• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.5
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• pp.1045-1051
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• 2005

We developed an orofacial pains diagnosis/therapy system which can enlarge a therapy effect through a new stimulation. Contrary to its established method, this therapy system(DDTS-1) is a treating method which absorbs a surplus ion charge- the cause of an outbreak of a pain-of the human body using a capacitor. Absorbing a surplus ion charge of the human body with effect, it obtained optimal parameters which is control signal to control charging/discharging a capacitor to be 6Hz, and capacitance to be $0.1\~0.33{\mu}F.$ Through clinical demonstration, experimented on among patients-namely dental pain patients, joint disorders patients, and trigeminal neuralgia patients to verification of system. In result, an EAST stimulater had a very low change of abnormal potential against normal potential before/after being placed under medical care. DDTS-1 showed obvious differences that two potentials are one and the same potential or one potential is similar to the other one. DDTS-1 comparing with EAST showed the remedial value of the comparative advantage in all the medical treatment of pains. Therefore, stimulation of DDTS-1 is more effective than the existing electric stimulation. We verified its validity of ion charge absorption in the human body using capacitor which presented the present thesis. That is, we verified theoretical adequacy of control action in a pain, and its efficiency as well as confidence.

• Tuberculosis and Respiratory Diseases
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• v.40 no.6
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• pp.683-693
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• 1993

Background: During movement the major inputs to nervous system come from firstly the muscle and joint to maintain posture and motion and secondly the chemoreceptors and baroreceptors to adjust the cardiovascular and respiratory function. Their complex relationships are generally studied for many years but the direct relation between the joint and respiratory system is not studied thoroughly until now. So this experiment was performed to determine whether the natural movement of knee joint can cause the enhancement of respiratory function by observation of the changes of respiratory rate, phrenic nerve activity and inspiratory neuron activity during the stimulation of knee joint in cat anesthetized with $\alpha$-chloralose. Method: Twenty six male adult cats were used and the extracelluar recording using bipolar platinum electrode and carbon filament electrode was done to record the changes in the activities of phrenic nerve and inspiratory neuron movement of knee joint, injection of chemicals into the joint cavity and electrical stimulation of articular nerve were done. Results: The 60 Hz. could not but 120 Hz. flexion-extension movement of knee joint increased respiratory rate(R.R.), tidal neural activity(TNA) and minute neural activity(MNA). Intra-articular injection of lactate could not increase R.R. but significantly increase TNA and MNA which represented the enhanced respiratory function. Injection of potassium chloride showed similar effects with the case of lactate but the duration of effect was shorter. The electrical stimulation of medial articular nerve with IV strength which could activate only group I and II afferents showed increased TNA and MNA during stimulation but 20 V stimulation which could activate all the afferents increased all the respiratory parameters. The changes of inspiratory neuron activity by knee joint stimulation was similar to that of phrenic nerve. Conclusion: The respiratory center could be directly stimulated by the activation of group I and II articular afferents and it seemed that the magnitude of the respiratory center enhancement is proportional to the amount of sensory information from the knee joint. These facts might suggest that the respiratory function could be enhanced even by the normal movement of knee joint.

• Journal of Haehwa Medicine
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• v.8 no.2
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• pp.317-327
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• 2000

Through the study about Che-Qi-Jung(諸氣證) concerned with phenomenon of stress, we concluded as fallow. 1. Stressors are recognized three parts, internal cause, external cause, non-interexternal cause, in the oriental medicine. And the reaction of the body about stressors, was expressed change of Qi(氣). 2. The vascular system and autonomic nervous system are tensed or relexed. Because the etiology of Yuk-Em(六淫), Chil-Jeong(七情) make lose up and down, in and out, circulation of Gi(氣). The symtom caused with stress are explained, divided into Chil-Qi(七氣), Gu-Qi(九氣), Joong-Qi(中氣), Qi-Tong(氣痛), Qi-Yuk(氣逆), Qi-Wool(氣鬱). 3. The symtom of Chil-Qi is recognized into psycholoQical stress and Mae-Haek-Qi(梅核氣). The symtom of Gu-Qi is composed of Chil-Qi and Han(寒), Youl(熱), Ro(勞). 4. The symtoms of Qi-Yuk and Joong-Qi are caused by the ascent of Hwa-Qi(火氣). And Hwa-Qi is made by rage and depression. Qi-Yuk is chronic symtom that the ascent of Hwa-Qi is made by out of function in up and down mechanism of Qi. Joong-Qi is acute symtom that patholoQical state of Qi-Yuk take place for a while by sudden psycholoQical shock. 5. The symtom of Qi-Wool is loss of funtion made by depressed state in physioloQical mechanism, and Qi-Wool is observed in depressive psychosis and hypochondriasis and psychogenic. 6. The symtom of Qi-Tong is the pain caused by interference of circulation of Qi-Hyul(氣血). PsycholoQical stimulation such as rage and depression, tense autonomic nervous system. This make convulsion in gastro-intestine or vascular circuluation or abdominal muscles, and the pain is caused by convulsion.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.671-676
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• 2005

In this study, we investigated the antioxidant effect of extract from Monascus pillosus, on the human wild-type p53 and p21 expressing A549 lung epithelial cell line and MCF-7 mammary adenocarcinoma cell line stimulated by NO. $P21^{waf/cip1}$ was identified as a gene induced in senescent cells. It is a cyclin-dependent kinase inhibitor and has been shown to cause cell cycle arrest and apoptosis. While p53-regulated stimulation of p21 appears to be central for the permanent growth-arrest, the role of p21 in p53-triggered cell death is unclear. Low dose of sodium nitroprusside (SNP) induced the development of senescence associated with increased expression of p53 and p21 in A549 cells. Inhibition of p21 transactivating activity requires high level correlates with the amount of p53 necessary to cause cell death. Association of p21 and p53 results in inhibition of p21-stimulated transcription. This requires a higher p53 level than is necessary for transcriptional activation of endogenous p53-responsive gene but correlates well with the level of p53 necessary to cause cell death. Exposure to W-1 inhibited oxidative stresses-induced senescence-like arrest, resulting in a significant reduction in p53 and p21 steady state levels. These results suggest that p53 and p21 play a central role in the onset of senescence. Thus, it is important to emphasize control of oxidative balance in tumor prevention and aging.

• Journal of Haehwa Medicine
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• v.16 no.1
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• pp.1-7
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• 2007

Tinnitus is noise from ear or head without any external sound stimulation and can cause hearing difficulties, psychologenic disturbances or many difficulties in everyday life. the etiology has yet been discussed and the management is also very difficult. Sensorineural hearing loss is defined as a sudden hearing impairment which was develope over a period of hours to days. I report one tinnitus case which accompanied with sudden sensorineural hearing loss. In the early and acute stage which judged as Dam-Wha, herbal treatment with Tong-myeong-ri-gi-tang was efficacious on the tinnitus. In the convalescent stage and judged as Sin-heo, herbal treatment with Ja-sin-tong-i-tang was efficacious on the tinnitus that accompanied with sudden sensorineural hearing loss.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7261-7266
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• 2015

Breast cancer, the most common cancer in the women, is the leading cause of death. Necrotic signaling pathways will enable targeted therapeutic agents to eliminate apoptosis-resistant cancer cells. In the present study, the effect of shikonin on the induction of cell necroptosis or apoptosis was evaluated using the T-47D breast cancer cell line. The cell death modes, caspase-3 and 8 activities and the levels of reactive oxygen species (ROS) were assessed. Cell death mainly occurred through necroptosis. In the presence of Nec-1, caspase-3 mediated apoptosis was apparent in the shikonin treated cells. Shikonin stimulates ROS generation in the mitochondria of T-47D cells, which causes necroptosis or apoptosis. Induction of necroptosis, as a backup-programmed cell death pathway via ROS stimulation, offers a new strategy for the treatment of breast cancer.

• Journal of Dental Anesthesia and Pain Medicine
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• v.15 no.1
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• pp.35-37
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• 2015

Atypical facial pain (AFP) is a type of facial pain which does not fulfill any other diagnosis. It has several features such as no objective signs, no obvious explanation of the cause and poor response to treatments. We report a case of a female patient with AFP on the left maxillary area. The pain was increased by cold innocuous stimulation and thermography showed that the temperature on the painful area was significantly decreased. The pain was successfully alleviated by stellate ganglion block (SGB). Therefore, SGB can be effectively used to treat AFP.

• Proceedings of the KIPE Conference
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• 2001.10a
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• pp.475-479
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• 2001

Compensation characteristics or active filters based on voltage detection are investigated. These active filters act equivalently as a passive circuit so that they may not cause practical problems such as stimulation of resonance in the distribution lines. Thus, these active filters can be used as the general-purpose active filters. On the other hand, these active filters may have a possibility of the anti-resonance associated with the line inductance of the distribution lines. In this paper, the relationship between the anti-resonance and the control parameters of the proposed active filters is clarified. Some methods to avoid the problems due to the anti-resonance are investigated. Experimental results are included to confirm the validity of the investigation presented in this paper.

• Journal of Korean Physical Therapy Science
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• v.2 no.3
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• pp.727-738
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• 1995

Myofascial pain syndrome is one of the major cause of chronic pain and trigger point injection, stretching, spray and electrical therapy are often used in clinical situation for treatment of myofascial pain syndrome. Myofascial pain syndrome is characterzied by the existence of a hypersensitive region, called the trigger point in a muscle or in the connective tissue, together with palpable noble, stiffness, limitation of motion and referred pain when trigger point is stimulated. Physiologically, they represent a self-sustaining vicious cycle of pain-spasm-pain. The purpose of this study is to illustrate mechanisms of pain by stimulation of acupuncture and trigger point, to introduce clinic application of orient and western stimulative point (acupuncture, trigger point)for treatment of MPS(myofascial pain syndrome), to make physiotherapist use both stimulative points for treatment of MPS.

• The Korean Journal of Pain
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• v.11 no.1
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• pp.113-115
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• 1998

Dysmenorrhea(cyclic pain associated with menses) is a frequent disorder, with as many as 50% of young women experiencing the symptom, and up to 10% being unable to function normally for some time each month. The most recent theory of the cause of the pain of dysmenorrhea incriminates uterine ischemia and sensitization of uterine pain fibers resulting from excessive myometrial contractility after prostaglandin stimulation. We administered stellate ganglion block for the treatment of dysmenorrhea and had good results in two cases. From our experience, we recommend the stellate ganglion block may be an effective treatment for a dysmenorrhea.