• Molecules and Cells
• /
• 제44권5호
• /
• pp.342-355
• /
• 2021

The microphthalmia-associated transcription factor family (MiT family) proteins are evolutionarily conserved transcription factors that perform many essential biological functions. In mammals, the MiT family consists of MITF (microphthalmia-associated transcription factor or melanocyte-inducing transcription factor), TFEB (transcription factor EB), TFE3 (transcription factor E3), and TFEC (transcription factor EC). These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. The best studied functions of MiT proteins include lysosome biogenesis and autophagy induction. In addition, they modulate cellular metabolism, mitochondria dynamics, and various stress responses. The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. In different immune cell types, each MiT family member is shown to play distinct or redundant roles and we expect that there is far more to learn about their functions and regulatory mechanisms in host defense and inflammatory responses.

• Steel and Composite Structures
• /
• 제38권2호
• /
• pp.189-211
• /
• 2021

An analytical solution is presented to analyze the thermoelastoplastic response of a rotating thick-walled cylindrical pressure vessel made of functionally graded material (FGM). The analysis is based on Tresca's yield condition, its associated flow rule and linear strain hardening material behaviour. The uncoupled theory of thermoelasticity is used, and the plane strain condition is assumed. The material properties except for Poisson's ratio, are assumed to vary nonlinearly in the radial direction. Elastic, partially plastic, fully plastic, and residual stress states are investigated. The heat conduction equation for the one-dimensional problem in cylindrical coordinates is used to obtain temperature distribution in the vessel. It is assumed that the inner surface is exposed to an airstream and that the outer surface is exposed to a uniform heat flux. Tresca's yield criterion and its associated flow rule are used to formulate six different plastic regions for a linearly hardening condition. All these stages are studied in detail. It is shown that the thermoelastoplastic stress response of a rotating FGM pressure vessel is affected significantly by the nonhomogeneity of the material and temperature gradient. The results are validated with those of other researchers for appropriate values of the system parameters and excellent agreement is observed.

• 대한중풍순환신경학회지
• /
• 제10권1호
• /
• pp.8-19
• /
• 2009

Scutellaria Radix, originated from Scutellaria baicalensis Georgi, is one of the most important medicine in traditional Oriental medicine, and possesses anti-bacterial activity and sedative effects, can be applied in the treatment of a range of conditions including diarrhea and hepatitis. It is reported that chronic global ischemia induces neuronal damage in selective, vulnerable regions of the brain, especially the hippocampus and cerebral cortex. In the present study, to investigate the effect of Scutellaria Radix extract on cerebral disease, the changes of regional cerebral blood flow and pial arterial diameter on ischemia/reperfusion state was determinated by Laser-Doppler Flowmetry and some parameters concerned with oxidative stress also measured. When SRe were administered for five days with the concentration of 100 mg/kg, GSH activity significantly increased. But SRe administeration showed no significant change in lipid peroxidation. When the activities of CAT, Cu, Zn-SOD and GSH were measured, CAT and GSH were activated by SRe administration. When 1 and 3 ㎍/㎖ SRe was applied to the neuronal cell cultures, the quantities of LDH was significantly reduced when compared with cultures treated only with NMDA. Through this study, it can be concluded that the ischemia/reperfusion induced brain stress may have contributed to cerebral damage in rats, and the present study provides clear evidence for the beneficial effect of SRe on ischemia induced brain injury.

• 한국산학기술학회논문지
• /
• 제22권3호
• /
• pp.536-545
• /
• 2021

본 연구는 전기향로를 이용한 침향 흡입이 스트레스와 뇌파에 미치는 영향을 파악하기 위해 시행되었다. 'H' 발달센터 공고로 모집한 성인 남녀 16명 대상으로 2019년도 09월부터 2020년 4월까지 실시하였다. 전기향로에 침향편(沈香片)을 올려놓고 침향 흡입 전과 후의 스트레스 반응과 뇌파 측정을 비교 분석하여 침향 흡입이 스트레스 대처자원의 가능성을 알아보고자 하는 것이다. 뇌파 측정은 19 Channel, Brainmaster Discovery로 하였으며, 분석은 NeuroGuide와 LORETA를 사용하였다. 수집된 자료는 SPSS/WIN 21.0 프로그램으로 기술 통계, Wilcoxon 부호 순위 검정을 하였다. 결과는 첫째, 침향 흡입 후 스트레스 반응 지수는 분노, 우울, 신체화 모든 항목에서 유의수준 0.01로 유의미한 차이로 감소하였다. 둘째, 침향 흡입 후 뇌파에서 측정 부위 19곳 중에서 FP1 1곳을 제외한 18곳에서 Alpha Wave가 증가하였고, 유의수준 0.05에서 확인되었다. 감정에 영향을 주는 영역(우측 측두엽, T6)에서 침향 흡입 전과 후의 차이가 가장 크게 나타났다. 셋째, LORETA 분석 결과 침향 흡입 후 기억과 정서적 활동에 중요한 뇌 영역(BA40)에서 Alpha Wave가 증가하였다. 이러한 결과로 전기향로를 이용한 침향 흡입이 스트레스와 뇌파에 긍정적인 영향을 미쳐 스트레스 대처 자원이 될 가능성을 확인하였다.

• 한국해안해양공학회지
• /
• 제4권2호
• /
• pp.72-82
• /
• 1992

현지 해안에서 발생하는 해빈류를 정확히 예측하기 위해서는, 해빈류의 기인력인 다방향불 규칙파낭에 의해서 발생하는 방사응력(radiation stress)에 대해서 충분히 파악해 둘 필요가 있다. 본 연구에서는, 이차원수리실험에 있어서 단일성분파, 이성분합성 파, Bretschneider-광역형의 불규칙파를 발생시켜서, 그들의 천수쇄파변형에 따른 전파특성에 대해서 고찰하고, 불규칙파의 천수쇄파변형을 해석할 경우 가정되어지는 3가지 방법, 즉 (1) 파별해석법, (2) 성분파법, (3) 대표파법의 적용성에 대해서 檢討했다. 파별해석법에 대해서는, zero-down cross 법에 의해, 파별해석되어진 불규칙파의 전파특성으로서, 통계파(최대파, 1/3유의파, rms파 등) 및 시계열중의 임의 특정의 개개파의 파고 및 주기의 천수변화라고 하는 관점으로부터 검토했다. 또한, 성분파법에 대해서는 Spectrum 해석에 의해, 입력신호인 기본주파수성분파 및 천수비파변형에 따라 증가하는 간섭주파수 성분파에 대한 파속 및 파고의 천수변형이라고 하는 관점으로부터 그 타당성에 대해서 검토했다.

• International Journal of Aeronautical and Space Sciences
• /
• 제13권2호
• /
• pp.229-237
• /
• 2012

In this study, the failure mechanism of sandwich-to-laminate T-joints under pull-off loading was investigated by experiment and the finite element method. A total of 26 T-joint specimens were manufactured and tested in order to investigate the effects of both adhesive thickness (0.4, 2.0, and 4.0 mm) and environmental conditions on the failure of the joints. The results showed that failure occurred mainly as intralaminar failure in the first layer of the sandwich face, which was contacted to the paste adhesive. The failure load did not significantly change with increasing adhesive thickness in both RTD (Room Temperature and Dry) and ETW (Elevated Temperature and Wet) conditions. In the case of ETW conditions, however, the failure load increased slightly with an increase in adhesive thickness. The joints tested in ETW conditions had higher failure loads than those tested in RTD conditions. In addition to the experiment, a finite element analysis was also conducted to investigate the failure of the joint. The stress inside the first ply of the sandwich face was of interest because during the experiment, failure always occurred there. The analysis results showed good agreement with the trend of experimental results, except for the case of the smallest adhesive thickness. The highest stress was predicted in the regions where initial failure was observed in the experiment. The maximum stress was almost constant when the adhesive thickness was beyond 2 mm.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권3호
• /
• pp.1125-1131
• /
• 2014

Background: Schistosomiasis is a parasitic disease causing chronic ill health in humans with a serious consequences for socio-economic development in tropical and subtropical regions. There is also evidence linking Schistosoma mansoni to colonic carcinoma occurrence. The aim of this study was to evaluate some inflammatory and oxidative stress biomarkers, as well as L-fucose as linkers between intestinal schistosomiasis and colonic dysplasia development in mice. Materials and Methods: This study was conducted upon 80 mice that were divided the control group (10 non infected mice) and infected group which was subdivided into 7 sub-groups (10 mice each) according to the time of sacrifaction in the post infection (p.i.) period, 10 mice being sacrificed every two weeks from 6 weeks p.i. to 18 weeks p.i. Tumor necrosis factor alpha (TNF-${\alpha}$), inducible nitric oxide synthase (iNOS), and pentraxin 3 (PTX3) levels were estimated by immunoassay. The L-fucose level, and thioredoxin reductase (TrxR) and lactate dehydrogenase (LDH) activities were also evaluated in colonic tissue. Results: The current study revealed statistically significant elevation in the studied biochemical markers especially at 16 and 18 weeks p.i. The results were confirmed by histopathological examination that revealed atypical architectural and cytological changes in the form of epithelial surface serration and nuclear hyper-chromatizia at 14, 16 and 18 weeks p.i. Conclusions: inflammation, oxidative stress and L-fucose together may form an important link between Schistosomal mansoni infection and colonic dysplasia and they can be new tools for prediction of colonic dysplasia development in experimental schistosomiasis.

• Asian-Australasian Journal of Animal Sciences
• /
• 제33권10호
• /
• pp.1691-1698
• /
• 2020

Objective: The study sought to estimate the relationship between body surface temperature (BST) and temperature humidity index (THI) and to present the validity of THI as a heat stress index in the field. Methods: Eight Hanwoo heifers (20 to 32 month) were examined in a field trial, with a space allowance of 10 ㎡ per head. The BST was measured using an infrared thermographic camera. The BST of five body regions (eyes, hindquarters, nose, part of horns, and ears), ambient temperature (AT), and relative humidity (RH) were measured 7 times daily (07, 09, 11, 13, 15, 17, and 19 h) during each season with three replicates. Results: The THI ranged 34.0 to 56.9 during spring (AT, -1.0℃ to 13.4℃), 75.1 to 84.7 during summer (AT, 24.9℃ to 33.6℃), 55.8 to 70.9 during autumn (AT, 13.0℃ to 26.0℃) and 17.5 to 39.2 during winter (AT, -10.4℃ to 1.0℃). In the regression analysis, the coefficient of determination (R²) between THI and BST was 0.88, 0.72, 0.83, 0.86, and 0.85 for the eyes, hindquarters, nose, part of horn, and ears area, respectively. This indicates that BST has a strong correlation with AT and RH. Expression equations were estimated as Y (THI) = 31.54+0.1085X (BST of eyes) and Y (THI) = 30.48+0.1147X (BST of hindquarters) by simple linear regression analysis in this experiment. Conclusion: Consequently, the upper bound for heat stress estimation can be specified ranging from THI of 65 (eyes) to 70 (hindquarters). From this we can expect a precise feeding system for Korean native cattle in the field.

• 한국구조물진단유지관리공학회 논문집
• /
• 제9권1호
• /
• pp.233-241
• /
• 2005

본 연구는 콘크리트로 충전한 절곡된 단면을 갖는 각형강관 기둥의 부착특성을 매입인발(Pull-out) 시험을 통해 평가하였다. 시험체는 단면 $250{\times}250mm$의 강관 단면에 콘크리트를 충진한 PSSC기둥으로 표준형(P), 사다리꼴(I), 직사각형(II), 역사다리꼴(III)의 4가지 형태(Fig. 3)와, 부착길이에 대한 폭비 (L/D=2.0, 2.5, 3.0) 단면의 폭두깨비(d/t)으로 설정하여 총 13로 하였다. 실험결과 얇은 판요소 절곡된 강관과 콘크리트의 부착거동은 일반적인 부착거동과 유사하게 화학적 부착과 기계적 부착의 형태로 거동하였으며, 부착응력은 강판의 절곡형태가 (equation omitted)순으로 높게 나타났다. 또한 (equation omitted)타입 시험체의 경우에는 얇은 판요소를 갖는 단면임에도 불구하고 AIJ에서 제시하고 있는 $0.147N/mm^2$의 값을 상회하는 것으로 나타나 부착응력을 고려할 수 있을 것으로 판단되었다.

• Wind and Structures
• /
• 제24권6호
• /
• pp.579-611
• /
• 2017

Bora is a strong, usually dry temporally and spatially transient wind that is common at the eastern Adriatic Coast and many other dynamically similar regions around the world. One of the Bora main characteristics is its gustiness, when wind velocities can reach up to five times the mean velocity. Bora often creates significant problems to traffic, structures and human life in general. In this study, Bora velocity and near-ground turbulence are studied using the results of three-level high-frequency Bora field measurements carried out on a meteorological tower near the city of Split, Croatia. These measurements are analyzed for a period from April 2010 until June 2011. This rather long period allows for making quite robust and reliable conclusions. The focus is on mean Bora velocity, turbulence intensity, Reynolds shear stress and turbulence length scale profiles, as well as on Bora velocity power spectra and thermal stratification. The results are compared with commonly used empirical laws and recommendations provided in the ESDU 85020 wind engineering standard to question its applicability to Bora. The obtained results report some interesting findings. In particular, the empirical power- and logarithmic laws proved to fit mean Bora velocity profiles well. With decreasing Bora velocity there is an increase in the power-law exponent and aerodynamic surface roughness length, and simultaneously a decrease in friction velocity. This indicates an urban-like velocity profile for smaller wind velocities and a rural-like velocity profile for larger wind velocities. Bora proved to be near-neutral thermally stratified. Turbulence intensity and lateral component of turbulence length scales agree well with ESDU 85020 for this particular terrain type. Longitudinal and vertical turbulence length scales, Reynolds shear stress and velocity power spectra differ considerably from ESDU 85020. This may have significant implications on calculations of Bora wind loads on structures.