Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Effects of Intraperitoneal Administration of Lactococcus lactis ssp. lactis Cellular Fraction on Immune Response

  • Kim, Ji-Yeon (Department of Food Standard Evaluation, Korea Food & Drug Administration) ;
  • Lee, Seong-Kyu (Department of Applied Biological Chemistry, The University of Tokyo) ;
  • Jeong, Do-Won (School of Agricultural Biotechnology, and Center of Agricultural Biomaterials, Seoul National University) ;
  • Hachimura, Satoshi (Department of Applied Biological Chemistry, The University of Tokyo) ;
  • Kaminogawa, Shuichi (Department of Food Science and Technology, College of Bioresource Science, Nihon University) ;
  • Lee, Hyong-Joo (School of Agricultural Biotechnology, and Center of Agricultural Biomaterials, Seoul National University)
  • Published : 2005.06.30
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Abstract

Cellular components of Lactococcus lactis ssp. lactis (heat-killed whole cells, cytoplasm, and cell walls) were tested for their in vivo immunopotentiating activities. Peritoneal macrophages from mice injected intraperitoneally with cell-wall fractions exhibited significantly greater phagocytic activity than groups injected with whole cells or cytoplasm fraction. Cytotoxicity of natural-killer cells was highest in cytoplasm fractions. Production of cytokines (IFN-${\gamma}$, IL-2, IL-6, and IL-12) in spleen cells was significantly higher when cellular components were injected intraperitoneally, and tended to be higher in whole-cell and cytoplasm groups than in cell-wall group. These results demonstrate lactic acid bacteria whole cells and their cytoplasm and cell-wall tractions have immunopotentiating activities.

Keywords

References

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