• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.50-50
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• 2003

We have identified and analysed a putative response regulator two-component gene (CaSKN7) from Candida albicans and its encoding protein (CaSkn7). CaSKN7 has an open reading frame of 1677bp. CaSKN7 encodes a 559 amino acid protein (CaSkn7) with an estimated molecular mass of 61.1 kDa. CaSKN7 is a homologue of a Saccharomyces cerevisiae SKN7 that is the regulator involved in the oxidative stress response. To study the role of CaSKN7, we constructed a CAI4-derived mutant strain carrying a homozygous deletion of the CaSKN7 gene. In the caskn7 disruptant cells, the formation of germ tube require shorter time than that in the congenic wild-type strain but the growth of mycelium delayed in liquid media. In contrast, the caskn7 disruptant cells attenuate the differentiation in solid media and the virulence in mouse model system. Expression level of hypha-specific and virulence genes - HYR1, ECE1, HWP1, and ALS1 - in the caskn7 disruptant cells increased as compared with that in the congenic wild-type strain in 10％ serum YPD. Skn7 in 5. cerevisiae was found to bind the HSE element from the SSA promoter, Also, CaSkn7 contains heat shock factor DNA-binding domain and the promoters of these genes have HSE-like sties. Therefore these results show that CaSKN7 regulate the differentiation and virulence of C. albicans.

• Wind and Structures
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• v.10 no.3
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• pp.233-247
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• 2007

The insertion of steel braces has become a common technique to limit the deformability of steel framed buildings subjected to wind loads. However, when this technique is inadequate to keep floor accelerations within acceptable levels of human comfort, dampers placed in series with the steel braces can be adopted. To check the effectiveness of braces equipped with viscoelastic (VEDs) or friction dampers (FRDs), a numerical investigation is carried out focusing attention on a three-bay fifteen-storey steel framed building with K-braces. More precisely, three alternative structural solutions are examined for the purpose of controlling wind-induced vibrations: the insertion of additional diagonal braces; the insertion of additional diagonal braces equipped with dampers; the insertion of both additional diagonal braces and dampers supported by the existing K-braces. Additional braces and dampers are designed according to a simplified procedure based on a proportional stiffness criterion. A dynamic analysis is carried out in the time domain using a step-by-step initial-stress-like iterative procedure. Along-wind loads are considered at each storey assuming the time histories of the wind velocity, for a return period $T_r=5$ years, according to an equivalent wind spectrum technique. The behaviour of the structural members, except dampers, is assumed linear elastic. A VED and an FRD are idealized by a six-element generalized model and a bilinear (rigid-plastic) model, respectively. The results show that the structure with damped additional braces can be considered, among those examined, the most effective to control vibrations due to wind, particularly the floor accelerations. Moreover, once the stiffness of the additional braces is selected, the VEDs are slightly more efficient than the FRDs, because they, unlike the FRDs, dissipate energy also for small amplitude vibrations.

• Journal of the Korean Magnetics Society
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• v.2 no.2
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• pp.91-98
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• 1992

In a $Co_{67}Fe_{4.5}Nb_{2}Si_{10}B_{15}$ amorphous alloy ribbon the effect to two-step annealing on the soft magnetic properties has been studied. By two-step annealing method which the second annealing at low temperature of $310^{\circ}C$ for 2 hours is undertaken after the primary annealing at high temperature above $480^{\circ}C$ for 20 minutes at the vacuum state, the coercive force and the squareness are not changed nearly but the initial permeability at d.c. and the effective permeability at a.c. are remark-ably increased compared with the one-step annealing. The maxima of the initial permeability and the effective permeability at 1 kHz after the two-step annealing are 290,000 and 41,000, respectively, which are 30% higher than those of the one-step annealing. The change of magnetic properties with annealing temperature is discussed in terms of the residual stress, the domain size, the cluster and the crystalline phase.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.4 no.4
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• pp.231-242
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• 1992

This study uses a numerical model to investigate the circulation patterns of the tidal and wind driven current components. The model is vertically averaged 2-D transient using explicit nume-rical scheme, based on equation of motion and continuity. forced by water elevation at open boundaries and wind stress. The model domain extends from 35$^{\circ}$N to 36$^{\circ}$40'N lat., and 125$^{\circ}$E to 126$^{\circ}$40'E long. with x, y grid spacing of 5 km. The model reproduces the tide and tidal currents by 4 major constituents successfully with more than 90% accuracy when compared to two offshore tidal records and currents at one offshore measurements for 22 days. Responses of coastal waters to six schematic wind events are analyzed in terms of current distribution patterns and local features. Regardless of wind directions. strong coastal currents were produced. Bottom topography plays a critical role in producing a local eddy Held whose center is located offshore Pu An with its major radius of 40 km.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.5
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• pp.1303-1310
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• 2010

Recently, researches related with automative mechanism have been widely studied to increase the driver's safety by continuously monitoring the driver's health condition to prevent driver's drowsiness. This paper describes the design of wearable chest belt for ECG and reflectance pulse oximetry for SpO2 sensors based on wireless sensor network to monitor the driver's healthcare status. ECG, SpO2 and heart rate signals can be transmitted via wireless sensor node to base station connected to the server. Intelligent monitoring system is designed at the server to analyze the SpO2 and ECG signals. HRV (Heart Rate Variability) signals can be obtained by processing the ECG and PPG signals. HRV signals are further analyzed based on time and frequency domain to determine the driver's drowsiness status.

• School Mathematics
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• v.18 no.2
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• pp.397-423
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• 2016

Mathematics learning motivation is an important variable which is not only the primary goal of learning mathematics but also mediates the effects of the mathematics learning. Nevertheless, the present learning environment is full of impeding factors which reduce learners' motivation to learn mathematics and mathematical self-regulatory efficacy. The purpose of this study is to offer various suggestions for program to enhance and forster mathematics learning motivation based on empirical findings and theories on motivation, self-regulatory learning, regulatory focus, reducing academic stress and math anxiety. The concrete and practical ideas are suggested in terms of mathematical self-regulatory efficacy, learners' characteristics, learning task. The analysis of the effects revealed a positive effect on mathematical self-regulatory learning.

• Plant Biotechnology Reports
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• v.5 no.4
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• pp.323-329
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• 2011

MuSI, a gene that corresponds to a domain that contains the rubber elongation factor (REF), is highly homologous to many stress-related proteins in plants. Since MuSI is up-regulated in the roots of plants treated with cadmium or copper, the involvement of MuSI in cadmium tolerance was investigated in this study. Escherichia coli cells overexpressing MuSI were more resistant to Cd than wild-type cells transfected with vector alone. MuSI transgenic plants were also more resistant to Cd. MuSI transgenic tobacco plants absorbed less Cd than wild-type plants. Cd translocation from roots to shoots was reduced in the transgenic plants, thereby avoiding Cd toxicity. The number of short trichomes in the leaves of wild-type tobacco plants was increased by Cd treatment, while this was unchanged in MuSI transgenic tobacco. These results suggest that MuSI transgenic tobacco plants have enhanced tolerance to Cd via reduced Cd uptake and/or increased Cd immobilization in the roots, resulting in less Cd translocation to the shoots.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.4
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• pp.775-786
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• 2002

A Mixed Volume and Boundary Integral Equation Method is applied for the effective analysis of elastic wave scattering problems and plane elastostatic problems in unbounded solids containing general anisotropic inclusions and voids or isotropic inclusions. It should be noted that this newly developed numerical method does not require the Green's function for anisotropic inclusions to solve this class of problems since only Green's function for the unbounded isotropic matrix is involved in their formulation for the analysis. This new method can also be applied to general two-dimensional elastodynamic and elastostatic problems with arbitrary shapes and number of anisotropic inclusions and voids or isotropic inclusions. In the formulation of this method, the continuity condition at each interface is automatically satisfied, and in contrast to finite element methods, where the full domain needs to be discretized, this method requires discretization of the inclusions only. Finally, this method takes full advantage of the pre- and post-processing capabilities developed in FEM and BIEM. Through the analysis of plane elastostatic problems in unbounded isotropic matrix with orthotropic inclusions and voids or isotropic inclusions, and the analysis of plane wave scattering problems in unbounded isotropic matrix with isotropic inclusions and voids, it will be established that this new method is very accurate and effective for solving plane wave scattering problems and plane elastic problems in unbounded solids containing general anisotropic inclusions and voids/cracks or isotropic inclusions.

• Journal of the Korean Society for Nondestructive Testing
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• v.20 no.6
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• pp.481-489
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• 2000

A time-frequency analysis method was developed to analyze the dispersive waves caused by impact loads in structural members such as beams and plates. Stress waves generated by ball drop and pencil lead break were recorded by ultrasonic transducers and acoustic emission (AE) sensors. Wavelet transform (WT) using Gabor function was employed to analyze the dispersive waves in the time-frequency domain, and then to find the arrival time of the waves as a function of frequency. The measured group velocities in the beam and the plate were compared with the predictions based on the Timoshenko beam theory and Rayleigh-Lamb frequency equations, respectively. The agreements were found to be very good.

• Journal of Korean Clinical Nursing Research
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• v.25 no.3
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• pp.251-264
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• 2019

Purpose: This study was a systematic review and meta-analysis to explore the factors related to quality of life in heart transplant recipients. Methods: To identify studies that suggested the factors related to the quality of life in heart transplant recipients, we searched the articles published from 1974 to November 2018 using Six databases, PubMed, CINAHL, EMBASE, Cochrane, KMBASE and RISS. A total of 22 studies were selected out of 5,234 for the systematic review and meta-analysis on the basis of the PRISMA flow. The quality of study was assessed by assessment tool form the NIH and meta-analysis was performed using the 'R 3.5.2' version to analyze the correlated effect sizes. Results: Factors related to quality of life in heart transplant recipients were categorized into six domains based on the health-related quality of life model introduced by Ferrans: individual, environmental, biological function, symptoms, functional status, and general health perception. In the meta-analysis, 34 factors were used and 17 factors having significant effect sizes were as follows: self-efficacy, demoralization, perceived control, current occupational status, age, marital status, health promotion life style in the individual characteristics; stress in environmental characteristics; physical function status, creatinine level, left ventricular ejection fraction (LVEF) in biological function; anxiety, depression, symptom frequency and distress in symptoms domain; coping, self-care compliance in functional status. Conclusion: The findings indicate that the multi-dimensional factors influencing the quality of life in heart transplant recipients and provide the evidence for developing effective interventions for improving the quality of life of recipients.