• Journal of Life Science
• /
• v.26 no.2
• /
• pp.265-274
• /
• 2016

Toxin-antitoxin (TA) systems are ubiquitous genetic modules that are evolutionally conserved in bacteria and archaea. TA systems composed of an intracellular toxin and its antidote (antitoxin) are currently classified into five types. Commonly, activation of toxins under stress conditions inhibits diverse cellular processes and consequently induces cell death or reversible growth inhibition. These effects of toxins play various physiological roles in such as regulation of gene expression, growth control (stress response), programmed cell arrest, persister cells, programmed cell death, phage protection, stabilization of mobile genetic elements or postsegregational killing of plasmid-free cells. Accordingly, bacterial TA systems are commonly considered as stress-responsive genetic modules. However, molecule screening for activation of toxin in TA system is available as development of antimicrobial agents. In addition, cytotoxic effect induced by toxin is used as effective cloning method with antitoxic effect of antitoxin; consequently cells containing cloning vector inserted a target gene can survive and false-positive transformants are removed. Also, TA system is applicable to efficient single protein production in biotechnology industry because toxins that are site-specific ribonuclease inhibit protein synthesis except for target protein. Furthermore, some TA systems that induce apoptosis in eukaryotic cells such as cancer cells or virus-infected cells would have a wide range of applications in eukaryotes, and it will lead to new ways of treating human disease. In this review, we summarize the current knowledge on bacterial TA systems and their applications.

• Journal of the Korean Society of Hazard Mitigation
• /
• v.11 no.3
• /
• pp.209-218
• /
• 2011

The present study proposes a new estimation relationship for the transmission rate of the steel breakwater which is expected to make up for the weakness points in existing hard solution for shore protection. The steel breakwater consists of the wave dissipator of the dual horizontal plates, the supporting columns and their foundations, and thus its respective designs should also be conducted one by one. Furthermore, the breakwater has to ensure both functions of shore protection and structure stabilization. The study produced experimental data for the stability and safety investigation of the steel breakwater. The forces acting on the steel breakwater were classified into two categories, one is vertical up and down loads for the pile resistance and the other was maximum difference of the vertical load acting on horizontally different position for the torsion. The study applied the stability force produced by the summation of maximum pressure at each point and the safety force acting on each point simultaneously. The regular wave corresponding to the significant wave was utilized for measuring wave pressure and force. The study showed the method for the proper position of submerged upper plate by considering occurrence frequency of tide level. The design process finally determined by trial and error is proposed in the present study.

• Journal of The Korean Society of Integrative Medicine
• /
• v.6 no.4
• /
• pp.39-45
• /
• 2018

Purpose : The purpose of this study is to investigate the effect of core motion pattern on abdominal muscle thickness on unstable support surface using sling suspension system and to provide an effective exercise program for therapeutic rehabilitation in clinical practice. Methods : In this study, we used the flank exercise using a sling. It was intended for 21 healthy men and 9 healthy women. Before and after the exercise of the subjects, abdominal muscles (EO, IO, TrA the thickness of the muscle) was determined using a diagnostic ultrasonic apparatus. The period of exercise was 3 times a week for 6 weeks. The exercise for each group started with 3 sets per week and 1 set per week was added. A description of the method and attitude of each exercise is as follows. First, the push-up flank 's exercise position is to put both feet on the sling and hold the floor with both hands. Second, the side flank's exercise postures take the side flanks, while the two legs hang on the sling and one arm supports the body with an articulated bend (about $90^{\circ}$). Third, the elbow flank's exercise position is to put the two legs on the sling, and take a flank posture with the arms bent and joint bending (about $90^{\circ}$). Results : There was a significant difference in the thickness of the muscle in the three flank movements after the exercise (p<.05). The most significant difference was in the change of the muscle thickness in the abdominal muscle, the outer muscle, and the stomach in the elbow flank exercise after exercise. There was a significant difference between the mean thickness of the abdominal muscles according to the flank type after exercise (p<.05). Conclusion : In flank exercise for core stabilization using sling, it is considered effective to strengthen the abdominal muscles by considering the support surface, difficulty level, change of movement pattern.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.49 no.5
• /
• pp.373-381
• /
• 2021

This paper details the result of flight experiment that examines performance of roll angle estimation algorithm of slowly rolling munition taking time delay of measurement into account when measurement comes in delayed fashion. As the measurement is passed through low pass filter for numerical stabilization and de-noising purpose which induces time delay, we design augmented state Kalman filter that incorporates distribution models of stochastic delay over time. Flight experiment was conducted to verify the algorithm at around 250m high AGL(Above Ground Level) conveying velocity of 28m/s from fixed-wing mother plane to the munition. Munition was made spun with respect to its roll axis using internal reaction wheel afterward. Numerical comparison of proposing method's roll estimation performance with that of commercial aerospace graded GPS/INS shows that proposed filter design can effectively compensate time delay of measurement.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
• /
• v.13 no.6
• /
• pp.590-596
• /
• 2020

In the island areas where system connection with the commercial power grid is difficult, it is quite important to find a method to efficiently manage energy produced with independent microgrids. In this paper, a prosumer management system for P2P power transaction was realized through the testing the power meter and the response rate of the collected data for the power produced in the small-scale microgrids in which hybrid models of solar power and wind power were implemented. The power network of the microgrid prosumer was composed of mesh structure and the P2P power transaction was tested through the power meter and DC power transmitter in the off-grid sites which were independently constructed in three places. The measurement values of the power meter showed significant results of voltage (average): 380V + 0.9V, current (average): + 0.01A, power: 1000W (-1W) with an error range within ±1%. Stabilization of the server was also confirmed with the response rate of 0.32 sec. for the main screen, 2.61 sec. for the cumulative power generation, and 0.11 sec for the power transaction through the transmission of 50 data in real time. Therefore, the proposed system was validated as a P2P power transaction system that can be used as an independent network without transmitted by Korea Electric Power Corporation (KEPCO).

• Journal of Aerospace System Engineering
• /
• v.16 no.4
• /
• pp.60-67
• /
• 2022

An Electro-Optical Tracking System (EOTS) is an electric optical system with EO/IR cameras, laser sensors, and an IMU. The EOTS calculates coordinates of targets, using attitude and acceleration measured by the IMU. In particular for an armed aircraft, the performance of the weapon system depends on how quickly and accurately it acquires the target coordinates. The IMU should be operated after alignment is complete, to meet the coordinate accuracy required by the weapon system so the initial stabilization time of the IMU should be reduced, by quickly measuring the attitude and acceleration. Alignment is the process of determining the initial attitude by resolving the attitude error of the IMU, and the IMU of mission equipment such as an airborne EOTS, uses velocity matching based on the velocity from GPS/INS for aircraft navigation. In this paper, a method is presented to improve the transfer alignment performance of the airborne EOTS, by maneuvering aircraft and the mission equipment. First, the performance factor of the alignment was identified, as a heading error through the velocity matching model and simulation results. Then acceleration maneuvers and attitude changes were necessary, to correct the error. As a result of flight tests applied to an EOTS on a OOO aircraft system, the transfer alignment performance was improved as the duration time was decreased, by more than five times when the aircraft accelerated by more than 0.2g and the EOTS was moving until 6.7deg/s.

• Journal of the Society of Disaster Information
• /
• v.17 no.4
• /
• pp.794-801
• /
• 2021

Purpose: The effectiveness of the transport vehicle management system of the Chemical Substances Control Act will be studies and used as basic data for future system improvement plans. Method: After the enforcement of the Chemical Substances Control Act, the effectiveness for the transport vehicle management system was studies by comparing the transport plan, guidance and inspection status, safety training completion management, ect., and the reduction rate of chemical accidents. Results: The average number of chemical accidents in transport vehicles nationwide is 20 each year. And It is decreasing with the stabilization of the Chemical Substances Control Act('15.1.1). The first reason for the decrease in chemical accidents is the increase in submission of transport plans. Second, as the guidance and inspection rate increased every year, the shipper company's management of transport companies was naturally strengthened. Finally, it is judged that chemical accident caused by transport vehicles decrease through safety education. Conclusion: The current tranport vehicle management system of the Chemical Substances Control Act is effective. However, further research is needed to improve the practical and efficient transport vehicle management system.

• Geomechanics and Engineering
• /
• v.32 no.1
• /
• pp.111-123
• /
• 2023

The slope of an open cut tunnel is located above the exit of the Leijia tunnel on the Changgan high-speed railway. During the excavation of the open cut tunnel foundation pit, the slope slipped twice, a large landslide of 92500 m³ formed. The landslide body and unstable slope body not only caused the foundation pit of the open cut tunnel to be buried and the anchor piles to be damaged but also directly threatened the operational safety of the later high-speed railway. Therefore, to study the stability change in the slope of the open cut tunnel under heavy rain and excavation conditions, a 3D numerical calculation model of the slope is carried out by Midas GTS software, the deformation mechanism is analyzed, anti-sliding measures are proposed, and the effectiveness of the anti-sliding measures is analyzed according to the field monitoring results. The results show that when rainfall occurs, rainwater collects in the open cut tunnel area, resulting in a transient saturation zone on the slope on the right side of the open cut tunnel, which reduces the shear strength of the slope soil; the excavation at the slope toe reduces the anti-sliding capacity of the slope toe. Under the combined action of excavation and rainfall, when the soil above the top of the anchor pile is excavated, two potential sliding surfaces are bounded by the top of the excavation area, and the shear outlet is located at the top of the anchor pile. After the excavation of the open cut tunnel, the potential sliding surface is mainly concentrated at the lower part of the downhill area, and the shear outlet moves down to the bottom of the open cut tunnel. Based on the deformation characteristics and the failure mechanism of the landslides, comprehensive control measures, including interim emergency mitigation measures and long-term mitigation measures, are proposed. The field monitoring results further verify the accuracy of the anti-sliding mechanism analysis and the effectiveness of anti-sliding measures.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.50 no.1
• /
• pp.1-10
• /
• 2024

In this study, a quercetin benton gel (QUERPLEX) that stabilized quercetin was prepared using organo hectorite, and its efficacy was confirmed. In addition, a comparative study was conducted on the stability and effectiveness of applying this to sunscreen cosmetics. It was confirmed that QUERPLEX remained stable without showing crystal precipitation and growth for 4 weeks. As a result of measuring antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), it showed antioxidant activity depending on the concentration, and showed a radical elimination ability of 70% or more at a concentration of 2,500 ppm or more, confirming a significant effect. Anti-inflammatory activity experiments using RAW 264.7 cells confirmed that NO production decreased in a concentration-dependent manner by reducing NO production by 8% at 25 ㎍/mL, 23% at 50 ㎍/mL, and 84% at 100 ㎍/mL. As a result of confirming the stability of the formulation according to the method of quercetin in the sunscreen formulation, the stability of the formulation was improved when quercetin was added directly to the formulation. It also improved the UV protection index on in vitro and in vivo, which is expected to have the potential as a component that can have a new boosting effect on UV protection. These results suggest that organo hectorite is very effective as a quercetin carrier and that it can be applied in cosmetic formulations by not only expressing the efficacy of quercetin but also bringing about additional effects.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.10 no.1
• /
• pp.45-53
• /
• 2012

The metal chloride wastes from a pyrochemical process to recover uranium and transuranic elements has been considered as a problematic waste difficult to apply to a conventional solidification method due to the high volatility and low compatibility with silicate glass. In this study, a dechlorination approach to treat LiCl-KCl waste for final disposal was adapted. In this study, a $SiO_2-Al_2O_3-P_2O_5$ (SAP) inorganic composite as a dechlorination agent was prepared by a conventional sol-gel process. By using a series of SAPs, the dechlorination behavior and consolidation of reaction products were investigated. Different from LiCl waste, the dechlorination reaction occurred mainly at two temperature ranges. The thermogravimetric test indicated that the first reaction range was about $400^{\circ}C$ for LiCl and the second was about $700^{\circ}C$ for KCl. The SAP 1071 (Si/Al/P=1/0.75/1 in molar) was found to be the most favorable SAP as a dechlorination agent under given conditions. The consolidation test revealed that the bulk shape and the densification of consolidated forms depended on the SAP/Salt ratios. The leaching test by PCT-A method was performed to evaluate the durability of consolidated forms. This study provided the basic information on the dechlorination approach. Based on the experimental results, the dechlorination method using a $SiO_2-Al_2O_3-P_2O_5$ (SAP) could be considered as one of alternatives for the immobilization of waste salt.