• 국제강구조저널
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• 제18권4호
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• pp.1440-1463
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• 2018

The Wagner coefficient is a key parameter used to describe the inelastic lateral-torsional buckling (LTB) behaviour of the I-beam, since even for a doubly-symmetric I-section with residual stress, it becomes a monosymmetric I-section due to the characteristics of the non-symmetrical distribution of plastic regions. However, so far no theoretical derivation on the energy equation and Wagner's coefficient have been presented due to the limitation of Vlasov's buckling theory. In order to simplify the nonlinear analysis and calculation, this paper presents a simplified mechanical model and an analytical solution for doubly-symmetric I-beams under pure bending, in which residual stresses and yielding are taken into account. According to the plate-beam theory proposed by the lead author, the energy equation for the inelastic LTB of an I-beam is derived in detail, using only the Euler-Bernoulli beam model and the Kirchhoff-plate model. In this derivation, the concept of the instantaneous shear centre is used and its position can be determined naturally by the condition that the coefficient of the cross-term in the strain energy should be zero; formulae for both the critical moment and the corresponding critical beam length are proposed based upon the analytical buckling equation. An analytical formula of the Wagner coefficient is obtained and the validity of Wagner hypothesis is reconfirmed. Finally, the accuracy of the analytical solution is verified by a FEM solution based upon a bi-modulus model of I-beams. It is found that the critical moments given by the analytical solution almost is identical to those given by Trahair's formulae, and hence the analytical solution can be used as a benchmark to verify the results obtained by other numerical algorithms for inelastic LTB behaviour.

• 농업과학연구
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• 제48권2호
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• pp.353-365
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• 2021

Previously, we reported that tissue factor (Tf) was included in the list of differentially expressed genes as an upregulated gene in a rejected porcine heart after xenotransplantation into monkey. In this study, we analyzed that expression of Tf in aortic endothelial cells (pAEC) isolated from alpha 1,3-galactosyltransferase knockout pig in response to allogeneic porcine serum and xenogeneic human serum. The consequence was significant upregulation of Tf expression by responding to human serum compared with porcine serum. To analyze the function of Tf gene as a promoter, we constructed reporter vectors for expression of luciferase linked to 1,246 and 787 base pairs of porcine Tf (pTF1246 and pTF787), and 535 base pairs of human TF (hTF535) sequences including putative promoter regions and AP-1 biding site at the 5' end. The reporter vectors were transfected into pAEC including cytomegalovirus enhancer/chicken β-actin (CAG)-luciferase vector as a control. Luciferase assay showed that all of the promoters were insufficient to express luciferase compared with CAG promoter in basic culture conditions. Notably, pTF1246, pTF787, and hTF535 led to a significant increase of luciferase expression in response to human serum compared with porcine serum while no change of CAG. pTF1246 and pTF787 showed higher expression than hTF535. Taken together, our findings suggest that pTF1246 and pTF787 promoters could mediate target gene expression specifically at xenogeneic stress condition.

• 대한한방내과학회지
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• 제43권4호
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• pp.606-624
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• 2022

Objective: The aim of this study was to compare the effects of different doses of Geumnyeonyijin-tang (GNYJT) water extracts with those of metformin (250 mg/kg) in mild diabetic-obese mice. Methods and Results: The 48 mice were divided into 1 normal pellet diet (NFD) group and 5 high-fat diet (HFD) groups. At the end of 12 weeks of oral administration of metformin (250 mg/kg) or GNYJT water extracts (400, 200, or100 mg/kg), the effects were evaluated. The HFD control mice showed noticeable increases in body weight, adipose tissue density, fat pad weight of the periovarian and abdominal wall, and insulin, blood glucose, and HbA1c levels, with decreases in serum HDL levels. Increases in the periovarian and dorsal abdominal fat pad, regions of steatohepatitis, adipocyte hypertrophy, and hepatocyte hypertrophy were also discovered. The HFD group showed a decline in glucose levels and elevation of hepatic gluconeogenesis, suggesting an HFD-induced AMPK downregulation related to glucose dysregulation, as well as lipid metabolism related to obese insulin-resistant type II diabetes, dyslipidemia, and oxidative stress related diabetic hepatopathy (non-alcoholic fatty liver disease, NAFLD). Conclusion: Assessment of the key parameters for inhibition of diabetes and related complications in HFD-fed diabetic-obese mice demonstrated that GNYJT water extracts have favorable ameliorating effects. The effect of GNYJT was manifested through the stimulation of AMPK upregulation of related hepatic glucose enzyme activities and expression of lipid metabolism-related genes. Therefore, appropriate oral dosages of GNYJT could be promising as a new preventive candidate for controlling diabetes and related complications. Further screening of biologically active compounds, elucidation of detailed mechanisms, and more animal studies are warranted.

• 항공우주시스템공학회지
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• 제16권5호
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• pp.78-85
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• 2022

산악이나 도서 지역으로의 물품수송, 재난지역의 영상정보 획득 및 긴급 구호물품 등을 수송하는데 멀티콥터 형태의 무인기를 활용하고자 하는 수요가 증가하고 있다. 이와 같은 임무를 성공적으로 수행하기 위해서는 비행 조건에 따라 발생하는 하중을 기체 구조물이 안전하게 지지하는 동시에 프롭로터의 진동 및 공탄성 안정성 확보 여부를 확인할 필요가 있다. 본 논문에서는 엔진과 발전기 조합의 하이브리드 동력 시스템이 장착된 탑재중량 40kg급 멀티콥터 무인기의 구조해석 모델 생성과 하중조건에 따른 변형 및 응력 분포 검토과정을 소개하였다. 또한 비행 속도와 기체의 피치각 조건에 따른 프롭로터 시스템의 진동 특성과 공탄성 안정성 해석 결과를 제시하였다. 프롭로터를 통해 발생하는 최대추력 및 정상, 비정상 착륙조건에 따라 기체에 작용하는 착륙하중을 검토하였으며, 구조물의 파손 없이 지지할 수 있음을 확인하였다. 기체의 비행 속도와 프롭로터의 회전속도에 따라 주요 모드별 감쇠 특성이 안정한 영역에 위치함을 확인하였다.

• BMB Reports
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• 제55권8호
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• pp.370-379
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• 2022

Human pregnancy is a delicate and complex process where multiorgan interactions between two independent systems, the mother, and her fetus, maintain pregnancy. Intercellular interactions that can define homeostasis at the various cellular level between the two systems allow uninterrupted fetal growth and development until delivery. Interactions are needed for tissue remodeling during pregnancy at both fetal and maternal tissue layers. One of the mechanisms that help tissue remodeling is via cellular transitions where epithelial cells undergo a cyclic transition from epithelial to mesenchymal (EMT) and back from mesenchymal to epithelial (MET). Two major pregnancy-associated tissue systems that use EMT, and MET are the fetal membrane (amniochorion) amnion epithelial layer and cervical epithelial cells and will be reviewed here. EMT is often associated with localized inflammation, and it is a well-balanced process to facilitate tissue remodeling. Cyclic transition processes are important because a terminal state or the static state of EMT can cause accumulation of proinflammatory mesenchymal cells in the matrix regions of these tissues and increase localized inflammation that can cause tissue damage. Interactions that determine homeostasis are often controlled by both endocrine and paracrine mediators. Pregnancy maintenance hormone progesterone and its receptors are critical for maintaining the balance between EMT and MET. Increased intrauterine oxidative stress at term can force a static (terminal) EMT and increase inflammation that are physiologic processes that destabilize homeostasis that maintain pregnancy to promote labor and delivery of the fetus. However, conditions that can produce an untimely increase in EMT and inflammation can be pathologic. These tissue damages are often associated with adverse pregnancy complications such as preterm prelabor rupture of the membranes (pPROM) and spontaneous preterm birth (PTB). Therefore, an understanding of the biomolecular processes that maintain cyclic EMT-MET is critical to reducing the risk of pPROM and PTB. Extracellular vesicles (exosomes of 40-160 nm) that can carry various cargo are involved in cellular transitions as paracrine mediators. Exosomes can carry a variety of biomolecules as cargo. Studies specifically using exosomes from cells undergone EMT can carry a pro-inflammatory cargo and in a paracrine fashion can modify the neighboring tissue environment to cause enhancement of uterine inflammation.

• Genomics & Informatics
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• 제20권2호
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• pp.19.1-19.15
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• 2022

Alfalfa (Medicago sativa) is an important food and feed crop which rich in mineral sources. The WUSCHEL-related homeobox (WOX) gene family plays important roles in plant development and identification of putative gene families, their structure, and potential functions is a primary step for not only understanding the genetic mechanisms behind various biological process but also for genetic improvement. A variety of computational tools, including MAFFT, HMMER, hidden Markov models, Pfam, SMART, MEGA, ProtTest, BLASTn, and BRAD, among others, were used. We identified 34 MsWOX genes based on a systematic analysis of the alfalfa plant genome spread in eight chromosomes. This is an expansion of the gene family which we attribute to observed chromosomal duplications. Sequence alignment analysis revealed 61 conserved proteins containing a homeodomain. Phylogenetic study sung reveal five evolutionary clades with 15 motif distributions. Gene structure analysis reveals various exon, intron, and untranslated structures which are consistent in genes from similar clades. Functional analysis prediction of promoter regions reveals various transcription binding sites containing key growth, development, and stress-responsive transcription factor families such as MYB, ERF, AP2, and NAC which are spread across the genes. Most of the genes are predicted to be in the nucleus. Also, there are duplication events in some genes which explain the expansion of the family. The present research provides a clue on the potential roles of MsWOX family genes that will be useful for further understanding their functional roles in alfalfa plants.

• Nutrition Research and Practice
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• 제16권6호
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• pp.755-764
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• 2022

BACKGROUND/OBJECTIVES: Cardiovascular diseases (CVDs) are the leading cause of death in Koreans, and eating habits, including diet quality, are among the etiologies of these diseases. Recently, various studies on regional health disparities have been conducted. However, there are limited studies on their relationship with nutritional factors. This study aimed to identify the magnitude of regional disparities in diet quality and prevalence of CVD in Korean adults. SUBJECTS/METHODS: This study included 17,646 participants aged ≥ 20 years from the 7^th (2013-2016) Korean National Health and Nutrition Examination Survey. Participants were classified into four groups based on their residential areas: City 1, City 2, City 3, and non-city. Demographic characteristics, health-related factors, body mass index (BMI), metabolic syndrome index, diet quality, and CVD prevalence were evaluated. RESULTS: In terms of demographic characteristics, age (P < 0.001), marital status (P < 0.001), educational level (P < 0.001), and income (P < 0.001) were lower in the non-city category. Health-related factors such as monthly drinking rate (P < 0.01) and mental stress (P < 0.05) were the highest in City 1 and lowest in the non-city group. Conversely, the current smoking rate (P < 0.05), BMI (P < 0.05), and prevalence of metabolic syndrome (P < 0.001) were the highest in the non-city group (P < 0.05). The non-city group also had the highest prevalence of CVDs (35.6%). This group had the lowest diet quality index (68.36 ± 0.22, P < 0.01), caused by low intake of fruit and calcium, a lack of sodium moderation, and an overall imbalance in the macronutrient and fatty acid ratio. When the diet quality index was increased by 1, the odds ratio for the prevalence of CVDs was reduced by 0.991 (P < 0.001), but this was not the case in all regions. CONCLUSIONS: This study provides useful information and data in identifying and resolving the regional health disparities related to CVD prevalence and implementation of public health nutrition systems.

• 대한토목학회논문집
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• 제26권3A호
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• pp.411-419
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• 2006

본 연구에서는 현재의 설계기준에서 명확하게 제시하지 못하고 있는 3차원 응력교란영역의 설계를 위해 3차원 스트럿-타이 모델을 이용하는 새로운 설계방법을 제안하였고, 실무자들이 이 방법에 따라 콘크리트 구조부재를 설계하는데 편리함을 제공해주는 실용적인 3차원 스트럿-타이 모델 전용 그래픽 프로그램을 개발하였다. 격자 스트럿-타이 모델을 사용함으로서 모델 선정에 따른 주관성을 배제하였고, 3차원 파괴면, 압축주응력 흐름의 방향, 그리고 스트럿의 방향 등을 이용하여 3차원 스트럿의 유효강도를 계산하는 방법을 개발하였다. 본 연구의 해석과정은 스트럿의 최대단면적과 필요단면적을 이용하여 최대하중을 계산한 다음, 계산된 타이의 필요단면적을 배근된 철근의 단면적으로 대치시켜 증분하중단계를 이용한 비선형 트러스 해석을 수행하는 방법이다. 설계과정은 주어진 설계하중에 대하여 필요철근량을 산정하고 스트럿과 절점의 강도를 검토하는 일련의 설계방법이다. 따라서 제안된 방법은 유한요소해석과의 상호작용을 통하여 스트럿-타이 모델의 단점을 보완하고 장점을 최대한 활용하기 위한 컴퓨터에 기반한 스트럿-타이 모델 방법으로 분류될 수 있다. 제안된 방법의 타당성을 검증하기 위하여 파괴실험이 수행된 9개의 말뚝기초 공시체의 파괴강도 예측 및 교각코핑부의 설계를 수행하였고, 그 결과를 기존의 연구결과 및 기존 설계기준에 의한 해석 및 설계결과와 비교하였다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.158-158
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• 2022

Ecological drought consequences have received a lot of attention in recent years. Thus, ecological drought was proposed as a new drought category to characterize the impact of drought on ecosystems. The current study used a unique drought index, the standardized supply-demand water index (SSDI), and a run theory to detect ecological drought occurrences and characteristics such as drought-affected area, drought severity, drought duration, drought frequency, and drought orientation in the Hwang River, an environmentally valuable region. Hence, to assess drought-prone areas, the bivariate probability and return period will be calculated using a two-dimensional joint copula. The core results show that (a) the Spatio-temporal characteristics of ecological drought were successfully recognized using the spatial and temporal identification approach; (b) in comparison to the SPEI meteorological drought index, the SSDI is more credible and can more readily and effectively capture the entire properties of ecological drought information; (c) the Hwang river had seen the most severe drought occurrences between the late 1990s and the mid-2020s, with 48.3 percent occurring before the twenty-first century; (d) Severe ecological drought occurrences occurred more frequently in most areas of the Hwang River (e) Only the drought duration and severity in the Hwang area were more responsive to temperature when temperatures rise around 1.1℃, the average drought duration and severity rise around 16 % and 26 %, respectively. This suggested that the Hwang River has been exposed to more severe heat stress in the twenty-first century. Thereupon droughts in the twenty-first century occurred with bigger affected regions, longer durations, higher frequency, and more intensity.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.206-206
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• 2022

Sustainable agriculture is a potential strategy to enable agricultural cultivation systems to feed the growing population under climate change. Sustainable agriculture consists of environment-friendly farming methods that allow the production of crops with minimal harm to the ecosystem. Early establishment in rice might be helpful to adopt sustainable agriculture with less inputs, such as water and phosphorus fertilizer. Two QTLs conferring tolerance to abiotic stress and low nutrition condition, DTY4.1 and Pup1, respectively, are effective for good establishment in the early growth stage under low water and phosphorus fertilizer application. We developed 'Sechanmi' and 'MSI 1-DTY' harboring Pup1 and DTY4.1 into MS11, a japonica rice variety adaptable to tropical regions, using Marker-Assisted Backcrossing (MABC). MS 11-PD lines were developed to meet the demand for less water and P fertilizer application throughout the growth stage of rice. In the F5 generation, water-saving or rainfed cultivation was performed in different P (phosphorus) content. Irrigation was applied only when severe drought was observed one month after transplanting. There was no significant difference observed between the parents and MS11-PD lines in low P conditions. However, MS11-PD lines had more tillers in P-supplied conditions compared to that of the parents 40 and 50 days after transplanting. Under the same amount of P, MS11-PD lines might have higher phosphorus uptake capacity than the parents, increasing the number of tillers and showing better early establishment. The better vegetative growth stage is one of the factors that can potentially increase production by way of higher number of panicles. Through this breeding strategy, it is possible to attain sustainable agriculture by applying less P and water to address the need of a growing population.