• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5177-5182
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• 2012

Purpose: To compare the efficacy and safety of epidermal growth factor receptor tyrosine kinase inhibitormonotherapy (EFGR-TKIs: gefitinib or erlotinib) with standard second-line chemotherapy (single agent docetaxel or pemetrexed) in previously treated advanced non-small-cell lung cancer (NSCLC). Methods: We systematically searched for randomized clinical trials that compared EGFR-TKI monotherapy with standard second-line chemotherapy in previously treated advanced NSCLC. The end points were overall survival (OS), progression-free survival (PFS), overall response rate (ORR), 1-year survival rate (1-year SR) and grade 3 or 4 toxicities. The pooled hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: Eight randomized controlled trials (totally 3218 patients) were eligible. Our meta-analysis results showed that EGFR-TKIs were comparable to standard second-line chemotherapy for advanced NSCLC in terms of overall survival (HR 1.00, 95%CI 0.92-1.10; p=0.943), progression-free survival (HR 0.90, 95%CI 0.75-1.08, P=0.258) and 1-year-survival rate (RR 0.97, 95%CI 0.87-1.08, P=0.619), and the overall response rate was higher in patients who receiving EGFR-TKIs(RR 1.50, 95%CI 1.22-1.83, P=0.000). Sub-group analysis demonstrated that EGFR-TKI monotherapy significantly improved PFS (HR 0.73, 95%CI: 0.55-0.97, p=0.03) and ORR (RR 1.96, 95%CI: 1.46-2.63, p=0.000) in East Asian patients, but it did not translate into increase in OS and 1-year SR. Furthermore, there were fewer incidences of grade 3 or 4 neutropenia, febrile neutropenia and neutrotoxicity in EGFR-TKI monotherapy group, excluding grade 3 or 4 rash. Conclusion: Both interventions had comparable efficacy as second-line treatments for patients with advanced NSCLC, and EGFR-TKI monotherapy was associated with less toxicity and better tolerability. Moreover, our data also demonstrated that EGFR-TKImonotherapy tended to be more effective in East Asian patients in terms of PFS and ORR compared with standard second-line chemotherapy. These results should help inform decisions about patient management and design of future trials.

• 한국실내디자인학회논문집
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• 제22권1호
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• pp.339-349
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• 2013

The primary purpose of this research was to set up the standard guidelines for the planning of interior architectural environments of the detention facilities at the Korean Police Stations. By visit-studying the actual interior environmental conditions of 5 different kinds' domestic Correcting Facilities and 5 domestic police detention facilities and 2 foreign police detention facilities, comparing them to the existing Korean correctional institutions' cell facilities, that the strengths and weaknesses had been analyzed to extract the main concepts and the planning scheme for the Standard Korean Police Detention Facilities. By reserching the National human Right Commitee's Anual Reports, three different indexes were picked out for those analysis : the Environmental control index, the Detention Service support index, the Environmental support index. These three indexes will be used as Key factors for the planning of interior architectural environments of the detention facilities at the Korean Police Stations.: (1)the Environmental control index to establish the Space Program, the Spatial Hierarchy and the horizontal & vertical Security Blocks, (2)the Detention Service support index for the central Environmental Control & Security System, the Secured Privacy for both detainees & police offices, (3)the Environmental support index for the gender-respected segregation of cell zones, the psychological & physical safety design factors, the construction standards of all rooms in a detention facility. The result of this study should be used as the guidelines for "The Standard Plans and Regulations for the Korean Police Detention Facilities" to respect fundamental human rights.

• 인터넷정보학회논문지
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• 제11권4호
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• pp.23-32
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• 2010

본 논문에서는 해쉬 기반 RFID 태그를 위한 보안성이 향상된 인증 프로토콜을 제안하고, 제안한 인증 프로토콜 기반으로 한 RFID 태그의 디지털 코덱을 설계한다. 제안한 프로토콜은 태그와 back-end 서버 사이에서 3-way 질의 응답 인증 프로토콜을 기본으로 하고 있으며, 안전한 인증 메커니즘을 구현하기 위해, ISO/IEC 18000-3 표준에서 규정된 3가지 타입의 프로토콜 패킷을 개선된 형태로 수정한다. 제안한 방법은 Man-in-the-middle과 Replay attacks과 같은 능동 공격의 방어에 특히 유효하다. 제안된 프로토콜의 효과를 검증하기 위하여 RFID 태그에서의 디지털 코덱은 Verilog HDL을 사용하여 설계하였고 Hynix $0.25\;{\mu}m$ standard-cell library을 갖춘 Synopsys Design Compiler을 이용하여 합성하였다. 보안 분석 및 실험결과를 통해, 본 논문에서 제안된 방법이 사용자의 데이터 보안, 태그 익명성, Man-in-the-middle attack 예방, replay attack, 위조방지 및 위치 추적 등에 서 성능이 개선됨을 보였다.

• 한국측량학회지
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• 제38권2호
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• pp.131-140
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• 2020

Recently the importance of BIM (Building Information Modeling) that enables 3D location-based design and construction work is being highlighted around the world. In Korea, the road map has been established to settle the design based on BIM using drone survey results by 2025. As the first step, BIM would be applied to road construction projects worth more than 50 billion Korean Won from 2020. On the other hand, drone survey regulation has been enacted and the data for drone survey cost were also included on Standard of construction estimate in 2020. However, more careful improvement is required to reflect drone survey results in BIM design and construction. Currently, Engineering instructions and Standard of construction estimate specifies that earthwork volume must be calculated by cross section method only. So it is required to add the method of DEM (Digital Elevation Model) based volume calculation on these regulations to realize BIM application. In order for that, this study verified the method of DEM based earthwork volume calculation. To get an accurate DEM for accurate volume computation, drone survey was carried out according to the drone survey regulation and then could get an accurate DEM data which have errors less than 3cm in X, Y and 6.8cm in H. As each DEM cell has 3D coordinate component, the volume of each cell can be calculated by obtaining the height of area of the cell then total volume is calculated by multiplying total number of cells by volume of each cell for the construction area. Verification for the new calculation method compare with existing method was carried out. The difference between DEM based volume by drone survey and cross section based volume by traditional survey was less than 1.33% and it can be seen that new DEM method will be able to be applied to BIM design and construction instead of cross section method.

• Journal of Microbiology and Biotechnology
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• 제16권5호
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• pp.786-790
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• 2006

Cellular components of Lactococcus lactis ssp. lactis (heat-killed whole cells, cytoplasm, and cell walls) were tested for their in vivo immunopotentiating activity. Peritoneal macrophages from mice orally administered with heat-killed whole cells exhibited significantly greater phagocytic activity than the groups administered with cell-wall fraction or cytoplasm fraction. The cytotoxicity of natural-killer cells was the highest in the group administered with whole cells, and the production of cytokines ($IFN-\gamma$, IL-2, and IL-12) in spleen cells was significantly higher, when cellular components were injected, and it tended to be higher in the cell-wall and cytoplasm groups than in the whole-cell group. Interestingly, the cytokine production of Peyer's patch cells was high, when cytoplasm fractions were administered. These results demonstrate that whole cells and cytoplasm and cell-wall fractions of L. lactis ssp. lactis have immunopotentiating activities, which are related to the stimulation of Peyer's patches.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2008년도 추계학술대회 논문집
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• pp.131-133
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• 2008

A serious problem of the 21st century is the supply of energy resources. Reserves of fossil fuels are facing depletion: renewable energy resources must be developed in this era. Dye sensitized solar cell (DSC) has been very economical and easy method to convert solar energy to electricity. Recently a novel tandem cell structure is proposed to improve photocurrent of DSC. To fabricated a tandem cell, the mesh structure of counter electrode is essential for the improvement in transmittance. In this study, we conducted the experiment to get the characteristic of DSC with mesh counter electrode. Under the standard test condition (AM 1.5, 100mW/$cm^2$), we obtained the maximum efficiency of 3.41% and the transmittance of 72% in the DSC with mesh counter electrode.

• International Journal of Automotive Technology
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• 제8권5호
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• pp.651-658
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• 2007

This paper presents a new type of fuzzy logic-based power control strategy for fuel cell hybrid electric vehicles designed to improve their fuel economy while maintaining the battery's state of charge. Since fuel cell systems have inherent limitations, such as a slow response time and low fuel efficiency, especially in the low power region, a battery system is typically used to assist them. To maximize the advantages of this hybrid type of configuration, a power distribution control strategy is required for the two power sources: the fuel cell system and the battery system. The required fuel cell power is procured using fuzzy rules based on the vehicle driving status and the battery status. In order to show the validity and effectiveness of the proposed power control strategy, simulations are performed using a mid-size vehicle for three types of standard drive cycle. First, the fuzzy logic-based power control strategy is shown to improves the fuel economy compared with the static power control strategy. Second, the robustness of the proposed power control strategy is verified against several variations in system parameters.

• Food Science and Biotechnology
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• 제14권3호
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• pp.405-409
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• 2005

Cellular components of Lactococcus lactis ssp. lactis (heat-killed whole cells, cytoplasm, and cell walls) were tested for their in vivo immunopotentiating activities. Peritoneal macrophages from mice injected intraperitoneally with cell-wall fractions exhibited significantly greater phagocytic activity than groups injected with whole cells or cytoplasm fraction. Cytotoxicity of natural-killer cells was highest in cytoplasm fractions. Production of cytokines (IFN-${\gamma}$, IL-2, IL-6, and IL-12) in spleen cells was significantly higher when cellular components were injected intraperitoneally, and tended to be higher in whole-cell and cytoplasm groups than in cell-wall group. These results demonstrate lactic acid bacteria whole cells and their cytoplasm and cell-wall tractions have immunopotentiating activities.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1891-1898
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• 2016

Imperata cylindrica, a tall tufted grass which has multiple pharmacological applications is one of the key ingredients in various traditional medicinal formula used in India. Previous reports have shown that I. cylindrica plant extract inhibited cell proliferation and induced apoptosis in various cancer cell lines. To our knowledge, no studies have been published on the effect of I. cylindrica leaf extract on human oral cancers. The present study was undertaken in order to evaluate the anticancer properties of the leaf extract of I. cylindrica using an oral squamous cell carcinoma cell line SCC-9 as an in vitro model system. A methanol extract from dried leaves of I. cylindrica (ICL) was prepared by standard procedures. Effects of the ICL extract on the morphology of SCC-9 cells was visualized by microscopy. Cytotoxicity was determined by MTT assay. Effects of the ICL extract on colony forming ability of SCC-9 cells was evaluated using clonogenic assay. Cell cycle analysis was performed by flow cytometry and induction of apoptosis was determined by DNA fragmentation assay. The ICL extract treatment caused cytotoxicity and induced cell death in vitro in SCC-9 cells in a dose-dependent manner. This treatment also significantly reduced the clonogenic potential and inhibited cell proliferation by arresting the cell cycle in the G2/M phase. Furthermore, DNA fragmentation assays showed that the observed cell death was caused by apoptosis. This is the first report showing the anticancer activity of the methanol extracts from the leaves of I. cylindrica in human oral cancer cell line. Our data indicates that ICL extract could be considered as one of the lead compounds for the formulation of anticancer therapeutic agents to treat/manage human oral cancers. The natural abundance of I. cylindrica and its wide geographic distribution could render it one of the primary resource materials for preparation of anticancer therapeutic agents.

• BMB Reports
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• 제56권4호
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• pp.258-264
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• 2023

As a high-grade soft-tissue sarcoma (STS), undifferentiated pleomorphic sarcoma (UPS) is highly recurrent and malignant. UPS is categorized as a tumor of uncertain differentiation and has few options for treatment due to its lack of targetable genetic alterations. There are also few cell lines that provide a representative model for UPS, leading to a dearth of experimental research. Here, we established and characterized new cell lines derived from two recurrent UPS tissues. Cells were obtained from UPS tissues by mincing, followed by extraction or dissociation using enzymes and culture in a standard culture environment. Cells were maintained for several months without artificial treatment, and some cell clones were found to be tumorigenic in an immunodeficient mouse model. Interestingly, some cells formed tumors in vivo when injected after aggregation in a non-adherent culture system for 24 h. The tissues from in vivo study and tissues from patients shared common histological characteristics. Pathways related to the cell cycle, such as DNA replication, were enriched in both cell clones. Pathways related to cell-cell adhesion and cell-cell signaling were also enriched, suggesting a role of the mesenchymal-to-epithelial transition for tumorigenicity in vivo. These new UPS cell lines may facilitate research to identify therapeutic strategies for UPS.