• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.27 no.3
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• pp.137-145
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• 2024

Stunting, a condition characterized by impaired growth and development in children, remains a major public health concern worldwide. Over the past decade, emerging evidence has shed light on the potential role of gut microbiota modulation in stunting. Gut microbiota dysbiosis has been linked to impaired nutrient absorption, chronic inflammation, altered short-chain fatty acid production, and perturbed hormonal and signaling pathways, all of which may hinder optimal growth in children. This review aims to provide a comprehensive analysis of existing research exploring the bidirectional relationship between stunting and the gut microbiota. Although stunting can alter the gut microbial community, microbiota dysbiosis may exacerbate it, forming a vicious cycle that sustains the condition. The need for effective preventive and therapeutic strategies targeting the gut microbiota to combat stunting is also discussed. Nutritional interventions, probiotics, and prebiotics are among the most promising approaches to modulate the gut microbiota and potentially ameliorate stunting outcomes. Ultimately, a better understanding of the gut microbiota-stunting nexus is vital for guiding evidence-based interventions that can improve the growth and development trajectory of children worldwide, making substantial strides toward reducing the burden of stunting in vulnerable populations.

• Archives of Pharmacal Research
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• v.27 no.4
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• pp.361-370
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• 2004

The discovery of insulin receptor substrate (IRS) proteins and their role to link cell surface receptors to the intracellular signaling cascades is a key step to understanding insulin and insulin-like growth factor (IGF) action. Moreover, IRS-proteins coordinate signals from the insulin and IGF receptor tyrosine kinases with those generated by proinflammatory cytokines and nutrients. The IRS2-branch of the insulin/IGF signaling cascade has an important role in both peripheral insulin response and pancreatic $\beta$-cell growth and function. Dysregulation of IRS2 signaling in mice causes the failure of compensatory hyperinsulinemia during peripheral insulin resistance. IRS protein signaling is down regulated by serine phosphorylation or protea-some-mediated degradation, which might be an important mechanism of insulin resistance during acute injury and infection, or chronic stress associated with aging or obesity. Under-standing the regulation and signaling by IRS1 and IRS2 in cell growth, metabolism and survival will reveal new strategies to prevent or cure diabetes and other metabolic diseases.

• BMB Reports
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• v.47 no.7
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• pp.405-410
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• 2014

ZBTB3 belongs to the Zinc finger and BTB/POZ domain containing transcription factor family; however, its biological role has rarely been studied. We demonstrate for the first time, to our knowledge, that ZBTB3 is an essential factor for cancer cell growth via the regulation of the ROS detoxification pathway. Suppression of ZBTB3 using two different short hairpin RNAs in human melanoma, lung carcinoma, and breast carcinoma results in diminished cell growth. In addition, we found that suppression of ZBTB3 activates a caspase cascade, including caspase-9, -3, and PARP leading to cellular apoptosis, resulting from failed ROS detoxification. We identified that ZBTB3 plays an important role in the gene expression of ROS detoxification enzymes. Our results reveal that ZBTB3 may play a critical role in cancer cell growth via the ROS detoxification system. Therefore, therapeutic strategies that target ZBTB3 could be used in selective cancer treatments.

• Korea Journal of Hospital Management
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• v.18 no.2
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• pp.127-152
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• 2013

The purpose of this study was to investigate the effect of balancing, coordinating and learning strategy on performance of private university hospitals. We think that the study will contribute to establish effective management strategy of private university hospitals. Data were collected from 69 private university hospitals. We measured balancing, coordinating and learning strategy, and perceived performance of the hospital by using 5-point Likert scale. Upper-grade general hospitals were significantly higher rate of growth and profitability than others. However, general hospitals were higher level in perceived performance than upper-grade general hospitals. Hospitals located in Seoul were significantly higher growth rate than those in other regions. Large-scale hospitals were significantly higher rate of growth and profitability than small hospitals. Qualitative performance did not different in any hospital characteristics. Growth of hospitals were significantly influenced from business strategies: selective strategy, formal coordinating strategy, and external learning strategy. Profitability of hospitals were also significantly influenced from business strategies: selective strategy, adaptive strategy, and external learning strategy. Subjective performance of hospitals were significantly influenced from external learning strategy. There were no factors that are significantly influencing on qualitative performance of hospital. To have successful performance in the competitive environment, it is recommended that private university hospitals should have to establish management strategy such as balancing, coordinating, and learning strategy.

• Proceedings of the Korean Aquaculture Society Conference
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• 2005.05a
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• pp.61-61
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• 2005

• Journal of the Korean Society of Environmental Restoration Technology
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• v.13 no.2
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• pp.52-62
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• 2010

This study was carried out in the Tropical Plant Resources Research Center of Korea National Arboretum to determine the optimum edaphic environment for the growth of tropical and subtropical plants. The physicochemical properties of artificial substrates and the growth characteristics of tropical and subtropical plants were investigated. Subtropical plants exhibited a high growth rate when cultivated in a substrate of Dry Zone that had physical properties similar to those of arid native soil. Mediterranean plants showed a low growth rate when grown in a substrate of Subtropical Zone that required changes in acidity. The substrate of Tropical Zone had high organic matter and mineral contents and therefore had good physical properties:this substrate has a good environment for the stimulation of the growth of tropical plants. Our results indicate that the chemical properties such as pH and mineral contents of most artificial substrates need to be more urgently improved than their physical properties in order to ensure better growth of tropical and subtropical plants. Initial management strategies for the construction of new tropical greenhouses were formulated, and data from monitoring studies will be continuously gathered and incorporated in the manual to keep it updated.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.1208-1211
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• 2009

This study compares and contrasts the market size, growth rates, business cycles, supply and demand of the of the FPD and Photovoltaic (PV) industries. Using historic, market metric, cycle, capacity and other comparative analysis techniques, implications for implementing effective business strategies are formed.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.19 no.4
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• pp.493-502
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• 2012

Purpose: The purpose of this study was to identify the influence of hope, core beliefs, and social support on the posttraumatic growth of mothers with chronically ill children. Methods: In this study, 94 mothers who gave written consent completed the questionnaires between July 21 and July 31, 2012 when they visited a university hospital in Seoul, Korea. Data were analyzed using t-test, ANOVA, Pearson correlation coefficient and stepwise multiple regression. Results: Hope, core belief and social support had positive correlations with posttraumatic growth. Models including these variables explained 64.8% (F=55.276, p<.001) of the variance for posttraumatic growth. Hope (${\beta}$=.441, p<.001) was the most influential factor. Conclusion: The findings demonstrate that it is essential for nurses to mediate and facilitate posttraumatic growth of mothers caring for chronically ill children. Furthermore, there is an need to develop and implement new strategies in clinical practice that will result in improvements in posttraumatic growth.

• Fisheries and Aquatic Sciences
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• v.11 no.1
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• pp.15-22
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• 2008

Excessive growth of phytoplankton is a common and severe problem in intensively farmed pangasiid catfish (Pangasius hypophthalmus) culture ponds. It can lead to cyanobacterial blooms, reduced fish growth, bad-tasting fish flesh, and lower market demand. To investigate how to manage undesirable phytoplankton growth, we evaluated three stocking strategies in nine rural fishponds (0.020-0.022 ha) owned by various farmers: a pangasiid catfish mono culture (treatment 1, $T_1$), and pangasiid catfish-silver carp (Hypophthalmichthys molitrix) polycultures at two stocking ratios of 1:1 (treatment 2, $T_2$) and 2:1 (treatment 3, $T_3$). The total density of all ponds was approximately 30,000 fishes/ha. Monoculture ($T_1$) resulted in significantly higher (p < 0.05) nutrient levels (nitrate and phosphate) in ponds than did polyculture ($T_2$ and $T_3$). Nutrient loads increased with culture time, resulting in increased growth of phytoplankton, including Cyanophyceae (9 genera), Chlorophyceae (15 genera), Bacillariophyceae (8 genera), and Euglenophyceae (3 genera). The introduction of silver carp as a co-species helped to regulate phytoplankton growth and to improve the water quality of pangasiid catfish culture ponds.

• Journal of the Korean association of regional geographers
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• v.14 no.5
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• pp.480-491
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• 2008

Recent globalization and de-industrialization have caused intensive competition among places; hence, cities worldwide are pursuing regeneration and enhanced competitiveness through cultural strategies. Focusing on the cultural strategies of local cities in Japan, this paper reveals that the concept of "being-a-region" is key to cultural strategies, and explores what logic is inherent in such regional developments. Since the period of rapid economic growth, Japanese local cities have played the role of "Furusato(home) for Japanese." With the recent decentralization, "being-a-region" is now emerging as a powerful discourse for the cultural strategies of local cities. This idea of "being-a-region" can be largely defined as a region's special character or even an existential sense of place, but in fact it is political relationships among agencies that define the region. "Being a region" in Japan appears to extend to "being a nation." Thus, it would be necessary to focus on the power relationships that surround the concept of "being a region" when we deal with the meaning of region in relationships to cultural strategies of local cities.