• Bulletin of the Korean Chemical Society
• /
• v.26 no.5
• /
• pp.729-734
• /
• 2005

A sensitive and selective method for quantitation of sofalcone and its active metabolite in human plasma has been established using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI/MS/MS). Plasma samples were transferred into 96-well plate using an automated sample handling system and spiked with 10 $\mu$L of 2 $\mu$g/mL $d_3$-sofalcone and $d_3$-sofalcone metabolite solutions (internal standard), respectively. After adding 0.5 mL of acetonitrile to the 96-well plate, the plasma samples were then vortexed for 30 sec. After centrifugation, the supernatant was transferred into another 96-well plate and completely evaporated at 40 ${^{\circ}C}$ under a stream of nitrogen. Dry residues were reconstituted with mobile phase and were injected into a $C_{18}$ reversed-phase column. The limit of quantitation of sofalcone and its metabolite was 2 ng/mL, using a sample volume of 0.2 mL for analysis. The reproducibility of the method was evaluated by analyzing 10 replicates over the concentration range of 2 ng/mL to 1000 ng/mL. The validation experiments of the method have shown that the assay has good precision and accuracy. Sofalcone and its metabolite produced a protonated precursor ion ([M+H]$^+$) of m/z 451 and 453, and a corresponding product ion of m/z 315 and 317, respectively. Internal standard ($d_3$-sofalcone and $d_3$-sofalcone metabolite) produced a protonated precursor ion ([M+H]$^+$) of m/z 454 and 456 and a corresponding product ion of m/z 315 and 317, respectively. The method has been successfully applied to a pharmacokinetic study of sofalcone and its active metabolite in human plasma.

• Korean Journal of Environmental Biology
• /
• v.35 no.1
• /
• pp.57-63
• /
• 2017

This study was conducted to determined the status and geographical distribution of the alien invasive Red-eared slider (Trachemys scripta elegans) turtle on Jeju Island. We found thirty-two Red-eared slider habitats including twenty-five ponds, five agricultural reservoirs, a puddle and a stream. Among those, thirteen sites are newly determined habitats of the turtle. The remaining nineteen are previously reported. However, we could not find any turtles at nine sites, which were documented as turtle habitats in earlier reports. A total of one hundred thirty-three turtles were observed. Among them, we determined that thirty-nine were juvenile turtles, found in nineteen different habitats, indicating estimating that Red-eared sliders produced their progeny in the wild of this island. Because of geographical isolation by the ocean, no freshwater turtle had been found until $19^{th}$ Century. Therefore, the increased number of finding sites and Red-eared sliders indicate the possibility of human release of their pets or for other purposes, and natural propagation in the wild on Jeju Island. Our findings will be useful for management planning to deal with this invasive species, and implementation of a conservation program for native wildlife on Jeju Island.

• Journal of Korean Society of Transportation
• /
• v.33 no.3
• /
• pp.256-267
• /
• 2015

The intelligent transportation systems allow us to have valuable opportunities for collecting wide-area coverage traffic data. The significant efforts have been made in many countries to provide the reliable traffic conditions information such as travel time. This study analyzes the impacts of the fog weather conditions on the traffic stream. Also, a strategy for predicting the long-term traffic speeds is developed under foggy weather conditions. The results show that the average of speed reductions are 2.92kph and 5.36kph under the slight and heavy fog respectively. The best prediction performance is achieved when the previous 45 pattern cases data is used, and the 14.11% of mean absolute percentage error(MAPE) is obtained. The outcomes of this study support the development of more reliable traffic information for providing advanced traffic information service.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.17 no.2
• /
• pp.109-123
• /
• 2014

Kaloula borealis is the species of Amphibia which belongs to Kaloula genus and it is the only species inhabiting in Korea. The population size and habitat of Kaloula borealis have been significantly decreased on a national scale due to the diversified developments and the uses of agricultural pesticides. Accordingly, the Ministry of Environment has designated and managed them as the class II of endangered species, in accordance with "Endangered Species Protection and Management Act"; however, a particular study focused on the ecological restoration of Kaloula borealis is desperately needed to prevent their extinction. This study was conducted to propose the HSI (Habit Suitability Index) of Kaloula borealis based on literature survey on ecology and habitats of Kaloula borealis, as well as their HSI. Factors to be investigated in HSI include: space, feed, cover, water(breeding) and threatening factors and the variables of each factor were also proposed. The distance from wetland, grassland, farm, stream and rice paddy, as well as the altitude of spawning pond were proposed as the variables of space, whereas the bed structure of forest and low-rise grassland were proposed as the variables of feeding. The variables of water (breeding) include the area of permanent and temporary wetlands, coverage of emerged pants (ratio of open water), water depth, water temperature, water quality, pH level, etc., whereas the presence of predator, distance from street and pollutants were proposed as the variables of threatening factor. The sub-standards by HSI factor of Kaloula borealis have been drawn from in-depth consultation with experts and based on this, the final HSI of Kaloula borealis was developed.

• Journal of Korea Spatial Information System Society
• /
• v.11 no.1
• /
• pp.63-70
• /
• 2009

3D GIS(Geographic Information System) processes, analyzes and presents various real-world 3D phenomena by building 3D spatial information of real-world terrain, facilities, etc., and working with visualization technique such as VR(Virtual Reality). It can be applied to such areas as urban management system, traffic information system, environment management system, disaster management system, ocean management system, etc,. In this paper, we propose video visualization technology based on 3D geographic information to provide effectively real-time information in 3D geographic information system and also present methods for establishing 3D building information data. The proposed video visualization system can provide real-time video information based on 3D geographic information by projecting real-time video stream from network video camera onto 3D geographic objects and applying texture-mapping of video frames onto terrain, facilities, etc.. In this paper, we developed sem i-automatic DBM(Digital Building Model) building technique using both aerial im age and LiDAR data for 3D Projective Texture Mapping. 3D geographic information system currently provide static visualization information and the proposed method can replace previous static visualization information with real video information. The proposed method can be used in location-based decision-making system by providing real-time visualization information, and moreover, it can be used to provide intelligent context-aware service based on geographic information.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.36 no.4
• /
• pp.705-713
• /
• 2016

For the soft ground construction, the factors not considered in the design stage occurs in the construction stage so that they cause the increase of the construction cost due to the structural stability and the design change. The subject of the study is the construction section of the industrial complex access road made in the Ochang region of Chungcheongbuk-do. The study is concerned with selecting the soft ground handling method such as the replacement method using rock debris and the surcharge reflecting the service load as the soft ground handling measure and analyzing the effect of reducing the construction cost with the stability of structures and the reduction of the construction period. The soft ground in the study section consists of sandy and cohesive soil and is 2.4m to 5.5m deep. It is distributed unevenly between the 1.5m to 5.9m stratums under the ground surface. Settlement is not serious, but the future uneven settlement and difference are expected so that the future settlement behavior is estimated by analyzing the site measurement results after the soft ground treatment. Moreover, in consideration of the regional characteristics and economic efficiency, soil with good quality is replaced with rock debris as the replacement material so that 29% of the construction cost is reduced due to the increase of stability and the reduction of duration. If the estimation of the dispersion of the pore water pressure within the dam body and the change of the underground water level and the relation of the actually measured soft ground with consolidation is studied further on the basis of the study, it is expected that the behavior of the soft ground will be correctly estimated in various site conditions.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.7
• /
• pp.249-256
• /
• 2017

Luxury goods products have a steady stream of consumers, and the latest trend is the sell and purchase markets. The consumers age groups also vary widely. This research examined the mediating effect of self-construal of the relationship between brand consistency and intention to purchase luxury fashion products. The analysis classified the brand consistency of luxury fashion products as social, actual, and the deal. First, the order of consistency that had an effect on self-construal appeared in the order of social cohesion, actual coincidence, and ideal coincidence. Second, an analysis of mediating effect of self-construal showed that only self-construal appeared to have a partial mediating effect on the relationship between the intention to purchase and the actual and ideal consistency. Such result can be interpreted as that when purchasing luxury fashion products, consumers have a tendency to desire that the brand would express their personal image and that it would match the perception they had of the brand, rather than a tendency to perceive the brand as a tool to help them perform their desired social role. These results suggest that consumers who consume the brand desire to have their personalities and subjective environmental conditions well expressed.

• KIPS Transactions on Software and Data Engineering
• /
• v.5 no.4
• /
• pp.171-180
• /
• 2016

As social networking services such as twitter become increasingly popular, data streams are widely prevalent these days. In order to search data accumulated from data streams efficiently, the use of an index structure is essential. In this paper, we propose an update-efficient, disk-based inverted index structure for efficient keyword search on data streams. When new data arrive at the data stream, the index needs to be updated to incorporate the new data. The traditional inverted index is very inefficient to update in terms of disk I/O, because all index data stored in the disk need to be read and written to the disk each time the index is updated. To solve this problem, we divide the whole inverted index into a sequence of inverted indices with exponentially increasing size. When new data arrives, it is first inserted into the smallest index and, later, the small indices are merged with the larger indices, which leads to a small amortize update cost for each new data. Furthermore, when indices stored in the disk are merged with each other, we minimize the disk I/O cost incurred for the merge operation, resulting in an even smaller update cost. Through various experiments, we compare the update efficiency of the proposed index structure with the previous one, and show the performance advantage of the proposed structure in terms of the update cost.

• Journal of Broadcast Engineering
• /
• v.16 no.5
• /
• pp.750-761
• /
• 2011

Currently, 3DTV technologies are being developed as the future services of the HD digital broadcast environment. As one of the various research topics to apply 3DTV technologies to the conventional broadcasting network, methods to configure stereoscopic videos are being studied. In this paper, we proposed a method to broadcast high quality stereoscopic videos based on analysis of a method to add a stereoscopic descriptor to the PMT of MPEG-2 transport streams and a method to transmit stereoscopic videos by the expansion of MPEG-C part 3 which are from precedent studies. The proposed technique maintains compatibility with conventional MPEG-2 transport streams by showing only reference video for models that do not support 3D broadcasting. Therefore, the compatibility between conventional broadcasting and stereoscopic videos should make this method useful when activating 3D services in the communications and broadcasting area

• Information Systems Review
• /
• v.7 no.1
• /
• pp.275-295
• /
• 2005

Changes in business environment caused by globalization of the world economy and the beginning of the knowledge society forced hospitals to equip with tools for the enhanced competitiveness. In other words, hospitals must aim three targets such as acquisition of advanced medical skills and equipments, improvement of service level for patients, and achievement of superior managerial performance simultaneously. This study has been done to suggest a way to reduce the possibility of hospital bill claim reduction as an alternative for the achievement of superior managerial performance. If the reduction rate of hospital bill claim is high, it will put negative impact on the hospital's revenue stream and hospital's reliability. Thus, if they want to stay competitive, hospitals need to device ways to cut the reduction rate as much as possible. In this study, a prototype system has been developed and implemented to check the possibility to cut the reduction rate through deep analysis of causes of reduction. The prototype first developed utilizing data mining techniques and the relation rules algorithm. Then the prototype was tested its performance using the D hospital's live data.