• 대한종양외과학회지
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• 제9권2호
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• pp.80-86
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• 2013

Purpose: Hypermethylation of human mut L homologue 1 (hMLH1) promoter region is known to cause sporadic microsatellite instability (MSI) colorectal cancers. 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folate metabolism, acting as a methyl donor for DNA methylation. In this study, we investigate whether the polymorphism of MTHFR 677C>T plays a role in the alteration of the promoter-specific hypermethylation, predisposing to MSI colorectal cancers. Methods: Total of 487 sporadic colorectal cancer patients in CHA Bundang Medical Center were collected. MSI was identified when two or more are positive among five microsatellite markers (BAT25, BAT26, D17S250, D5S346, D2S123). The others were classified as microsatellite stable (MSS). Polymorphism of MTHFR 677C>T was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: MSI was observed in 65 of 487 patients (12.73%). MSI colorectal cancers showed similar clinicopathological features with previously reported; younger age onset, right-sided preponderance, mucinous and poorly differentiated histology, lower stage, fewer lymph node metastases than MSS tumors (each P<0.05). The frequency of MTHFR 677TT genotype was 17.7% in the MSI group higher than 14.6% in the MSS group (P=0.17). Although not statistically significant, compared to the MTHFR 677CC referent, MTHFR 677 CT+TT genotype was more likely to have MSI than MSS (odds ratio, 1.81; 95% confidence interval, 0.94 to 3.68; P=0.06). Conclusion: This study demonstrated higher frequency of MTHFR 677TT genotype in MSI colorectal cancers. Furthermore, individuals with MTHFR 677CT+TT variant type might potentially develop MSI rather than MSS colorectal cancers.

• Structural Monitoring and Maintenance
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• 제4권4호
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• pp.331-350
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• 2017

Based on the alternative stabilization diagram by varying the time lag parameter in the stochastic subspace identification analysis, this study aims to investigate the measurements from several cases of civil structures for extending the applicability of a recently noticed criterion to ensure stable identification results. Such a criterion demands the time lag parameter to be no less than a critical threshold determined by the ratio of the sampling rate to the fundamental system frequency and is firstly validated for its applications with single measurements from stay cables, bridge decks, and buildings. As for multiple measurements, it is found that the predicted threshold works well for the cases of stay cables and buildings, but makes an evident overestimation for the case of bridge decks. This discrepancy is further explained by the fact that the deck vibrations are induced by multiple excitations independently coming from the passing traffic. The cable vibration signals covering the sensor locations close to both the deck and pylon ends of a cable-stayed bridge provide convincing evidences to testify this important discovery.

• 대한기계학회논문집A
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• 제31권8호
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• pp.817-825
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• 2007

During thirty years, deterministic chaos has moved center stage in many areas of applied mathematics. One important stimulus for this, particularly in the early 1970s, was work on nonlinear aspects of the dynamics of plant and animal populations. There are many situations, at least to a crude first approximation, by a simple first-order difference equation. Past studies have shown that such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behavior, from stable points, to a bifurcating hierarchy of stable cycles, to apparently random fluctuations. But higher-order spectral analyses of such behavior are usually not considered. Higher-order spectra of a signal contain important information that is not present in its power spectrum. So, if we find the spectral pattern and get information from it, it will be able to be used effectively in so many fields. Hence, this paper uses auto bicoherence and bicoherence residue which are sort of bispectrum. Applying these to behavior of logistic difference equation, which is typical chaotic signal, the phenomenon of phase coupling and the appearance of frequency band can be analyzed. Such information means that bispectral analysis is useful to detect nonlinearity of signal.

• 한국농공학회논문집
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• 제63권2호
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• pp.61-74
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• 2021

Agriculture is most closely related to weather, and the government pursues stable food production by weather research. However, abnormal weather conditions have occurred frequently around the world in recent years, and stable food production has been threatened. Among them, heavy snow in winter tends to increase in frequency and size, which causes serious damage to greenhouses. Therefore, it is imperative to build a system reflecting various demands to reduce the damage to agricultural facilities caused by heavy snow. A business model can realize this as a way of commercialization, however, no suitable model has been presented to date. Therefore, this study aims to design a representative business model that can establish a safety system by distributing a greenhouse disaster prevention warning system for heavy snow to farms.

• 한국전자파학회논문지
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• 제23권11호
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• pp.1239-1247
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• 2012

본 논문에서는 GaN HEMT 소자를 이용한 X-대역 반도체 전력 증폭 장치(SSPA)의 설계 및 제작에 대하여 논의한다. 반도체 전력 증폭 장치는 안정적인 전원을 공급해 주는 전원공급기, 통신과 내부 모듈을 제어하기 위한 제어부, RF 신호를 증폭하기 위한 RF부로 구성된다. 특히, RF부를 구성하는 능동 소자로 TriQuint사의 GaN HEMT Bare 소자를 이용하였다. RF부는 초단, 드라이브 단, 메인 출력 단으로 구성되어 있으며, 각 앰프는 입 출력 정합을 통하여 구현하였다. 제작된 반도체 전력 증폭 장치는 X-대역(500 MHz 대역폭)에서 duty 26 %, 최장 펄스 100 us 조건에서 300 W 이상의 출력을 얻을 수 있었으며, 향후 선박용 레이더 시스템에 적용할 예정이다.

• 한국전자파학회논문지
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• 제28권12호
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• pp.1007-1010
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• 2017

본 논문에서는 건물 내에서 통신성능 저하의 원인이 되는 인접 채널의 신호를 제어하기 위해 대역 저지 특성을 갖는 주파수 선택 표면구조를 설계하였다. 제안된 구조는 입사파의 편파 및 입사각에 안정적인 주파수 특성 구현을 위해 프랙탈 형상 기반의 소형화된 단위구조를 사용하였으며, 실제 적용성을 고려, 적은 제작비용으로 대량생산이 용이한 인쇄전자 기술을 이용하여 얇은 필름형 주파수 선택 표면구조를 제작하였다. 전통적인 회로제작 방식인 PCB 공정이 아닌 전도성 Ag 잉크를 이용한 스크린 프린팅 공정을 통해 생산성 및 환경성을 개선하였으며, 설계한 결과를 바탕으로 자유공간 측정을 통해 입사파의 편파 및 입사각에 대한 안정적인 특성을 검증하고, 실제 건물 내벽에 적용 후, 수신 신호강도 측정을 통해 주파수 선택 성능을 확인하였다.

• Journal of Magnetics
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• 제15권4호
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• pp.213-220
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• 2010

Since the hypothalamus immediately reacts to a nerve by processing all the information from the human body and the external stimulus being conducted, it performs a significant role in internal secretion; thus, a diverse and rapid stimulus pulse is required. By detecting Zero Detector accurately via the application of AVR on-Chip (ATMEL) using commercial electricity, chopping generates a stimulus pulse to the brain using an IGBT gate to designate a new magnetic stimulation following treatment and diagnosis. To simplify and generate a diverse range of stimuli for the brain, chopping can be used as a free magnetic stimulator. Then, commercial frequency (60Hz) is chopped precisely at the first level of the leakage transformer to deliver an appropriate stimulus pulse towards the hypothalamus when necessary. Discharge becomes stable, and the chopping frequency and duty-ratio provide variety after authorizing a high-pressure chopping voltage at the second level of the magnetic stimulator. These methods have several aims. The first is to apply a variable stimulus pulse via accurate switching frequency control by a voltaic pulse or a pulse repetition rate, according to the diagnostic purpose for a given hypothalamus. Consequently, the efficiency tends to increase. This experiment was conducted at a maximum of 210 W, a magnetic induced amplitude of 0.1~2.5 Tesla, a pulse duration of $200{\sim}350\;{\mu}s$, magnetic inducement of 5 Hz, stimulus frequency of 0.1~60 Hz, and a duration of stimulus train of 1~10 sec.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.91-96
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• 2013

Background: p53 alterations have been implicated in the development of many cancers, such as gastric cancer, but there is no evidence of p53 intron alterations in gastritis lesions. The aim of this study was to investigate the p53 intron alterations in gastritis along with p53 and mismatch repair protein expression and microsatellite status. Materials and Methods: PCR-sequencing was conducted for introns 2-7 on DNA extracted from 97 paired samples of gastritis lesions and normal adjacent tissue. Abnormal accumulation of p53 and mismatch repair proteins was investigated using immunohistochemistry. In addition, microsatellite status was evaluated with reference to five mononucleotide markers. Results: Gastritis cases included 41 males and 56 females in the age range of 15-83 years, 87.6% being H.pylori positive. IVS2+38, IVS3ins16 and IVS7+72 were the most polymorphic sites. Their minor allele frequency values were as follows: 0.38, 0.21 and 0.06, respectively. Samples with GG genotype at IVS2+38 and CT at IVS7+72 had no insertion. Moreover, most of the stable samples (91.9 %) had a G allele at IVS2+38. All of the samples were IHC negative for p53 protein, microsatellite stable and expressed mismatch repair proteins. p53 alterations were prominent in the H. Pylori+ group, but without statistical significance. Conclusions: According to our results, some p53 polymorphisms such as IVS2+38, IVS3ins16 and IVS7+72, because of their correlations together or with microsatellite status may contribute to gastritis development. However, so far effects on p53 expression and function remain unclear. Therefore, a comprehensive survey is needed to delineate their biological significance.

• 운동과학
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• 제26권2호
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• pp.103-114
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• 2017

INTRODUCTION: Regulation of skeletal muscle protein mass is implicated not only in exercise performance but in metabolic health. Exercise in combination with nutrition, particularly dietary protein/amino acid intake, are the pragmatic approach that effectively induces muscle anabolic response (i.e., muscle hypertrophy) through regulating protein synthesis and breakdown. PURPOSE: The purpose of this review was to summarize available data on the effect of exercise intervention and amino acids intake on muscle protein synthesis and breakdown and provide an insight into development of an effective exercise intervention and amino acids supplements, applicable to training practice. METHODS: In this review, we have reviewed currently available data mainly from stable isotope tracer studies with respect to the effect of exercise intervention and protein or amino acid supplement on muscle protein anabolic response. CONCLUSIONS: Taken together, exercise alone may not be effective in achieving a positive net muscle protein balance due to the fact that protein breakdown still exceeds protein synthesis until nutrition intake such as protein/amino acids. It appears that muscle anabolic response increases in proportional to the amount of protein intake up to 20 - 35 g depending on quality of protein, age, differences on exercise intensity, duration, and frequency, and individual's training status

• 한국추진공학회지
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• 제20권3호
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• pp.96-102
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• 2016

7톤 엔진 시험 전에 엔진 시동/정격구동/종료 특성을 확인하고자 나로우주센터 터보펌프 실매질 시험설비에서 파워팩 시험을 수행하였다. 가스발생기 연소실의 동압은 0.2 bar이하로 측정되어 연소 불안정을 발생하지 않았고, 터보펌프에 장착된 RPM 및 가속도 센서 신호 분석 결과, 예측 RPM 범위 안에서 파워팩 시험이 안정하게 수행되었다는 것을 확인하였다.