• 제목/요약/키워드: standard reference materials

Search Result 355, Processing Time 0.028 seconds

A Study on the Development of Soil-based PTMs for Analysis of Benzo[a]pyrene - Focusing on the Evaluation of Homogeneity and Stability for the Certification of Benzo[a]pyrenecandidate Reference Materials - (Benzo[a]pyrene 분석용 토양 숙련도 표준시료 개발에 관한 연구 - 후보 표준물질의 인증을 위한 균질성, 안정성 평가를 중심으로 -)

  • Lee, Minhyo;Lee, Guntaek;Joo, Changkyu;Kim, Yonghun;Lee, Bupyoel;Choe, Sunghun;Kim, Myeongock;Hong, Sukyoung;Kim, Gumhee;Lee, Wonseok
    • Journal of Soil and Groundwater Environment
    • /
    • v.19 no.6
    • /
    • pp.49-58
    • /
    • 2014
  • This study was implemented as a part of the experiment to develop two kinds of soil-based Benzo[a]pyrene (BaP) proficiency testing materials (PTMs) for soil analysis. A test was carried out for the check of solubility of the reference material (high purity reagent) using several solvents. Another test was also conducted for the evaluation of homogeneity and stability of two kinds of candidate soil reference materials. The test analysis of BaP in terms of the candidate materials was conducted according to the Standard Soil Analytical Methods by Ministry of Environment. Dissolution of the reference material was shown to vary depending on solvent type and was higher in the order of Dichloromethane > Acetone > Acetone/MeOH (9 : 1) > N-hexane. In addition, the slope on calibration curve for BaP standard solutions was largest on BaP standard solutions prepared with dichloromethane of the tested solvents. Such tendency appeared egually in the commercial BaP standard solution. Therefore, it is thought to be reasonable to use dichloromethane as the solvent in case of the standard stock solution that is used for the measurement of BaP concentration in soil. ISO 13528 and IUPAC protocol were used for verification of homogeneity on the two kinds of soil candidate materials, Both candidate materials were sufficiently homogeneous. Stability assessment of the two candidate materials was made according to ISO Guide 35 and the result showed that both batches did not have any long-term and short term stability issues that might occur during shipping. However, monitoring results of BaP concentration in soil showed that BaP concentration of the two batches measured at 15 days after the sample preparation was reduced by about 24~37% compared with that of the samples measured on 0 day of the sample preparation. Identification was done with several treatments such as irradiation and sterilization etc. The major cause was shown to be irradiation to the samples.

Effects of Expert-Determined Reference Standards in Evaluating the Diagnostic Performance of a Deep Learning Model: A Malignant Lung Nodule Detection Task on Chest Radiographs

  • Jung Eun Huh; Jong Hyuk Lee;Eui Jin Hwang;Chang Min Park
    • Korean Journal of Radiology
    • /
    • v.24 no.2
    • /
    • pp.155-165
    • /
    • 2023
  • Objective: Little is known about the effects of using different expert-determined reference standards when evaluating the performance of deep learning-based automatic detection (DLAD) models and their added value to radiologists. We assessed the concordance of expert-determined standards with a clinical gold standard (herein, pathological confirmation) and the effects of different expert-determined reference standards on the estimates of radiologists' diagnostic performance to detect malignant pulmonary nodules on chest radiographs with and without the assistance of a DLAD model. Materials and Methods: This study included chest radiographs from 50 patients with pathologically proven lung cancer and 50 controls. Five expert-determined standards were constructed using the interpretations of 10 experts: individual judgment by the most experienced expert, majority vote, consensus judgments of two and three experts, and a latent class analysis (LCA) model. In separate reader tests, additional 10 radiologists independently interpreted the radiographs and then assisted with the DLAD model. Their diagnostic performance was estimated using the clinical gold standard and various expert-determined standards as the reference standard, and the results were compared using the t test with Bonferroni correction. Results: The LCA model (sensitivity, 72.6%; specificity, 100%) was most similar to the clinical gold standard. When expert-determined standards were used, the sensitivities of radiologists and DLAD model alone were overestimated, and their specificities were underestimated (all p-values < 0.05). DLAD assistance diminished the overestimation of sensitivity but exaggerated the underestimation of specificity (all p-values < 0.001). The DLAD model improved sensitivity and specificity to a greater extent when using the clinical gold standard than when using the expert-determined standards (all p-values < 0.001), except for sensitivity with the LCA model (p = 0.094). Conclusion: The LCA model was most similar to the clinical gold standard for malignant pulmonary nodule detection on chest radiographs. Expert-determined standards caused bias in measuring the diagnostic performance of the artificial intelligence model.

The Environmental Load Comparison Evaluation of The Apartment House for Main Construction Materials of Standard Apartment House (표준공동주택의 주요 건설자재 설정을 통한 공동주택 환경부하 비교평가에 관한 연구)

  • Woo, Jee-Hwan;Shin, Sung-Woo
    • KIEAE Journal
    • /
    • v.10 no.1
    • /
    • pp.85-90
    • /
    • 2010
  • The study set up the models of a general standard apartment house and a super high-rise standard apartment house, which were based on the 5 floor plans of the assessment reference houses of the "green homes" provided by the government; such main construction materials as to account for more than 80% of the entire amount of $CO_2$ emission in a construction work were selected; a database was built up for evaluating the environmental loads of the main materials according to the house types that were different from each other in area, block type, combination of living units or floor; and using the database, an attempt was made to develop the technology to assess $CO_2$ emission from the production of construction materials used in the stage of construction.

F.E.M for Analysis of Magnetic Circuits with thin Magnetic Materials (얇은 자성체를 갖는 자기회로의 자장해석을 위한 유한요소법)

  • Kim, Kwon-Sik;Lee, Joon-Ho;Lee, Ki-Sik;Lee, Bok-Yong
    • Proceedings of the KIEE Conference
    • /
    • 1992.07b
    • /
    • pp.573-576
    • /
    • 1992
  • This paper presents a method, which couples the boundary integral terms in the thin magnetic materials with standard FEM used to analyze the rest of it, for analyzing the magnetic fields. The proposed method retains the sparsity and symmetry of the final system matrix, the merits of standard FEM and eliminates the need for fininte elements in the thin magnetic materials, thereby reducing necessary capacity of computer memory and computing time. To verify the usefulness of the proposed alogorithmn, an examples, coil with source currents and thin magnetic materials, is chosen and analyzed. the results are compared with those of the standard FEM by coarse mesh and the proposed method, using standard FEM by fine mesh as a reference.

  • PDF

Ultrasonic Test Criterion for the Explosively Welded Fe-Naval Brass Bonding Quality (초음파법에 의한 폭발접합 이종금속 접합품질 판정레벨 설정에 관한 연구)

  • 장영권;백영남
    • Journal of Welding and Joining
    • /
    • v.19 no.1
    • /
    • pp.40-48
    • /
    • 2001
  • An ultrasonic test method, as a nondestructive test is applied to ensure the clad interface quality assessment. According to the reference codes and standards, not only korea Industrial Standard(KS) but also American Society for Testing and Materials (ASTM) Standard, ultrasonic examination procedures use the pulse-echo, A-scan, back reflection signal drop method and/or side drilled reference hole used to establish the acceptance criteria of clad material test. But the variety of bonding materials and sizes makes it difficult to produce the reference blocks, or thus the criteria. In order to overcome these practical difficulties, new ultrasonic testing criterion is suggested. In this new method, the theoretical interface reflection signal amplitude level is calculated and suggested as an acceptance criteria with the back reflection signal set to 100% FSH(Full Screen Height) which is based on acoustic impedance mismatch at the clad interface for the explosive clad ultrasonic inspection. Applicability of suggested criterion, for the explosive clad Fe-Naval Brass with different bonding quality is confirmed to the pre-existed KS and ASTM specifications and verified by using SEM (Seanning Electron Microscope) micrograph. The results obtained by the suggested method is more conservative than the results according to the KS B 0234 and ASTM A 578 specifications The suggested method could be applicable to any other combination of explosive clad ultrasonic inspection.

  • PDF

A Study of Analytical Sensitivity on TDM Test Kit in Clinical Chemistry (약물검사 키트의 분석 민감도에 대한 연구)

  • Chang, Sang Wu;Kim, Nam Yong;Lee, Hee Gyung;Kim, Hyun Jung;Lee, Yun Jung;Jin, Ok Bae;Kim, Mi Gyung
    • Korean Journal of Clinical Laboratory Science
    • /
    • v.36 no.2
    • /
    • pp.127-130
    • /
    • 2004
  • Analytical sensitivity on TDM test is the lowest concentration that can be distinguished from background noise. The aim of study was to evaluate analytical sensitivity that is also referred to as the lower limit of detection(LLD) about difference between zero calibrator and isotonic saline sample. We tested for 10 days with zero calibrators and 0.85% saline samples while running trilevel control samples under control. Raw data divided by two groups calculated mean and standard deviation from two sample populations and analytical sensitivity by ${\bar{X}}+2SD$. In comparison with isotonic saline samples and zero calibrators, there were significant differences in phenytoin, phenobarbital and vancomycin, etc. Especially analytical sensitivity on phenytoin is at the same level as the upper limit of analytical measurement range with $40{\mu}g/mL$. We think the cause of this is matrix interference. In conclusion, we were sure that standard protocol for analytical sensitivity as lower limit of analytical measurement range on TDM test must be measured with zero standard rather than an isotonic saline sample and type 1 reagent DW for reducing matrix effects within interactions between different materials in a mixture.

  • PDF

A LINKING METHOD OF INFORMATION FACTORS FOR ADOPTING STANDARD MATERIALS INTO APARTMENT HOUSING CONSTRUCTION

  • Geun-Soo Park;Seok-Ho Lim
    • International conference on construction engineering and project management
    • /
    • 2009.05a
    • /
    • pp.1148-1154
    • /
    • 2009
  • This study focus on the suggestion of application manual using assembling reference plane design & standard finish material basis upon material classification code. We see it will function as a tool of a linkage between building design and construction standarization in order to enlarge the applicability of house building material that is produced by the module plan. For a estabilishing of this condition, it is neccessary to link the standardization's result of material--design--construction field. According to this neccessity, we are going to suggest information factor that can make relative business manager easily approach to the standardization practical task.

  • PDF

Validation of Suitability on Proficiency Testing Samples for Acute Toxicity Test with Daphnia magna (생태독성 숙련도 시료의 적절성 평가)

  • Shin, Kisik;Park, Woosang;Lee, Jungseo;Yu, Soonju;Park, Taejin;Kim, Jongmin
    • Journal of Korean Society on Water Environment
    • /
    • v.31 no.1
    • /
    • pp.49-54
    • /
    • 2015
  • Acute toxicity test with Daphnia magna has a variety of factors such as incubation condition of test species, food quality and proficiency of laboratory workers. Therefore, proper proficiency testing samples were required for evaluating the competence of laboratory workers. This study aims to propose some appropriate proficiency testing samples for laboratory workers of acute toxicity test with Daphnia magna. Proposed four kinds of standard samples (Sample A, B, C, and D) for proficiency testing were selected from reference materials which were recommended from Canada and USA WET(Whole Effluent Toxicity) authorities. Proposed standard samples were tested by trial application of proficiency testing, homogeneity and stability checks using repeatability test. Sample A, C and D were estimated ad the suitable candidates for proficiency test standard samples except for Sample B. In addition, Sample A was proved to be the most suitable sample.