• Biomolecules & Therapeutics
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• 제31권1호
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• pp.108-115
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• 2023

Numerous psychotropic and addictive substances possess structural features similar to those of β-phenethylamine (β-PEA). In this study, we selected 29 β-PEA derivatives and determined their structure-activity relationship (SAR) to their ability to inhibit dopamine (DA) reuptake; conducted docking simulation for two selected compounds; and identified their potential functionals. The compounds were subdivided into arylethylamines, 2-(alkyl amino)-1-arylalkan-1-one derivatives and alkyl 2-phenyl-2-(piperidin-2-yl)acetate derivatives. An aromatic group, alkyl group, and alkylamine derivative were attached to the arylethylamine and 2-(alkyl amino)-1-arylalkan-1-one derivatives. The inhibitory effect of the compounds on dopamine reuptake increased in the order of the compounds substituted with phenyl, thiophenyl, and substituted phenyl groups in the aromatic position; compounds with longer alkyl groups and smaller ring-sized compounds at the alkylamine position showed stronger inhibitory activities. Docking simulation conducted for two compounds, 9 and 28, showed that the (S)-form of compound 9 was more stable than the (R)-form, with a good fit into the binding site covered by helices 1, 3, and 6 of human dopamine transporter (hDAT). In contrast, the (R, S)-configuration of compound 28 was more stable than that of other isomers and was firmly placed in the binding pocket of DAT bound to DA. DA-induced endocytosis of dopamine D₂ receptors was inhibited when they were co-expressed with DAT, which lowered extracellular DA levels, and uninhibited when they were pretreated with compound 9 or 28. In summary, this study revealed critical structural features responsible for the inhibition of DA reuptake and the functional role of DA reuptake inhibitors in regulating D₂ receptor function.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권2호
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• pp.483-503
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• 2014

In this paper, human action recognition using pyramid histograms of oriented gradients and collaborative multi-task learning is proposed. First, we accumulate global activities and construct motion history image (MHI) for both RGB and depth channels respectively to encode the dynamics of one action in different modalities, and then different action descriptors are extracted from depth and RGB MHI to represent global textual and structural characteristics of these actions. Specially, average value in hierarchical block, GIST and pyramid histograms of oriented gradients descriptors are employed to represent human motion. To demonstrate the superiority of the proposed method, we evaluate them by KNN, SVM with linear and RBF kernels, SRC and CRC models on DHA dataset, the well-known dataset for human action recognition. Large scale experimental results show our descriptors are robust, stable and efficient, and outperform the state-of-the-art methods. In addition, we investigate the performance of our descriptors further by combining these descriptors on DHA dataset, and observe that the performances of combined descriptors are much better than just using only sole descriptor. With multimodal features, we also propose a collaborative multi-task learning method for model learning and inference based on transfer learning theory. The main contributions lie in four aspects: 1) the proposed encoding the scheme can filter the stationary part of human body and reduce noise interference; 2) different kind of features and models are assessed, and the neighbor gradients information and pyramid layers are very helpful for representing these actions; 3) The proposed model can fuse the features from different modalities regardless of the sensor types, the ranges of the value, and the dimensions of different features; 4) The latent common knowledge among different modalities can be discovered by transfer learning to boost the performance.

• The Journal of the Acoustical Society of Korea
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• 제14권2E호
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• pp.5-11
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• 1995

본 연구에서는 화상에 있어서 패턴의 공간적인 특징을 추출하기위한 목적으로 신경회로망을 적용하는 방법을 제안하였다. 적용한 신경회로망은 3중의 구조를 가지며, 그 학습방법으로는 back-propagation 알고리즘을 사용하였다. 또한 이동이나 회전과 같은 패턴의 변위에 대응하기 위하여, 화상으로부터 co-occurrence matrix를 구하여, 신경회로망의 입력패턴으로 사용하였다. 제안한 방법을 평가하기 위하여 종래의 대표적방법인 화소의 spectral 정보를 이용한 최대유도법(maximum likelihood method)으로는 식별이 곤란한 시가지지역과 모래지역을 선정하여, 본 방법과 Haralick에 의하여 제안된 teture features를 이용하여 분류한 결과, texture features를 이용한 방법으로는 67%~89%의 식별률을 얻었음에 반하여, 본 연구에서 제안한 신경회로망을 사용한 방법으로는 80%~98%의 안정되고 높은 식별률을 얻었다.

• 한국ITS학회 논문지
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• 제12권6호
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• pp.108-115
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• 2013

영상취득 장치를 이용한 지능화된 감시 장치의 개발 기술 또한 발전하고 있다. 이 분야의 기술 영역은 감시하고 있는 장소에 어떤 사람이나 물체를 탐지하는 전경 분리 기술과 사람이나 물체의 이동 경로를 파악하는 추적 기술로 나뉜다. 본 논문에서는 이동체를 탐지하는 기술로서 잡음이나 조도의 변화에 비교적 안정적인 엔진개발을 위한 개선된 알고리즘을 제안한다. 논문의 제안 알고리즘은 사람이나, 동물, 또는 비교적 저속 운행 중인 차량 등의 탐지에 적합한 모델로서, 조도의 변화나 잡음에 안정적이면서 실시간 처리가 가능한 방법을 고안하는 데 주안점을 두고 있다.

• 생물정신의학
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• 제21권1호
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• pp.1-13
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• 2014

Normal aging causes changes in the brain volume, connection, function and cognition. The brain changes with increases in age and difference of gender varies at all levels. Studies about normal brain aging using various brain magnetic resonance imaging (MRI) variables such as gray and white matter structural imaging, proton spectroscopy, apparent diffusion coefficient, diffusion tensor imaging and functional MRI are reviewed. Total volume of brain increases after birth but decreases after 9 years old. During adulthood, total volume of brain is relatively stable. After 35 years old, brain shrinks gradually. The changes of gray and white matters by aging show different features. N-acetylaspartate decreases or remains unchanged but choline, creatine and myo-inositol increase with aging. Apparent diffusion coefficient decreases till 20 years old and then becomes stable during adulthood and increase after 60 years old. Diffusion tensor properties in white matter tissue are variable during aging. Resting-state functional connectivity decreases after middle age. Structural and functional brain changes with normal aging are important for studying various psychiatric diseases such as dementia, schizophrenia and bipolar disorder. Our review may be helpful for studying longitudinal changes of these diseases and successful aging.

• 유통과학연구
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• 제12권11호
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• pp.35-43
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• 2014

Purpose - This study evaluates the mutual influential power regarding the trade volumes of Japan and USA, based on a literature review and an empirical analysis. Through the literature review, I could evaluate each country's actual import-export volume and its status. Further, I could evaluate how each country could influence its trade outcome, through empirical analysis. Research design, data, and methodology - This study aims to review the trade structure to improve Japan-USA economic and social cooperation, as the two countries have reciprocal complementary features, and to examine trade weaknesses and analyze factors influencing trade and its direction, as well as to identify ways to expand trade. Results - The intra-economic potential cooperation fields are numerous. Additionally, anticipated profits from these fields are stable as compared to other fields in the regional economic integration. Conclusion - The interrelations between the two economic identities can provide optimal opportunities for industrial technology cooperation. Under the current aggravated competition in industrial fields, it is advisable to identify ways to secure stable resource suppliers, including the development of export markets.

• BMB Reports
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• 제33권3호
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• pp.268-275
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• 2000

In contrast to the pyrimidine (6-4)pyrimidone photoproduct [(6-4) adduct], its Dewar valence isomer (Dewar product) is low mutagenic and produces a broad range of mutations with a 42 % replicating error frequency. In order to determine the origin of the mutagenic property of the Dewar product, we used experimental NMR restraints and molecular dynamics to determine the solution structure of a Dewar·lesion DNA decamer duplex, which contains a mismatched base pair between the 3'-T residue and an opposed G residue. The 3'-T of the Dewar lesion forms stable hydrogen bonds with the opposite G residue. The helical bending and unwinding angles of the DW/GA duplex, however, are much higher than those of the DW/AA duplex. The stable hydrogen bonding of the G 15 residue does not increase the thermal stability of the overall helix. It also does not restore the distorted backbone conformation of the DNA helix that is caused by the forming of a Dewar lesion. These structural features implicate that no thermal stability, or conformational benefits of G over A opposite the 3'-T of the Dewar lesion, facilitate the preferential incorporation of an A. This is in accordance with the A rule during translesion replication and leads to the low frequent $3'-T{\rightarrow}C$ mutation at this site.

• 지질공학
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• 제12권3호
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• pp.295-303
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• 2002

암반사면의 붕괴형태는 원호, 평면, 쐐기 또는 전도파괴로 구분하며, 각각의 붕괴는 역학적인 안정조건을 벗어날 경우 붕괴가 발생하는 것으로 평가한다. 특히, 암반사면 평면파괴는 절리면의 방향성에 대하여 일반적으로 '활동가능성이 있는 면의 주향과 절취사면의 주향의 차이가 약 20$^{\circ}$ 이상일 경우에는 발생하지 않는 것으로 알려져 있고 설계되고 있다. 그러나, 이러한 안정조건을 만족한 경우라도 사면의 붕괴가 빈번히 발생하고 있는 실정이다. 따라서, 본 논문에서는 이러한 안정된 사면조건에도 불구하고 현장 지형여건상 붕괴가 발생한 사례를 중심으로 국내 암반사면의 평면파괴조건을 제시하였다.

• Journal of Microbiology and Biotechnology
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• 제1권2호
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• pp.90-95
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• 1991

A ${\alpha}-galactosidase{\;}({\alpha}-D-galactoside$ galactohydrolase; EC 3.2.1.22) was purified from the culture filtrate of Penicillium purpurogenum by DEAE-cellulose column chromatography, gel filtration of Bio gel p-l00, and subsequent SP-Sephadex C-25 chromatography. The final preparation thus obtained showed a single band on polyacrylamide disc-gel and SDS-polyacrylamide gel electrophoresis. The molecular weight and isoelectric point were determined to be 63,000 and pH 4.0 by SDS-polyacrylamide gel electrophoresis and isoelectric focusing, respectively. The galactosidase exhibited maximum activity at pH 4.5 and $55^{\circ}C$, and was stable between pH 2 and 5, and also stable up to $40^{\circ}C$. The enzyme activity was not affected considerably by treatment with other metal compounds except mercuric chloride and silver nitrate. Copra galactomannan was finally hydrolyzed to galactose, mannose and mannobiose through the sequential actions of the purified galactosidase and mannanase from the same strain. The enzyme hydrolyzed melibiose and raffinose, but not lactose.

• 디지털산업정보학회논문지
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• 제6권4호
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• pp.57-65
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• 2010

Application of WBAN technology in medical field facilitates the prevention of diseases by collecting the vital signs remotely. It also enables to prevent the accidental emergency situation in advance plus long-tem monitoring of patients with chronic diseases such as heart diseases, hypertension, or the elderly and infirm. For emergency patients, major vital signal information collected by the 'Sensing' should have the top priority and such information should be transferred as promptly as possible without competition. In addition, when an emergency occurs to a patient, a priority mechanism is necessitated for a urgent message to get through to the final destination. However, LR-WPAN IEEE 802.15.4 technology does not consider such emergency message handling features. To deal with aforementioned issues, the IEEE 802.15.4 super frame protocol structure has been designed for stable transfer of emergency information in WBAN environment in this study, and alternation to super frame structures have been made, allowing GTS(Guaranteed Time Slot) can be used first at CFP (Contention Free Period) by reserving the resources in advance and prioritize the emergency signals. NS-2 has been utilized for the performance test and analysis.