• Journal of radiological science and technology
• /
• v.23 no.1
• /
• pp.39-47
• /
• 2000

In this study, we showed a comparison and analysis making use of DWI(diffusion weighted image) using early diagnosis of cerebral Infarction and with the classified T2 weighted image, FLAIR images signal intensity for brain infarction period. period of cerebral infarction after the condition of a disease by ischemic stroke. To compare 3 types of image, we performed polynomial warping and affined transform for image matching. Using proposed algorithm, calculated signal intensity difference between T2WI, DWI, FLAIR and DWI. The quantification values between hand made and calculated data are almost the same. We quantified the each period and performed pseudo color mapping by comparing signal intensity each other according to previously obtained hand made data, and compared the result of this paper according to obtained quantified data to that of doctors decision. The examined mean and standard deviation for each brain infarction stage are as follows ; the means and standard deviations of signal intensity difference between DWI and T2WI for each period are $197.7{\pm}6.9$ in hyperacute, $110.2{\pm}5.4$ in acute, and $67.8{\pm}7.2$ in subacute. And the means and standard deviations of signal intensity difference between DWI and FLAIR for each period are $199.8{\pm}7.5$ in hyperacute, $115.3{\pm}8.0$ in acute, and $70.9{\pm}5.8$ in subacute. We can quantificate and decide cerebral infarction period objectively. According to this study, DWI is very exact for early diagnosis. We classified the period of infarction occurrence to analyze the region of disease and normal region in DW, T2WI, FLAIR images.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.12
• /
• pp.5265-5272
• /
• 2016

Objective: The present study was conducted to evaluate invasive and noninvasive diagnostic methods for detection of Helicobacter pylori (H. pylori) in patients admitted with dyspeptic complaints and to compare sensitivities and specificities. Method: Sets of four gastric biopsy specimens were obtained from a total of 126 patients included in the study. The presence of H. pylori was determined by invasive tests including culture, rapid urease test, polymerase chain reaction (PCR) and histopathology. Among noninvasive tests, urea breath test, serological tests and enzyme-linked immunosorbent assay (ELISA) were performed. Results: H. pylori was isolated in 79 (62.7%) gastric biopsy cultures, whereas positivity was concluded for 105 (83.3%) patients by rapid urease test, for 106 (84.1%) by PCR, for 110 (87.3%) by histopathology, for 119 (94.4%) by urea breath test, and for 107 (84.9%) by ELISA. In the present study, the culture findings and histopathological examination findings were accepted as gold standard. According to the gold standard, urea breath test had the highest sensitivity (96.5%) and the lowest specificity (30%), whereas culture and histopathology had the highest specificities (100%). Conclusion: The use of PCR invasively with gastric biopsy samples yielded parallel results with the gold standard. PCR can be recommended for routine use in the diagnosis of H. pylori.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.26 no.1
• /
• pp.88-97
• /
• 2012

DSOM(Diagnosis System of Oriental Medicine), questionnaire for oriental medical(medicine) diagnosis is an online survey system containing 152 questions for female, 149 questions for male that asking the basic symtoms of 16 pathogenic factors(病機). The result of DSOM denotes reliability according to the level of major symptoms of each pathogenic factor. Standard level of reliability is equal to all 16 pathogenic factor basically except phlegm(痰). In case of phlegm(痰) we give different weight depending on whether the factor includes gray color under the orbit(痰飮氣) or not. To examine reliability of DSOM, statistical analysis has been done to the data of felmale 10101, male 1564 except for bad responses and stored between 1st April 2000 to 3rd June 2011. Based on the study, the conclusions were as follows. Reliability of DSOM. For female, all pathogenic factors showed over 85% confidence level except for phlegm 82.6%. For male, all pathogenic factors showed more than 90% confidence level except two factors, phlegm(痰) indicates 87.% and damp(濕) indicates 89.8%. HH rates among pathogenic factors were more than 50 points. For female, HH rates of other 14 pathogenic factors were all over 80% except for heat(熱) 78.2% and insufficiency of Yang(陽虛) 75.3%. For male HH rates of all pathogenic factors were more than 80% except HH rates of heat 78.2% and damp 77.8%. Research based on a degree of satisfaction of reliability derived from pathogenic factors with scores of HH results in for all 16 pathogenic factors showed over 85% of relatively high level of satisfaction for both sexes whose reliability standard come under 5~4 points. Comparing appearance frequency of pathogenic factors for both sexes. Male only displays higer than female in heat(熱). Whereas female were higher than male for other 15 pathogenic factors and the difference was biggest in heart(心) and least in insufficiency of Yin(陰虛). Comparing appearance frequency order of pathogenic factors for both sexes. Female outdistanced male in blood stasis(血瘀) coldness(寒) blood-deficiency(血虛) phlegm(痰), while male outdistance female in heat(熱) insufficiency of Yin(陰虛) deficiency of qi(氣虛). Male had lower average of each pathogenic factors than female except heat(熱) as well as deficiency of qi(氣虛).

• The Journal of Korean Medicine
• /
• v.28 no.3 s.71
• /
• pp.126-137
• /
• 2007

Objectives : Standardization of pattern identification for stroke and development of a diagnostic tool for Korean medicine. Methods : We organized a committee for stroke diagnosis standardization of Korean traditional medicine and submitted the Korean standard differentiation of the symptoms and signs for stroke (KSDSS). We collected cases through a multi-center network consisting of twelve university hospitals and one local hospital. We analyzed the data with discriminant function and logistic regression. Results : 321 cases were confirmed by diagnosis of medical specialists and residents. They were divided into qi deficiency 30.84%, dampness & phlegm 25.55%, fire & heat 22.43%, eum deficiency 18.69% and blood stasis 2.49%. The accordance rate between discriminant function and doctor's diagnosis was calculated. Conclusions : To make a stroke diagnostic program, we must raise the accordance rate between doctor's diagnosis and the program.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.9
• /
• pp.3595-3604
• /
• 2015

Hepatocellular carcinoma (HCC) has been one of the most fatal malignant tumors worldwide and its associated morbidity and mortality remain of significant concern. Based on in-depth reviews of serological diagnosis of HCC, in addition to AFP, there are other biomarkers: Lens culinaris agglutinin-reactive AFP (AFP-L3), descarboxyprothrombin (DCP), tyrosine kinase with Ig and eprdermal growth factor (EGF) homology domains 2 (TIE2)-espressing monocytes (TEMs), glypican-3 (GPC3), Golgi protein 73 (GP73), interleukin-6 (IL-6), and squamous cell carcinoma antigen (SCCA) have been proposed as biomarkers for the early detection of HCC. The diagnosis of HCC is primarily based on noninvasive standard imaging methods, such as ultrasound (US), dynamic multiphasic multidetector-row CT (MDCT) and magnetic resonance imaging (MRI). Some experts advocate gadolinium diethyl-enetriamine pentaacetic acid (Gd-EOB-DTPA) MRI and contrast-enhanced US as the promising imaging madalities of choice. With regard to recent advancements in tissue markers, many cuting-edge technologies using genome-wide DNA microarrays, qRT-PCR, and proteomic and inmunostaining studies have been implemented in an attempt to identify markers for early diagnosis of HCC. Only less than half of HCC patients at initial diagnosis are at an early stage treatable with curative options: local ablation, surgical resection, or liver transplant. Transarterial chemoembolization (TACE) is considered the standard of care with palliation for intermediate stage HCC. Recent innovative procedures using drug-eluting-beads and radioembolization using Yttrium-90 may exhibit beneficial effects in HCC treatment. During the past few years, several molecular targeted agents have been evaluated in clinical trials in advanced HCC. Sorafenib is currently the only approved systemic treatment for HCC. It has been approved for the therapy of asymptomatic HCC patients with well-preserved liver function who are not candidates for potentially curative treatments, such as surgical resection or liver transplantation. In the USA, Europe and particularly Japan, hepatitis C virus (HCV) related HCC accounts for most liver cancer, as compared with Asia-Pacific regions, where hepatitis B virus (HBV) may play a more important role in HCC development. HBV vaccination, while a vaccine is not yet available against HCV, has been recognized as a best primary prevention method for HBV-related HCC, although in patients already infected with HBV or HCV, secondary prevention with antiviral therapy is still a reasonable strategy. In addition to HBV and HCV, attention should be paid to other relevant HCC risk factors, including nonalcoholic fatty liver disease due to obesity and diabetes, heavy alcohol consumption, and prolonged aflatoxin exposure. Interestingly, coffee and vitamin K2 have been proven to provide protective effects against HCC. Regarding tertiary prevention of HCC recurrence after surgical resection, addition of antiviral treatment has proven to be a rational strategy.

• Journal of the Korean Institute of Gas
• /
• v.28 no.2
• /
• pp.93-104
• /
• 2024

Facility diagnosis is essential for the smooth operation and life extension of rotating equipment used in industrial sites. Compared to other diagnostic methods, vibration diagnosis can find most of the initial defects, such as unbalance, alignment failure, bearing defects and resonance, compared to other diagnostic methods. Therefore, vibration analysis is the most commonly used facility diagnosis method in industrial sites, and is usefully used as a predictive preservation (PdM) technology to manage the condition of the facility. However, since the vibration diagnosis method is performed based on experience based on the standard, it is carried out by experts. Therefore, it is intended to contribute to the reliability of the facility by establishing a system that anyone can easily judge defects by establishing a vibration diagnosis method performed based on experience as a knowledgeable code system. An algorithm was developed based on the ISO-20816 standard for vibration measurement, and the reliability was verified by comparing the results of vibration measurement at various demonstration sites such as petrochemical plant compressors, hydrogen charging stations, and industrial machinery with the results of analysis using a development system. The developed algorithm can contribute to predictive maintenance (PdM) technology that anyone can diagnose the condition of the rotating machine at industrial sites and identify defects early to replace parts at the exact time of replacement. Furthermore, it is expected that it will contribute to reducing maintenance costs and downtime due to the failure of rotating machines when applied to various industrial sites such as oil refining facilities, transportation, production facilities, and aviation facilities.

• 한국환경농학회:학술대회논문집
• /
• 2009.07a
• /
• pp.240-272
• /
• 2009

Recently, as Foot and Mouth disease(FMD) outbreaks in South-East Asia, Taiwan, China, we cannot loose our tense to sustain our FMD free country status. And we have increasing possibility of disease inflow because of continual outbreaks of FMD type A, O and Asia 1 in neighbored countries, foreign visitor and foreign workers. So we have to be urgently ready for strengthen surveillance, early-report and early-diagnosis. So the most important things in epidemic control of livestock are co-work between central and local epidemic control office and field epidemic control. However, potential risk for FMD recurrence and sporadic occurrence of epidemic disease still threaten our livestock farmhouse, so we have to be ready for bio-security against these threatening. For these reasons, I will introduce the concept, etiology and epidemiology of disease and investment/ analysis of health management standard of main animals like cattle and pig which is applied to the inside and outside of country. With these references, we have to manage livestock health management thoroughly by establishing livestock health management standard and notifying special veterinarian and livestock farmer of these standard. Later on, prevention and quarantine of epidemic outbreak and establishing livestock health management standard should be undertaken primarily for sustainable growth and stability of livestock farm industry.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.22 no.1
• /
• pp.262-266
• /
• 2008

We plan to make the standardization of the pattern identifications for stroke and differentiate them by tongue diagnosis. We make a case report form which has questionnaires for tongue diagnosis in stroke patients. And we collected cases from the multi center network which consists of twelve university hospitals and one local hospital. The cases confirmed by diagnosis of medical specialists and residents are 321 cases. They are divided into Qi Defficiency 30.84%, Dampness& Phlegm 25.55%, Fire & Heat 22.43%, Eum Defficiency 18.69% and Blood Stasis 2.49%. We analyzed the markers which classified into the color of tongue body, the color of fur, the quality of fur, the dryness of tongue, the shape of tongue. To make a stroke pattern identification standard, we must try variable ways.

• Imaging Science in Dentistry
• /
• v.50 no.2
• /
• pp.153-159
• /
• 2020

Purpose: This study was conducted evaluate the influence of reconstruction parameters of micro-computed tomography (micro-CT) images on bone mineral density (BMD) analyses. Materials and Methods: The sample consisted of micro-CT images of the maxillae of 5 Wistar rats, acquired using a SkyScan 1174 unit (Bruker, Kontich, Belgium). Each acquisition was reconstructed following the manufacturer's recommendations(standard protocol; SP) for the application of artifact correction tools(beam hardening correction [BHC], 45%; smoothing filter, degree 2; and ring artifact correction [RAC], level 5). Additionally, images were reconstructed with 36 protocols combining different settings of artifact correction tools (P0 to P35). BMD analysis was performed for each reconstructed image. The BMD values obtained for each protocol were compared to those obtained using the SP through repeated-measures analysis of variance with the Dunnett post hoc test(α=0.05). Results: The BMD values obtained from all protocols that used a BHC of 45% did not significantly differ from those obtained using the SP (P>0.05). The other protocols all yielded significantly different BMD values from the SP(P<0.05). The smoothing and RAC tools did not affect BMD values. Conclusion: BMD values measured on micro-CT images were influenced by the BHC level. Higher levels of BHC induced higher values of BMD.

• Genomics & Informatics
• /
• v.21 no.4
• /
• pp.52.1-52.10
• /
• 2023

Accurate and efficient microbial diagnosis is crucial for effective molecular diagnostics, especially in the field of human healthcare. The gold standard equipment widely employed for detecting specific microorganisms in molecular diagnosis is quantitative real-time polymerase chain reaction (qRT-PCR). However, its limitations in low metagenomic DNA yield samples necessitate exploring alternative approaches. Digital PCR, by quantifying the number of copies of the target sequence, provides absolute quantification results for the bacterial strain. In this study, we compared the diagnostic efficiency of qRT-PCR and digital PCR in detecting a particular bacterial strain (Staphylococcus aureus), focusing on skin-derived DNA samples. Experimentally, specific primer for S. aureus were designed at transcription elongation factor (greA) gene and the target amplicon were cloned and sequenced to validate efficiency of specificity to the greA gene of S. aureus. To quantify the absolute amount of microorganisms present on the skin, the variable region 5 (V5) of the 16S rRNA gene was used, and primers for S. aureus identification were used to relative their amount in the subject's skin. The findings demonstrate the absolute convenience and efficiency of digital PCR in microbial diagnostics. We suggest that the high sensitivity and precise quantification provided by digital PCR could be a promising tool for detecting specific microorganisms, especially in skin-derived DNA samples with low metagenomic DNA yields, and that further research and implementation is needed to improve medical practice and diagnosis.