• 핵의학기술
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• 제28권1호
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• pp.81-87
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• 2024

Purpose: CA 19-9 is the most widely used tumor marker for the diagnosis of digestive system tumor, especially pancreatic and biliary tract cancer. This study was conducted to improve the result value near reference range by comparing the reagents of CA 19-9 one step method and two step method. In addition, it was intended to establish a standard for selecting reagents. Material and Methods: 120 patients who visited the National Cancer Center in 2023 were selected as subjects for this study. The reagents used in the study were CA 19-9 IRMA kits (Shinjin, Korea) and three types of reagents were compared. Two step method reagent that is currently being used (A), one step method reagent (B) and two step method reagent improved by request (C) were compared and regression analysis was performed on their data. And we also performed recovery test, linearity test and hook effect test for each reagent. Result: There were 46 cases of reagent B in which the concentration value was lower than the result measured in reagent A that was previously used, and 77 cases of reagent C. As a result of regression analysis of reagents A, B, and C, the coefficients of determination of reagents A and B, reagents A and C, and reagents B and C were 0.653, 0.577, and 0.875. In the recovery rate test and the linearity test, the results of all reagents were good, and in the hook effect test, reagent B showed a hook effect at a low value. Conclusion: The improved reagent C appears to have been improved based on the concentration value of reagent B, which the manufacturer judged to be more stable at low concentrations. The hook effect in reagent B can be a fatal reason for disqualification when selecting reagents in general patient samples which high-concentration samples appear frequently. The first improved reagent C will be able to be used once it is confirmed that it has more stability for various concentration values.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1997년도 하계학술대회 논문집 D
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• pp.903-906
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• 1997

When large capacity generation stations that consist of several large units tend to pull out of step from main power system, stabilizing control scheme as emergency control for preventing loss of synchronism of the whole stations with the remaining system is devided into two steps that the first step is to perform on-line prediction for out-of-step and the next step is on-line calculation of the amount of generation shedding for the rest of generators to be in step when out of step is expected. This paper presents on-line prediction scheme for out-of-step based on P-$\delta$ curve estimation using real-time measurement and on-line calculation of generation shedding. The proposed stabilizing scheme was applied to case study of real power system and the results obtained by the method compare well with the results by simulation.

• 소성∙가공
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• 제12권5호
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• pp.449-456
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• 2003

Multi-step induction heating process was applied to the powder compact melting technique as a new heating process to achieve pinpoint accuracy, faster cycle time, repeatability, non-contact and energy-efficient heat in a minimal amount of time. The objective of this study is the establishment of the input data diagram of multi step induction heating process for automation of the fabrication process of 6061 Al foams with desired density. At first, proper induction coil was designed to obtain a uniform temperature distribution over the entire cross sectional area of specimen. By using this coil, foaming experiments were performed to investigate the multi-step induction heating conditions such as capacity, temperature and time conditions of each heating and holding step. On the basis of the obtained multi-step induction heating conditions, relationship between final heating temperature and fraction of porosity was investigated.

• Clinical and Experimental Reproductive Medicine
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• 제19권2호
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• pp.143-152
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• 1992

The present experiments were focussed to modify a short slow-cooling protocol used for freezing of early stage embryo(Testart et al., 1986) and also to apply the modified method for the cryopreservation of hamster oocytes with Zona or without. The protocol was modified by changing the 4-step equilibration into 1-step and the 1-step thawing into 2-step. The oocytes were added in 1.5M PROH and 0.1M Sucrose, seeded at $-7^{\circ}C$, slow cooled($0.3^{\circ}C$/min) to $-30^{\circ}C$ before plunging to $-196^{\circ}C$. The oocytes were thawed at $23-25^{\circ}C$ air(20sec/150sec) and/or 33-35 water(10sec). The survival of the frozen-thawed oocytes was determined by morphologic criteria and their fertilizing ability was also estimated by Sperm Penetration Assay(SPA) system(Chang et al, 1990) using fertile men semen sample. One-step equilibration showed slightly higher survival rate(83.9% vs. 71.0%) and fertilization rate(83.9% vs. 71.0%) compared with four-step(p>0.05). And two-step thawing(air & water exposing) of oocytes frozen after 1-step equilibration showed significantly higher survival rate(96.3%) than one-step thawing at air(85.2%) or water(65.0%) only(p<0.05). Therefore, by the modified method(l-step equilibration & 2-step thawing), Zona-intact(ZI) and Zona-free(ZF) oocytes were frozen and thawed. ZI-oocytes showed significantly higher survival rate(95.4%, 308/323 vs. 67.6%, 240/355) than ZF-oocytes(P<0.01). But the survival of ZF-oocytes was as high as ZI-oocytes in fourteen of twenty-four replicates. ZI-oocytes was also significantly higher fertilization rate($92.4{\pm}8.9%$ vs. $63.7{\pm}18.5%$) and higher mean number of penetrated sperm($6.2{\pm}4.2$ vs. $3.9{\\pm}3.3$) than ZF-oocytes, but not higher than control(fresh oocytes;$99.3{\pm}2.4%$, $8.4{\pm}4.2$)(P<0.001). Conclusively, this modified method will contribute to freeze effectively the hamster oocytes for simplifing of the logical consideration of performing SPA and also to freeze the human and other animal oocytes.

• Journal of Power Electronics
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• 제15권2호
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• pp.487-496
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• 2015

In order to ensure that photovoltaic (PV) systems work at the maximum power point (MPP) and maximize the economic benefits, maximum power point tracking (MPPT) techniques are normally applied to these systems. One of the most widely applied MPPT methods is the incremental conductance (INC) method. However, the choice of the step size still remains controversial. This paper presents an improved variable step size INC MPPT algorithm that uses four different step sizes. This method has the advantages of INC but with the ability to validly adjust the step size to adapt to changes of the PV's power curve. The presented algorithm also simultaneously achieves increased rapidity and accuracy when compared with the conventional fixed step size INC MPPT algorithm. In addition, the theoretical derivation and specific applications of the proposed algorithm are presented here. This method is validated by simulation and experimental results.

• 한국의류산업학회지
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• 제11권6호
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• pp.857-866
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• 2009

The objective of this study was to design a fashion storytelling method, which is a strategic instrument for constructing a fashion show with artistry and popularity, based on the principle and structure of storytelling. In order to understand the concept and principle of storytelling composed of story and telling and to introduce storytelling into fashion shows, we associated fashion design with the substance of a story, a show with the form of telling, and a fashion show with storytelling. Based on these associations, we analyzed the relationship between fashion show and storytelling and developed basic elements and structure necessary to design a fashion storytelling method. Through this study, we designed a fashion storytelling method with five steps, which are story planning, story development, fashion show structure design, fashion show production, and fashion show execution. These steps were again classified into contents setting step, structure design step, and expression step. The contents setting step included story planning and development for creating stories, and the structure design step means the design of fashion show structure that adds telling to the stories. Lastly, the expression step included fashion show production and execution that forms a storytelling by combining the stories and the telling.

• Nuclear Engineering and Technology
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• 제43권6호
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• pp.531-546
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• 2011

The backward differentiation formula (BDF) method is applied to a three-dimensional reactor kinetics calculation for efficient yet accurate transient analysis with adaptive time step control. The coarse mesh finite difference (CMFD) formulation is used for an efficient implementation of the BDF method that does not require excessive memory to store old information from previous time steps. An iterative scheme to update the nodal coupling coefficients through higher order local nodal solutions is established in order to make it possible to store only node average fluxes of the previous five time points. An adaptive time step control method is derived using two order solutions, the fifth and the fourth order BDF solutions, which provide an estimate of the solution error at the current time point. The performance of the BDF- and CMFD-based spatial kinetics calculation and the adaptive time step control scheme is examined with the NEACRP control rod ejection and rod withdrawal benchmark problems. The accuracy is first assessed by comparing the BDF-based results with those of the Crank-Nicholson method with an exponential transform. The effectiveness of the adaptive time step control is then assessed in terms of the possible computing time reduction in producing sufficiently accurate solutions that meet the desired solution fidelity.

• 반도체디스플레이기술학회지
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• 제9권3호
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• pp.5-9
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• 2010

Recently, the important issues of solar cell are low cost and high efficiency. Making low cost and high efficiency solar cell, there are many effects to development of inexpensive wafer, simplify process and improve optical, electrical properties. In this the study, the 2 step texturing method using micro blaster was developed to decrease reflection of incident lights. Air bridge electrode structure is suggested to expand the effective surface area and decrease the series resistance of finger electrode. The effects of 1 step texturing and 2 step texturing by micro blaster are compared. Reflectance of 1 step and 2 step texturing are measured 28.7% and 25.5%, respectively. The reflectance of 2 step texturing sample is lower about 3.2% than 1 step textured sample.

• 한국수자원학회논문집
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• 제44권4호
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• pp.275-283
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• 2011

미래 기온변화 정보를 제공하는 General Circulation Model (GCM) 자료, 즉 광역 기온자료를 이용하여 우리나라의 국지 수온변화를 추정하는 연구를 수행하였다. 국지수온 추정은 마산만, 시화호, 낙동강 하구를 대상으로 Two-step 접근방법과 One-step 접근방법을 적용하여 각각의 추정오차를 비교 분석하였다. Two-step 추정방법은 광역 기온으로 국지기온을 추정하는 제1단계에서는 선형회귀분석 기법을 적용하였으며, 모든 지점에서 결정계수가 0.98~0.99 정도로 매우 높게 나타났다. 그리고 국지기온으로 국지수온을 추정하는 제2단계에서는 S-형태함수의 비선형 회귀분석기법을 적용하였으며 이 경우 RMS(Root-mean squared) 오차는 마산만에서 2.07 (온도 증가시기), 1.93 (온도 감소시기), 시화호에서는 2.59, 낙동강 하구에서는 1.58로 파악되었다. 반면 동일한 S-형태함수를 이용한 비선형 회귀분석기법으로 광역기온자료로부터 바로 국지 수온을 추정하는 One-step 접근방법을 적용한 경우, RMS 오차는 마산만이 2.28 (온도증가시기), 1.89 (온도감소시기), 시화호에서는 2.55, 낙동강하구는 1.52로 Two-step 접근방법과 비슷한 수준의 오차를 보이는 것으로 파악되었다. 따라서 광역 기온자료를 이용하여 국지 수온을 추정하는 경우에는 One-step 접근방법도 유용하고 실용적인 것으로 판단된다.

• Structural Engineering and Mechanics
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• 제5권1호
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• pp.59-68
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• 1997

A two-step method is presented for the optimum design of trusses with available sections under stress and Euler buckling constraints. The shape design of the truss is used as a means to convert the discrete solution into a continuous one. In the first step of the method, a continuous solution is obtained by sizing and shape design using an approximate polynomial expression for the buckling coefficients. In the second step, the member sizes obtained are changed to the nearest available sections and the truss is reconfigured by using the exact values for the buckling coefficients. The optimizer used is based on the sequential quadratic programming and the gradients are evaluated in closed form. The method is illustrated by two numerical examples.