading. Soil specimens were prepared by wet-tamping method as same void ratio and specimen's silt contents on total weights was changed from 0% to 20%. Also, effects of the silt contents on the stress-strain response were studied at different anisotropic consolidation ratio, Kc=1.0, 1.5, 2.0 condition. As a result, cyclic shear strength decreased as silt contents increased in same stress ratios. In same silt contents, cyclic shear strength increased as Kc increased in lower silt contents, but in higher silt contents, it had reverse results.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2001년도 봄 학술발표회 논문집
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• pp.485-492
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• 2001

Weathered soil is one of the most representative soils in Korea. In this study, a series of cyclic triaxial tests was carried out to predict the post-cyclic deformation behavior of weathered soils in case of non-liquefaction. Excess pore pressure response during cyclic loading and volumetric strain during the dissipation of excess pore pressure were measured varying the confining pressure, relative density and cyclic stress ratio. Based on the test results, it Is found that the modified excess pore pressure ratio, excess pore pressure ratio normalized by cyclic stress ratio, is uniquely correlated with the number of cycles irrespective of confining pressure and cyclic stress ratio. Using the newly proposed MEPPR(modified excess pore pressure ratio) concept, it is possible to easily evaluate the excess pore pressure and the settlement of weathered soils due to cyclic loading by greatly reduced number of tests. It is also verified that the reconsolidation volumetric strain is independent of the way how the excess pore pressure was generated.

• Journal of Microbiology and Biotechnology
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• 제20권12호
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• pp.1630-1636
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• 2010

During the fermentation process of Saccharomyces cerevisiae, yeast cells must rapidly respond to a wide variety of external stresses in order to survive the constantly changing environment, including ethanol stress. The accumulation of ethanol can severely inhibit cell growth activity and productivity. Thus, the response to changing ethanol concentrations is one of the most important stress reactions in S. cerevisiae and worthy of thorough investigation. Therefore, this study examined the relationship between ethanol tolerance in S. cerevisiae and a unique protein called alcohol sensitive RING/PHD finger 1 protein (Asr1p). A real-time PCR showed that upon exposure to 8% ethanol, the expression of Asr1 was continuously enhanced, reaching a peak 2 h after stimulation. This result was confirmed by monitoring the fluorescence levels using a strain with a green fluorescent protein tagged to the C-terminal of Asr1p. The fluorescent microscopy also revealed a change in the subcellular localization before and after stimulation. Furthermore, the disruption of the Asr1 gene resulted in hypersensitivity on the medium containing ethanol, when compared with the wild-type strain. Thus, when taken together, the present results suggest that Asr1 is involved in the response to ethanol stress in the yeast S. cerevisiae.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2004년도 춘계 학술발표회 제16권1호
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• pp.18-21
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• 2004

This paper discusses how steel cord and PVA hybrid fibers enhance the performance of high performance fiber reinforced cementitious composites (HPRFCC) in terms of elastic limit, strain hardening response and post peak of the composites. The effect of microfiber(PVA) blending ratio is presented. For this purpose flexure, direct tension and split tension tests were conducted. It was found that HFRCC specimen shows multiple cracking in the area subjected to the greatest bending tensile stress. Uniaxial tensile test confirms the range of tensile strain capacity from 0.5 to $1.5\%$ when hybrid fiber is used. The cyclic loading test results identified a unique unloading and reloading response for this ductile composite. Cyclic loading in tension appears not to affect the tensile response of the material if the uniaxial compressive strength during loading is not exceeded.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2006년도 PAN PACIFIC CONFERENCE vol.2
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• pp.489-494
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• 2006

The strain distribution in the vicinity of a hole in a tensile strip was measured using an image correlation method. The objective of this study is to evaluate the capability of predicting the strain component response using a constitutive model that was developed for use with paper materials. The need for a special constitutive model for paper derives from the characteristics of pronounced anisotropy and the fact that the material behaves differently under compressive loading than it does under tensile loading. The results of the simulation showed that predictions of strain distribution around the hole were in agreement with the experimental result trends, however, the agreement deteriorated as the edge of the hole was reached. It was observed that there is extensive inelastic strain that takes place around the hole prior to failure of the tensile strip. The simulation results showed that any difference between tensile and compressive behavior that may exist for paper material does not have any significant effect for the problem of this study because the level of compressive stress is quite low in comparison with compressive failure values.

• 대한토목학회논문집
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• 제35권1호
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• pp.101-110
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• 2015

최근 Hsu는 전단시험장치를 이용해 순수전단이 작용하는 9개 RC패널요소의 전단시험을 수행하였다(ACI 1997). 최신 트러스모델(수정압축장이론, 회전각연성트러스모델)은 평형조건과 적합조건 그리고 2축 상태에서 RC 막판넬의 연성 응력-변형률 관계를 이용하여 2중 루프의 시행착오방법으로 복잡한 비선형해석을 수행하고 있다. 본 연구는 스트럿과 타이의 파괴기준에 기반한 개선된 모어변형적합방법을 사용해 효율적인 알고리즘을 제안하였고, 이 알고리즘을 이용하여 Hsu가 실험한 전단이력 해석을 빠른 수렴속도로 개선한 것이다. 해석결과에 의하면 전단변형률 증폭상태의 전단변형에너지는 주압축 응력-변형률에 크게 지배받는 것으로 나타났다.

• Geomechanics and Engineering
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• 제29권4호
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• pp.451-461
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• 2022

The roadways surrounded by rock and coal will lose their stability or even collapse under rock burst. Rock burst mainly involves an evolution of dynamic loading which behaves quite differently from static or quasi-static loading. To compare the dynamic response of coal and rocks with different static strengths, three different rocks and bituminous coal were selected for testing at three different dynamic loadings. It's found that the dynamic compression strength of rocks and bituminous coal is much greater than the static compression strength. The dynamic compression strength and dynamic increase factor of the rocks both increase linearly with the increase of the strain rate, while those of the bituminous coal are irregular due to the characteristics of multi-fracture and heterogeneity. Moreover, the absorbed energy of the rocks and bituminous coal both increase linearly with an increase in the strain rate. And the ratio of absorbed energy to the total energy of bituminous coal is greater than that of rocks. With the increase of dynamic loading, the failure degree of the sample increases, with the increase of the static compressive strength, the damage degree also increases. The static compassion strength of the bituminous coal is lower than that of rocks, so the number of small-scale fragments was the largest after bituminous coal rupture.