• Title/Summary/Keyword: stress-dependent

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Repressed Quorum Sensing by Overexpressing LsrR Hampers Salmonella Evasion from Oxidative Killing Within Macrophages

  • Choi, Jeong-Joon;Park, Joo-Won;Ryu, Sang-Ryeol
    • Journal of Microbiology and Biotechnology
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    • v.20 no.12
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    • pp.1624-1629
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    • 2010
  • Bacterial cell-to-cell communication, termed quorum sensing (QS), leads to coordinated group behavior in a cell-density-dependent fashion and controls a variety of physiological processes including virulence gene expression. The repressor of the lsr operon, LsrR, is the only known regulator of LuxS/AI-2-mediated QS in Salmonella. Although lack of lsrR did not result in noticeable differences in Salmonella survival, the down-regulation of QS as a result of lsrR overexpression decreased Salmonella survival within macrophages. We found that impaired growth of Salmonella overexpressing lsrR within macrophages was due largely to its hypersensitivity to NADPH-dependent oxidative stress. This, in turn, was a result of decreased expression of genes involved in the oxidative stress response, such as sodA, sodCI, and sodCII, when lsrR was overexpressed. These results suggest that down-regulation of QS by excess LsrR can lower Salmonella virulence by hampering Salmonella evasion from oxidative killing within macrophages.

Delamination of non-linear viscoelastic beams under bending in the plane of layers

  • Victor I. Rizov
    • Coupled systems mechanics
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    • v.12 no.4
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    • pp.297-313
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    • 2023
  • This paper deals with delamination analysis of non-linear viscoelastic multilayered beam subjected to bending in the plane of the layers. For this purpose, first, a non-linear viscoelastic model is presented. In order to take into account the non-linear viscoelastic behaviour, a non-linear spring and a non-linear dashpot are assembled in series with a linear spring connected in parallel to a linear dashpot. The behaviours of the non-linear spring and dashpot are described by applying non-linear stress-strain and stress-rate of strain relationships, respectively. The constitutive law of the model is derived. Due to the non-linear spring and dashpot, the constitutive law is non-linear. This law is used for describing the time-dependent mechanical behaviour of the beam under consideration. The material properties involved in the constitutive law vary along the beam length due to the continuous material inhomogeneity of the layers. Solution of the strain energy release rate for the delamination is obtained by analyzing the balance of the energy with considering of the non-linear viscoelastic behaviour. The strain energy release rate is found also by using the complementary strain energy for verification. A parametric study is carried-out by using the solution obtained. The solutions derived and the results obtained help to understand the time-dependent delamination of non-linear viscoelastic beams under loading in the plane of layers.

The study on the job stress of dental hygienists by the personality type (치과위생사 성격유형에 따른 업무 스트레스 연구)

  • Jung, Mee-Hee
    • Journal of Korean society of Dental Hygiene
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    • v.3 no.1
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    • pp.45-57
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    • 2003
  • The purpose of this study is to identify the factors affecting job stress and relationship between dental hygienists personal characteristics and them. Final purpose of this study provides the basic data of dental hygienists interventions to help dental hygienists' job stress reduction program. Data were drawn from a convenient sample of 401 dental hygienists who were working for dental clinic, general hospitals, and university hospitals in Seoul and Kyungi areas. The results were analyzed with spsswin 10.0 and the conclusion is as follow: 1. General special quality distribution of dental hygienist is 25-59 and respondent who work in the dentist's office by maiden less than was most. 2. The dental hygienists' job stress was 2.68, it indicates considerably high compare to normal another groups. 3. 'By work, feel fatigue' appeared highest by 3.60 in 5 points full marks from item of business amount connection stress. 4. Only business amount connection stress was expose that is significant in relation with job stress and individual character type. 5. Age, dependent's number, faith, character type variable appeared to keep in mind for connection factor which influence in job stress. 6. Job stress connection factor by character type was expose by variable savages significant thing 'that do work year all as dental hygienist' in A type.

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Stress Relaxation Properties of Cucumber under Bending Moment (휨 모멘트에 대한 오이의 응력이완(應力弛緩) 특성(特性))

  • Song, C.H.;Kim, M.S.;Park, J.M.
    • Journal of Biosystems Engineering
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    • v.18 no.3
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    • pp.262-269
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    • 1993
  • Stress relaxation behaviors of the cucumber under bending moment were tested with UTM at three levels of loading rate and initial deflection ratio. Sample cucumber was selected from three cultivars of cucumber, Cheongjangmadi, Baekdadagi, and Gyeousalicheongjang, because these cultivars are the most popular grown cultivars in Korea. When the bending moment was applied to the cucumber sample, the effective span between simple supports was held a constant value of 116mm with consideration of the selected sample length. The objectives of this study were to develop the rheological models such as linear and nonlinear models of the stress relaxation for the cucumber samples, and to investigate the effects of loading rate and initial deflection ratio on the stress relaxation behavior of the cucumber. The results of this study may be summarized as follows : 1. Stress relaxation behavior of the cucumber could be well described by the generalized Maxwell model for each level of deflection ratio. But the stress relaxation behavior of the sample was found to be initial deflection ratio and time dependent, and it was represented the nonlinear viscoelastic model as a function of initial deflection ratio and time. 2. Stress relaxation behavior of the cucumber samples was very highly affected by the loading rate and the initial deflection ratio. The more loading rate and initial deflection ratio resulted in the more initial bending stress and after stress relaxation progressed more rapidly. 3. At the same test conditions, it was found that the stress relaxation rate of Cheongjangmadi was faster than that of other cultivars.

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Stress Coping Process in Elderly People: Grounded Theory Approach (노인의 스트레스 대처과정에 대한 근거 이론적 접근)

  • Kim Ae-Kyung
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.10 no.3
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    • pp.345-353
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    • 2003
  • Purpose: The purpose of this study was to explore the stress-coping process used by elderly people. Method: This study was based on the grounded theory methodology of Strauss & Corbin. The participants were 15 elders selected by theoretical sampling. Over a period of 3 months, in-depth interviews using audiotape recording were used to collect the data. The data were analyzed simultaneously by a constant comparative method in which new data were continuously coded in categories and properties according to Strauss and Corbin's methodology, Result: Stress in elderly people is caused by illness, family conflict, and loss of economic power. Stress occurred in connection with aging and limitation of social activity. The central incidents for stress were fear, alienation and anxiety. It was found that action/interactional strategies of stress-coping behavior were related to social support and mobility disorders. Action/interactional strategies to stress-coping in elderly people were dependent on medical treatment, mind control, participation of social activity, and renunciation of offensive behavior. Stress-coping in elderly people resulted in stability or instability in body and mind. Conclusion: It is suggested that the results of this study may contribute to the development stress-coping strategies for elderly people. There is need to develop social support systems and a positive environment to avoid negative coping strategies.

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Social Support and COVID-19 Stress Among Immigrants in South Korea

  • Souhyun Jang;Paul Youngbin Kim;Min-Sun Kim;Hoyoun Koh;Kyungmin Baek
    • Asian Journal for Public Opinion Research
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    • v.11 no.2
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    • pp.163-178
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    • 2023
  • Individuals have been under more stress since the COVID-19 pandemic began than they were before the pandemic. While social support is a known stress buffer among the general population, its impact on stress among vulnerable populations, such as immigrants and those living in rural areas, has received little attention in the context of South Korea. Accordingly, we examined the relationship between different types of social support and COVID-19 stress among young adult immigrants based on where they live (rural vs. urban). We conducted a survey of 300 young adult immigrants aged 25-34 years and analyzed the results. The dependent variable was COVID-19 stress, and the independent variables were four types of social support: emotional, appraisal, instrumental, and informational. We discovered that young adult immigrants in rural areas perceived higher-level social supportin all aspects compared with those in urban areas. Furthermore, social support was not related to COVID-19 stress in urban areas, while appraisal support was positively and informational support was negatively related to COVID-19 stress in rural areas. Our findings suggest that a contextualized understanding of social support is critical to understanding COVID-related stress during the COVID-19 pandemic.

Pore Water Pressure Behavior due to Undrained Creep of Saturated Clay (포화점성토의 비배수 CREEP 성질에 의한 공극수압의 거동)

  • 강우묵;조성섭;지인택
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.30 no.3
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    • pp.38-50
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    • 1988
  • carried out to present a rheology model which is able to treat time-dependent properties of clay. The results were summarized as follow ; 1. The slope (a(e1)) of deviator stress in strain rate test was independent on axial strain, and pore water pressure was decreased with increment of strain rate. 2. The pore water pressure in a stress relaxation condition was not changed when the strain rate before stress relaxation was 0.05%/min., but it was increased with increment of time when the strain rate before stress relaxation was 0.2%/min 3. The greater the stress condition (q/qmax) and the strain rate before creep test became, the greater the increment rate of axial strain in creep test became. 4. SEKIGUCHI's constitutive equation was slightly overpredicted while empirical equation proposed in the study was well coincided with measured values. 5. The constitutive equation induced by a strain function could be dealed with a behavior of the pore water pressure increased with increment of elapsed time after primary consolidation.

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Nonlinear vibration of hybrid composite plates on elastic foundations

  • Chen, Wei-Ren;Chen, Chun-Sheng;Yu, Szu-Ying
    • Structural Engineering and Mechanics
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    • v.37 no.4
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    • pp.367-383
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    • 2011
  • In this paper, nonlinear partial differential equations of motion for a hybrid composite plate subjected to initial stresses on elastic foundations are established to investigate its nonlinear vibration behavior. Pasternak foundation and Winkler foundations are used to represent the plate-foundation interaction. The initial stress is taken to be a combination of pure bending stress plus an extensional stress in the example problems. The governing equations of motion are reduced to the time-dependent ordinary differential equations by the Galerkin's method. Then, the Runge-Kutta method is used to evaluate the nonlinear vibration frequency and frequency ratio of hybrid composite plates. The nonlinear vibration behavior is affected by foundation stiffness, initial stress, vibration amplitude and the thickness ratio of layer. The effects of various parameters on the nonlinear vibration of hybrid laminated plate are investigated and discussed.

Numerical Simulation of Effects of TGO Growth and Asperity Ratio on Residual Stress Distributions in TC-BC-TGO Interface Region for Thermal Barrier Coatings (열차폐 코팅의 TGO 성장과 형상비에 따른 TC-BC-TGO 계면에서의 잔류응력 변화에 대한 유한요소해석)

  • Jang, Jung-Chel;Choi, Sung-Churl
    • Journal of the Korean Ceramic Society
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    • v.43 no.7 s.290
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    • pp.415-420
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    • 2006
  • The residual stresses in the interface region of the Thermal Barrier Coating (TBC)/Thermally Grown Oxide (TGO)/Bond Coat (BC) were calculated on the TBC-coated superalloy samples using a Finite Element Method (FEM). It was found that the stress distribution of the interface boundary was dependent upon mainly the geometrical shape or its aspect ratio and the thickness of TGO layer, which was formed by growth and swelling behavior of oxide layer. Maximum compressive residual stress in the TBC/TGO interface is higher than that of the TGO/bond coat interface, and the tensile stress had nothing to do with change of an aspect ratio. The compressive residual stresses in the TBC/TGO and TGO/bond coat interface region increased gradually with the TGO growth.

The role of peroxidases in the pathogenesis of atherosclerosis

  • Park, Jong-Gil;Oh, Goo-Taeg
    • BMB Reports
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    • v.44 no.8
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    • pp.497-505
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    • 2011
  • Reactive oxygen species (ROS), which include superoxide anions and peroxides, induce oxidative stress, contributing to the initiation and progression of cardiovascular diseases involving atherosclerosis. The endogenous and exogenous factors hypercholesterolemia, hyperglycemia, hypertension, and shear stress induce various enzyme systems such as nicotinamide adenine dinucleotide (phosphate) oxidase, xanthine oxidase, and lipoxygenase in vascular and immune cells, which generate ROS. Besides inducing oxidative stress, ROS mediate signaling pathways involved in monocyte adhesion and infiltration, platelet activation, and smooth muscle cell migration. A number of antioxidant enzymes (e.g., superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins) regulate ROS in vascular and immune cells. Atherosclerosis results from a local imbalance between ROS production and these antioxidant enzymes. In this review, we will discuss 1) oxidative stress and atherosclerosis, 2) ROS-dependent atherogenic signaling in endothelial cells, macrophages, and vascular smooth muscle cells, 3) roles of peroxidases in atherosclerosis, and 4) antioxidant drugs and therapeutic perspectives.