• 한국작물학회지
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• 제66권1호
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• pp.8-17
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• 2021

자포니카 벼의 저온 스트레스 내성 증진을 위하여, RIL 계통을 이용하여 저온 스트레스 내성 QTL을 탐색하였다. 이를 통하여 (1) 5, 9번 염색체에서 저온발아에 관련한 '기호벼' 유래 QTL, qLTG5와 qLTG9를 확인하였으며, 7, 9번 염색체에서 저온 발아속도에 관련한 '밀양23호' 및 '기호벼' 유래 QTL, qOGCV7, qOGCV9를 확인하였다. (2) Duncan 검정결과, 그룹VII [qLTG5+qLTG9 (qOGCV9)], 그룹VIII [qLTG5+qOGCV7+qLTG9 (qOGCV9)]의 계통들이 저온 스트레스에 내성이 있는 것으로 확인 되었다. (3) 최근 발표된 RIL 집단 담수내성 계통과 비교한 결과, 저온 스트레스에도 내성이 있으면서 담수발아에도 내성이 있는 것으로 확인된 총 2개의 유망 유전자원을 선발하였다. 본 연구의 결과를 통해 저온 및 혐기 관련 QTL의 집적은 벼의 저온에서의 발아 및 초기 입모율을 높여 저온스트레스 내성 개선에 도움이 되는 것으로 판단 되었으며, 선발된 유망 계통은 향후 직파재배 품종 육성에 유용한 유전자원으로 활용되어 직파재배의 안정성 증대에 기여할 것으로 기대된다.

• 대한기계학회논문집A
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• 제22권1호
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• pp.238-246
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• 1998

Surface residual stresses as well as wall thickness and ovality changes after U-bending process on UNS N06690 row-1 heat exchanger tubes, were estimated. Surface residual stresses were measured by Hole Drilling Method(HDM), calculating the stresses from relieved strains of 3 rosette strain gages. After bending of the tubes, dimensional tolerances for wall thickness and ovality were satisfied with ASTM requirements. Residual stresses at the extrados were introduced with compressive stress(-) by bending operations, and its maximum value reached-319 MPa in axial direction at ${\phi}=0^{\circ}$ in position. Tensile residual stresses(+) of ${\sigma}_zz=45$ MPa,${\sigma}_zz=25$ MPa were introduced in the intrados surface at position of ${\phi}=0^{\circ}$ Maximum tensile residual stress of 170 MPa was detected on the flank side at position of ,${\phi}=95^{\circ}$i.e., at apex region. It appeared that higher stress gradients were generated at the irregular transition regions. In the trend of residual stress changes with U-bend position, the extrados is related with the changes of ovality and the intrados is related with the changes of wall thickness.

• 대한의용생체공학회:의공학회지
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• 제19권1호
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• pp.53-58
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• 1998

본 연구에서는 슬개골의 골밀도와 Von Mises 응력의 분포를 조사하였다. 18개 슬개골의 골밀도는 컴퓨터 단층촬영과 영상분석 소프트웨어를 사용하여 결정하였다. 슬개골의 골밀도는 위치에 따라 변화됨을 발견하였다. 골밀도값은 상외측부에서 가장 크고 아래쪽 혹은 내쪽으로 갈수록 감소하였다. 이 분포는 슬개골 안에서 소주의 조직과 일치됨을 보였다. 각 슬개골에서 2차원 유한요소법을 실행한 결과 슬개골의 최대 Von Mises응력은 비관절 표면 위에 있는 피질외피에 따라 발생하였다. 소주의 최대 Von Mises응력은 슬개골의 후방부에 존재했다. 이 발견들은 생체내의 유한요소 연구에 대한 잠재적 가능성을 증명하였다. 따라서 이러한 연구들은 주문형, 환자특성에 맞는 슬개골 인공보철물들의 개발을 유도할 수 있게 한다.

• 생물정신의학
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• 제8권1호
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• pp.3-19
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• 2001

Recent basic and clinical studies demonstrate a major role for neural plasticity in the etiology and treatment of depression and stress-related illness. The neural plasticity is reflected both in the birth of new cell in the adult brain(neurogenesis) and the death of genetically healthy cells(apoptosis) in the response to the individual's interaction with the environment. The neural plasticity includes adaptations of intracellular signal transduction pathway and gene expression, as well as alterations in neuronal morphology and cell survival. At the cellular level, repeated stress causes shortening and debranching of dendrite in the CA3 region of hippocampus and suppress neurogenesis of dentate gyrus granule neurons. At the molecular level, both form of structural remodeling appear to be mediated by glucocorticoid hormone working in concert with glutamate and N-methyl-D-aspartate(NMDA) receptor, along with transmitters such as serotonin and GABA-benzodiazepine system. In addition, the decreased expression and reduced level of brain-derived neurotrophic factor(BDNF) could contribute the atrophy and decreased function of stress-vulnerable hippocampal neurons. It is also suggested that atrophy and death of neurons in the hippocampus, as well as prefrontal cortex and possibly other regions, could contribute to the pathophysiology of depression. Antidepressant treatment could oppose these adverse cellular effects, which may be regarded as a loss of neural plasticity, by blocking or reversing the atrophy of hippocampal neurons and by increasing cell survival and function via up-regulation of cyclic adenosine monophosphate response element-binding proteins(CREB) and BDNF. In this article, the molecular and cellular mechanisms that underlie stress, depression, and action of antidepressant are precisely discussed.

• 약학회지
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• 제49권4호
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• pp.347-354
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• 2005

Lipopolysaccharide (LPS) induces synthesis of several inflammatory cytokines and nitric oxide (NO). NO in brain is involved not only in the regulation of important metabolic pathways via intracellular cyclic GMP-dependent path­ways, but also in neurotoxic damage by reacting with superoxide ion leading to form peroxynitrite radical. Oxidative stress has suggested to be related to the inhibition of NO synthase/cyclic GMP pathway. OQ21 is a new fluorinated quinone compound that is recently known to have inhibitory effects on both NO synthase (NOS) and guanylyl cyclase (GC). In this study, we examined effects of OQ21, other known NOS or GC inhibitors, or an antioxidant, melatonin, on the oxidative stress produced by LPS in rat brain. Oxidative stress was observed by using the 2',7'-dichlorofluorescin diacetate to measure intra-cellular reactive oxygen species (ROS) production and by measuring the formation of thiobarbituric acid reactive substances to measure lipid peroxidation. LPS induced significant increase in both ROS produdction and lipid peroxidation in all brain regions tested (striatum, hippocampus and cortex), which were dissected 6hr after intraperitoneal administration of LPS to rats. Direct striatal injection of two NOS inhibitors, N-nitro-L-arginine methyl ester and diphenyleneiodonium, or a GC inhibitor, IH-[1,2,4]oxadiazolo[4,3-a]quinoxaline-l-one, produced no significant ROS increase. However, OQ21 enhanced ROS formation in striatal tissues from LPS-treated rats. Melatonin decreased LPS-induced ROS formation and decreased ROS formation increased by OQ21 in striatum of LPS-treated rats.

• 구강회복응용과학지
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• 제19권1호
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• pp.7-15
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• 2003

This study used FEM(Finite Element method) based on micro-CT images to see the effects of occlusal force distribution with varying bone density and structure. the mandibular premolar region from human cadaver, thickness of 10mm was imaged using micro-CT. the cross sectional images were taken every $10{\mu}m$. these were reconstructed and the longitudinal image at the mid point of mesiodistal of the speciman was obtained for the specimen for the FEM. The stress disribution produced by a vertical force at 100N and 100N horizontal were analyzed by MSC Nastran FEM Package. according to the result of this study the occlusal force distribution depends on the structure of cancellus bone and for further information on the occlusal force distribution on the tooth and the surrounding structure requires further studies on cancellus bone structure. CEJ of all model show the highest peak and region whice meet teeth and bone show second high peak. Original model and cortical bone add model show different stress distribution. Stress distribution changed according to bone structures and densities.

• 한국지진공학회논문집
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• 제13권3호
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• pp.67-80
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• 2009

내진설계의 기본적인 개념은 지진 시 요구되는 연성도 이상의 변형성능을 확보하는 것이다. 기둥의 경우 소성힌지 영역에 적절한 횡철근을 배근함으로써 이를 실현할 수 있다. 가장 경제적인 설계를 위해서는 횡구속 콘크리트의 응력-변형률 특성에 기초하여 횡철근량을 산정하는 것이다. 우리나라(도로교 설계기준)에서는 목표연성도를 단일화하여 동일한 횡철근을 제공하고 있으나 일본에서는 횡구속된 콘크리트의 응력-변형률 곡선식을 제공함으로써 경제적으로 소요 횡철근량을 산정하고 있다. 이러한 재료레벨(응력-변형도)의 특성을 사용하면 설계는 어려워지지만 보다 경제적인 설계가 가능하며 이는 성능에 기반한 내진설계의 경향과도 부합된다. 이 연구에서는 현행 도로교설계기준의 갈고리상세에 부합되는 횡철근을 배치한 부재에 대해 횡철근량을 변수로 하여 응력-변형률 실험을 수행하였다. 응력-변형률 특성을 정량적으로 평가할 수 있는 인자를 도입하여 실험결과와 기존의 콘크리트 모델식을 비교 분석하였다.

• Restorative Dentistry and Endodontics
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• 제20권2호
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• pp.655-669
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• 1995

Restorative procedures can lead to weakening tooth due to reduction and alteration of tooth structure. It is essential to prevent fractures to conserve tooth. Among the several parameters in cavity designs, cavity isthmus is very important. In this study, amalgam 0 cavity was prepared on maxillary first premolar. Two dimensional finite element models were made by serial photographic method and isthmus(1/4, 1/3, 1/2, 2/3 of intercuspal distance) were varied. Three or four-nodal mesh were used for the two dimensional finite element models. The periodontal ligament and alveolar bone surrounding the tooth were excluded in these models. 1S model was sound tooth with no amalgam cavity. B model was assumed perfect bonding between the restoration and cavity wall. Both compressive and tensile forces were distributed directly to the adjacent regions. A load of 500N was applied vertically at the first node from the lingual slope of the buccal cusp tip. This study analysed von Mises stress, 1 and 2 directional normal stress and Y and Z axis translation with FEM software Super SAPII Version 5.2 (Algor Interactive System Co.) and hardware 486 DX2 PC. The results were as :follows : 1. 1S model was slightly different with 1B model in stress distibution. 1S, 2B, 3B, 4B models showed similiar stress distribution. 2. 1S model and four B models showed similiar pattern in Y axis and Z axis translation. 3. 1S model and four B models showed the bending phenomenon in the translation. 4. As increasing of the width of the cavity, experimental group was similiar with the control group in stress distribution. 5. As increasing of the width of the cavity, experimental group was similiar with the control group in Y and Z axis tranlation.

• 융합정보논문지
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• 제11권5호
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• pp.50-56
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• 2021

본 연구는 임부의 사회적 지지, 임신 스트레스 그리고 불안이 삶의 질에 영향을 미치는 영향요인을 파악하기 위해 시도 되었다. 본 연구는 2개 지역 D 와 S 지역에 거주하는 임부 117명을 대상으로 한 서술적 조사연구이다. 설문 전 연구의 취지와, 목적, 절차에 대하여 설명을 하고 진행하였다. 자료는 SPSS 21.0 을 이용하였고, 빈도분석, 분산분석, t검증, 상관분석, 희귀분석으로 실시하였다. 자료 수집은 2020년 1월부터 2월까지 하였다. 본 연구결과는 일반적 특성에 따른 임부의 삶의 질 차이는 수면시간, 경제수준, 건강상태, 활동량, 임신주기에서 유의미한 차이를 보였다. 삶의 질에 영향을 미치는 변수는 사회적 지지(β= .432, p= .000), 임신 스트레스(β=- .407, p= .000), 불안(β=- .182, p= .010) 순으로 확인되었다. 임부는 임신 스트레스와 불안 등을 경험하는 삶의 질 저하문제로 이어질 수 있어 임부에 대한 건강증진 프로그램 개발을 해야 할 것이며 삶의 질 증진을 위한 적극적인 간호중재 제공에 대한 필요성이 제기된다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.292-292
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• 2022

Since 1992, the Rural Development Administration (RDA), Republic of Korea in collaboration with International Rice Research Institute (IRRI) has developed 6 japonica rice varieties(MS11, Japonica 1, 2, 6, 7 and Cordillera 4) that are adaptable to tropical regions. However, these varieties show moderate resistance or susceptibility to certain biotic and abiotic stress. The development of varieties with more stable forms of resistance is highly desirable, and this could be possibly achieved through rapid introgression of known biotic and abiotic resistant genes. In this study, we analyzed the allele types of major biotic stress resistant genes including Xa5, Xa13, Xa21 and Xa25 for bacterial leaf blight, Pi5, Pi40, Pish and Pita2 for blast, tsv1 for rice tungro spherical virus, and Bph6, Bph9, Bph17, Bph18 and Bph32 for brown planthopper by using gene-specific molecular markers. In addition, seed quality related genes Sdr4 for preharvest sprouting and qLG-9 for seed longevity were also analyzed. The results revealed that2h5 and Xa25 resistance alleles showed in all varieties while Pi5 resistance allele showed only in MS11. The Pish resistance allele were present in five varieties except for Japonica 1. Meanwhile, for the rest of the genes, no presence of resistance alleles found in six varieties. In conclusions, most of tropical japonica varieties are lack of the major biotic stress resistant genes and seed quality genes (Sdr4 and qLG-9). Moreover, the results indicated that rapid deployment of a few major genes in the current tropical japonica rice varieties is urgent to increase durability and spectrum of biotic stress resistance and also seed dormancy/longevity which are essential traits for tropical environments.