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Significant Association of Alpha-Methylacyl-CoA Racemase Gene Polymorphisms with Susceptibility to Prostate Cancer: a Meta-Analysis

  • Chen, Nan;Wang, Jia-Rong;Huang, Lin;Yang, Yang;Jiang, Ya-Mei;Guo, Xiao-Jiang;He, Ya-Zhou;Zhou, Yan-Hong
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.5
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    • pp.1857-1863
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    • 2015
  • Background: Alpha-methylacyl-CoA racemase(AMACR) is thought to play key roles in diagnosis and prognosis of prostate cancer. However, studies of associations between AMACR gene polymorphisms and prostate cancer risk reported inconsistent results. Therefore, we conducted the present meta-analysis to clarify the link between AMACR gene polymorphisms and prostate cancer risk. Materials and Methods: A literature search was performed in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to assess the strength of any association between AMACR polymorphisms and prostate cancer risk. Subgroup analyses by ethnicity, source of controls, quality control and sample size were also conducted. Results: Five studies covering 3,313 cases and 3,676 controls on five polymorphisms (D175G, M9V, S201L, K277E and Q239H) were included in this meta-analysis. Significant associations were detected between prostate cancer and D175G (dominant model: OR=0.89, 95%CI=0.80-0.99, P=0.04) and M9V (dominant model: OR=0.87, 95%CI=0.78-0.97, P=0.01) polymorphisms as well as that in subgroup analyses. We also observed significant decreased prostate cancer risk in the dominant model (OR=0.90, 95%CI=0.81-0.99, P=0.04) for the S201L polymorphism. However, K277E and Q239H polymorphisms did not appear to be related to prostate cancer risk. Conclusions: The current meta-analysis indicated that D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer. The S201L polymorphism might also be linked with prostate cancer risk to some extent. However, no association was observed between K277E or Q239H polymorphisms and susceptibility to prostate cancer.

Improvement of Durability and Change of Pore Structure for Concrete Surface by the Penetrative Surface Protection Agent (함침계 표면보호제에 의한 콘크리트 표면의 세공구조 변화 및 내구성 향상)

  • Kang, Suk-Pyo;Kim, Jung-Hwan
    • Journal of the Korea Concrete Institute
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    • v.18 no.1 s.91
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    • pp.125-132
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    • 2006
  • Recently, surface finishing and protection materials were developed to restore performance of the deteriorated concrete and inhibiting corrosion of the reinforcing-bar. For this purpose, surface protection agent as well as coatings are used. Coatings have the advantage of low Permeability of $CO_2,\;SO_2$ and water. However, for coatings such as epoxy, urethane and acryl, long-term adhesive strength is reduced and the formed membrane of those is blistered by various causes. Also when organic coatings are applied to the wet surface of concrete, those have a problem with adhesion. On the other hand, surface protection agent penetrates into pore structure in concrete through capillary and cm make a dense micro structure in concrete as a result of filling effect. Furthermore, the chemical reaction between silicate from surface protection agent and cement hydrates can also make a additional hydration product which is ideally compatible with concrete body. The aim of this study is to examine the effect of penetrative surface protection agent(SPA) by evaluating several concrete durability characteristics. The results show that the concrete penetrated surface protection agent exhibited higher durability characteristics for instance, carbonation velocity coefficient, resistance to chemical attack and chloride ion penetration than the plain concrete. These results due to formation of a discontinuous macro-pore system which inhibits deterioration factors of concrete by changed the pore structure(porosity and pore size distributions) of the concrete penetrated surface protection agent.

Micromorphological Characteristics of Buddhist Temple Woods Treated with Eire-retardant (방염 처리 고목재의 미생물 분해의 미시형태적 특징)

  • Wi, Seung Gon;Kim, Ik-Joo;Park, Young Man;Kim, Yoon Soo
    • 한국문화재보존과학회:학술대회논문집
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    • 2001.11a
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    • pp.27-34
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    • 2001
  • Following the recommendations made by the cultural authorities the wooden cultural properties (WCP) had been treated with fire-retardants for fire protection. However, visual inspections of some of the WCPs treated with fire-retardants showed microbial decay. The work was extended to examine the micromorphological characteristics of the WCPs in a Buddhist temple which had been treated with fire-retardant. Microscopic examination showed the presence of typical soft rot cavities along the length of microfibrils in the secondary wall. Bacterial attack was also observed by scanning and transmission electron microscopy. It is interesting that the decay patterns observed in the Buddhist temple were very similar to those observed in the waterlogged woods. Presumably chemicals in the fire-retardants used rendered the wood susceptible to attack by soft-rot and bacterial decay by causing an increase in the moisture content of wood. Further studies are needed to investigate the effect of fire-retardants used currently on the hygroscopicity and the strength of wood materials in the WCPs. Microbial attacks caused degradation of the secondary cell walls and in some cases also of the middle lamella. In addition, the cell walls in the outer parts of wood were also degraded due to weathering, and cell separation occurred from total disintegration of the middle lamella.

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Evaluation of the Physical Properties for Lightweight Bricks Made from Sewage Sludge and Wasted Glass (하수슬러지로 제조한 경량 벽돌의 물성평가)

  • Jeong, Jae-Ah;Son, Yeong-Geum;Lee, Woo-Keun
    • Journal of Korean Society of Environmental Engineers
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    • v.35 no.11
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    • pp.781-784
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    • 2013
  • Ocean dumping of sewage sludge is banned. Therefore, it is needed to develop alternative treatment method. Sewage sludge and waste glass are used to prepare lightweight brick. Large amount of energy is consumed to prepare building material, because of its high preparation temperature, or above $1,200^{\circ}C$. We study to prepare lightweight brick, using sewage sludge and waste glass as raw materials in this research. Lightweight brick was made at low temperature of below $800^{\circ}C$ to reduce $CO_2$ emission by geopolymer technique. Calcination temperature, mixing ratio of sewage sludge/waste glass and water glass/water were discussed to evaluate their effect on the brick prepared. In this study, the optimal conditions for preparing bricks was $750^{\circ}C$ of firing temperature, 1.5 of mixing ratio for water glass/water and 10 : 90 wt% of sewage sludge/waste glass. At this condition, compressive strength and specific gravity of brick prepared were 5.1 MPa and 0.46, respectively. These values satisfy the criteria on a lightweight brick.

Numerical Study on Inverse Analysis Based on Levenberg-Marquardt Method to Predict Mode-I Adhesive Behavior of Fiber Metal Laminate (섬유금속적층판의 모드 I 접합 거동 예측을 위한 Levenberg-Marquardt 기법 기반의 역해석 기법에 관한 수치적 연구)

  • Park, Eu-Tteum;Lee, Youngheon;Kim, Jeong;Kang, Beom-Soo;Song, Woojin
    • Composites Research
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    • v.31 no.5
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    • pp.177-185
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    • 2018
  • Fiber metal laminate (FML) is a type of hybrid composites which consist of metallic and fiber-reinforced plastic sheets. As the FML has a drawback of the delamination that is a failure of the interfacial adhesive layer, the nominal stresses and the energy release rates should be determined to identify the delamination behavior. However, it is difficult to derive the nominal stresses and the energy release rates since the operating temperature of the equipment is restricted. For this reason, the objective of this paper is to predict the mode-I nominal stress and the mode-I energy release rate of the adhesive layer using the inverse analysis based on the Levenberg-Marquardt method. First, the mode-I nominal stress was assumed as the tensile strength of the adhesive layer, and the mode-I energy release rate was obtained from the double cantilever beam test. Next, the finite element method was applied to predict the mode-I delamination behavior. Finally, the mode-I nominal stress and the mode-I energy release rate were predicted by the inverse analysis. In addition, the convergence of the parameters was validated by trying to input two cases of the initial parameters. Consequently, it is noted that the inverse analysis can predict the mode-I delamination behavior, and the two input parameters were converged to similar values.

Mechanical Properties of Epoxy Paint using Oxidized Graphene Nanoplatelet as a Reinforcement (산화 그래핀 나노플레이트릿을 강화제로 사용한 에폭시 도료의 역학적 특성)

  • Seo, Won-Woo;Kim, Gyu-Yong;Yoon, Min-Ho;Lee, Bo-Kyeong;Nam, Jeong-Soo
    • Journal of the Korea Institute of Building Construction
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    • v.17 no.5
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    • pp.465-471
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    • 2017
  • In this study, oxidized graphene nanoplatelet(GO) was prepared by oxidizing graphene nanoplatelet(GNP) with nitric acid in order to solve the problem of dispersion of GNP, one of nano materials. The surface chemical composition of the prepared GO was analyzed by fourier transform infrared spectroscopy(FT-IR) before incorporation into the epoxy paint, and the dispersibility in the solvent was confirmed. Meanwhile, GNP/Epoxy and GO/Epoxy paint were prepared by mixing GNP, GO with 0.1, 0.3, 0.5 and 1.0wt.% in epoxy paint and the mechanical properties were evaluated. As a result, GNP/Epoxy and GO/Epoxy paints showed better mechanical properties than Neat Epoxy which did not incorporate GNP, GO. Especially, when 0.3wt.% of GO was incorporated into epoxy resin, it showed higher tensile strength than Neat Epoxy. It was confirmed that acid treatment of GNP was effective in improving the mechanical properties of epoxy paint.

Magmatism and Metamorphism of the Proterozoic in the Northeastern Part of Korea : Petrogenetic and Geochemical Characteristics of the Okbang Amphibolites (한국(韓國) 북동부지역(北東部地域) 원생대(原生代)의 화성활동(火成活動)과 변성작용(變成作用) : 옥방(玉房) 앰피볼라이트의 암석성인(岩石成因)과 지구화학적(地球化學的) 특징(特徵))

  • Chang, Ho-Wan;Lee, Dong-Hwa;Park, Kye-Hun
    • Economic and Environmental Geology
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    • v.26 no.4
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    • pp.489-498
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    • 1993
  • The Okbang amphibolites occurring as sill-shaped bodies within the Precambrian Wonnam Group have been studied in terms of geochemical characteristics for their tectonomagmatic environments. The amphibolites fall in the ortho-amphibolite fields in Ni and Cr versus Cu diagrams. They belong to subalkaline and tholeiitic series in total alkali versus silica and ternary AFM diagrams, respectively. They show the compositional variation corresponding to the differentiation trend of tholeiitic suites. In discrimination diagrams using high-field-strength elements such as Ti, Zr, Nb and Y, the amphibolites show geochemical affinities to both of volcanic-arc tholeiites and normal (depleted) mid-oceanic ridge tholeiites. The REE patterns of the amphibolites are nearly flat and extremely similar to those of back-arc tholeiites. $(La/Yb)_{CN}$ ratios vary from 0.89 to 2.02 with an average value of 1.23. Such low light-REE abundances in the amphibolites suggest that they were derived from the upper mantle source depleted in these elements. In view of geochemical characteristics showing strong enrichments of incompatible elements such as K and Rb, distinctive negative Nb anomalies, depletions of light-REE observed also in normal (depleted) mid-oceanic ridge tholeiites, and unfractionated immobile elements such as Y and Yb, the tholeiitic magmas, from which the parent rocks of the amphibolites were formed, would be generated from a depleted upper mantle source and contaminated by continental crustal materials en route to surface. Tectonomagmatic environment for the amphibolites can be assumed to be continental back-arc basin.

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A Study on the Evaluation of Greening Level of Domestic Public Libraries (국내 공공도서관의 녹색화 수준 평가 연구)

  • Noh, Younghee
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.28 no.2
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    • pp.5-34
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    • 2017
  • This study measured greening level on the 978 public libraries nationwide, making and distributing questionnaires based on green library evaluation indicators developed to measure the greening level of public libraries. As a result of analyzing the averages by evaluation area, among the green library evaluation areas, the whole average of the library resources was the highest by 1.93, and followed by land use and traffic 1.81, indoor environment 1.30, management of water circulation 1.20, etc. The greening evaluation area which shows the best strength in the surveyed public libraries, was the area of the library resource, and it turned out that it use spaces effectively like effective use of the entire area, effectiveness of conservation of books, use and management of eco-friendly products etc., or use the equipments in eco-friendly way which are purchased or used frequently in the libraries, and, as for the land use and traffic area, most of the libraries had bicycle racks, and chose the location of the libraries, considering accessibility to public transportation and a distance between central urban area and libraries. Also, it turns out that, in the area of materials and resources, most of the libraries were equipped with hand dryers and rolling towels and maintained the eco-friendly view.

Mechanical Properties of The CO2 Free Vacuum Carburized in SCM415H (CO2 무 배출 침탄 열처리된 SCM415H 소재의 기계적 성질)

  • Byun, Jae-Hyuk;Ro, Seung-Hoon;Lee, Jong-Hyung;Lee, Chang-Hun;Yang, Seong-Hyeon
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.36 no.9
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    • pp.971-978
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    • 2012
  • Vacuum carburizing is supposed to be the superior process to the gas carburizing. However, the vacuum carburizing has the stage in which hydrocarbon gas is supplied into the furnace to be pyrolysis, and consequently the stable heat treatment is hard to achieve due to the soot from the hydrocarbon pyrolysis. Recently, many studies have been made which utilize acetylene gas to overcome this defects. In this paper, the carburizing and the diffusion periods have been selected based on the Harris experimental formula, and the mechanical properties of the vacuum carburized specimen have been compared with those of the gas carburized SCM415H specimen to identify the feasibility of the $CO_2$ free vacuum carburizing process. The result showed that the vacuum carburized materials used have no oxidization of the grain boundaries, and show the 29.8% higher effective hardness depth and the acceptable tensile strength.

Quality Attributes of Frozen Dough Mixed with Milk Protein-Polysaccharide Materials (우유단백질과 다당류 혼합물을 첨가한 냉동반죽의 품질 특성)

  • Shon, Jin-Han;Jeung, Jeung-Il;Oh, Deog-Hwan;Kim, Jai-Moung;Eun, Jong-Bang
    • Food Science and Preservation
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    • v.16 no.4
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    • pp.518-524
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    • 2009
  • The quality attributes of frozen dough mixed with milk proteins (casein: C and whey protein: W) and polysaccharides (sodium alginate: A and ${\kappa}-carrageenan:$ K), and with 1.6% (w/w) wheat flour, were investigated to improve the quality of dough. Addition of milk protein-polysaccharide mixtures increased water absorption, as assessed by farinography, compared with control material. Dough prepared with CA and WA mixtures showed longer development times and increased valorimeter values compared with control samples. However, addition of milk protein-polysaccharide mixtures decreased dough stability, elasticity, and strength. Gelatinization temperature and the temperature at maximum viscosity, as measured by amylography, increased on addition of milk protein-polysaccharide mixtures, but the maximum viscosity decreased compared with control samples. The control showed a lower dough volume than did dough prepared with CA and WA mixtures. These results indicate that addition of milk protein-polysaccharide mixtures, especially CA and WA, improved the quality of frozen dough,and could be useful to prevent bread becoming stale.