• 센서학회지
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• 제30권3호
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• pp.165-169
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• 2021

The objective of this study was to fabricate a novel hydrophobic stent for reducing restenosis by employing electron beam equipment. The stent was fabricated from a CoCr alloy tube by using a femtosecond laser and was treated with argon plasma. Subsequently, the stent's surface specification changed from hydrophilic to hydrophobic. Application of the electron beam offers several advantages such as a short processing time, whole surface reforming, and enhancement of material properties. As the surface of the stent was rendered hydrophobic, it can provide equivalent or enhanced mechanical properties and greater functionality with a higher radial force at the extended stent in a blood vessel. The obtained results corresponding to the mechanical properties indicate that the contact angle increased to approximately 130°, and the radial force increased to approximately 3 N. Furthermore, cell culture experiments were conducted for verifying whether cells were cultured on the surface-modified CoCr surface. Based on the obtained results, it is believed that an effective reduction in the restenosis of inserted vascular stents is possible.

• 문화기술의 융합
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• 제10권6호
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• pp.309-314
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• 2024

의료기기 산업은 최신 과학 기술 발전을 적용하며 급속하게 변화하고 있다. 특히, 생명공학의 발달로 혈액 등 체액을 분석하여 질병을 진단하는 체외진단 의료기기와 인체 조직 및 장기의 역할을 대체할 수 있는 임플란트 의료기기의 비중이 최근 급격히 증가하였다. 새롭게 변화하는 의료기기 산업분야의 인력을 교육하여 공급하기 위해서는 새로운 실습 교육 과정의 개발이 필요하다. 우리는 본 논문에서 니티놀 스텐트와 모형 스텐트 삽입기를 이용한 실습 교육 과정을 개발하여 보고한다. 이 실습 교육의 모형 삽입기는 제조회사에서 사용하는 원자재를 이용하여 쉽게 만들 수 있으며 실습에 사용하는 스텐트들은 의료기기 회사에서 제공하였다. 이 실습을 통하여 학생들은 실제 의료기기 회사 업무의 일부를 경험할 수 있고, 의료기기에 적용되는 공학적 이론들을 실습을 통하여 이해할 수 있게 된다. 한국 의료기기 산업의 글로벌 선두권 진입을 위해서는 대학과 산업체의 긴밀한 협조를 통한 실습 교육과정 개발이 필요하다.

• Journal of Korean Neurosurgical Society
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• 제63권1호
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• pp.34-44
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• 2020

Objective : Despite widespread use of flow diverters (FDs) to treat aneurysms, the exact healing mechanism associated with FDs remains poorly understood. We aim to describe the healing process of aneurysms treated using FDs by demonstrating the histopathologic progression in a canine aneurysm model. Methods : Twenty-one side wall aneurysms were created in common carotid artery of eight dogs and treated with two different FDs. Angiographic follow-ups were done immediately after placement of the device, 4 weeks and 12 weeks. At last follow-up, the aneurysm and the device-implanted parent artery were harvested. Results : Histopathologic findings of aneurysms at 4 weeks follow-up showed intra-aneurysm thrombus formation in laminating fashion, and neointimal thickening at the mid-segment of aneurysm. However, there are inhomogenous findings in aneurysms treated with the same type of FD showing same angiographic outcomes. At 12 weeks, aneurysms of complete and near-complete occlusion revealed markedly shrunken aneurysm filled with organized connective tissues with thin neointima. Aneurysms of incomplete occlusion at 12 weeks showed small amount of organized thrombus around fringe neck and large empty space with thick neointmal formation. Neointimal thickness and diameter stenosis was not significantly different between the groups of FD specification and follow-up period. Conclusion : Intra-aneurysmal thrombus formation and organization seem to be an important factor for the complete occlusion of aneurysms treated using the FD. Neointimal formation could occur along the struts of the FD independently of intra-aneurysmal thrombus formation. However, neointimal formation could not solely lead to complete aneurysm healing.